y 27632 has been researched along with sphingosine in 28 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (sphingosine) | Trials (sphingosine) | Recent Studies (post-2010) (sphingosine) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 8,325 | 117 | 3,459 |
| Protein | Taxonomy | y 27632 (IC50) | sphingosine (IC50) |
|---|---|---|---|
| ubiquitin-conjugating enzyme E2 N | Homo sapiens (human) | 6.3125 | |
| cAMP-dependent protein kinase catalytic subunit alpha | Rattus norvegicus (Norway rat) | 0.098 | |
| Sphingosine kinase 2 | Homo sapiens (human) | 1.56 | |
| Sphingosine kinase 1 | Homo sapiens (human) | 3.86 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (57.14) | 29.6817 |
| 2010's | 12 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hokazono, Y; Kobayashi, S; Kusuda, T; Miyake, T; Mizukami, Y; Mogami, K; Sato, M; Suzuki, S; Todoroki-Ikeda, N; Yamagata, H; Yamamoto, K | 1 |
| Hashiba, Y; Kimura, T; Nagano, T; Okajima, F; Saito, N; Sasaki, T; Tosaka, M; Watanabe, T | 1 |
| Ikeda, H; Kazama, F; Ohmori, T; Osada, M; Ozaki, Y; Takafuta, T; Yatomi, Y | 1 |
| Hinson, JS; Lockman, K; Mack, CP; Medlin, MD; Morris, D; Taylor, JM | 1 |
| Aaronson, PI; Leach, RM; Patel, R; Snetkov, VA; Thomas, GD; Ward, JP | 1 |
| Schubert, R | 1 |
| Ahn, DS; Cho, YE; Choi, SK; Kim, YH; Lee, YH; Morgan, KG; Ryu, SK | 1 |
| Arnold, W; Bolz, SS; Lidington, D; Oestreicher, E; Pohl, U; Scherer, EQ | 1 |
| Brown, DL; Kohama, K; Kumagai, H; Li, S; Nakamura, A; Tanaka, H; Thatcher, SE; Wang, HH; Wright, GL; Yoshiyama, S | 1 |
| Annabi, B; Duhamel, S; Galipeau, J; Lejeune, L; Meriane, M | 1 |
| Chellini, F; Formigli, L; Francini, F; Meacci, E; Naro, F; Nosi, D; Sassoli, C; Squecco, R; Zecchi-Orlandini, S | 1 |
| Aroonsakool, N; Giles, WR; Haga, JH; Hu, BS; Landeen, LK | 1 |
| Hu, C; Minnear, FL; Vincent, PA; Waters, CL; Wysolmerski, RB; Xu, M | 1 |
| Hashiba, Y; Imai, H; Saito, N; Sasaki, T; Shimizu, T; Tosaka, M | 1 |
| Han, ES; Kim, H; Kim, HJ; Kim, JJ; Kim, KM; Koh, JY; Lee, CH; Noh, MS; Park, SM | 1 |
| Adachi, S; Hanai, Y; Kozawa, O; Matsushima-Nishiwaki, R; Minamitani, C; Mizutani, J; Otsuka, T; Takai, S; Tokuda, H | 1 |
| Grinnell, F; Ho, CH; Rhee, S | 1 |
| Adyshev, DM; Dudek, SM; Elangovan, VR; Garcia, JG; Moldobaeva, NK | 1 |
| Kim, JH; Kim, KH; Kim, MB; Kim, YM; Ko, HC; Lee, MJ | 1 |
| Asano, T; Hasegawa, Y; Kondo, M; Kume, H; Sashio, T; Shimokata, K; Takeda, N; Tsuji, S | 1 |
| Hasegawa, Y; Honjo, H; Kamiya, K; Kume, H; Makino, Y; Oguma, T; Shiraki, A; Sugishita, M | 1 |
| Bredow, M; Brünnert, D; Ehrhardt, J; Goyal, P; Piccenini, S; Zygmunt, M | 1 |
| Butler, JP; Carman, CV; Fredberg, JJ; Hardin, C; Krishnan, R; Manomohan, G; Martinelli, R; Rajendran, K; Tambe, DT | 1 |
| Cheng, R; Hu, T; Pan, HY; Shao, MY; Xu, J; Yang, H; Zhang, P | 1 |
| Fujii, M; Ishihara, H; Kagawa, Y; Koizumi, H; Nomura, S; Oka, F; Owada, Y; Sadahiro, H; Shinoyama, M; Shirao, S; Sugimoto, K; Suzuki, M; Tamechika, M; Yoneda, H | 1 |
| Anjum, I; Denizalti, M; Durlu-Kandilci, NT; Kandilci, HB; Sahin-Erdemli, I | 1 |
| Asghar, MY; Kemppainen, K; Lassila, T; Törnquist, K | 1 |
| Balogh, A; Benyó, Z; Dancs, PT; Fülöp, Á; Kerék, M; Móré, D; Offermanns, S; Panta, CR; Proia, RL; Ruisanchez, É; Tigyi, GJ | 1 |
28 other study(ies) available for y 27632 and sphingosine
| Article | Year |
|---|---|
Sphingosylphosphorylcholine induces Ca(2+)-sensitization of vascular smooth muscle contraction: possible involvement of rho-kinase.
