Page last updated: 2024-09-03

y 27632 and h 1152

y 27632 has been researched along with h 1152 in 6 studies

Compound Research Comparison

Studies
(y 27632)
Trials
(y 27632)
Recent Studies (post-2010)
(y 27632)
Studies
(h 1152)
Trials
(h 1152)
Recent Studies (post-2010) (h 1152)
1,92438911004

Protein Interaction Comparison

ProteinTaxonomyy 27632 (IC50)h 1152 (IC50)
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)0.1035
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)0.1035
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)0.1035
Chain I, cAMP-dependent protein kinase inhibitor alphasynthetic construct0.1035
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)0.1035
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)0.1035
Chain I, cAMP-dependent protein kinase inhibitor alphasynthetic construct0.1035
Rho-associated protein kinase 2Homo sapiens (human)0.0097
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)0.3254
Rho-associated protein kinase 1Homo sapiens (human)0.005
Rho-associated protein kinase 2Bos taurus (cattle)0.3254
Leucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)0.244

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bellon, S; Doran, J; Fleming, M; Hayakawa, K; Jacobs, M; Swenson, L; Taslimi, P1
Bonn, S; Bossemeyer, D; Breitenlechner, CB; Engh, RA; Erlbruch, A; Gassel, M; Herrero, S; Lehmann, W1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Büttner, FH; Cywin, CL; Dahmann, G; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Mao, W; Marshall, D; Morwick, T; Paw, Z; Shih, CK; Wu, F; Young, E1
Duggan, N; Hollingworth, G; Kosaka, T; Schuler, W; Shaw, D; Soldermann, N; Sprague, E; Thomas, M; van Eis, MJ; Vangrevelinghe, E; Waters, N1

Other Studies

6 other study(ies) available for y 27632 and h 1152

ArticleYear
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
    The Journal of biological chemistry, 2006, Jan-06, Volume: 281, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Amino Acid Sequence; Binding Sites; Binding, Competitive; Cyclic AMP-Dependent Protein Kinases; Dimerization; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Molecular Sequence Data; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyridines; rho-Associated Kinases; Structure-Activity Relationship

2006
Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity.
    The Journal of biological chemistry, 2006, Aug-25, Volume: 281, Issue:34

    Topics: Animals; Benzamides; Cattle; Cyclic AMP-Dependent Protein Kinases; Erlotinib Hydrochloride; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Models, Molecular; Mutagenesis, Site-Directed; Piperazines; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Quinazolines; Recombinant Fusion Proteins; rho-Associated Kinases; Structure-Activity Relationship; Substrate Specificity

2006
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.
    Journal of medicinal chemistry, 2010, Jan-28, Volume: 53, Issue:2

    Topics: Animals; Aorta; Bisbenzimidazole; Drug Discovery; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Protein Kinase Inhibitors; Rats; rho-Associated Kinases; Structure-Activity Relationship; Urea

2010
Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension.
    Bioorganic & medicinal chemistry letters, 2014, Oct-15, Volume: 24, Issue:20

    Topics: Animals; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; rho-Associated Kinases; Structure-Activity Relationship

2014