Page last updated: 2024-09-03

y 27632 and nocodazole

y 27632 has been researched along with nocodazole in 16 studies

Compound Research Comparison

Studies
(y 27632)
Trials
(y 27632)
Recent Studies (post-2010)
(y 27632)
Studies
(nocodazole)
Trials
(nocodazole)
Recent Studies (post-2010) (nocodazole)
1,92438913,0780655

Protein Interaction Comparison

ProteinTaxonomyy 27632 (IC50)nocodazole (IC50)
Chain A, Glutathione-requiring prostaglandin D synthaseHomo sapiens (human)65
nuclear receptor subfamily 0 group B member 1Homo sapiens (human)0.8334
Tyrosine-protein kinase ABL1Homo sapiens (human)0.64
Tubulin alpha-1A chainSus scrofa (pig)1.3775
Tubulin beta chainSus scrofa (pig)0.76
Tubulin beta-4A chainHomo sapiens (human)1.2975
Tubulin beta chainHomo sapiens (human)1.2975
Tubulin alpha-3C chainHomo sapiens (human)1.2975
Adenosine receptor A2aHomo sapiens (human)7.509
Tubulin alpha-1B chainHomo sapiens (human)1.2975
Tubulin alpha-4A chainHomo sapiens (human)1.2975
Tubulin beta-4B chainHomo sapiens (human)1.2975
Sodium-dependent dopamine transporter Homo sapiens (human)6.232
Tubulin beta-3 chainHomo sapiens (human)1.2975
Tubulin beta-2A chainHomo sapiens (human)1.2975
Tubulin beta-8 chainHomo sapiens (human)1.2975
Tubulin beta-2B chainBos taurus (cattle)2.3
Tubulin alpha-3E chainHomo sapiens (human)1.2975
Tubulin alpha-1A chainHomo sapiens (human)1.2975
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)2.3
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)2.3
Tubulin alpha-1C chainHomo sapiens (human)1.2975
Tubulin beta-6 chainHomo sapiens (human)1.2975
Tubulin beta-2B chainHomo sapiens (human)1.2975
Tubulin beta-1 chainHomo sapiens (human)1.2975

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (56.25)29.6817
2010's7 (43.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jin, N; Li, L; Rhoades, RA; Swartz, DR; Wang, Z; Yancey, KW; Zhang, D1
Bonder, EM; Feder, HH; Gelfand, IM; Omelchenko, T; Vasiliev, JM1
Dobbie, IM; Dunn, GA; Gray, C; Holt, MR; Monypenny, J; Soong, DY; Zicha, D1
Giehl, K; Goppelt-Struebe, M; Graness, A; Iwanciw, D; Ott, C1
Alieva, I; Birukov, KG; Birukova, AA; Garcia, JG; Kaibuchi, K; Liu, F; Natarajan, V; Ricks-Cord, A; Smurova, K; Usatyuk, P; Verin, AD1
Coleman, ML; Croft, DR; Li, S; Olson, MF; Robertson, D; Stewart, CL; Sullivan, T1
Dunn, G; Kelly, G; Martin, P; Redd, MJ; Way, M1
Blum, M; Mihatsch, J; Möller, W; Rösner, H; Wassermann, T1
Giehl, K; Goppelt-Struebe, M; Graness, A1
Alieva, IB; Smurova, KM; Verin, AD1
Itoh, H; Satoh, N; Takahashi, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N; Zhang, H1
Bodennec, S; Delanoë-Ayari, H; Ferri, K; Mertani, HC; Mgharbel, A; Rieu, JP; Stirbat, TV1
Kurniawan, NA; Lim, CT; Sun, W1
Liu, Y; Ma, T; Tsai, AC; Yuan, X1
Gracias, DH; Kuo, S; Lehmann, M; Lewis, S; Li, J; Romer, LH; Serbo, JV1
Barbier, P; Bastonero, S; Breuzard, G; Kovacic, H; Malesinski, S; Pagano, A; Parat, F; Peyrot, V1

