Page last updated: 2024-09-03

y 27632 and phenylephrine

y 27632 has been researched along with phenylephrine in 52 studies

Compound Research Comparison

Studies (y 27632)	Trials (y 27632)	Recent Studies (post-2010) (y 27632)	Studies (phenylephrine)	Trials (phenylephrine)	Recent Studies (post-2010) (phenylephrine)
1,924	3	891	13,797	857	2,083

Research

Studies (52)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	36 (69.23)	29.6817
2010's	14 (26.92)	24.3611
2020's	2 (3.85)	2.80

Authors

Authors	Studies
Brautigan, DL; Eto, M; Kitazawa, T; Woodsome, TP	1
Akahane, S; Anabuki, J; Hayakawa, K; Hori, M; Karaki, H; Ozaki, H	1
Cellek, S; Moncada, S; Ralph, DJ; Rees, RW; Royle, M	1
Gong, MC; Gorenne, I; Jia, T; Nakamoto, RK; Read, P; Somlyo, AP; Somlyo, AV	1
Jin, N; Li, L; Rhoades, RA; Swartz, DR; Wang, Z; Yancey, KW; Zhang, D	1
Spaan, JA; van der Meulen, ET; VanBavel, E	1
Abe, M; Hasegawa, K; Kawamura, T; Morimoto, T; Sasayama, S; Wada, H; Yanazume, T	1
Beattie, DK; Davies, AH; Gosling, M; McGregor, E; Powell, JT; Ribbons, DM	1
Chitaley, K; Webb, RC	1
Eddinger, TJ; Meehl, JT; Ratz, PH	1
Cho, KW; Kim, SH; Kim, YG; Koh, GY; Lee, SO; Park, JK	1
Eto, M; Khalequzzaman, M; Kitazawa, T; Woodsome, TP	1
Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Takahashi, R	1
Ark, M; Büyükafşar, K; Levent, A	1
Cellek, S; Foxwell, NA; Kell, PD; Moncada, S; Ralph, DJ; Rees, RW	1
Didion, SP; Faraci, FM; Mathur, S; Ryan, MJ; Sigmund, CD	1
Büyükafsar, K; Levent, A	1
Arikan, O; Ark, M; Büyükafşar, K; Kubat, H; Ozveren, E	1
Funfar, MR; Korpi, NL; McCoy, AC; Olmschenk, SM; Provost, JJ; Thronson, HL; Wallert, MA	1
Jiang, MJ; Tsai, MH	2
Alvarez de Sotomayor, M; Herrera, MD; Marhuenda, E; Márquez-Martín, A; Pérez-Guerrero, C	1
Jiang, SZ; Li, ZL; Wang, DS; Wang, HJ; Yuan, M	1
Sims, SM; Yaghi, A	1
Brock, JA; Yeoh, M	1
Hester, RL; Naik, JS; Xiang, L	1
Jin, L; Palmer, T; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z	1
Ito, M; Kim, I; Kim, JI; Kim, SO; Kureishi, Y; Lim, DG; Nakano, T; Park, WH; Seok, Y	1
Anderson, ME; El-Armouche, A; Eschenhagen, T; Grimm, M; Zhang, R	1
Archer, SL; Bonnet, SN; Haromy, A; Harry, G; Hashimoto, K; Kajimoto, H; Michelakis, ED; Moudgil, R; Nakanishi, T; Rebeyka, I; Thébaud, B	1
Lewis, SJ; Lewis, TH; Moore, JN; Noschka, E; Peroni, JF; Robertson, TP	1
Prieto, D; Simonsen, U; Stankevicius, E; Villalba, N	1
Kim, SC; Lee, MY; Lee, SY; Myung, SC; Park, SH; Yum, SH	1
Fry, CH; Roosen, A; Sui, G; Wu, C	1
Baufreton, C; Belin de Chantemèle, EJ; Bocquet, A; Domenga, V; Guihot, AL; Henrion, D; Joutel, A; Lemaire, B; Loufrani, L; Pinaud, F; Retailleau, K; Vessières, E	1
Dorrance, AM; Leite, R; Linder, AE; Mills, TM; Webb, RC	1
Chang, IH; Han, JH; Kim, HJ; Kim, W; Lee, MY; Lee, SY; Myung, SC	1
Cole, WC; Hollywood, M; McHale, N; Sergeant, G; Thornbury, K; Walsh, MP	1
Contreras, C; García-Sacristán, A; Hernández, M; Prieto, D; Villalba, N	1
Hedlund, P; Kauffels, W; Kuczyk, MA; Ückert, S; Waldkirch, ES	1
Bailey, SR; Borer, KE; Elliott, J; Harris, PA	1
da Silva-Santos, JE; Gonçalves, RP; Guarido, KL; Júnior, AG	1
Alexandre, EC; Alves Junior, MJ; Antunes, E; Báu, FR; Calmasini, FB; Leiria, LO; Mónica, FZ; Silva, FH	1
Ark, M; Aypar, E; Demirtaş, A; Gözübüyük, G; Ozdemir, A; Şahan, G; Turan, NN	1
Astarci, E; Aydinoglu, F; Balli, E; Ergurhan Kiroglu, O; Ogulener, N	1
Seawright, JW; Trache, A; Wilson, E; Woodman, CR	1
Bai, YL; Dong, DL; Gao, JL; Jin, J; Li, SL; Liu, MY; Shen, X; Wang, CG; Wei, YY; Yan, J; Zhang, LS; Zhang, YH; Zhang, YQ; Zhao, Y; Zhen, CL	1
Crestani, S; da Silva-Santos, JE; Webb, RC	1
Chess-Williams, R; Lim, I; Sellers, D	1
Batista-Lima, FJ; da Silva, MTB; de Brito, TS; de Carvalho, EF; de Oliveira, DMN; Dos Santos, AA; Gadelha, KKL; Lima-Silva, K; Magalhães, PJC; Paula, SM	1
Balogh, A; Benyó, Z; Dancs, PT; Fülöp, Á; Kerék, M; Móré, D; Offermanns, S; Panta, CR; Proia, RL; Ruisanchez, É; Tigyi, GJ	1
Bae, SI; Hwang, Y; Kim, JY; Lee, SH; Ok, SH; Sohn, JT; Subbarao, RB; Tak, S	1

