Page last updated: 2024-09-03

y 27632 and indomethacin

y 27632 has been researched along with indomethacin in 8 studies

Compound Research Comparison

Studies
(y 27632)
Trials
(y 27632)
Recent Studies (post-2010)
(y 27632)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
1,924389129,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyy 27632 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (75.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hosaka, K; Mizuno, R; Ohhashi, T1
Chiba, Y; Misawa, M; Sakai, H1
Jin, L; Palmer, T; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z1
Ito, S; Ito, Y; Kondo, M; Kume, H; Naruse, K; Oguma, T; Shimokata, K; Suki, B1
Fitzgibbon, J; Morrison, JJ; O'Brien, M; Smith, TJ1
Dorrance, AM; Leite, R; Linder, AE; Mills, TM; Webb, RC1
Chang, IH; Han, JH; Kim, HJ; Kim, W; Lee, MY; Lee, SY; Myung, SC1
Abe, S; Watabe, H; Yoshitomi, T1

Other Studies

8 other study(ies) available for y 27632 and indomethacin

ArticleYear
Rho-Rho kinase pathway is involved in the regulation of myogenic tone and pump activity in isolated lymph vessels.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:6

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Lymphatic System; Male; Muscle Tonus; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Okadaic Acid; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho GTP-Binding Proteins; rho-Associated Kinases; Vasoconstrictor Agents

2003
Endothelin-1-induced translocation of RhoA is mediated by endothelin ET(A) receptors in rat bronchial smooth muscle.
    European journal of pharmacology, 2005, Jul-11, Volume: 517, Issue:3

    Topics: Amides; Animals; Atropine; Blotting, Western; Bronchi; Cell Membrane; Cytosol; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Oligopeptides; Peptides, Cyclic; Piperidines; Protein Transport; Pyridines; Rats; Rats, Wistar; Receptor, Endothelin A; rhoA GTP-Binding Protein; Time Factors

2005
Expression and functional role of the RhoA/Rho-kinase pathway in rat coeliac artery.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:10

    Topics: Amides; Animals; Blotting, Western; Celiac Artery; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Guanine Nucleotide Exchange Factors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rho Guanine Nucleotide Exchange Factors; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2005
Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle.
    European journal of pharmacology, 2006, Dec-15, Volume: 552, Issue:1-3

    Topics: Amides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cations; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gadolinium; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Ion Channels; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitrobenzenes; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; rho-Associated Kinases; Simvastatin; Stress, Mechanical; Sulfonamides; Trachea

2006
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin.
    Reproductive biology and endocrinology : RB&E, 2009, Jan-08, Volume: 7

    Topics: Amides; Cell Culture Techniques; Cell Line; Collagen; Female; Humans; Indomethacin; Muscle Contraction; Myocytes, Smooth Muscle; Myometrium; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thrombin; Tumor Necrosis Factor-alpha

2009
Erectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production.
    The journal of sexual medicine, 2009, Volume: 6 Suppl 3

    Topics: Amides; Animals; Antihypertensive Agents; Erectile Dysfunction; Ganglion Cysts; Hypertension; Indomethacin; Kidney; Male; Nitric Oxide; Nitroprusside; Penis; Phenylephrine; Pressure; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases

2009
Effect of low concentrations of hydrogen peroxide on the contractile responses of rat detrusor smooth muscle strips.
    European journal of pharmacology, 2010, Jul-25, Volume: 638, Issue:1-3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Amides; Animals; Calcium; Dose-Response Relationship, Drug; Drug Synergism; Hydrogen Peroxide; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Phenylephrine; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; Urinary Bladder; Verapamil; Vitamin E

2010
Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.
    Japanese journal of ophthalmology, 2011, Volume: 55, Issue:4

    Topics: Amides; Animals; Calcium; Ciliary Arteries; Dose-Response Relationship, Drug; Fluorophotometry; Indomethacin; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Pyridines; Rabbits; rho-Associated Kinases; Vasodilation

2011