Page last updated: 2024-09-03

y 27632 and histamine

y 27632 has been researched along with histamine in 16 studies

Compound Research Comparison

Studies
(y 27632)
Trials
(y 27632)
Recent Studies (post-2010)
(y 27632)
Studies
(histamine)
Trials
(histamine)
Recent Studies (post-2010) (histamine)
1,924389137,7181,3723,457

Protein Interaction Comparison

ProteinTaxonomyy 27632 (IC50)histamine (IC50)
Histamine H1 receptorRattus norvegicus (Norway rat)0.1585
Histamine H1 receptorHomo sapiens (human)0.1585

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (62.50)29.6817
2010's6 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brautigan, DL; Eto, M; Kitazawa, T; Woodsome, TP1
Hokazono, Y; Kobayashi, S; Kusuda, T; Miyake, T; Mizukami, Y; Mogami, K; Sato, M; Suzuki, S; Todoroki-Ikeda, N; Yamagata, H; Yamamoto, K1
Eichholtz, T; Potempa, S; Ridley, AJ; Wójciak-Stothard, B1
Brautigan, DL; Eto, M; Kitazawa, T; Mukai, H; Ono, Y; Yazawa, M1
Arakawa, H; Iizuka, K; Kato, M; Mochizuki, H; Morikawa, A; Nishimura, H; Saga, R; Tokuyama, K1
Hayashi, H; Honjo, H; Ito, S; Katoh, H; Kodama, I; Kume, H; Yamaki, K1
Fang, YI; Hashimoto, T; Momose, K; Nakano, Y; Ohata, H; Yamashita, M1
Glynos, K; Papapetropoulos, A; Pizurki, L; Roussos, C; Zhou, Z1
Meurs, H; Nelemans, SA; Schaafsma, D; Zaagsma, J; Zuidhof, AB1
Akça, T; Aydin, S; Büyükafşar, K; Nalan Tiftik, R; Sahan-Firat, S1
Joh, S; Kawaguchi, T; Kuji, A; Satoh, K1
Breslin, JW1
Calzetta, L; Cazzola, M; Kanabar, V; Lauro, D; Matera, MG; Novelli, L; Page, CP; Rogliani, P1
Butler, JP; Carman, CV; Fredberg, JJ; Hardin, C; Krishnan, R; Manomohan, G; Martinelli, R; Rajendran, K; Tambe, DT1
Adams, RH; Amornphimoltham, P; Ando, K; Chavakis, T; Fukuhara, S; Gutkind, JS; Masedunskas, A; Mikelis, CM; Mochizuki, N; Offermanns, S; Sakurai, A; Simaan, M; Weigert, R; Zheng, Y1
Beyerle, A; Bischoff, I; Fürst, R; Hornburger, MC; Mayer, BA; Wegener, J1

Other Studies

16 other study(ies) available for y 27632 and histamine

ArticleYear
Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility.
    The Journal of biological chemistry, 2000, Apr-07, Volume: 275, Issue:14

    Topics: Amides; Animals; Cell Membrane Permeability; Enzyme Inhibitors; Femoral Artery; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Histamine; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phenylephrine; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Type C Phospholipases

2000
Sphingosylphosphorylcholine induces Ca(2+)-sensitization of vascular smooth muscle contraction: possible involvement of rho-kinase.
    FEBS letters, 2000, Sep-29, Volume: 482, Issue:1-2

    Topics: Amides; Animals; Calcium; Coronary Vessels; Cytosol; Enzyme Inhibitors; Guanosine Triphosphate; Histamine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylcholine; Potassium; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sphingosine; Swine

2000
Rho and Rac but not Cdc42 regulate endothelial cell permeability.
    Journal of cell science, 2001, Volume: 114, Issue:Pt 7

    Topics: Actins; Adherens Junctions; Amides; cdc42 GTP-Binding Protein; Cell Adhesion; Cell Membrane Permeability; Cells, Cultured; Cytoskeleton; Endothelium, Vascular; Enzyme Inhibitors; Histamine; Humans; Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Pyridines; rac1 GTP-Binding Protein; rho-Associated Kinases; rhoA GTP-Binding Protein; Thrombin; Tight Junctions

2001
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms.
    The Journal of biological chemistry, 2001, Aug-03, Volume: 276, Issue:31

    Topics: Amides; Amino Acid Sequence; Animals; Aorta; Carbazoles; Chromatography; Chromatography, Affinity; Chromatography, Ion Exchange; Durapatite; Enzyme Activation; Enzyme Inhibitors; Histamine; In Vitro Techniques; Indoles; Isoenzymes; Kinetics; Maleimides; Molecular Sequence Data; Muscle Contraction; Muscle Proteins; Muscle Relaxants, Central; Muscle, Smooth, Vascular; Myelin Basic Protein; Myosin-Light-Chain Phosphatase; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Pyridines; Recombinant Proteins; Substrate Specificity; Swine; Vasoconstriction

2001
Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo.
    Pharmacology, 2002, Volume: 64, Issue:4

    Topics: Airway Obstruction; Airway Resistance; Amides; Animals; Blood Pressure; Bronchoconstriction; Bronchodilator Agents; Capillary Permeability; Enzyme Inhibitors; Guinea Pigs; Histamine; Intracellular Signaling Peptides and Proteins; Leukotriene D4; Male; Procaterol; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Specific Pathogen-Free Organisms; Time Factors