Other Studies

52 other study(ies) available for y 27632 and phenylephrine

Article	Year
Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. The Journal of biological chemistry, 2000, Apr-07, Volume: 275, Issue:14 Topics: Amides; Animals; Cell Membrane Permeability; Enzyme Inhibitors; Femoral Artery; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Histamine; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phenylephrine; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Type C Phospholipases	2000
Muscarinic stimulation does not induce rhoA/ROCK-mediated Ca2+ sensitization of the contractile element in chicken gizzard smooth muscle. Pflugers Archiv : European journal of physiology, 2000, Volume: 441, Issue:2-3 Topics: Amides; Animals; Calcium; Carbachol; Chickens; Enzyme Inhibitors; Female; Gene Expression; Gizzard, Avian; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Verapamil	2000
Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum. British journal of pharmacology, 2001, Volume: 133, Issue:4 Topics: Amides; Animals; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle Relaxants, Central; NG-Nitroarginine Methyl Ester; Penis; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Synaptic Transmission; Vasoconstrictor Agents	2001
Regulation by GDI of RhoA/Rho-kinase-induced Ca2+ sensitization of smooth muscle myosin II. American journal of physiology. Cell physiology, 2001, Volume: 281, Issue:1 Topics: Amides; Animals; Calcium; Cell Membrane; Enzyme Inhibitors; Escin; Guanine Nucleotide Dissociation Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Ileum; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle, Smooth; Muscle, Smooth, Vascular; Phenylephrine; Portal Vein; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Rabbits; Recombinant Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Urinary Bladder; Vasoconstrictor Agents; Yeasts	2001
Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle. Journal of muscle research and cell motility, 2001, Volume: 22, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antineoplastic Agents; Aorta; Azepines; Calcium; Colchicine; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Male; Microtubules; Muscle Contraction; Muscle, Smooth, Vascular; Nocodazole; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstrictor Agents	2001
Role of Rho-associated protein kinase in tone and calcium sensitivity of cannulated rat mesenteric small arteries. Experimental physiology, 2001, Volume: 86, Issue:5 Topics: Amides; Animals; Calcium; Drug Interactions; Intracellular Signaling Peptides and Proteins; Ionomycin; Ionophores; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxants, Central; Muscle Tonus; Muscle, Smooth, Vascular; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Vasoconstriction; Vasoconstrictor Agents	2001
Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. The Journal of biological chemistry, 2002, Mar-08, Volume: 277, Issue:10 Topics: 3T3 Cells; Actins; Amides; Animals; Blotting, Northern; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; COS Cells; DNA-Binding Proteins; Enzyme Activation; GATA4 Transcription Factor; Hypertrophy; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Luciferases; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Myocardium; Phenylephrine; Phosphorylation; Plasmids; Protein Binding; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; Thiazoles; Thiazolidines; Transcription Factors; Transcription, Genetic; Transfection; Zinc Fingers	2002
Circumferential stretching of saphenous vein smooth muscle enhances vasoconstrictor responses by Rho kinase-dependent pathways. Cardiovascular research, 2002, Volume: 53, Issue:1 Topics: Adenosine; Amides; Cromakalim; Cycloheximide; Enzyme Inhibitors; Gadolinium; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Pulsatile Flow; Pyridines; rho-Associated Kinases; Saphenous Vein; Serotonin; Signal Transduction; Stents; Vasoconstrictor Agents; Vasodilator Agents	2002
Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling. Hypertension (Dallas, Tex. : 1979), 2002, Volume: 39, Issue:2 Pt 2 Topics: Amides; Androstadienes; Animals; Aorta; Calcium Channel Blockers; Calcium Channels; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Relaxants, Central; Nitric Oxide; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstriction; Vasodilation; Wortmannin	2002
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction. British journal of pharmacology, 2002, Volume: 137, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Stomach; Urinary Bladder	2002
