Page last updated: 2024-09-03

y 27632 and u 0126

y 27632 has been researched along with u 0126 in 21 studies

Compound Research Comparison

Studies
(y 27632)
Trials
(y 27632)
Recent Studies (post-2010)
(y 27632)
Studies
(u 0126)
Trials
(u 0126)
Recent Studies (post-2010) (u 0126)
1,92438912,81621,213

Protein Interaction Comparison

ProteinTaxonomyy 27632 (IC50)u 0126 (IC50)
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)0.29
Serine/threonine-protein kinase B-rafHomo sapiens (human)0.25
Amine oxidase [flavin-containing] BRattus norvegicus (Norway rat)0.07
Dual specificity mitogen-activated protein kinase kinase 2Homo sapiens (human)0.2816
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)0.2529

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's16 (76.19)29.6817
2010's5 (23.81)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Caivano, M; Cohen, P; Davies, SP; Reddy, H1
McGovern, SL; Shoichet, BK1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Helfman, DM; Pawlak, G1
Hinson, JS; Lockman, K; Mack, CP; Medlin, MD; Morris, D; Taylor, JM1
Funfar, MR; Korpi, NL; McCoy, AC; Olmschenk, SM; Provost, JJ; Thronson, HL; Wallert, MA1
Boettiger, D; Guvakova, MA; Lynch, L; Vodyanik, PI1
Jiang, MJ; Tsai, MH1
Goldshmidt, A; Hamill, CE; Hepler, JR; Lyuboslavsky, P; McKeon, RJ; Nicole, O; Sastre, A; Sorensen, SD; Traynelis, SF1
Goez, P; Hagelgans, A; Hempel, U; Heyne, B; Jaross, W; Menschikowski, M; Neumeister, V; Siegert, G1
Chen, CP; Chen, JC; Ho, FM; Hsu, HB; Jeng, KC; Lee, ST; Lin, WW1
Matsusaka, S; Wakabayashi, I1
Hetman, M; Kalita, K; Kharebava, G; Zheng, JJ1
Chakraborty, C; Chirpac, A; Lala, PK; Nicola, C1
Chau, Z; Forzani, B; Jhanwar-Uniyal, M; Murali, R; Zohrabian, VM1
Ju, Y; Song, G; Xu, B1
Cui, Y; Fang, Y; Gao, Y; Kohama, K; Lin, HS; Qin, YH; Su, WM; Sun, YW; Wei, XQ; Zhao, Y1
Cheng, R; Hu, T; Pan, HY; Shao, MY; Xu, J; Yang, H; Zhang, P1
Fallica, B; Maffei, JS; Srivastava, J; Zaman, MH1
Chen, Z; Guo, J; Liu, C; Liu, G; Ma, C; Paus, R; Qin, J; Su, Y; Wu, X; Xie, Z; Zhang, X; Zhou, Q1

Other Studies

21 other study(ies) available for y 27632 and u 0126

ArticleYear
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

2000
Kinase inhibitors: not just for kinases anymore.
    Journal of medicinal chemistry, 2003, Apr-10, Volume: 46, Issue:8

    Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation

2003
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts.
    Molecular biology of the cell, 2002, Volume: 13, Issue:1

    Topics: Actin Cytoskeleton; Amides; Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; Chromones; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Oncogene Protein p21(ras); Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; Transcription, Genetic; Transfection

2002
Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors.
    The Journal of biological chemistry, 2004, Oct-08, Volume: 279, Issue:41

    Topics: Amides; Animals; Aorta; Apoptosis Regulatory Proteins; Blotting, Western; Butadienes; Cell Differentiation; Cell Division; Cells, Cultured; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Enzyme Inhibitors; ets-Domain Protein Elk-1; Fibroblasts; Genes, Dominant; Genes, Reporter; Glutathione Transferase; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Muscle, Smooth; Myocytes, Smooth Muscle; NIH 3T3 Cells; Nitriles; Nuclear Proteins; Phosphorylation; Polymerase Chain Reaction; Proto-Oncogene Proteins; Pyridines; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; RNA, Messenger; Serum Response Factor; Signal Transduction; Sphingosine; Time Factors; Trans-Activators; Transcription Factors; Transfection; Up-Regulation

