y 27632 and u 0126

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation

Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

Topics: Actin Cytoskeleton; Amides; Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; Chromones; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Oncogene Protein p21(ras); Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; Transcription, Genetic; Transfection

Topics: Amides; Animals; Aorta; Apoptosis Regulatory Proteins; Blotting, Western; Butadienes; Cell Differentiation; Cell Division; Cells, Cultured; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Enzyme Inhibitors; ets-Domain Protein Elk-1; Fibroblasts; Genes, Dominant; Genes, Reporter; Glutathione Transferase; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Muscle, Smooth; Myocytes, Smooth Muscle; NIH 3T3 Cells; Nitriles; Nuclear Proteins; Phosphorylation; Polymerase Chain Reaction; Proto-Oncogene Proteins; Pyridines; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; RNA, Messenger; Serum Response Factor; Signal Transduction; Sphingosine; Time Factors; Trans-Activators; Transcription Factors; Transfection; Up-Regulation

Topics: Amides; Animals; Butadienes; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Hydrogen-Ion Concentration; Intracellular Signaling Peptides and Proteins; Lysophospholipids; MAP Kinase Kinase 1; Nitriles; Phenylephrine; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Pyridines; Receptors, Adrenergic, alpha; Receptors, G-Protein-Coupled; rho-Associated Kinases; Signal Transduction; Sodium-Hydrogen Exchangers; Transfection

Topics: Actins; Amides; Blotting, Western; Breast Neoplasms; Butadienes; Carcinoma; Catalysis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; CSK Tyrosine-Protein Kinase; Culture Media, Serum-Free; Depsipeptides; Down-Regulation; Fibronectins; Flow Cytometry; Humans; Immunoprecipitation; Insulin-Like Growth Factor I; Integrin alpha5beta1; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Microscopy, Phase-Contrast; Models, Biological; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; src-Family Kinases; Time Factors

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Butadienes; Calcium; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Genistein; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Nitriles; Phenylephrine; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley

Topics: Amides; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Blotting, Northern; Blotting, Western; Brain Injuries; Bromodeoxyuridine; Butadienes; Cell Count; Cell Movement; Cell Proliferation; Cells, Cultured; Coculture Techniques; Colforsin; Cyclin D1; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Functional Laterality; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Male; MAP Kinase Kinase Kinases; Mice; Mice, Knockout; Microglia; Nitriles; Oligopeptides; Pyridines; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thrombin; Time Factors

Topics: Amides; Aorta; Atorvastatin; Bacterial Proteins; Bacterial Toxins; Butadienes; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Drug Synergism; Flavonoids; Group II Phospholipases A2; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Janus Kinase 2; Lovastatin; Myocytes, Smooth Muscle; NF-kappa B; Nitriles; Phospholipases A; Phospholipases A2; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Pyrroles; RNA Stability; Up-Regulation

Topics: Amides; Animals; Antioxidants; Ascorbic Acid; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Hemin; I-kappa B Kinase; Immunoblotting; Interferon Regulatory Factor-1; Interferon-gamma; Lipopolysaccharides; Luciferases; Mice; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Phosphorylation; Pyridines; Quercetin; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor; Transcription Factor AP-1; Transfection

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aorta; Benzamides; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cells, Cultured; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Fluoxetine; Humans; Microscopy, Video; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Pyridines; rhoA GTP-Binding Protein; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Antagonists; Stress Fibers; Time Factors

Topics: 4-Aminopyridine; Amides; Animals; Animals, Newborn; Bicuculline; Brain-Derived Neurotrophic Factor; Butadienes; Cells, Cultured; Cerebral Cortex; Chlorocebus aethiops; Chromones; COS Cells; Cysteine-Rich Protein 61; Gene Expression Regulation; Genes, fos; Hippocampus; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; N-Methylaspartate; Neurons; Nitriles; Potassium Chloride; Prosencephalon; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; RNA Interference; Serum Response Factor; Signal Transduction; Synaptic Transmission; Transcription Factors; Transcription, Genetic; Transfection

Topics: Amides; Butadienes; Cell Line; Cell Movement; Chorionic Villi; Dinoprostone; Enzyme Inhibitors; Female; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Pregnancy; Pregnancy Trimester, First; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Trophoblasts

Topics: Amides; Butadienes; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Fibronectins; Glioblastoma; Humans; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Platelet-Derived Growth Factor; Pyridines; rho-Associated Kinases

Topics: Adipocytes; Adipogenesis; Amides; Butadienes; Cells, Cultured; Cytochalasin D; Cytoskeleton; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; Mesenchymal Stem Cells; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinolones; rho-Associated Kinases; rhoA GTP-Binding Protein; Sulfones

Topics: Amides; Animals; Aorta; Atherosclerosis; Becaplermin; Butadienes; Cell Line; Cell Movement; Gene Expression Regulation; Humans; Imidazoles; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-sis; Pyridines; Rats; rho-Associated Kinases

Topics: Adolescent; Adult; Amides; Apoptosis; Blotting, Western; Butadienes; Cell Culture Techniques; Cell Proliferation; Chromones; Dental Pulp; Homeostasis; Humans; In Vitro Techniques; Lysophospholipids; Membrane Potential, Mitochondrial; Molar, Third; Morpholines; Nitriles; Pyridines; Signal Transduction; Sphingosine

Topics: Amides; Butadienes; Cell Line; Cell Movement; Computer Simulation; Enzyme Inhibitors; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxamic Acids; Immunoblotting; In Vitro Techniques; Matrix Metalloproteinases; Microscopy, Confocal; Models, Theoretical; Nitriles; Pyridines; RNA, Small Interfering; Signal Transduction

Topics: Adult; Aged; Amides; Breast; Butadienes; Cell Differentiation; Cell Proliferation; Enzyme Inhibitors; Epidermis; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Keratinocytes; Middle Aged; Nitriles; Organ Culture Techniques; Organ Preservation Solutions; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Skin; Skin Physiological Phenomena