y 27632 has been researched along with h 1152 in 6 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (h 1152) | Trials (h 1152) | Recent Studies (post-2010) (h 1152) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 10 | 0 | 4 |
| Protein | Taxonomy | y 27632 (IC50) | h 1152 (IC50) |
|---|---|---|---|
| Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit | Bos taurus (cattle) | 0.1035 | |
| Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit | Bos taurus (cattle) | 0.1035 | |
| Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit | Bos taurus (cattle) | 0.1035 | |
| Chain I, cAMP-dependent protein kinase inhibitor alpha | synthetic construct | 0.1035 | |
| Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit | Bos taurus (cattle) | 0.1035 | |
| Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit | Bos taurus (cattle) | 0.1035 | |
| Chain I, cAMP-dependent protein kinase inhibitor alpha | synthetic construct | 0.1035 | |
| Rho-associated protein kinase 2 | Homo sapiens (human) | 0.0097 | |
| cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (cattle) | 0.3254 | |
| Rho-associated protein kinase 1 | Homo sapiens (human) | 0.005 | |
| Rho-associated protein kinase 2 | Bos taurus (cattle) | 0.3254 | |
| Leucine-rich repeat serine/threonine-protein kinase 2 | Homo sapiens (human) | 0.244 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellon, S; Doran, J; Fleming, M; Hayakawa, K; Jacobs, M; Swenson, L; Taslimi, P | 1 |
| Bonn, S; Bossemeyer, D; Breitenlechner, CB; Engh, RA; Erlbruch, A; Gassel, M; Herrero, S; Lehmann, W | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Büttner, FH; Cywin, CL; Dahmann, G; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Mao, W; Marshall, D; Morwick, T; Paw, Z; Shih, CK; Wu, F; Young, E | 1 |
| Duggan, N; Hollingworth, G; Kosaka, T; Schuler, W; Shaw, D; Soldermann, N; Sprague, E; Thomas, M; van Eis, MJ; Vangrevelinghe, E; Waters, N | 1 |
6 other study(ies) available for y 27632 and h 1152
| Article | Year |
|---|---|
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Amino Acid Sequence; Binding Sites; Binding, Competitive; Cyclic AMP-Dependent Protein Kinases; Dimerization; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Molecular Sequence Data; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyridines; rho-Associated Kinases; Structure-Activity Relationship | 2006 |
Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity.
Topics: Animals; Benzamides; Cattle; Cyclic AMP-Dependent Protein Kinases; Erlotinib Hydrochloride; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Models, Molecular; Mutagenesis, Site-Directed; Piperazines; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Quinazolines; Recombinant Fusion Proteins; rho-Associated Kinases; Structure-Activity Relationship; Substrate Specificity | 2006 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.
Topics: Animals; Aorta; Bisbenzimidazole; Drug Discovery; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Protein Kinase Inhibitors; Rats; rho-Associated Kinases; Structure-Activity Relationship; Urea | 2010 |
Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension.
Topics: Animals; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; rho-Associated Kinases; Structure-Activity Relationship | 2014 |