y 27632 has been researched along with imatinib mesylate in 5 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (imatinib mesylate) | Trials (imatinib mesylate) | Recent Studies (post-2010) (imatinib mesylate) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 11,477 | 960 | 5,773 |
| Protein | Taxonomy | y 27632 (IC50) | imatinib mesylate (IC50) |
|---|---|---|---|
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | 0.31 | |
| Mast/stem cell growth factor receptor Kit | Homo sapiens (human) | 0.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Jones, SB; Lu, HY; Lu, Q | 1 |
| Harbott, LK; Nobes, CD | 1 |
| Adams, J; Burthem, J; Lucas, GS; Mottram, R; Rees-Unwin, K; Spooncer, E; Whetton, AD | 1 |
| Basbous, S; Bourmeyster, N; Brizard, F; Gombert, JM; Guilhot, F; Herbelin, A; Levescot, A; Piccirilli, N; Roy, L | 1 |
5 other study(ies) available for y 27632 and imatinib mesylate
| Article | Year |
|---|---|
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Abl tyrosine kinase promotes dendrogenesis by inducing actin cytoskeletal rearrangements in cooperation with Rho family small GTPases in hippocampal neurons.
Topics: Actin Cytoskeleton; Actins; Amides; Animals; Axons; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; cdc42 GTP-Binding Protein; Cells, Cultured; Cytoskeleton; Dendrites; Hippocampus; Imatinib Mesylate; Microtubule-Associated Proteins; Neurons; Piperazines; Proto-Oncogene Proteins c-abl; Pyridines; Pyrimidines; rac1 GTP-Binding Protein; Rats; rho GTP-Binding Proteins; Signal Transduction; Thiazoles; Thiazolidines | 2004 |
A key role for Abl family kinases in EphA receptor-mediated growth cone collapse.
Topics: 3T3 Cells; Amides; Animals; Benzamides; Cell Communication; Chick Embryo; Cytoskeleton; Enzyme Inhibitors; Fibroblasts; Growth Cones; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Mice; Piperazines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-abl; Pseudopodia; Pyridines; Pyrimidines; Receptors, Eph Family; Retinal Ganglion Cells; rho-Associated Kinases | 2005 |
The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Antigens, CD34; Benzamides; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; rho-Associated Kinases; Stem Cells; Tumor Cells, Cultured | 2007 |
The Rho-ROCK pathway as a new pathological mechanism of innate immune subversion in chronic myeloid leukaemia.
Topics: Amides; Antigens, CD1d; Cell Differentiation; Dendritic Cells; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunity, Innate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Myeloid Cells; Natural Killer T-Cells; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases | 2016 |