2004
Two G protein-coupled receptors activate Na+/H+ exchanger isoform 1 in Chinese hamster lung fibroblasts through an ERK-dependent pathway.
    Cellular signalling, 2005, Volume: 17, Issue:2

    Topics: Amides; Animals; Butadienes; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Hydrogen-Ion Concentration; Intracellular Signaling Peptides and Proteins; Lysophospholipids; MAP Kinase Kinase 1; Nitriles; Phenylephrine; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Pyridines; Receptors, Adrenergic, alpha; Receptors, G-Protein-Coupled; rho-Associated Kinases; Signal Transduction; Sodium-Hydrogen Exchangers; Transfection

2005
Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells.
    Molecular biology of the cell, 2005, Volume: 16, Issue:1

    Topics: Actins; Amides; Blotting, Western; Breast Neoplasms; Butadienes; Carcinoma; Catalysis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; CSK Tyrosine-Protein Kinase; Culture Media, Serum-Free; Depsipeptides; Down-Regulation; Fibronectins; Flow Cytometry; Humans; Immunoprecipitation; Insulin-Like Growth Factor I; Integrin alpha5beta1; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Microscopy, Phase-Contrast; Models, Biological; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; src-Family Kinases; Time Factors

2005
Extracellular signal-regulated kinase1/2 in contraction of vascular smooth muscle.
    Life sciences, 2005, Jan-07, Volume: 76, Issue:8

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Butadienes; Calcium; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Genistein; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Nitriles; Phenylephrine; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley

2005
Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Apr-27, Volume: 25, Issue:17

    Topics: Amides; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Blotting, Northern; Blotting, Western; Brain Injuries; Bromodeoxyuridine; Butadienes; Cell Count; Cell Movement; Cell Proliferation; Cells, Cultured; Coculture Techniques; Colforsin; Cyclin D1; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Functional Laterality; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Male; MAP Kinase Kinase Kinases; Mice; Mice, Knockout; Microglia; Nitriles; Oligopeptides; Pyridines; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thrombin; Time Factors

2005
Statins potentiate the IFN-gamma-induced upregulation of group IIA phospholipase A2 in human aortic smooth muscle cells and HepG2 hepatoma cells.
    Biochimica et biophysica acta, 2005, Apr-15, Volume: 1733, Issue:2-3

    Topics: Amides; Aorta; Atorvastatin; Bacterial Proteins; Bacterial Toxins; Butadienes; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Drug Synergism; Flavonoids; Group II Phospholipases A2; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Janus Kinase 2; Lovastatin; Myocytes, Smooth Muscle; NF-kappa B; Nitriles; Phospholipases A; Phospholipases A2; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Pyrroles; RNA Stability; Up-Regulation

2005
Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.
    European journal of pharmacology, 2005, Oct-03, Volume: 521, Issue:1-3

    Topics: Amides; Animals; Antioxidants; Ascorbic Acid; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Hemin; I-kappa B Kinase; Immunoblotting; Interferon Regulatory Factor-1; Interferon-gamma; Lipopolysaccharides; Luciferases; Mice; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Phosphorylation; Pyridines; Quercetin; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor; Transcription Factor AP-1; Transfection

2005
5-Hydroxytryptamine as a potent migration enhancer of human aortic endothelial cells.
    FEBS letters, 2005, Dec-19, Volume: 579, Issue:30

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aorta; Benzamides; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cells, Cultured; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Fluoxetine; Humans; Microscopy, Video; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Pyridines; rhoA GTP-Binding Protein; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Antagonists; Stress Fibers; Time Factors

2005
Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Sep-27, Volume: 26, Issue:39

