y 27632 and geranylgeranyl pyrophosphate

Topics: ADP Ribose Transferases; Amides; Aorta; Botulinum Toxins; Calcium; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Fluid; Intracellular Signaling Peptides and Proteins; Lysophosphatidylcholines; Membrane Potentials; Mevalonic Acid; Patch-Clamp Techniques; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Type C Phospholipases

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amides; Arteriosclerosis; Base Sequence; Botulinum Toxins; Cells, Cultured; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Monocytes; Plasminogen Activator Inhibitor 1; Polyisoprenyl Phosphates; Pravastatin; Protein Prenylation; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Signal Transduction

Topics: ADP Ribose Transferases; Amides; Animals; Atrial Natriuretic Factor; Botulinum Toxins; Cell Size; Cells, Cultured; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Mevalonic Acid; Myocytes, Cardiac; Phenylalanine; Polyisoprenyl Phosphates; Pravastatin; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger

Topics: Amides; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid Endopeptidases; Brain; Cell Line, Tumor; Endopeptidases; Enzyme Inhibitors; Guanosine Triphosphate; Humans; Ibuprofen; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Peptide Fragments; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Sesquiterpenes; Signal Transduction; Sulindac; Transfection

Topics: Amides; Atorvastatin; Cell Division; Cells, Cultured; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Mevalonic Acid; Peptidyl-Dipeptidase A; Phosphorylation; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; rho-Associated Kinases; RNA, Messenger; Sesquiterpenes; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Amides; Animals; Antineoplastic Agents; Apoptosis; Blotting, Southern; Blotting, Western; Caspases; Cell Survival; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Lovastatin; Male; Mevalonic Acid; Mice; Neoplasms; Neoplasms, Experimental; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured

Topics: 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; ADP Ribose Transferases; Amides; Animals; Atorvastatin; Botulinum Toxins; Dose-Response Relationship, Drug; Glucose; Glucose Transporter Type 4; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Phosphorylation; Polyisoprenyl Phosphates; Pravastatin; Protein Kinase Inhibitors; Protein Prenylation; Protein Transport; Proto-Oncogene Proteins c-akt; Pyridines; Pyrroles; rab4 GTP-Binding Proteins; Receptor, Insulin; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction

Topics: Alkaline Phosphatase; Amides; Aminoquinolines; Animals; Bone Morphogenetic Protein 2; Cell Differentiation; Cells, Cultured; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Muscle Fibers, Skeletal; Myoblasts, Skeletal; Myogenin; Osteoblasts; Polyisoprenyl Phosphates; Protein Kinase Inhibitors; Pyridines; Pyrimidines; rac GTP-Binding Proteins; Recombinant Proteins; rho-Associated Kinases; Sesquiterpenes; Signal Transduction; Simvastatin

Topics: Amides; Animals; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Cytoskeleton; Dimerization; Drug Interactions; Enzyme Activation; ErbB Receptors; Head and Neck Neoplasms; Humans; Lovastatin; Lung Neoplasms; Mice; NIH 3T3 Cells; Polyisoprenyl Phosphates; Proto-Oncogene Proteins c-akt; Pyridines; rho-Associated Kinases; Signal Transduction

Topics: Alkyl and Aryl Transferases; Amides; Bronchi; Bronchoconstriction; Electric Stimulation; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; In Vitro Techniques; Leucine; Lipopolysaccharides; Male; Methionine; Middle Aged; Naphthalenes; Polyisoprenyl Phosphates; Protein Kinase Inhibitors; Protein Prenylation; Pyridines; ras Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; Sesquiterpenes; Signal Transduction; Simvastatin; Time Factors

Topics: Actins; Amides; Animals; Aorta; Atorvastatin; Blotting, Western; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Microfilament Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Polyisoprenyl Phosphates; Potassium Chloride; Pyridines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; Trans-Activators; Vasoconstriction

Topics: Amides; Chemokine CCL2; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Lysophosphatidylcholines; Phospholipases A2, Secretory; Polyisoprenyl Phosphates; Pyridines; Quinolines; RNA, Messenger; RNA, Small Interfering; Tumor Necrosis Factor-alpha

Topics: Amides; Animals; Aorta, Thoracic; Atorvastatin; Endothelin-1; Endothelium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Norepinephrine; Phosphorylation; Polyisoprenyl Phosphates; Potassium Chloride; Prenylation; Protein Phosphatase 1; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Sesquiterpenes

Topics: 3T3-L1 Cells; Acetyltransferases; Adipocytes; Amides; Animals; Atorvastatin; Cell Survival; Delta-5 Fatty Acid Desaturase; Fatty Acid Desaturases; Fatty Acid Elongases; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Polyisoprenyl Phosphates; Pyridines; rho-Associated Kinases; Signal Transduction

Topics: Amides; Atorvastatin; Cell Survival; Delta-5 Fatty Acid Desaturase; Dose-Response Relationship, Drug; Eicosanoic Acids; Fatty Acid Desaturases; Fatty Acid Elongases; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Humans; Mevalonic Acid; Polyisoprenyl Phosphates; Pyridines; rho-Associated Kinases; Signal Transduction; Up-Regulation