Topics: Amides; Animals; Calcium; Coronary Vessels; Cytosol; Enzyme Inhibitors; Guanosine Triphosphate; Histamine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylcholine; Potassium; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sphingosine; Swine | 2000 |
Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo: possible role in pathogenesis of cerebral vasospasm.
Topics: Amides; Animals; Basilar Artery; Blood; Cerebral Angiography; Cerebrospinal Fluid; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; In Vitro Techniques; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Lysophospholipids; Male; Protein Serine-Threonine Kinases; Pyridines; Radioligand Assay; rho-Associated Kinases; Sphingosine; Vascular Patency; Vasoconstriction; Vasospasm, Intracranial | 2001 |
Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.
Topics: Acute-Phase Proteins; Amides; Blood Platelets; Cells, Cultured; Coronary Vessels; Humans; In Vitro Techniques; Lysophospholipids; Muscle, Smooth, Vascular; Pyrazoles; Pyridines; Signal Transduction; Sphingosine; Vasoconstriction | 2003 |
Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors.
Topics: Amides; Animals; Aorta; Apoptosis Regulatory Proteins; Blotting, Western; Butadienes; Cell Differentiation; Cell Division; Cells, Cultured; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Enzyme Inhibitors; ets-Domain Protein Elk-1; Fibroblasts; Genes, Dominant; Genes, Reporter; Glutathione Transferase; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Muscle, Smooth; Myocytes, Smooth Muscle; NIH 3T3 Cells; Nitriles; Nuclear Proteins; Phosphorylation; Polymerase Chain Reaction; Proto-Oncogene Proteins; Pyridines; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; RNA, Messenger; Serum Response Factor; Signal Transduction; Sphingosine; Time Factors; Trans-Activators; Transcription Factors; Transfection; Up-Regulation | 2004 |
Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry.
Topics: Amides; Animals; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Signaling; Dose-Response Relationship, Drug; G-Protein-Coupled Receptor Kinase 1; In Vitro Techniques; Lanthanum; Lysophospholipids; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphorylcholine; Pulmonary Artery; Pyridines; Rats; Sphingosine; Thapsigargin; Type C Phospholipases; Vasoconstriction | 2005 |
Non-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue.
Topics: Amides; Animals; Biological Transport; Calcium; Cell Membrane; Enzyme Activation; G-Protein-Coupled Receptor Kinase 1; Humans; Muscle, Smooth, Vascular; Phosphorylcholine; Pyridines; Rats; Sphingosine; Vasoconstrictor Agents | 2005 |
Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat.
Topics: Amides; Animals; Calcium; Flavonoids; Hypertension; Mesenteric Arteries; Mitogen-Activated Protein Kinases; Myosin Light Chains; Naphthalenes; Phosphorylation; Phosphorylcholine; Protein Kinase C; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Sphingosine; Vasoconstriction | 2006 |
Sphingosine-1-phosphate modulates spiral modiolar artery tone: A potential role in vascular-based inner ear pathologies?
