y 27632 has been researched along with ha 1100 in 12 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (ha 1100) | Trials (ha 1100) | Recent Studies (post-2010) (ha 1100) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 75 | 0 | 37 |
| Protein | Taxonomy | y 27632 (IC50) | ha 1100 (IC50) |
|---|---|---|---|
| Rho-associated protein kinase 2 | Homo sapiens (human) | 0.4565 | |
| C-C motif chemokine 2 | Homo sapiens (human) | 6.9183 | |
| Rho-associated protein kinase 1 | Homo sapiens (human) | 0.7793 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bellon, S; Doran, J; Fleming, M; Hayakawa, K; Jacobs, M; Swenson, L; Taslimi, P | 1 |
| Büttner, FH; Cywin, CL; Dahmann, G; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Mao, W; Marshall, D; Morwick, T; Paw, Z; Shih, CK; Wu, F; Young, E | 1 |
| Adam, J; Bennett, J; Black, D; Boucharens, S; Brown, AR; Cook, A; de Man, J; Epemolu, O; Fletcher, D; Haunso, A; Huggett, M; Jones, P; Laats, S; Lyons, A; Mestres, J; Morphy, R; Rankovic, Z; Ray, P; Sherborne, B; Sherry, L; van Straten, N; Westwood, P; Wright, J; Zaman, GZ | 1 |
| Cox, KJ; Gaj, A; Ghosh, I; Jester, BW; Shomin, CD | 1 |
| Bandarage, UK; Cao, J; Court, J; Gao, H; Green, J; Jacobs, M; Marhefka, C; Nakayama, T; Newsome, D; Rodems, S; Shah, S; Taslimi, P | 1 |
| Barnes, M; Beaumont, V; Cachope, R; Chauhan, A; Dominguez, C; Gallati, C; Haughan, AF; Kempf, G; Ladduwahetty, T; Lee, MR; Luckhurst, CA; Maillard, MC; Matthews, K; McAllister, G; Mitchell, P; Munoz-Sanjuan, I; Patel, H; Rose, M; Saville-Stones, E; Steinbacher, S; Stott, AJ; Thatcher, E; Tierney, J; Todd, D; Urbonas, L | 1 |
| Shimokawa, H | 1 |
| Ohnaka, K; Takayanagi, R | 1 |
| Asano, T; Huang, Z; Kim, HH; Liao, JK; Moskowitz, MA; Rikitake, Y; Seto, M; Yano, K | 1 |
| Abe, H; Fujikura, Y; Ina, K; Kitamura, H; Miyazaki, T; Tatsukawa, S | 1 |
| Heaps, CL; Parker, JL; Robles, JC; Sturek, M | 1 |
| Altay, O; Duris, K; Fujii, M; Sherchan, P; Soejima, Y; Zhang, JH | 1 |
2 review(s) available for y 27632 and ha 1100
| Article | Year |
|---|---|
Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiovascular Diseases; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vasodilator Agents | 2002 |
[Rho-kinase inhibitor].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Drug Design; Humans; Intracellular Signaling Peptides and Proteins; Osteogenesis; Osteoporosis; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases | 2004 |
10 other study(ies) available for y 27632 and ha 1100
| Article | Year |
|---|---|
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Amino Acid Sequence; Binding Sites; Binding, Competitive; Cyclic AMP-Dependent Protein Kinases; Dimerization; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Molecular Sequence Data; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyridines; rho-Associated Kinases; Structure-Activity Relationship | 2006 |
Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.
Topics: Animals; Aorta; Bisbenzimidazole; Drug Discovery; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Protein Kinase Inhibitors; Rats; rho-Associated Kinases; Structure-Activity Relationship; Urea | 2010 |
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Topics: Amines; Animals; Binding Sites; Computer Simulation; Crystallography, X-Ray; Drug Evaluation, Preclinical; Isoquinolines; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; rho-Associated Kinases; Structure-Activity Relationship | 2011 |
Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.
Topics: Animals; Binding, Competitive; Catalytic Domain; Cell-Free System; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Databases, Factual; Genes, Reporter; Luciferases; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Recombinant Fusion Proteins; Structure-Activity Relationship | 2012 |
Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
Topics: Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Structure-Activity Relationship | 2015 |
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.
Topics: Animals; Brain; Disease Models, Animal; Huntingtin Protein; Huntington Disease; Mice; Protein Kinase Inhibitors; rho-Associated Kinases | 2022 |
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Analysis of Variance; Animals; Antihypertensive Agents; Aorta; Blotting, Northern; Blotting, Western; Brain Ischemia; Cattle; Cell Line; Cells, Cultured; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypoxia; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Serine-Threonine Kinases; Pyridines; Regional Blood Flow; rho-Associated Kinases; RNA, Messenger; Stroke; Time Factors; Umbilical Veins; Up-Regulation | 2005 |
Contraction of tubulointerstitial fibrosis tissue in diabetic nephropathy, as demonstrated in an in vitro fibrosis model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cells, Cultured; Collagen; Cytochalasin D; Diabetic Nephropathies; Diacetyl; Fibroblasts; Fibrosis; Kidney Tubules; Microscopy, Electron, Transmission; Models, Biological; Myosin Light Chains; Phosphorylation; Pyridines; Rats; rho-Associated Kinases; Transforming Growth Factor beta1; Wound Healing | 2007 |
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Collateral Circulation; Coronary Vessels; Endothelin-1; Enzyme Inhibitors; Female; Muscle Contraction; Naphthalenes; Phorbol 12,13-Dibutyrate; Physical Conditioning, Animal; Protein Kinase C; Pyridines; rho-Associated Kinases; Swine; Vasodilator Agents | 2011 |
Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Blood-Brain Barrier; Blotting, Western; Body Water; Brain Chemistry; Brain Edema; Enzyme Inhibitors; Functional Laterality; Male; Membrane Proteins; Neurosurgical Procedures; Occludin; Phosphoproteins; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Subarachnoid Hemorrhage; Tight Junctions; Treatment Outcome; Zonula Occludens-1 Protein | 2012 |