Role of rho-kinase activity in angiotensin II-induced contraction of rabbit clitoral cavernosum smooth muscle. International journal of impotence research, 2002, Volume: 14, Issue:6 Topics: Amides; Angiotensin II; Animals; Azepines; Clitoris; Enzyme Inhibitors; Female; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Naphthalenes; Nitric Oxide; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction	2002
Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle. The Journal of physiology, 2003, Feb-01, Volume: 546, Issue:Pt 3 Topics: Amides; Animals; Calcium; Electrophysiology; Endothelin-1; Enzyme Inhibitors; Indoles; Isoenzymes; Male; Maleimides; Muscle Proteins; Muscle, Smooth; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Permeability; Phenylephrine; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Portal Vein; Pyridines; Rabbits; Type C Phospholipases; Vas Deferens; Vasoconstriction	2003
Modulation of Ca2+ sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle. The Journal of urology, 2003, Volume: 169, Issue:6 Topics: Adrenergic alpha-Agonists; Amides; Animals; Calcium; Enzyme Inhibitors; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Penis; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Type C Phospholipases	2003
Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens. British journal of pharmacology, 2003, Volume: 140, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Blotting, Western; Electric Stimulation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanethidine; Intracellular Signaling Peptides and Proteins; Male; Mice; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vas Deferens	2003
Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. The Journal of urology, 2003, Volume: 170, Issue:6 Pt 1 Topics: Adrenergic alpha-Agonists; Amides; Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Humans; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Norepinephrine; Phenylephrine; Prostate; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases	2003
Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:5 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Amides; Angiotensin II; Animals; Aorta; Carotid Arteries; Infusion Pumps, Implantable; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitroprusside; Papaverine; Phenylephrine; Potassium Chloride; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; Sequence Deletion; Serotonin; Superoxides; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents	2004
Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter. British journal of pharmacology, 2004, Volume: 143, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sheep; Tetrodotoxin; Ureter; Vasoconstrictor Agents; Vasodilator Agents	2004
Upregulation of Rho-kinase (ROCK-2) expression and enhanced contraction to endothelin-1 in the mesenteric artery from lipopolysaccharide-treated rats. European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3 Topics: Acetylcholine; Amides; Angiotensin II; Animals; Blotting, Western; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Female; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Mesenteric Arteries; Nitrates; Nitrites; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; Sodium Chloride; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents	2004
Two G protein-coupled receptors activate Na+/H+ exchanger isoform 1 in Chinese hamster lung fibroblasts through an ERK-dependent pathway. Cellular signalling, 2005, Volume: 17, Issue:2 Topics: Amides; Animals; Butadienes; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Hydrogen-Ion Concentration; Intracellular Signaling Peptides and Proteins; Lysophospholipids; MAP Kinase Kinase 1; Nitriles; Phenylephrine; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Pyridines; Receptors, Adrenergic, alpha; Receptors, G-Protein-Coupled; rho-Associated Kinases; Signal Transduction; Sodium-Hydrogen Exchangers; Transfection	2005
Extracellular signal-regulated kinase1/2 in contraction of vascular smooth muscle. Life sciences, 2005, Jan-07, Volume: 76, Issue:8 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Butadienes; Calcium; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Genistein; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Nitriles; Phenylephrine; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley	2005
Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin. Pharmacology, 2005, Volume: 74, Issue:4 Topics: Amides; Animals; Aorta, Thoracic; Calcium Chloride; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; In Vitro Techniques; Indoles; Male; Mevalonic Acid; Muscle Relaxants, Central; Norepinephrine; Phenylephrine; Potassium Chloride; Pyridines; Rats; Rats, Inbred SHR; Simvastatin; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2005