Topics: Amides; Animals; Arteries; Biological Transport; Calcium; Dose-Response Relationship, Drug; Ear, Inner; Endothelium, Vascular; Gerbillinae; Immunohistochemistry; In Vitro Techniques; Lysophospholipids; Muscle, Smooth, Vascular; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; RNA, Messenger; Sphingosine; Vasoconstrictor Agents | 2006 |
Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation.
Topics: Actins; Amides; Animals; Azepines; Cell Movement; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; GTP-Binding Proteins; Guinea Pigs; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Myosin Light Chains; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Phosphorylcholine; Pyridines; Signal Transduction; Sphingosine | 2006 |
Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived str
Topics: Actin Cytoskeleton; Amides; Animals; Bone Marrow Cells; Cell Shape; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Focal Adhesion Protein-Tyrosine Kinases; Hydroxamic Acids; Indoles; Intracellular Signaling Peptides and Proteins; Lysophospholipids; MAP Kinase Kinase 1; MAP Kinase Signaling System; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Paxillin; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Sphingosine; Stromal Cells | 2006 |
Cytoskeleton/stretch-activated ion channel interaction regulates myogenic differentiation of skeletal myoblasts.
Topics: Actins; Amides; Animals; Calcium Signaling; Cell Differentiation; Cell Line; Cytochalasin B; Cytoskeleton; Enzyme Inhibitors; Gadolinium; Intracellular Signaling Peptides and Proteins; Ion Channels; Lysophospholipids; Membrane Potentials; Mice; Microscopy, Confocal; Muscle Development; Muscle Spindles; Myoblasts, Skeletal; Patch-Clamp Techniques; Phenotype; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sphingosine; Stress Fibers; Time Factors | 2007 |
Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions.
Topics: Amides; Animals; Becaplermin; Cell Communication; Cell Culture Techniques; Cell Separation; Cells, Cultured; Chemotaxis; Discoidin Domain Receptors; Fibroblasts; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Phenotype; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-sis; Pyridines; Receptor Protein-Tyrosine Kinases; Receptors, Lysosphingolipid; Receptors, Mitogen; Research Design; rho-Associated Kinases; RNA, Messenger; Serum; Sphingosine; Sphingosine-1-Phosphate Receptors; Time Factors; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2007 |
Sphingosine 1-phosphate rapidly increases endothelial barrier function independently of VE-cadherin but requires cell spreading and Rho kinase.
Topics: Actins; Amides; Antibodies; Antigens, CD; Bridged Bicyclo Compounds, Heterocyclic; Cadherins; Calcium; Capillary Permeability; Cell Shape; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Egtazic Acid; Electric Impedance; Electrophysiology; Endothelial Cells; Enzyme Inhibitors; Humans; Intercellular Junctions; Lysophospholipids; Pyridines; rho-Associated Kinases; RNA, Small Interfering; Sphingosine; Thiazolidines | 2007 |
Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries.
Topics: Amides; Animals; Basilar Artery; Calcium; Dinoprost; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Myosin Light Chains; Phosphorylation; Phosphorylcholine; Pyridines; Sphingosine; Vasodilation | 2007 |
Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632.
Topics: Amides; Animals; Antipruritics; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Injections, Intradermal; Ketotifen; Male; Mice; Mice, Inbred ICR; Muscle Relaxants, Central; Naltrexone; Narcotic Antagonists; Phosphorylcholine; Pruritus; Pyridines; rho-Associated Kinases; Sphingosine | 2008 |
Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Line; HSP27 Heat-Shock Proteins; Lysophospholipids; Mice; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; Sphingosine | 2009 |
Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis.
Topics: Actins; Amides; Cell Aggregation; Cell Culture Techniques; Cell Line, Transformed; Cell Movement; Cell Shape; Collagen; Enzyme Inhibitors; Fibroblasts; Heterocyclic Compounds, 4 or More Rings; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Male; Myosin Type II; Oncogene Protein p21(ras); Platelet-Derived Growth Factor; Pyridines; rho-Associated Kinases; Serum; Sphingosine; Vinculin | 2010 |
Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.