2002
Regulation of capacitative and noncapacitative receptor-operated Ca2+ entry by rho-kinase in tracheal smooth muscle.
    American journal of respiratory cell and molecular biology, 2002, Volume: 26, Issue:4

    Topics: Actins; Amides; Animals; Calcium Channel Blockers; Calcium Signaling; Cytoskeleton; Enzyme Inhibitors; Guinea Pigs; Histamine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Sarcoplasmic Reticulum; Signal Transduction; Trachea

2002
Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs.
    Japanese journal of pharmacology, 2002, Volume: 88, Issue:3

    Topics: Acetylcholine; Amides; Animals; Bronchial Hyperreactivity; Enzyme Inhibitors; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Ketotifen; Lung; Lysophospholipids; Male; Muscle Contraction; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; Pyrilamine; rho-Associated Kinases; Structure-Activity Relationship

2002
Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production.
    British journal of pharmacology, 2003, Volume: 139, Issue:2

    Topics: Amides; Angiopoietin-1; Animals; Bradykinin; Capillary Permeability; Cattle; Cell Adhesion; Cell Line; Cells, Cultured; Endothelium, Vascular; Histamine; Humans; Interleukin-8; Intracellular Signaling Peptides and Proteins; Lung; Neutrophils; Platelet Activating Factor; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Thrombin

2003
Inhibition of Rho-kinase normalizes nonspecific hyperresponsiveness in passively sensitized airway smooth muscle preparations.
    European journal of pharmacology, 2006, Feb-15, Volume: 531, Issue:1-3

    Topics: Amides; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Histamine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Ovalbumin; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Time Factors; Trachea

2006
Contribution of Rho-kinase in human gallbladder contractions.
    European journal of pharmacology, 2006, Jul-01, Volume: 540, Issue:1-3

    Topics: Aged; Amides; Blotting, Western; Carbachol; Cholecystokinin; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Female; Gallbladder; Histamine; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Muscle Contraction; Neurokinin A; Peptide Fragments; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Serotonin

2006
Features of distinct contractions induced with a high and a low concentration of KCl, noradrenaline, and histamine in swine lingual artery.
    Naunyn-Schmiedeberg's archives of pharmacology, 2010, Volume: 381, Issue:2

    Topics: Amides; Animals; Arteries; Boron Compounds; Calcium; Dose-Response Relationship, Drug; Endothelium, Vascular; Histamine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Norepinephrine; Potassium Chloride; Pyridines; rho-Associated Kinases; Signal Transduction; Swine; Tongue; Vasoconstrictor Agents

2010
ROCK and cAMP promote lymphatic endothelial cell barrier integrity and modulate histamine and thrombin-induced barrier dysfunction.
    Lymphatic research and biology, 2011, Volume: 9, Issue:1

    Topics: Adult; Amides; Azepines; Capillary Permeability; Cells, Cultured; Cyclic AMP; Endothelial Cells; Enzyme Inhibitors; Histamine; Humans; Myosin-Light-Chain Kinase; Naphthalenes; Pyridines; rho-Associated Kinases; Signal Transduction; Thrombin

2011
High glucose enhances responsiveness of human airways smooth muscle via the Rho/ROCK pathway.
    American journal of respiratory cell and molecular biology, 2012, Volume: 47, Issue:4

    Topics: Acetylcholine; Amides; Bradykinin; Bronchi; Calcium Signaling; Cells, Cultured; Enzyme Activation; Female; Glucose; Histamine; Humans; Hyperglycemia; Imidazoles; In Vitro Techniques; Male; Mannitol; Middle Aged; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Phosphatase; Osmolar Concentration; Oxadiazoles; Phosphorylation; Protein Processing, Post-Translational; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases

2012
Glassy dynamics, cell mechanics, and endothelial permeability.
    The journal of physical chemistry. B, 2013, Oct-24, Volume: 117, Issue:42

    Topics: Amides; Cell Line; Cell Membrane Permeability; Cytoskeleton; Endothelial Cells; Fluorescent Dyes; Hepatocyte Growth Factor; Histamine; Humans; Hydrogen Peroxide; Lysophospholipids; Microscopy, Confocal; Phase Transition; Pyridines; Sphingosine; Thrombin

2013
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.
    Nature communications, 2015, Apr-10, Volume: 6

    Topics: Adherens Junctions; Amides; Anaphylaxis; Animals; Capillary Permeability; Endothelial Cells; Endothelium, Vascular; Female; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gq-G11; Histamine; Humans; Male; Mice; Mice, Knockout; Phospholipase C beta; Protein Kinase Inhibitors; Pyridines; Receptors, Histamine H1; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Skin

2015
Pitfalls in assessing microvascular endothelial barrier function: impedance-based devices versus the classic macromolecular tracer assay.
    Scientific reports, 2016, Mar-30, Volume: 6

    Topics: Amides; Biological Assay; Capillary Permeability; Cells, Cultured; Electric Impedance; Endothelial Cells; Endothelium, Vascular; Histamine; Humans; Pyridines

2016