y 27632 and simvastatin

Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

Topics: 3T3 Cells; ADP Ribose Transferases; Amides; Animals; Botulinum Toxins; Cytoskeletal Proteins; Enzyme Inhibitors; Extracellular Matrix; Fibrin; Fibroblasts; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Mice; Microscopy, Fluorescence; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Rats; Recombinant Proteins; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Stress Fibers; Tenascin; Vinculin; Wound Healing

Topics: Actins; Amides; Bacterial Proteins; Bacterial Toxins; Botulinum Toxins; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Colchicine; Connective Tissue Growth Factor; Cytochalasin D; Cytoskeleton; Fibroblasts; Gene Expression Regulation; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Nocodazole; Paclitaxel; Pyridines; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Stress, Mechanical; Thiazoles; Thiazolidines

Topics: Amides; Animals; Aorta, Thoracic; Calcium Chloride; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; In Vitro Techniques; Indoles; Male; Mevalonic Acid; Muscle Relaxants, Central; Norepinephrine; Phenylephrine; Potassium Chloride; Pyridines; Rats; Rats, Inbred SHR; Simvastatin; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

Topics: Amides; Antibiotics, Antineoplastic; Bacterial Proteins; Bacterial Toxins; Blotting, Western; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mesothelioma; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Pyridines; Simvastatin

Topics: Amides; Animals; Astrocytes; Cells, Cultured; Cerebral Hemorrhage; Drug Evaluation, Preclinical; Enzyme Induction; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neuroprotective Agents; Protein Serine-Threonine Kinases; Pyridines; Rats; Recombinant Proteins; rho-Associated Kinases; Signal Transduction; Simvastatin; Stroke

Topics: ADP Ribose Transferases; Alkyl and Aryl Transferases; Amides; Anti-Asthmatic Agents; Botulinum Toxins; Bronchi; cdc42 GTP-Binding Protein; Cell Membrane; Cell Proliferation; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Mitogens; Muscle, Smooth; Phosphorylation; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; rac1 GTP-Binding Protein; rho-Associated Kinases; rhoA GTP-Binding Protein; Simvastatin; Terpenes

Topics: Actins; Amides; Animals; Antibodies, Monoclonal; Aorta; Bacterial Toxins; Cell Movement; Cells, Cultured; Chromones; Complement C3; Cytoskeleton; Dose-Response Relationship, Drug; Enterotoxins; Escherichia coli Proteins; Extracellular Matrix Proteins; Genes, tat; Hyaluronan Receptors; Hyaluronic Acid; Intracellular Signaling Peptides and Proteins; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; rac GTP-Binding Proteins; Rats; Recombinant Fusion Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Signal Transduction; Simvastatin; Stimulation, Chemical

Topics: Amides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cations; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gadolinium; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Ion Channels; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitrobenzenes; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; rho-Associated Kinases; Simvastatin; Stress, Mechanical; Sulfonamides; Trachea

Topics: Amides; Benzamides; Cell Line; Collagen Type I; Depression, Chemical; Dioxoles; Enzyme Inhibitors; Epithelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Pigment Epithelium of Eye; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Transfection; Transforming Growth Factor beta2

Topics: Actins; Amides; Cell Movement; Cells, Cultured; Cytoskeleton; Fibroblasts; Gene Expression Regulation, Enzymologic; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; Matrix Metalloproteinase 9; Myocardium; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; RNA, Messenger; Signal Transduction; Simvastatin; Transcription, Genetic; Tumor Necrosis Factor-alpha

Topics: 3T3-L1 Cells; Adipocytes; Amides; Animals; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Mevalonic Acid; Mice; Monomeric GTP-Binding Proteins; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Pravastatin; Pyridines; rho-Associated Kinases; Simvastatin; Tumor Necrosis Factor-alpha

Topics: Acyl Coenzyme A; Amides; Anticholesteremic Agents; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-6; Kidney; Leucine; Lipopolysaccharides; NF-kappa B; Pravastatin; Pyridines; Signal Transduction; Simvastatin; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