Topics: Actins; Amides; Antigens, CD; Bacterial Proteins; Bacterial Toxins; Cadherins; Cell Membrane; Cells, Cultured; Chelating Agents; Cytoskeletal Proteins; Cytoskeleton; Egtazic Acid; Electric Impedance; Endothelial Cells; Gene Knockdown Techniques; Humans; Imidazoles; Lysophospholipids; Membrane Proteins; Microfilament Proteins; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Permeability; Phosphorylation; Protein Kinase C; Pulmonary Artery; Pyridines; Receptors, Lysosphingolipid; rho GTP-Binding Proteins; rho-Associated Kinases; RNA Interference; Sphingosine; Thiophenes | 2011 |
Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells.
Topics: Amides; Blotting, Western; Cell Differentiation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Mesenchymal Stem Cells; Myocytes, Smooth Muscle; Phosphorylcholine; Pyridines; rhoA GTP-Binding Protein; Simvastatin; Sphingosine | 2012 |
Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA pathways in adherence of eosinophils to pulmonary endothelium.
Topics: ADP Ribose Transferases; Amides; Botulinum Toxins; Cell Adhesion; Cell Line; Endothelium, Vascular; Eosinophils; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Leucine; Lung; Lysophospholipids; Pyridines; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Vascular Cell Adhesion Molecule-1 | 2012 |
Role of sphingosine-1-phosphate inβ-adrenoceptor desensitization via Ca(2+) sensitization in airway smooth muscle.
Topics: Adrenergic beta-Agonists; Amides; Animals; Asthma; Calcium Signaling; Cells, Cultured; Guinea Pigs; Humans; Isoproterenol; Lysophospholipids; Myocytes, Smooth Muscle; Pertussis Toxin; Pyridines; Receptors, Adrenergic, beta; rho-Associated Kinases; Sphingosine; Trachea | 2012 |
Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways.
Topics: Amides; Aminoquinolines; Cell Line; Chromones; Cycloheximide; Dactinomycin; Female; Humans; Interleukin-6; Lysophospholipids; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Pregnancy; Pyrazoles; Pyridines; Pyrimidines; rac1 GTP-Binding Protein; Receptors, Lysosphingolipid; rho GTP-Binding Proteins; rho-Associated Kinases; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Trophoblasts | 2013 |
Glassy dynamics, cell mechanics, and endothelial permeability.
Topics: Amides; Cell Line; Cell Membrane Permeability; Cytoskeleton; Endothelial Cells; Fluorescent Dyes; Hepatocyte Growth Factor; Histamine; Humans; Hydrogen Peroxide; Lysophospholipids; Microscopy, Confocal; Phase Transition; Pyridines; Sphingosine; Thrombin | 2013 |
Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.
Topics: Adolescent; Adult; Amides; Apoptosis; Blotting, Western; Butadienes; Cell Culture Techniques; Cell Proliferation; Chromones; Dental Pulp; Homeostasis; Humans; In Vitro Techniques; Lysophospholipids; Membrane Potential, Mitochondrial; Molar, Third; Morpholines; Nitriles; Pyridines; Signal Transduction; Sphingosine | 2015 |
A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts.
Topics: Amides; Animals; Antihypertensive Agents; Basilar Artery; beta-Cyclodextrins; Carotid Artery, Internal; Cholesterol; Dietary Fats; Male; Membrane Microdomains; Membrane Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylcholine; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Sphingosine; Vasospasm, Intracranial | 2015 |
Enhancement of S1P-induced contractile response in detrusor smooth muscle of rats having cystitis.
Topics: Amides; Animals; Calcium; Cystitis; Female; Gene Expression Regulation; Indoles; Lysophospholipids; Maleimides; Muscle Contraction; Muscle, Smooth; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Urinary Bladder | 2017 |
Sphingosine 1-phosphate attenuates MMP2 and MMP9 in human anaplastic thyroid cancer C643 cells: Importance of S1P2.
Topics: Amides; Calpain; Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Pyridines; Receptors, Lysosphingolipid; rho-Associated Kinases; Sphingosine; Thyroid Carcinoma, Anaplastic | 2018 |
Sphingosine-1-Phosphate Enhances α
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Drug Synergism; Lysophospholipids; Mice, Inbred C57BL; Mice, Knockout; Phenylephrine; Pyridines; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2019 |