    Topics: 4-Aminopyridine; Amides; Animals; Animals, Newborn; Bicuculline; Brain-Derived Neurotrophic Factor; Butadienes; Cells, Cultured; Cerebral Cortex; Chlorocebus aethiops; Chromones; COS Cells; Cysteine-Rich Protein 61; Gene Expression Regulation; Genes, fos; Hippocampus; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; N-Methylaspartate; Neurons; Nitriles; Potassium Chloride; Prosencephalon; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; RNA Interference; Serum Response Factor; Signal Transduction; Synaptic Transmission; Transcription Factors; Transcription, Genetic; Transfection

2006
Roles of Rho guanosine 5'-triphosphatase A, Rho kinases, and extracellular signal regulated kinase (1/2) in prostaglandin E2-mediated migration of first-trimester human extravillous trophoblast.
    Endocrinology, 2008, Volume: 149, Issue:3

    Topics: Amides; Butadienes; Cell Line; Cell Movement; Chorionic Villi; Dinoprostone; Enzyme Inhibitors; Female; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Pregnancy; Pregnancy Trimester, First; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Trophoblasts

2008
Rho/ROCK and MAPK signaling pathways are involved in glioblastoma cell migration and proliferation.
    Anticancer research, 2009, Volume: 29, Issue:1

    Topics: Amides; Butadienes; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Fibronectins; Glioblastoma; Humans; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Platelet-Derived Growth Factor; Pyridines; rho-Associated Kinases

2009
Role of p38, ERK1/2, focal adhesion kinase, RhoA/ROCK and cytoskeleton in the adipogenesis of human mesenchymal stem cells.
    Journal of bioscience and bioengineering, 2014, Volume: 117, Issue:5

    Topics: Adipocytes; Adipogenesis; Amides; Butadienes; Cells, Cultured; Cytochalasin D; Cytoskeleton; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; Mesenchymal Stem Cells; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinolones; rho-Associated Kinases; rhoA GTP-Binding Protein; Sulfones

2014
Platelet-derived growth factor-BB induces matrix metalloproteinase-2 expression and rat vascular smooth muscle cell migration via ROCK and ERK/p38 MAPK pathways.
    Molecular and cellular biochemistry, 2014, Volume: 393, Issue:1-2

    Topics: Amides; Animals; Aorta; Atherosclerosis; Becaplermin; Butadienes; Cell Line; Cell Movement; Gene Expression Regulation; Humans; Imidazoles; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-sis; Pyridines; Rats; rho-Associated Kinases

2014
Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.
    International endodontic journal, 2015, Volume: 48, Issue:5

    Topics: Adolescent; Adult; Amides; Apoptosis; Blotting, Western; Butadienes; Cell Culture Techniques; Cell Proliferation; Chromones; Dental Pulp; Homeostasis; Humans; In Vitro Techniques; Lysophospholipids; Membrane Potential, Mitochondrial; Molar, Third; Morpholines; Nitriles; Pyridines; Signal Transduction; Sphingosine

2015
Combinative in vitro studies and computational model to predict 3D cell migration response to drug insult.
    Integrative biology : quantitative biosciences from nano to macro, 2014, Volume: 6, Issue:10

    Topics: Amides; Butadienes; Cell Line; Cell Movement; Computer Simulation; Enzyme Inhibitors; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxamic Acids; Immunoblotting; In Vitro Techniques; Matrix Metalloproteinases; Microscopy, Confocal; Models, Theoretical; Nitriles; Pyridines; RNA, Small Interfering; Signal Transduction

2014
Y-27632 preserves epidermal integrity in a human skin organ-culture (hSOC) system by regulating AKT and ERK signaling pathways.
    Journal of dermatological science, 2019, Volume: 96, Issue:2

    Topics: Adult; Aged; Amides; Breast; Butadienes; Cell Differentiation; Cell Proliferation; Enzyme Inhibitors; Epidermis; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Keratinocytes; Middle Aged; Nitriles; Organ Culture Techniques; Organ Preservation Solutions; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Skin; Skin Physiological Phenomena

2019