[Role of ROK in contraction of rat femoral arteries after 14 d tail suspension]. Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering, 2004, Volume: 17, Issue:5 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Body Weight; Femoral Artery; Hindlimb Suspension; Intracellular Signaling Peptides and Proteins; Male; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Vasoconstriction; Vasoconstrictor Agents; Weightlessness Simulation	2004
Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle. American journal of physiology. Lung cellular and molecular physiology, 2005, Volume: 289, Issue:6 Topics: Active Transport, Cell Nucleus; Amides; Animals; Calcium; Calcium Signaling; Cell Nucleus; Cyclosporine; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hydroxyeicosatetraenoic Acids; Lung Diseases; Male; Muscle Contraction; Muscle, Smooth; NFATC Transcription Factors; Organ Culture Techniques; Phenylephrine; Protein Isoforms; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents	2005
Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro. British journal of pharmacology, 2005, Volume: 146, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amides; Animals; Arteries; Clonidine; Electric Stimulation; Electrophysiology; Female; Idazoxan; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Phenylephrine; Prazosin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Suramin; Tail; Vasoconstriction	2005
Enhanced role for RhoA-associated kinase in adrenergic-mediated vasoconstriction in gracilis arteries from obese Zucker rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:1 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic Agents; Aging; Amides; Animals; Arteries; Calcium Signaling; Gene Expression Regulation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Obesity; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Zucker; rho-Associated Kinases; rhoA GTP-Binding Protein; Thinness; Vasoconstriction	2006
Expression and functional role of the RhoA/Rho-kinase pathway in rat coeliac artery. Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:10 Topics: Amides; Animals; Blotting, Western; Celiac Artery; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Guanine Nucleotide Exchange Factors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rho Guanine Nucleotide Exchange Factors; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2005
Heat shock-induced augmentation of vascular contractility is independent of rho-kinase. Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:3 Topics: Actins; Amides; Animals; Aorta, Thoracic; Blotting, Western; Hot Temperature; HSP72 Heat-Shock Proteins; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myosin Light Chains; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Shock; Vasoconstrictor Agents	2006
Rho-kinase-mediated regulation of receptor-agonist-stimulated smooth muscle contraction. Pflugers Archiv : European journal of physiology, 2006, Volume: 453, Issue:2 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Actins; Amides; Animals; Arteries; Carrier Proteins; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Molecular Sequence Data; Muscle Proteins; Muscle, Smooth, Vascular; Myosin Light Chains; Phenylephrine; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Threonine; Vasoconstrictor Agents	2006
Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition. Journal of molecular and cellular cardiology, 2007, Volume: 42, Issue:3 Topics: Amides; Animals; Boron Compounds; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Heart; Mice; Myocardial Contraction; Myocardium; Phenylephrine; Protein Kinase Inhibitors; Pyridines; Receptors, Adrenergic, alpha; Time Factors	2007
Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction. Circulation, 2007, Apr-03, Volume: 115, Issue:13 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Ductus Arteriosus; Enzyme Activation; Enzyme Induction; Feedback, Physiological; Female; Fetal Heart; Gestational Age; Humans; Hydrogen Peroxide; Hypoplastic Left Heart Syndrome; Infant, Newborn; Intracellular Signaling Peptides and Proteins; Male; Mitochondria, Heart; Nifedipine; Organ Culture Techniques; Oxidation-Reduction; Oxygen; Partial Pressure; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rabbits; Reactive Oxygen Species; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Superoxides; Vasoconstriction	2007
Effects of Rho-kinase and Src protein tyrosine kinase inhibition on agonist-induced vasoconstriction of arteries and veins of the equine laminar dermis. American journal of veterinary research, 2007, Volume: 68, Issue:8 Topics: Amides; Animals; Arteries; Calcium; Dose-Response Relationship, Drug; Endothelin-1; Foot; Intracellular Signaling Peptides and Proteins; Phenylephrine; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; Pyrimidines; rho-Associated Kinases; Serotonin; Signal Transduction; src-Family Kinases; Vasoconstriction; Vasoconstrictor Agents; Veins	2007
