Page last updated: 2024-09-03

y 27632 and y 27632, dihydrochloride, (4(r)-trans)-isomer

y 27632 has been researched along with y 27632, dihydrochloride, (4(r)-trans)-isomer in 2 studies

Compound Research Comparison

Studies (y 27632)	Trials (y 27632)	Recent Studies (post-2010) (y 27632)	Studies (y 27632, dihydrochloride, (4(r)-trans)-isomer)	Trials (y 27632, dihydrochloride, (4(r)-trans)-isomer)	Recent Studies (post-2010) (y 27632, dihydrochloride, (4(r)-trans)-isomer)
1,924	3	891	9	0	5

Protein Interaction Comparison

Protein	Taxonomy	y 27632, dihydrochloride, (4(r)-trans)-isomer (IC50)
Rho-associated protein kinase 2	Homo sapiens (human)	0.061
Protein kinase C epsilon type	Homo sapiens (human)	0.335
Rho-associated protein kinase 1	Homo sapiens (human)	0.046
Serine/threonine-protein kinase N2	Homo sapiens (human)	0.07

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M	1
Büttner, FH; Chen, R; Cywin, CL; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Paw, Z; Prokopowicz, A; Shih, CK; Snow, R; Wu, F; Young, E	1

Other Studies

2 other study(ies) available for y 27632 and y 27632, dihydrochloride, (4(r)-trans)-isomer

Article	Year
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51 Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases	2007
Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorganic & medicinal chemistry letters, 2010, Jun-01, Volume: 20, Issue:11 Topics: Animals; Antihypertensive Agents; Blood Pressure; Crystallography, X-Ray; Drug Discovery; Isoquinolines; Models, Molecular; Protein Kinase Inhibitors; Rats; rho-Associated Kinases	2010

Article

Year

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007

Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account.

Bioorganic & medicinal chemistry letters, 2010, Jun-01, Volume: 20, Issue:11

Topics: Animals; Antihypertensive Agents; Blood Pressure; Crystallography, X-Ray; Drug Discovery; Isoquinolines; Models, Molecular; Protein Kinase Inhibitors; Rats; rho-Associated Kinases

2010