Page last updated: 2024-09-03

y 27632 and ro 31-8220

y 27632 has been researched along with ro 31-8220 in 11 studies

Compound Research Comparison

Studies
(y 27632)
Trials
(y 27632)
Recent Studies (post-2010)
(y 27632)
Studies
(ro 31-8220)
Trials
(ro 31-8220)
Recent Studies (post-2010) (ro 31-8220)
1,9243891587164

Protein Interaction Comparison

ProteinTaxonomyy 27632 (IC50)ro 31-8220 (IC50)
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)0.008
Serine/threonine-protein kinase 10Homo sapiens (human)0.099
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)0.9
Serine/threonine-protein kinase pim-1Homo sapiens (human)0.01
Protein kinase C alpha typeHomo sapiens (human)0.033
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)0.0068
Ribosomal protein S6 kinase beta-1Homo sapiens (human)0.015
Mitogen-activated protein kinase kinase kinase 8Homo sapiens (human)9.95
Glycogen synthase kinase-3 betaHomo sapiens (human)0.0116
Ribosomal protein S6 kinase alpha-3Homo sapiens (human)0.01
Protein kinase C beta typeRattus norvegicus (Norway rat)0.01
Homeodomain-interacting protein kinase 1Homo sapiens (human)0.621
NAD-dependent protein deacetylase sirtuin-2Homo sapiens (human)0.875
Mitogen-activated protein kinase kinase kinase kinase 1Homo sapiens (human)0.0529
NAD-dependent protein deacetylase sirtuin-1Homo sapiens (human)3.9
Serine/threonine-protein kinase VRK1Homo sapiens (human)0.743
NAD-dependent protein deacetylase sirtuin-3, mitochondrialHomo sapiens (human)3.7
Serine/threonine-protein kinase TBK1Homo sapiens (human)0.656

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (90.91)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Caivano, M; Cohen, P; Davies, SP; Reddy, H1
McGovern, SL; Shoichet, BK1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Cox, KJ; Gaj, A; Ghosh, I; Jester, BW; Shomin, CD1
Brautigan, DL; Eto, M; Kitazawa, T; Mukai, H; Ono, Y; Yazawa, M1
Hidaka, H; Hosoya, T; Ikenoya, M; Sasaki, Y; Suzuki, M; Yamamoto, N1
Assaloni, R; Bartoli, E; Cavarape, A; Endlich, K; Endlich, N; Parekh, N; Steinhausen, M1
Bauer, J; Parekh, N1
Doi, M; Kawasaki, S; Kimura, S; Koji, T; Nishikawa, Y; Ogawa, A; Sasaki, K; Watanabe, M1
Brock, JA; Yeoh, M1
Prieto, D; Simonsen, U; Stankevicius, E; Villalba, N1

Other Studies

11 other study(ies) available for y 27632 and ro 31-8220

ArticleYear
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

2000
Kinase inhibitors: not just for kinases anymore.
    Journal of medicinal chemistry, 2003, Apr-10, Volume: 46, Issue:8

    Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation

2003
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.
    Journal of medicinal chemistry, 2012, Feb-23, Volume: 55, Issue:4

    Topics: Animals; Binding, Competitive; Catalytic Domain; Cell-Free System; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Databases, Factual; Genes, Reporter; Luciferases; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Recombinant Fusion Proteins; Structure-Activity Relationship

2012
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms.
    The Journal of biological chemistry, 2001, Aug-03, Volume: 276, Issue:31

    Topics: Amides; Amino Acid Sequence; Animals; Aorta; Carbazoles; Chromatography; Chromatography, Affinity; Chromatography, Ion Exchange; Durapatite; Enzyme Activation; Enzyme Inhibitors; Histamine; In Vitro Techniques; Indoles; Isoenzymes; Kinetics; Maleimides; Molecular Sequence Data; Muscle Contraction; Muscle Proteins; Muscle Relaxants, Central; Muscle, Smooth, Vascular; Myelin Basic Protein; Myosin-Light-Chain Phosphatase; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Pyridines; Recombinant Proteins; Substrate Specificity; Swine; Vasoconstriction

2001
Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.
    Journal of neurochemistry, 2002, Volume: 81, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Calcium-Binding Proteins; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glucosidases; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Neurons; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Substrate Specificity

2002
Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivo.
    Journal of the American Society of Nephrology : JASN, 2003, Volume: 14, Issue:1

    Topics: Adenosine; Amides; Animals; Endothelins; Enzyme Inhibitors; Female; Guanylate Cyclase; Indoles; Intracellular Signaling Peptides and Proteins; Oxadiazoles; Peptide Fragments; Protein Kinase C; Protein Serine-Threonine Kinases; Purinergic P1 Receptor Agonists; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptor, Endothelin B; Receptors, Endothelin; Renal Circulation; rho-Associated Kinases; Signal Transduction; Vasoconstriction; Vasomotor System

2003
Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.
    Kidney international, 2003, Volume: 63, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Calcium Channel Blockers; Enzyme Inhibitors; Female; Gallic Acid; Indoles; Nifedipine; Norepinephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; Signal Transduction; Staurosporine; Vasoconstrictor Agents

2003
The role of rho and rho-dependent kinase in serotonin-induced contraction observed in bovine middle cerebral artery.
    The Tohoku journal of experimental medicine, 2003, Volume: 201, Issue:4

    Topics: ADP Ribose Transferases; Amides; Animals; Azepines; Bacterial Proteins; Bacterial Toxins; Botulinum Toxins; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cerebral Arteries; Cytotoxins; Dose-Response Relationship, Drug; Enterotoxins; Enzyme Inhibitors; Indoles; Intracellular Signaling Peptides and Proteins; Middle Cerebral Artery; Myosin-Light-Chain Kinase; Naphthalenes; Potassium; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Serotonin; Sulfonamides; Time Factors

2003
Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.
    British journal of pharmacology, 2005, Volume: 146, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amides; Animals; Arteries; Clonidine; Electric Stimulation; Electrophysiology; Female; Idazoxan; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Phenylephrine; Prazosin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Suramin; Tail; Vasoconstriction

2005
Rho kinase is involved in Ca2+ entry of rat penile small arteries.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:4

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Amides; Animals; Arteries; Bacterial Toxins; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Dose-Response Relationship, Drug; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Male; Membrane Potentials; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Penis; Phenylephrine; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents

2008