Rho kinase is involved in Ca2+ entry of rat penile small arteries. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:4 Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Amides; Animals; Arteries; Bacterial Toxins; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Dose-Response Relationship, Drug; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Male; Membrane Potentials; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Penis; Phenylephrine; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents	2008
Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladder. The journal of sexual medicine, 2008, Volume: 5, Issue:5 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Adrenergic alpha-Agonists; Amides; Animals; Antihypertensive Agents; Calcium Channel Agonists; Clitoris; Dose-Response Relationship, Drug; Endothelin-1; Female; Isometric Contraction; Models, Animal; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Oligopeptides; Peptides, Cyclic; Phenylephrine; Piperidines; Potassium; Pyridines; Rabbits; Urinary Bladder, Overactive; Vasodilator Agents	2008
Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms. Cell calcium, 2009, Volume: 45, Issue:1 Topics: Amides; Animals; Calcium Signaling; Carbachol; Guinea Pigs; Indoles; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Phenylephrine; Protein Kinase C; Pyridines; Receptor Cross-Talk; Receptors, Adrenergic; Receptors, Muscarinic; rho-Associated Kinases; Signal Transduction; Urinary Bladder	2009
Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries. Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:12 Topics: Acetylcholine; Amides; Animals; Arteries; Cerebral Arteries; Enzyme Inhibitors; Male; Mice; Mice, Knockout; Phenylephrine; Pyridines; Receptor, Notch3; Receptors, Notch; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Tail; Vascular Resistance; Vasoconstriction; Vasodilation	2008
Erectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production. The journal of sexual medicine, 2009, Volume: 6 Suppl 3 Topics: Amides; Animals; Antihypertensive Agents; Erectile Dysfunction; Ganglion Cysts; Hypertension; Indomethacin; Kidney; Male; Nitric Oxide; Nitroprusside; Penis; Phenylephrine; Pressure; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases	2009
Effect of low concentrations of hydrogen peroxide on the contractile responses of rat detrusor smooth muscle strips. European journal of pharmacology, 2010, Jul-25, Volume: 638, Issue:1-3 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Amides; Animals; Calcium; Dose-Response Relationship, Drug; Drug Synergism; Hydrogen Peroxide; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Phenylephrine; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; Urinary Bladder; Verapamil; Vitamin E	2010
Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation. American journal of physiology. Renal physiology, 2011, Volume: 300, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Electric Stimulation; Male; Muscle Contraction; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phenylephrine; Phosphorylation; Potassium Chloride; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Urethra	2011
Impaired Ca2+ handling in penile arteries from prediabetic Zucker rats: involvement of Rho kinase. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:6 Topics: Amides; Animals; Arteries; Calcium; Enzyme Inhibitors; Male; Models, Animal; Penis; Phenylephrine; Prediabetic State; Pyridines; Rats; Rats, Zucker; rho-Associated Kinases; Vasoconstriction; Vasoconstrictor Agents	2011
Rho kinase-related proteins in human vaginal arteries: an immunohistochemical and functional study. The journal of sexual medicine, 2011, Volume: 8, Issue:10 Topics: Amides; Arteries; Arterioles; Female; Humans; Middle Aged; Phenylephrine; Pyridines; rho-Associated Kinases; Signal Transduction; Vagina	2011
Contractile responses of isolated equine digital arteries under hypoxic or hyperoxic conditions in vitro: role of reactive oxygen species and Rho kinase. Journal of veterinary pharmacology and therapeutics, 2013, Volume: 36, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arteries; Cadaver; Hindlimb; Horses; NADPH Oxidases; Oxygen; Phenylephrine; Pyridines; Reactive Oxygen Species; rho-Associated Kinases; Vasoconstriction	2013
