y 27632 has been researched along with mocetinostat in 10 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (mocetinostat) | Trials (mocetinostat) | Recent Studies (post-2010) (mocetinostat) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 21,735 | 390 | 8,606 |
| Protein | Taxonomy | y 27632 (IC50) | mocetinostat (IC50) |
|---|---|---|---|
| Histone deacetylase 3 | Homo sapiens (human) | 0.7851 | |
| Nuclear receptor corepressor 1 | Homo sapiens (human) | 0.022 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.57 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.102 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.102 | |
| Histone deacetylase 4 | Homo sapiens (human) | 0.5717 | |
| Histone deacetylase 1 | Homo sapiens (human) | 0.3433 | |
| Histone deacetylase 7 | Homo sapiens (human) | 0.6725 | |
| Histone deacetylase 2 | Homo sapiens (human) | 0.3537 | |
| Histone deacetylase 11 | Homo sapiens (human) | 0.6386 | |
| Histone deacetylase 8 | Homo sapiens (human) | 0.6725 | |
| Histone deacetylase 6 | Homo sapiens (human) | 0.5717 | |
| Histone deacetylase 5 | Homo sapiens (human) | 0.6725 | |
| Nuclear receptor corepressor 2 | Homo sapiens (human) | 0.045 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
| Fujita, M; Fukai, M; Furukawa, H; Jin, MB; Nakayama, M; Sakurai, T; Shimamura, T; Suzuki, T; Takeda, K; Taniguchi, M; Todo, S | 1 |
| Kurata, H; Matsumura, Y; Nakajima, A; Takaoka, M; Teraishi, K | 1 |
| Büyükafşar, K; Cinel, L; Değirmenci, U; Kaplan, MB; Köksel, O; Kubat, H; Ozdülger, A; Tamer, L; Tiftik, RN; Yildirim, C | 1 |
| Jeppsson, B; Mihaescu, A; Santén, S; Thorlacius, H | 1 |
| Abdulla, A; Awla, D; Hartman, H; Rahman, M; Regnér, S; Thorlacius, H; Zhang, S | 1 |
| Ayaz, L; Canacankatan, N; Cuez, T; Gorur, A; Kacan, M; Kemal Buharalioglu, C; Korkmaz, B; Sahan Firat, S; Sari, AN; Sucu, N; Tamer Gumus, L; Tunctan, B; Unsal, D; Vezir, O | 1 |
| Akerman, S; Fisher, M; Kanthou, C; Mukherjee, D; Reyes-Aldasoro, CC; Tozer, GM; Williams, LJ | 1 |
| Ding, R; Han, J; Hu, Z; Ma, X; Zhao, D | 1 |
| Adam, M; Aytekin, M; Baldus, S; Berghausen, E; Berlin, M; Dweik, RA; Friedrichs, K; Hazen, SL; Hennigs, JK; Heresi, GA; Kaltwasser, C; Klinke, A; Klose, H; Kubala, L; Lau, D; Manchanda, K; Mehrkens, D; Michaëlsson, E; Mollenhauer, M; Molz, S; Ravekes, T; Remane, L; Rosenkranz, S; Rudolph, TK; Rudolph, V; Schermuly, RT | 1 |
10 other study(ies) available for y 27632 and mocetinostat
| Article | Year |
|---|---|
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats.
Topics: Alanine Transaminase; Amides; Animals; Blood Pressure; Endothelin-1; Enzyme Inhibitors; Heart Rate; Hyaluronic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Liver; Liver Circulation; Male; Malondialdehyde; Peroxidase; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; rho-Associated Kinases; Survival Rate | 2003 |
Preventive effect of Y-27632, a selective Rho-kinase inhibitor, on ischemia/reperfusion-induced acute renal failure in rats.
Topics: Acute Kidney Injury; Amides; Animals; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Function Tests; Male; Peroxidase; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; rho-Associated Kinases; Time Factors | 2004 |
Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632.
Topics: Amides; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Injections, Intravenous; Intracellular Signaling Peptides and Proteins; Lung; Male; Malondialdehyde; Nitrates; Nitrites; Oleic Acid; Peroxidase; Protein Serine-Threonine Kinases; Pyridines; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; Tyrosine; Up-Regulation | 2005 |
Rho kinase signalling mediates radiation-induced inflammation and intestinal barrier dysfunction.
Topics: Amides; Animals; Biomarkers; Chemokines; Colitis; Colon; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Leukocytes; Male; Mice; Mice, Inbred C57BL; Permeability; Peroxidase; Platelet Activation; Pyridines; Radiation Injuries, Experimental; rho-Associated Kinases; Signal Transduction | 2011 |
Rho-kinase signalling regulates trypsinogen activation and tissue damage in severe acute pancreatitis.
Topics: Amides; Amylases; Animals; Chemokine CXCL2; Cholagogues and Choleretics; Enzyme Inhibitors; Flow Cytometry; Male; Mice; Mice, Inbred C57BL; Necrosis; Neutrophil Infiltration; Pancreas; Pancreatitis; Peroxidase; Pyridines; rho-Associated Kinases; Signal Transduction; Taurocholic Acid; Trypsinogen | 2011 |
Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats.
Topics: Amides; Animals; Catalase; Glutathione; Inflammation; Kidney; Male; Malondialdehyde; MAP Kinase Kinase 1; MAP Kinase Signaling System; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Pyridines; Rats; Rats, Wistar; Reperfusion Injury; rho-Associated Kinases; rhoA GTP-Binding Protein; Superoxide Dismutase; Tyrosine | 2014 |
An in vivo role for Rho kinase activation in the tumour vascular disrupting activity of combretastatin A-4 3-O-phosphate.
Topics: Amides; Animals; Antineoplastic Agents, Phytogenic; Blood Pressure; Colorectal Neoplasms; Female; Humans; Male; Mice, SCID; Peroxidase; Pyridines; rho-Associated Kinases; Stilbenes | 2014 |
Pretreatment with Rho-kinase inhibitor ameliorates lethal endotoxemia-induced liver injury by improving mitochondrial function.
Topics: Alanine Transaminase; Amides; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Cyclooxygenase 2; DNA-Binding Proteins; Endotoxemia; Female; Hepatocytes; High Mobility Group Proteins; Lipopolysaccharides; Liver; Liver Diseases; Male; Malondialdehyde; Mice, Inbred C57BL; Mitochondria; Organophosphorus Compounds; Peroxidase; Piperidines; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Superoxide Dismutase | 2016 |
Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase.
Topics: Adult; Amides; Animals; Cohort Studies; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Hypoxia; Infusions, Intravenous; Kaplan-Meier Estimate; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Peroxidase; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; rho-Associated Kinases; Vascular Remodeling; Vasoconstriction | 2018 |