Other Studies

16 other study(ies) available for y 27632 and nocodazole

ArticleYear
Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.
    Journal of muscle research and cell motility, 2001, Volume: 22, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antineoplastic Agents; Aorta; Azepines; Calcium; Colchicine; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Male; Microtubules; Muscle Contraction; Muscle, Smooth, Vascular; Nocodazole; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstrictor Agents

2001
Mechanisms of polarization of the shape of fibroblasts and epitheliocytes: Separation of the roles of microtubules and Rho-dependent actin-myosin contractility.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Aug-06, Volume: 99, Issue:16

    Topics: Actins; Amides; Animals; Cell Line; Cell Polarity; Cell Size; Enzyme Inhibitors; Epithelial Cells; Fibroblasts; Intracellular Signaling Peptides and Proteins; Microtubules; Myosins; Nocodazole; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases

2002
Rapid actin transport during cell protrusion.
    Science (New York, N.Y.), 2003, Apr-04, Volume: 300, Issue:5616

    Topics: Actins; Amides; Animals; Azepines; Bacterial Proteins; Biological Transport, Active; Biopolymers; Cell Line, Transformed; Cell Movement; Depsipeptides; Diffusion; Enzyme Inhibitors; Fluorescence; Fluorescence Recovery After Photobleaching; Fluorometry; Green Fluorescent Proteins; Image Processing, Computer-Assisted; Intracellular Signaling Peptides and Proteins; Luminescent Proteins; Microscopy, Confocal; Monte Carlo Method; Myosin-Light-Chain Kinase; Naphthalenes; Nocodazole; Peptides, Cyclic; Photobleaching; Protein Serine-Threonine Kinases; Protein Transport; Pseudopodia; Pyridines; Rats; Recombinant Fusion Proteins; rho-Associated Kinases; Tumor Cells, Cultured

2003
Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton.
    The Journal of biological chemistry, 2003, Nov-07, Volume: 278, Issue:45

    Topics: Actins; Amides; Bacterial Proteins; Bacterial Toxins; Botulinum Toxins; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Colchicine; Connective Tissue Growth Factor; Cytochalasin D; Cytoskeleton; Fibroblasts; Gene Expression Regulation; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Nocodazole; Paclitaxel; Pyridines; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Stress, Mechanical; Thiazoles; Thiazolidines

2003
Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms.
    Journal of cellular physiology, 2004, Volume: 201, Issue:1

    Topics: Actin Cytoskeleton; Amides; Animals; Antineoplastic Agents; Calcium; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Microtubules; Myosin Light Chains; Nocodazole; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases

2004
Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.
    The Journal of cell biology, 2005, Jan-17, Volume: 168, Issue:2

    Topics: Actins; Amides; Animals; Apoptosis; Caspase Inhibitors; Caspases; Cell Nucleus; Cycloheximide; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Fibroblasts; Intracellular Signaling Peptides and Proteins; Lamins; Lim Kinases; Mice; Microscopy, Electron, Transmission; Microtubules; Mutation; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Myosins; NIH 3T3 Cells; Nocodazole; Nuclear Lamina; Nuclear Proteins; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Transfection; Tumor Necrosis Factor-alpha

2005
Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammation.
    Cell motility and the cytoskeleton, 2006, Volume: 63, Issue:7

    Topics: Amides; Animals; Chemotaxis; Embryo, Nonmammalian; Enzyme Inhibitors; Green Fluorescent Proteins; Inflammation; Intracellular Signaling Peptides and Proteins; Macrophages; Microscopy, Video; Microtubules; Nocodazole; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Wounds and Injuries; Yolk Sac; Zebrafish

2006
Attenuation of actinomyosinII contractile activity in growth cones accelerates filopodia-guided and microtubule-based neurite elongation.
    Brain research, 2007, Oct-24, Volume: 1176

