y 27632 has been researched along with h 89 in 12 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (h 89) | Trials (h 89) | Recent Studies (post-2010) (h 89) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 1,619 | 0 | 409 |
| Protein | Taxonomy | y 27632 (IC50) | h 89 (IC50) |
|---|---|---|---|
| Rho-associated protein kinase 2 | Homo sapiens (human) | 1.9504 | |
| Ribosomal protein S6 kinase alpha-5 | Homo sapiens (human) | 0.12 | |
| cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (cattle) | 0.073 | |
| cAMP-dependent protein kinase catalytic subunit alpha | Mus musculus (house mouse) | 0.381 | |
| cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (human) | 0.6365 | |
| cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens (human) | 0.6365 | |
| cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens (human) | 0.6365 | |
| Ribosomal protein S6 kinase beta-1 | Homo sapiens (human) | 0.08 | |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | 1.9886 | |
| RAC-beta serine/threonine-protein kinase | Homo sapiens (human) | 0.5417 | |
| Rho-associated protein kinase 2 | Rattus norvegicus (Norway rat) | 0.27 | |
| RAC-gamma serine/threonine-protein kinase | Homo sapiens (human) | 0.3207 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Cox, KJ; Gaj, A; Ghosh, I; Jester, BW; Shomin, CD | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Boutillier, S; Leemhuis, J; Meyer, DK; Schmidt, G | 1 |
| Awazu, M; Fujita, H; Hida, M; Ishikura, K | 1 |
| Tachibana, H; Umeda, D; Yamada, K | 1 |
| Chang, TC; Chen, CH; Chen, YC; Hsing, EW; Ko, BS; Liou, JY; Wu, KK; Yang, MH | 1 |
| Wei, Y; Xu, J; Xu, X; Xu, Y; Zhang, L | 1 |
| Eto, M; Itsumi, M; Kajioka, S; Kareman, E; Lee, K; Maki, T; Shiota, M | 1 |
12 other study(ies) available for y 27632 and h 89
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.
Topics: Animals; Binding, Competitive; Catalytic Domain; Cell-Free System; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Databases, Factual; Genes, Reporter; Luciferases; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Recombinant Fusion Proteins; Structure-Activity Relationship | 2012 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase.
Topics: Amides; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Enzyme Inhibitors; Genetic Vectors; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Isoquinolines; Microscopy, Confocal; Neurites; Neurons; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Sulfonamides; Transfection; Tumor Cells, Cultured | 2002 |
Trapidil inhibits platelet-derived growth factor-induced migration via protein kinase A and RhoA/Rho-associated kinase in rat vascular smooth muscle cells.
Topics: Amides; Animals; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzymes; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Isoquinolines; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Sulfonamides; Thymidine; Trapidil; Tritium | 2005 |
H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation.
Topics: Actins; Amides; Cell Proliferation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Humans; Isoquinolines; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Sulfonamides | 2008 |
Rho kinases regulate the renewal and neural differentiation of embryonic stem cells in a cell plating density-dependent manner.
Topics: Alkaline Phosphatase; Amides; Animals; Blotting, Western; Cell Differentiation; Cell Line; Cell Proliferation; Embryonic Stem Cells; Enzyme Inhibitors; Gene Expression; Intermediate Filament Proteins; Isoquinolines; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Nestin; Neurons; Octamer Transcription Factor-3; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; RNA Interference; Stem Cells; Sulfonamides | 2010 |
Protein kinase A inhibitor, H89, enhances survival and clonogenicity of dissociated human embryonic stem cells through Rho-associated coiled-coil containing protein kinase (ROCK) inhibition.
Topics: Amides; Animals; Cardiac Myosins; Cell Line; Cell Proliferation; Cell Separation; Cell Shape; Cell Survival; Clone Cells; Coculture Techniques; Colony-Forming Units Assay; Cyclic AMP-Dependent Protein Kinases; Human Embryonic Stem Cells; Humans; Isoquinolines; Kinetics; Mice; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphorylation; Pluripotent Stem Cells; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Pyridines; rho-Associated Kinases; Sulfonamides | 2016 |
Mirabegron induces relaxant effects via cAMP signaling-dependent and -independent pathways in detrusor smooth muscle.
Topics: Acetanilides; Adenylyl Cyclase Inhibitors; Aged; Amides; Animals; Carbachol; Cyclic AMP; Female; Humans; Indoles; Isoquinolines; Male; Maleimides; Muscle Relaxation; Muscle, Smooth; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction; Sulfonamides; Swine; Thiazoles; Urinary Bladder; Urological Agents | 2019 |