Increased activation of the Rho-A/Rho-kinase pathway in the renal vascular system is responsible for the enhanced reactivity to exogenous vasopressin in endotoxemic rats. Critical care medicine, 2014, Volume: 42, Issue:6 Topics: Amides; Analysis of Variance; Animals; Arterial Pressure; Endotoxemia; Enzyme Inhibitors; Heart; Kidney; Male; Myosin-Light-Chain Phosphatase; Perfusion; Phenylephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; rho-Associated Kinases; Vasoconstrictor Agents; Vasopressins	2014
Increased Rho-kinase-mediated prostate contractions associated with impairment of β-adrenergic-cAMP-signaling pathway by chronic nitric oxide deficiency. European journal of pharmacology, 2015, Jul-05, Volume: 758 Topics: Adenosine Triphosphate; Amides; Animals; Carbachol; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phenylephrine; Prostate; Pyridines; Rats; rho-Associated Kinases; Signal Transduction	2015
Chronic ouabain treatment induces Rho kinase activation. Archives of pharmacal research, 2015, Volume: 38, Issue:10 Topics: Amides; Animals; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Male; Myosin-Light-Chain Phosphatase; Ouabain; Phenylephrine; Potassium Chloride; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases	2015
Effects of ethanol on RhoA/Rho-kinase-mediated calcium sensitization in mouse lung parenchymal tissue. European journal of pharmacology, 2015, Oct-05, Volume: 764 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Ethanol; Lung; Male; Mice; Microscopy, Electron; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction	2015
Short-duration increases in intraluminal pressure improve vasoconstrictor responses in aged skeletal muscle feed arteries. European journal of applied physiology, 2016, Volume: 116, Issue:5 Topics: Aging; Amides; Angiotensin II; Animals; Arteries; Endothelium, Vascular; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Physical Conditioning, Animal; Pressure; Pyridines; Rats; Rats, Inbred F344; rho-Associated Kinases; Vasoconstriction; Vasoconstrictor Agents	2016
Mitochondrial Fission of Smooth Muscle Cells Is Involved in Artery Constriction. Hypertension (Dallas, Tex. : 1979), 2016, Volume: 68, Issue:5 Topics: Amides; Analysis of Variance; Animals; Aorta; Cells, Cultured; Drug Interactions; Humans; Mesenteric Arteries; Mitochondrial Dynamics; Models, Animal; Muscle Cells; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylephrine; Pyridines; Quinazolinones; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Diseases; Vasoconstriction; Vasodilation	2016
High-Salt Intake Augments the Activity of the RhoA/ROCK Pathway and Reduces Intracellular Calcium in Arteries From Rats. American journal of hypertension, 2017, Apr-01, Volume: 30, Issue:4 Topics: Amides; Animals; Aorta; Calcium; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate Receptors; Male; Mesenteric Arteries; Myocytes, Smooth Muscle; ORAI1 Protein; Phenylephrine; Phosphorylation; Protein Phosphatase 1; Pyridines; Rats; Rats, Wistar; rho GTP-Binding Proteins; rho-Associated Kinases; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Sodium Chloride, Dietary; Stromal Interaction Molecule 1; Vasoconstriction; Vasoconstrictor Agents	2017
Altered ureteral contractility with ageing: Role of the rho-kinase pathway. Mechanisms of ageing and development, 2018, Volume: 171 Topics: Aging; Amides; Animals; Dose-Response Relationship, Drug; Female; Mice; Muscle Contraction; Phenylephrine; Pyridines; rho-Associated Kinases; Serotonin; Swine; Ureter	2018
Neryl butyrate induces contractile effects on isolated preparations of rat aorta. Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:1 Topics: Adrenergic alpha-Agonists; Amides; Animals; Aorta, Thoracic; Butyrates; Calcium; Estrenes; Heart Atria; In Vitro Techniques; Male; Phenylephrine; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Pyridines; Pyrrolidinones; Rats, Wistar; Vasoconstriction; Vasoconstrictor Agents	2020
Sphingosine-1-Phosphate Enhances α International journal of molecular sciences, 2019, Dec-17, Volume: 20, Issue:24 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Drug Synergism; Lysophospholipids; Mice, Inbred C57BL; Mice, Knockout; Phenylephrine; Pyridines; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents	2019
Nitric oxide-mediated inhibition of phenylephrine-induced contraction in response to hypothermia is partially modulated by endothelial Rho-kinase. International journal of medical sciences, 2020, Volume: 17, Issue:1 Topics: Amides; Animals; Aorta; Endothelium, Vascular; Humans; Hypothermia, Induced; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase Type III; Phenylephrine; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Rats; rho-Associated Kinases; Signal Transduction; Vasoconstriction	2020