    Topics: Actomyosin; Amides; Animals; Central Nervous System; Chick Embryo; Contractile Proteins; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibronectins; Growth Cones; Heterocyclic Compounds, 4 or More Rings; Laminin; Microtubules; Neural Pathways; Neurites; Neurogenesis; Nocodazole; Paclitaxel; Pseudopodia; Pyridines; rho GTP-Binding Proteins; Tubulin Modulators

2007
The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression.
    American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:2

    Topics: Actins; Amides; Aminoquinolines; Animals; Cell Adhesion; Cell Shape; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Focal Adhesions; Gene Expression; Mesangial Cells; Microtubules; Nocodazole; Paxillin; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Thrombospondin 1

2008
[The effect of Rho-kinase inhibition depends on the nature of factors that modify endothelial permeability].
    Tsitologiia, 2011, Volume: 53, Issue:4

    Topics: Actin Cytoskeleton; Amides; Cell Line; Cell Membrane Permeability; Endothelial Cells; Endothelium, Vascular; Fluorescent Antibody Technique; Humans; Microtubules; Nocodazole; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Thrombin

2011
Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Amides; Animals; Calcium; Cattle; Cells, Cultured; Cytochalasin D; Dose-Response Relationship, Drug; Nocodazole; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Time Factors; Up-Regulation

2012
Fine tuning of tissues' viscosity and surface tension through contractility suggests a new role for α-catenin.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Actin Cytoskeleton; alpha Catenin; Amides; Animals; Biomechanical Phenomena; Cell Adhesion; Cell Communication; Cell Line, Tumor; Cell Movement; Computer Simulation; Embryo, Mammalian; Gene Knockout Techniques; Heterocyclic Compounds, 4 or More Rings; Mechanotransduction, Cellular; Mice; Nocodazole; Pyridines; Surface Tension; Viscosity

2013
Mechanistic adaptability of cancer cells strongly affects anti-migratory drug efficacy.
    Journal of the Royal Society, Interface, 2014, Oct-06, Volume: 11, Issue:99

    Topics: Amides; Antineoplastic Agents; Breast Neoplasms; Cell Movement; Cytochalasin D; Dipeptides; Extracellular Matrix; Female; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Microscopy, Confocal; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplastic Cells, Circulating; Nocodazole; Pyridines; Statistics, Nonparametric; Time-Lapse Imaging

2014
Compaction, fusion, and functional activation of three-dimensional human mesenchymal stem cell aggregate.
    Tissue engineering. Part A, 2015, Volume: 21, Issue:9-10

    Topics: Actins; Amides; Caspase Inhibitors; Caspases; Cell Adhesion; Cell Aggregation; Cell Communication; Cell Culture Techniques; Cell Fusion; Cell Hypoxia; Cell Movement; Cell Shape; Cell Size; Cell Survival; Cytochalasin D; Humans; Lysophospholipids; Mesenchymal Stem Cells; Nocodazole; Pyridines; rho-Associated Kinases

2015
Patterning of Fibroblast and Matrix Anisotropy within 3D Confinement is Driven by the Cytoskeleton.
    Advanced healthcare materials, 2016, Jan-07, Volume: 5, Issue:1

    Topics: Actin Depolymerizing Factors; Actins; Amides; Anisotropy; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cytoskeleton; Dimethylpolysiloxanes; Extracellular Matrix; Fibroblasts; Fibronectins; Gene Knockdown Techniques; Humans; Microtubules; Nocodazole; Pyridines; RNA, Small Interfering; Thiazolidines

2016
Tau regulates the microtubule-dependent migration of glioblastoma cells via the Rho-ROCK signaling pathway.
    Journal of cell science, 2019, 02-11, Volume: 132, Issue:3

    Topics: Actin Cytoskeleton; Actins; Amides; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Focal Adhesion Kinase 1; Gene Expression Regulation; Guanine Nucleotide Exchange Factors; Humans; Microtubules; Neuroglia; Nocodazole; Pyridines; Repressor Proteins; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; tau Proteins

2019