y 27632 has been researched along with fasudil in 139 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (fasudil) | Trials (fasudil) | Recent Studies (post-2010) (fasudil) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 965 | 40 | 552 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (1.44) | 18.2507 |
| 2000's | 81 (58.27) | 29.6817 |
| 2010's | 50 (35.97) | 24.3611 |
| 2020's | 6 (4.32) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| McGovern, SL; Shoichet, BK | 1 |
| Bellon, S; Doran, J; Fleming, M; Hayakawa, K; Jacobs, M; Swenson, L; Taslimi, P | 1 |
| Bonn, S; Bossemeyer, D; Breitenlechner, CB; Engh, RA; Erlbruch, A; Gassel, M; Herrero, S; Lehmann, W | 1 |
| Bamford, M; Behm, DJ; Bentley, R; Chen, Z; Doe, C; Dul, E; Grygielko, E; Hu, E; Jolivette, L; Jung, D; Khandekar, S; Kirkpatrick, R; Lafferty, R; Lee, D; Marino, JP; Panchal, T; Smith, GK; Stavenger, R; Webb, C; Willette, R; Wright, LL; Yi, T | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Herbert, JM; Hofmeister, A; Ivashchenko, Y; Janiak, P; Kadereit, D; Kannt, A; Kohlmann, M; Linz, W; Löhn, M; O'Connor, SE; Plettenburg, O; Ruetten, H; Schaefer, M | 1 |
| Büttner, FH; Cywin, CL; Dahmann, G; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Mao, W; Marshall, D; Morwick, T; Paw, Z; Shih, CK; Wu, F; Young, E | 1 |
| Büttner, FH; Chen, R; Cywin, CL; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Paw, Z; Prokopowicz, A; Shih, CK; Snow, R; Wu, F; Young, E | 1 |
| Adam, J; Bennett, J; Black, D; Boucharens, S; Brown, AR; Cook, A; de Man, J; Epemolu, O; Fletcher, D; Haunso, A; Huggett, M; Jones, P; Laats, S; Lyons, A; Mestres, J; Morphy, R; Rankovic, Z; Ray, P; Sherborne, B; Sherry, L; van Straten, N; Westwood, P; Wright, J; Zaman, GZ | 1 |
| Cox, KJ; Gaj, A; Ghosh, I; Jester, BW; Shomin, CD | 1 |
| Alexander, B; Forinash, KD; Guida, WC; Lawrence, NJ; Martin, MP; Pireddu, R; Schönbrunn, E; Sebti, SM; Sun, NN; Sung, SS; Zhu, JY | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
| Bandarage, UK; Cao, J; Court, J; Gao, H; Green, J; Jacobs, M; Marhefka, C; Nakayama, T; Newsome, D; Rodems, S; Shah, S; Taslimi, P | 1 |
| Domokos, D; Falkay, G; Fülöp, F; Gáspár, R | 1 |
| Ito, M; Nakano, T; Narumiya, S; Nishikawa, M; Sasaki, Y; Shiku, H; Suzuki, Y; Wada, H; Yamamoto, M | 1 |
| Daniel, JL; Kunapuli, SP; Paul, BZ | 1 |
| Amano, M; Fukata, Y; Kaibuchi, K; Shimokawa, H | 1 |
| Inagaki, M; Ishizaki, T; Kosako, H; Matsumura, F; Narumiya, S; Yoshida, T | 1 |
| Epstein, HF; Hartshorne, DJ; Hirano, K; Ito, M; Liu, F; Murányi, A; Zhang, R | 1 |
| Leopoldt, D; Lunn, JA; Rozengurt, E; Sinnett-Smith, J | 1 |
| Jin, N; Li, L; Rhoades, RA; Swartz, DR; Wang, Z; Yancey, KW; Zhang, D | 1 |
| Brady, JD; Jezior, JR; McCammon, KA; Miner, AS; Ratz, PH; Rosenstein, DI | 1 |
| Shimokawa, H | 1 |
| Hishinuma, S; Mita, M; Saito, M; Walsh, MP; Yanagihara, H | 1 |
| Ishibashi, T; Maruyama, Y; Nagata, K; Ohkawara, H; Sakamoto, T; Sakurada, S; Shindo, J; Sugimoto, K; Takuwa, Y; Teramoto, T; Yokoyama, K | 1 |
| Grenett, HE; Ku, DD; Urthaler, F; Wolkowicz, PE | 1 |
| Eddinger, TJ; Meehl, JT; Ratz, PH | 1 |
| Calvert, JW; Huang, L; Louis Harkey, H; Miao, L; Sung, JK; Zhang, JH | 1 |
| Barros, F; de la Pena, P; Dupuy, SG; Garcia-Manso, D; Giraldez, T; Gomez-Varela, D | 1 |
| Lan, C; Vollrath, B; Wickman, G | 1 |
| Büyükafşar, K; Levent, A | 2 |
| Bauer, J; Parekh, N | 1 |
| Dubyak, GR; Estacion, M; Schilling, W; Verhoef, PA | 1 |
| Abe, K; Misawa, M | 1 |
| Büyükafşar, K; Un, I | 1 |
| Gugliotta, W; Marroquin, BA; Moore, M; Tse, R; White, SR | 1 |
| Ark, M; Büyükafşar, K; Levent, A | 1 |
| Kikuta, K; Masamune, A; Satoh, K; Satoh, M; Shimosegawa, T | 1 |
| Breslin, JW; Yuan, SY | 1 |
| Bossemeyer, D; Breitenlechner, C; Engh, RA; Gassel, M; Hidaka, H; Huber, R; Kinzel, V | 1 |
| Grigoriadis, AE; Harmey, D; Lax, AJ; Nobes, CD; Stenbeck, G | 1 |
| Ohnaka, K; Takayanagi, R | 1 |
| Amano, M; Kaibuchi, K; Kawabata, S; Nakayama, M; Takefuji, M | 1 |
| Arikan, O; Ark, M; Büyükafsar, K; Korkmaz, B; Kubat, H; Ozveren, E; Songu-Mize, E; Yazici, G | 1 |
| Fagan, KA; Gebb, SA; McMurtry, IF; Morris, KG; Nagaoka, T; Oka, M; Shimokawa, H; Suzuki, T | 1 |
| Amano, M; Kaibuchi, K; Kaneko, T; Katsumi, A; Kawabata, S; Nakayama, M; Takefuji, M | 1 |
| Fang, CX; Ren, J | 1 |
| Jarajapu, YP; Knot, HJ | 1 |
| Brock, JA; Yeoh, M | 1 |
| Asano, T; Huang, Z; Kim, HH; Liao, JK; Moskowitz, MA; Rikitake, Y; Seto, M; Yano, K | 1 |
| Shimoda, LA; Sylvester, JT; Weigand, L | 1 |
| Hayashi, K; Kanda, T; Wakino, S | 1 |
| Amobi, NI; Chung, IP; Smith, IC | 1 |
| Jeppsson, B; Laschke, MW; Menger, MD; Slotta, JE; Thorlacius, H; Thorlacius, K; Wang, Y | 1 |
| Chen, S; Dul, E; Hu, E; Khandekar, SS; Kirkpatrick, RB; Lee, D; Scott, GF; Smith, GK; Wright, LL; Yi, T | 1 |
| Abman, SH; Grover, TR; Parker, TA; Roe, G | 1 |
| Baxter, GF; Bower, HS; Hamid, SA | 1 |
| Brown, JH; Del Re, DP; