y 27632 has been researched along with wortmannin in 25 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (wortmannin) | Trials (wortmannin) | Recent Studies (post-2010) (wortmannin) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 4,066 | 2 | 726 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 24 (96.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| McGovern, SL; Shoichet, BK | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Niggli, V | 2 |
| Bao, J; Kishi, H; Kohama, K | 1 |
| Amano, M; Araki, S; Feng, J; Hartshorne, DJ; Isaka, N; Ito, M; Kaibuchi, K; Kureishi, Y; Machida, H; Nakano, T | 1 |
| Arita, N; Fujikawa, H; Kaibuchi, K; Sato, M; Tani, E; Yamaura, I | 1 |
| Asazuma, N; Kainoh, M; Ozaki, Y; Satoh, K; Suzuki-Inoue, K; Tanaka, T; Yatomi, Y | 1 |
| Baker, RC; Farley, JM; Mamoon, AM | 1 |
| Chitaley, K; Webb, RC | 1 |
| Burdyga, T; Ford, LE; Mitchell, RW; Ragozzino, J | 1 |
| Aktories, K; Barth, H; Boutillier, S; Brock, C; Feuerstein, TJ; Leemhuis, J; Meyer, DK; Nürnberg, B | 1 |
| Hashimoto, N; Kawanabe, Y; Masaki, T | 1 |
| Fujii, K; Fukuhara, M; Iida, M; Lin, Y; Matsumura, K; Tsuchihashi, T | 1 |
| Butcher, JT; García, AJ; Nerem, RM; Penrod, AM | 1 |
| Alteraifi, AM; Chodniewicz, D; Zhelev, DV | 1 |
| Molenaar, P; Russell, FD | 1 |
| Baxter, GF; Bower, HS; Hamid, SA | 1 |
| Ishibashi, F | 1 |
| Groeneveld, AB; Musters, RJ; Sipkema, P; van der Heijden, M; van Nieuw Amerongen, GP; Versteilen, AM | 1 |
| Fukushima, H; Hirata, H; Kobayashi, N; Koguchi, W; Machida, Y; Mamada, Y; Matsuoka, H; Shinoda, M; Suzuki, N; Tabei, K; Takeshima, H; Yokotsuka, F | 1 |
| Ichihara, K; Itagaki, M; Kaneta, S; Kano, S; Satoh, K; Takaguri, A | 1 |
| Fu, X; Huang, J; Simoncini, T; Tan, Z; Wang, T; Xiang, Q; Zhang, Y; Zheng, S; Zhou, K | 1 |
25 other study(ies) available for y 27632 and wortmannin
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Kinase inhibitors: not just for kinases anymore.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation | 2003 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
A membrane-permeant ester of phosphatidylinositol 3,4, 5-trisphosphate (PIP(3)) is an activator of human neutrophil migration.
Topics: Actins; Amides; Androstadienes; Cell Membrane Permeability; Cell Movement; Cell Polarity; Cell Size; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esters; Humans; Intracellular Signaling Peptides and Proteins; Neutrophils; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Wortmannin | 2000 |
Inhibitory effects of ML-9, wortmannin, and Y-27632 on the chemotaxis of vascular smooth muscle cells in response to platelet-derived growth factor-BB.
Topics: Amides; Androstadienes; Animals; Aorta; Azepines; Becaplermin; Cells, Cultured; Chemotaxis; Enzyme Inhibitors; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pyridines; Rabbits; Wortmannin | 2000 |
Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase.
Topics: Amides; Androstadienes; Animals; Arachidonic Acid; Calcium; Cell Membrane Permeability; Detergents; Enzyme Inhibitors; Femoral Artery; Glutathione Transferase; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Octoxynol; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Pyridines; Rabbits; Recombinant Fusion Proteins; rho-Associated Kinases; Type C Phospholipases; Wortmannin | 2001 |
Importance of Rho-kinase-mediated phosphorylation of myosin light chain in vasospasm.
Topics: Amides; Androstadienes; Animals; Basilar Artery; Chelating Agents; Dogs; Egtazic Acid; Enzyme Inhibitors; Genistein; Guanine Nucleotide Dissociation Inhibitors; Immunoblotting; Intracellular Signaling Peptides and Proteins; Isoenzymes; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rho-Specific Guanine Nucleotide Dissociation Inhibitors; rhoA GTP-Binding Protein; Vasodilation; Vasospasm, Intracranial; Wortmannin | 2001 |
Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1).
Topics: Amides; Androstadienes; Antibodies; Antigens, CD; Apyrase; Blood Platelets; cdc42 GTP-Binding Protein; Collagen; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoglobulin Fab Fragments; Integrin alpha2; Integrin beta1; Integrins; p21-Activated Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Adhesiveness; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; Pyrimidines; rac GTP-Binding Proteins; Receptors, Collagen; Wortmannin | 2001 |
Activation of phospholipase D in porcine tracheal smooth muscle: role of phosphatidylinositol 3-kinase and RhoA activation.
Topics: Acetylcholine; Amides; Androstadienes; Animals; Calcium; Chromones; Enzyme Activation; In Vitro Techniques; Male; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phospholipase D; Pyridines; rhoA GTP-Binding Protein; Swine; Tetradecanoylphorbol Acetate; Trachea; Wortmannin | 2001 |
Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling.
