Page last updated: 2024-09-03

y 27632 and ha 1100

y 27632 has been researched along with ha 1100 in 12 studies

Compound Research Comparison

Studies
(y 27632)
Trials
(y 27632)
Recent Studies (post-2010)
(y 27632)
Studies
(ha 1100)
Trials
(ha 1100)
Recent Studies (post-2010) (ha 1100)
1,924389175037

Protein Interaction Comparison

ProteinTaxonomyy 27632 (IC50)ha 1100 (IC50)
Rho-associated protein kinase 2Homo sapiens (human)0.4565
C-C motif chemokine 2Homo sapiens (human)6.9183
Rho-associated protein kinase 1Homo sapiens (human)0.7793

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (41.67)29.6817
2010's6 (50.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Bellon, S; Doran, J; Fleming, M; Hayakawa, K; Jacobs, M; Swenson, L; Taslimi, P1
Büttner, FH; Cywin, CL; Dahmann, G; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Mao, W; Marshall, D; Morwick, T; Paw, Z; Shih, CK; Wu, F; Young, E1
Adam, J; Bennett, J; Black, D; Boucharens, S; Brown, AR; Cook, A; de Man, J; Epemolu, O; Fletcher, D; Haunso, A; Huggett, M; Jones, P; Laats, S; Lyons, A; Mestres, J; Morphy, R; Rankovic, Z; Ray, P; Sherborne, B; Sherry, L; van Straten, N; Westwood, P; Wright, J; Zaman, GZ1
Cox, KJ; Gaj, A; Ghosh, I; Jester, BW; Shomin, CD1
Bandarage, UK; Cao, J; Court, J; Gao, H; Green, J; Jacobs, M; Marhefka, C; Nakayama, T; Newsome, D; Rodems, S; Shah, S; Taslimi, P1
Barnes, M; Beaumont, V; Cachope, R; Chauhan, A; Dominguez, C; Gallati, C; Haughan, AF; Kempf, G; Ladduwahetty, T; Lee, MR; Luckhurst, CA; Maillard, MC; Matthews, K; McAllister, G; Mitchell, P; Munoz-Sanjuan, I; Patel, H; Rose, M; Saville-Stones, E; Steinbacher, S; Stott, AJ; Thatcher, E; Tierney, J; Todd, D; Urbonas, L1
Shimokawa, H1
Ohnaka, K; Takayanagi, R1
Asano, T; Huang, Z; Kim, HH; Liao, JK; Moskowitz, MA; Rikitake, Y; Seto, M; Yano, K1
Abe, H; Fujikura, Y; Ina, K; Kitamura, H; Miyazaki, T; Tatsukawa, S1
Heaps, CL; Parker, JL; Robles, JC; Sturek, M1
Altay, O; Duris, K; Fujii, M; Sherchan, P; Soejima, Y; Zhang, JH1

Reviews

2 review(s) available for y 27632 and ha 1100

ArticleYear
Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.
    Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiovascular Diseases; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vasodilator Agents

2002
[Rho-kinase inhibitor].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Drug Design; Humans; Intracellular Signaling Peptides and Proteins; Osteogenesis; Osteoporosis; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases

2004

Other Studies

10 other study(ies) available for y 27632 and ha 1100

ArticleYear
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
    The Journal of biological chemistry, 2006, Jan-06, Volume: 281, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Amino Acid Sequence; Binding Sites; Binding, Competitive; Cyclic AMP-Dependent Protein Kinases; Dimerization; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Molecular Sequence Data; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyridines; rho-Associated Kinases; Structure-Activity Relationship

2006
Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.
    Journal of medicinal chemistry, 2010, Jan-28, Volume: 53, Issue:2

    Topics: Animals; Aorta; Bisbenzimidazole; Drug Discovery; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Protein Kinase Inhibitors; Rats; rho-Associated Kinases; Structure-Activity Relationship; Urea

2010
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
    Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

    Topics: Amines; Animals; Binding Sites; Computer Simulation; Crystallography, X-Ray; Drug Evaluation, Preclinical; Isoquinolines; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; rho-Associated Kinases; Structure-Activity Relationship

2011
Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.
    Journal of medicinal chemistry, 2012, Feb-23, Volume: 55, Issue:4

    Topics: Animals; Binding, Competitive; Catalytic Domain; Cell-Free System; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Databases, Factual; Genes, Reporter; Luciferases; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Recombinant Fusion Proteins; Structure-Activity Relationship

2012
Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
    Journal of medicinal chemistry, 2015, Jun-25, Volume: 58, Issue:12

    Topics: Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Structure-Activity Relationship

2015
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.
    Journal of medicinal chemistry, 2022, 07-28, Volume: 65, Issue:14

    Topics: Animals; Brain; Disease Models, Animal; Huntingtin Protein; Huntington Disease; Mice; Protein Kinase Inhibitors; rho-Associated Kinases

2022
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
    Stroke, 2005, Volume: 36, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Analysis of Variance; Animals; Antihypertensive Agents; Aorta; Blotting, Northern; Blotting, Western; Brain Ischemia; Cattle; Cell Line; Cells, Cultured; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypoxia; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Serine-Threonine Kinases; Pyridines; Regional Blood Flow; rho-Associated Kinases; RNA, Messenger; Stroke; Time Factors; Umbilical Veins; Up-Regulation

2005
Contraction of tubulointerstitial fibrosis tissue in diabetic nephropathy, as demonstrated in an in vitro fibrosis model.
    Virchows Archiv : an international journal of pathology, 2007, Volume: 451, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cells, Cultured; Collagen; Cytochalasin D; Diabetic Nephropathies; Diacetyl; Fibroblasts; Fibrosis; Kidney Tubules; Microscopy, Electron, Transmission; Models, Biological; Myosin Light Chains; Phosphorylation; Pyridines; Rats; rho-Associated Kinases; Transforming Growth Factor beta1; Wound Healing

2007
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Collateral Circulation; Coronary Vessels; Endothelin-1; Enzyme Inhibitors; Female; Muscle Contraction; Naphthalenes; Phorbol 12,13-Dibutyrate; Physical Conditioning, Animal; Protein Kinase C; Pyridines; rho-Associated Kinases; Swine; Vasodilator Agents

2011
Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats.
    Neurochemistry international, 2012, Volume: 60, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Blood-Brain Barrier; Blotting, Western; Body Water; Brain Chemistry; Brain Edema; Enzyme Inhibitors; Functional Laterality; Male; Membrane Proteins; Neurosurgical Procedures; Occludin; Phosphoproteins; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Subarachnoid Hemorrhage; Tight Junctions; Treatment Outcome; Zonula Occludens-1 Protein

2012