Topics: Alkaline Phosphatase; Amides; Aminoquinolines; Animals; Bone Morphogenetic Protein 2; Cell Differentiation; Cells, Cultured; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Muscle Fibers, Skeletal; Myoblasts, Skeletal; Myogenin; Osteoblasts; Polyisoprenyl Phosphates; Protein Kinase Inhibitors; Pyridines; Pyrimidines; rac GTP-Binding Proteins; Recombinant Proteins; rho-Associated Kinases; Sesquiterpenes; Signal Transduction; Simvastatin

Topics: Amides; Androstadienes; Animals; Caspase 3; Cell Culture Techniques; Cell Survival; Creatine Kinase; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fibroblasts; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Infusions, Intravenous; L Cells; Mice; Muscle, Skeletal; Pravastatin; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Simvastatin; Subcellular Fractions; Time Factors; Wortmannin

Topics: Amides; Animals; Bleomycin; Connective Tissue Growth Factor; Cytoskeleton; Endomyocardial Fibrosis; Female; Heart; Lung; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Pravastatin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Radiation Injuries; Radiation Pneumonitis; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; rho-Associated Kinases; rhoB GTP-Binding Protein; Simvastatin; Smad Proteins; Thorax

Topics: Actins; Amides; Animals; Becaplermin; Cell Proliferation; Cells, Cultured; Male; Myocytes, Smooth Muscle; Phenotype; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; RNA, Messenger; Simvastatin

Topics: Amides; Animals; Complement C3; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Synthase Type III; Pain Threshold; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Spinal Cord; Streptozocin; Time Factors

Topics: Alkyl and Aryl Transferases; Amides; Bronchi; Bronchoconstriction; Electric Stimulation; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; In Vitro Techniques; Leucine; Lipopolysaccharides; Male; Methionine; Middle Aged; Naphthalenes; Polyisoprenyl Phosphates; Protein Kinase Inhibitors; Protein Prenylation; Pyridines; ras Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; Sesquiterpenes; Signal Transduction; Simvastatin; Time Factors

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arginase; Boronic Acids; Cattle; Cell Line; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Imidazoles; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; Simvastatin

Topics: Amides; Blotting, Western; Cell Differentiation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Mesenchymal Stem Cells; Myocytes, Smooth Muscle; Phosphorylcholine; Pyridines; rhoA GTP-Binding Protein; Simvastatin; Sphingosine

Topics: Amides; Animals; Basilar Artery; Blood Pressure; Cell Proliferation; Cerebrovascular Circulation; Disease Models, Animal; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocytes, Smooth Muscle; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin

Topics: Actin Cytoskeleton; Amides; Animals; Cofilin 1; Cytoskeleton; Lim Kinases; Male; Neuralgia; Phosphorylation; Pyridines; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin

Topics: Adult; Aged; Amides; Arthritis, Rheumatoid; Case-Control Studies; Cells, Cultured; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-17; Interleukins; Lupus Erythematosus, Systemic; Male; Middle Aged; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; T-Lymphocytes; Th17 Cells

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cyclohexenes; Cytokines; Diphosphonates; Fibroblasts; Fluvastatin; Gene Expression Regulation; Heart; Heart Diseases; Humans; Interleukin-33; Lovastatin; Mevalonic Acid; Monoterpenes; Myocardium; Myocytes, Cardiac; Pravastatin; Pyridines; rhoA GTP-Binding Protein; Simvastatin; Thiazolidines

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cervical Ripening; Cervix Uteri; Female; In Vitro Techniques; Muscle Contraction; Pregnancy; Pyridines; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Simvastatin

Topics: Amides; Anticholesteremic Agents; Cells, Cultured; Humans; Intracellular Signaling Peptides and Proteins; Male; Myofibroblasts; Penile Induration; Pyridines; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; Simvastatin

Topics: Adult; Amides; Cell Differentiation; Female; Fibrosis; Graves Ophthalmopathy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; MAP Kinase Signaling System; Middle Aged; Myofibroblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Primary Cell Culture; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Simvastatin; Transforming Growth Factor beta