Topics: Amides; Androstadienes; Animals; Aorta; Calcium Channel Blockers; Calcium Channels; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Relaxants, Central; Nitric Oxide; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstriction; Vasodilation; Wortmannin | 2002 |
Microtubule-disruption-induced and chemotactic-peptide-induced migration of human neutrophils: implications for differential sets of signalling pathways.
Topics: Amides; Androstadienes; Cell Movement; Colchicine; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Microtubules; Myosin Light Chains; Neutrophils; Oligopeptides; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Wortmannin | 2003 |
Force and myosin light chain phosphorylation in dog airway smooth muscle activated in different ways.
Topics: Acetylcholine; Amides; Androstadienes; Animals; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Isometric Contraction; Marine Toxins; Muscle, Smooth; Myosin Light Chains; Oxazoles; Phosphorylation; Potassium Chloride; Pyridines; Tetany; Trachea; Wortmannin | 2003 |
Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites.
Topics: Amides; Androstadienes; Animals; Brain; Colforsin; Dendrites; Enzyme Inhibitors; Genes, Reporter; Glioma; Glutathione Transferase; Humans; Kinetics; Myosin-Light-Chain Kinase; Neuroblastoma; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Recombinant Fusion Proteins; rho GTP-Binding Proteins; Rolipram; Transfection; Tumor Cells, Cultured; Wortmannin | 2004 |
Characterization of G proteins involved in activation of nonselective cation channels and arachidonic acid release by norepinephrine/alpha1A-adrenergic receptors.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Amides; Androstadienes; Animals; Arachidonic Acid; Calcium Channels; Cation Transport Proteins; CHO Cells; Cricetinae; Enzyme Inhibitors; Estrenes; GTP-Binding Proteins; Mutagenesis; Norepinephrine; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Receptors, Adrenergic, alpha-1; Transfection; Wortmannin | 2004 |
Role of ERK and Rho kinase pathways in central pressor action of urotensin II.
Topics: Amides; Androstadienes; Animals; Blood Pressure; Consciousness; Drug Synergism; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Urotensins; Wortmannin | 2004 |
Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments.
Topics: Amides; Androstadienes; Aorta; Aortic Valve; Cell Polarity; Cell Shape; Endothelial Cells; Endothelium; Endothelium, Vascular; Focal Adhesions; Glycoproteins; Intracellular Signaling Peptides and Proteins; Organ Specificity; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rheology; rho-Associated Kinases; Signal Transduction; Stress, Mechanical; Sus scrofa; Wortmannin | 2004 |
Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants.
Topics: Actins; ADP Ribose Transferases; Amides; Anaphylatoxins; Androstadienes; Botulinum Toxins; Chemotactic Factors; Chemotaxis; Humans; Interleukin-8; Intracellular Signaling Peptides and Proteins; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pseudopodia; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Wortmannin | 2004 |
Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart.
Topics: Alkaloids; Amides; Androstadienes; Benzophenanthridines; Endothelin-1; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Myocardial Contraction; Myocardium; Myosin-Light-Chain Kinase; Phenanthridines; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Urotensins; Wortmannin | 2004 |
Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Androstadienes; Animals; Apoptosis; Cardiotonic Agents; Coronary Circulation; Cytoskeletal Proteins; Enzyme Activation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Microfilament Proteins; Multiprotein Complexes; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Wortmannin | 2007 |
High glucose increases phosphocofilin via phosphorylation of LIM kinase due to Rho/Rho kinase activation in cultured pig proximal tubular epithelial cells.
Topics: Amides; Androstadienes; Animals; Chromones; Cofilin 1; Enzyme Activation; Enzyme Inhibitors; Glucose; Kidney Tubules, Proximal; Lim Kinases; LLC-PK1 Cells; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction; Swine; Wortmannin | 2008 |
Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis.
Topics: Actins; Amides; Androstadienes; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cytochalasin D; Depsipeptides; Endothelium, Vascular; Humans; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Reperfusion Injury; rho-Associated Kinases; Thiazolidines; Wortmannin | 2008 |
Cardioprotective effects of pitavastatin on cardiac performance and remodeling in failing rat hearts.
Topics: Amides; Androstadienes; Animals; Cardiotonic Agents; Heart; Heart Failure; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Quinolines; Rats; Rats, Inbred Dahl; rhoA GTP-Binding Protein; Ventricular Remodeling; Wortmannin | 2009 |
Possible mechanisms underlying statin-induced skeletal muscle toxicity in L6 fibroblasts and in rats.
Topics: Amides; Androstadienes; Animals; Caspase 3; Cell Culture Techniques; Cell Survival; Creatine Kinase; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fibroblasts; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Infusions, Intravenous; L Cells; Mice; Muscle, Skeletal; Pravastatin; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Simvastatin; Subcellular Fractions; Time Factors; Wortmannin | 2009 |
Progesterone enhances vascular endothelial cell migration via activation of focal adhesion kinase.
Topics: Amides; Androstadienes; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Endothelial Cells; Estrenes; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Furans; Human Umbilical Vein Endothelial Cells; Humans; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Progesterone; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Receptors, Progesterone; rho-Associated Kinases; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Wortmannin | 2012 |