Compounds > y 27632
Page last updated: 2024-09-03

y 27632 and timolol

y 27632 has been researched along with timolol in 4 studies

Compound Research Comparison

Studies
(y 27632)		Trials
(y 27632)		Recent Studies (post-2010)
(y 27632)		Studies
(timolol)		Trials
(timolol)		Recent Studies (post-2010) (timolol)
1,92438913,9321,198805

Protein Interaction Comparison

ProteinTaxonomyy 27632 (IC50)timolol (IC50)
Beta-2 adrenergic receptorHomo sapiens (human)0.0003
Beta-1 adrenergic receptorHomo sapiens (human)0.0026
Beta-3 adrenergic receptorHomo sapiens (human)0.452
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)2.712
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)2.712

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abuin, A; Eberhart, DE; Gerhardt, B; Harrison, B; Mixon, T; Rice, DS; Whitlock, NA; Wilson, A; Yu, XQ1
Arnold, JJ; Challa, P; Chapleau, CA; Gorman, GS; Hansen, MS; Hunsinger, RN; Inoue, T; Pozzo-Miller, L; Rao, V; Spellen, S; Stamer, WD1
Bahler, CK; Bertrand, JA; Dosa, PI; Fautsch, MP; Holman, BH; Millar, JC; Overby, DR; Rinkoski, TA; Roy Chowdhury, U; Sherwood, JM; Stoltz, KL1
Ibrahim, DG; Iwata, W; Kiuchi, Y; Ko, JA; Okumichi, H1

Other Studies

4 other study(ies) available for y 27632 and timolol

ArticleYear
Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2009, Volume: 25, Issue:3

    Topics: Acetazolamide; Administration, Topical; Adrenergic beta-Antagonists; Amides; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Intraocular Pressure; Latanoprost; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscarinic Agonists; Pilocarpine; Prostaglandins F, Synthetic; Pyridines; rho-Associated Kinases; Timolol

2009
The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate.
    Investigative ophthalmology & visual science, 2013, Feb-07, Volume: 54, Issue:2

    Topics: Adrenergic beta-Antagonists; Amides; Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Chromatography, Liquid; Conjunctiva; Cornea; Diffusion Chambers, Culture; Enzyme Inhibitors; Iris; Lens, Crystalline; Male; Microscopy, Confocal; Microscopy, Electron, Scanning; Platelet Endothelial Cell Adhesion Molecule-1; Pyridines; Rabbits; rho-Associated Kinases; Sotalol; Sulfonamides; Swine; Tandem Mass Spectrometry; Thiazines; Timolol; Tissue Distribution

2013
Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents.
    Investigative ophthalmology & visual science, 2017, 11-01, Volume: 58, Issue:13

    Topics: Amides; Animals; Anterior Eye Segment; Antihypertensive Agents; Aqueous Humor; Cromakalim; Drug Synergism; Drug Therapy, Combination; Female; Humans; Intraocular Pressure; Latanoprost; Male; Mice; Mice, Inbred C57BL; Middle Aged; Ophthalmic Solutions; Prodrugs; Prostaglandins F, Synthetic; Pyridines; Rabbits; Sclera; Timolol; Tonometry, Ocular; Venous Pressure

2017
An in vitro study of scarring formation mediated by human Tenon fibroblasts: Effect of Y-27632, a Rho kinase inhibitor.
    Cell biochemistry and function, 2019, Volume: 37, Issue:2

    Topics: Amides; Cicatrix; Collagen; Fibroblasts; Humans; Latanoprost; Pyridines; rho-Associated Kinases; Signal Transduction; Tenon Capsule; Timolol; Transforming Growth Factor beta

2019