y 27632 has been researched along with spironolactone in 4 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (spironolactone) | Trials (spironolactone) | Recent Studies (post-2010) (spironolactone) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 7,222 | 960 | 1,923 |
| Protein | Taxonomy | y 27632 (IC50) | spironolactone (IC50) |
|---|---|---|---|
| Chain A, Mineralocorticoid receptor | Homo sapiens (human) | 0.049 | |
| Chain A, Mineralocorticoid receptor | Homo sapiens (human) | 0.049 | |
| Estrogen receptor | Homo sapiens (human) | 5.702 | |
| Glucocorticoid receptor | Homo sapiens (human) | 4.0745 | |
| Progesterone receptor | Homo sapiens (human) | 1.675 | |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Mineralocorticoid receptor | Homo sapiens (human) | 0.0315 | |
| Androgen receptor | Homo sapiens (human) | 0.3585 | |
| Androgen receptor | Rattus norvegicus (Norway rat) | 0.406 | |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | 1.9025 | |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 6.92 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diah, S; Gang, L; Hamid, MR; Hitomi, H; Kimura, S; Nagai, Y; Nishiyama, A; Tamiya, T; Zhang, GX; Zhang, W | 1 |
| Ji, H; Li, X; Luo, W; Meng, Y; Wu, P; Xiao, B; Zhang, X; Zhang, Z | 1 |
| Chen, D; Han, H; Huang, Y; Li, W; Li, Z; Ma, C; Peng, Y; Wei, J; Wu, W; Zhan, F | 1 |
| Ji, H; Wang, B | 1 |
4 other study(ies) available for y 27632 and spironolactone
| Article | Year |
|---|---|
Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells.
Topics: Aldosterone; Amides; Animals; Cell Transdifferentiation; Collagen; Eplerenone; Gene Expression Regulation; Hypertrophy; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Muscle Development; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; rho-Associated Kinases; Signal Transduction; Spironolactone | 2008 |
Aldosterone induction of hepatic stellate cell contraction through activation of RhoA/ROCK-2 signaling pathway.
Topics: Aldosterone; Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Cell Size; Cells, Cultured; Hepatic Stellate Cells; Irbesartan; Male; Mineralocorticoid Receptor Antagonists; Myosin Light Chains; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Spironolactone; Stress Fibers; Tetrazoles | 2011 |
Rho kinase pathway is likely responsible for the profibrotic actions of aldosterone in renal epithelial cells via inducing epithelial-mesenchymal transition and extracellular matrix excretion.
Topics: Actins; Aldosterone; Amides; Cadherins; Cell Line; Collagen Type I; Collagen Type III; Epithelial Cells; Epithelial-Mesenchymal Transition; Eplerenone; Extracellular Matrix; Gene Expression Regulation; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Protein Kinase Inhibitors; Pyridines; Receptors, Mineralocorticoid; rho-Associated Kinases; RNA, Messenger; Signal Transduction; Spironolactone | 2013 |
[Aldosterone promotes migration of rat hepatic stellate cells via activation of RhoA/ROCK signaling pathway].
Topics: Aldosterone; Amides; Animals; Cell Movement; Cells, Cultured; Hepatic Stellate Cells; Pyridines; Rats; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Spironolactone | 2019 |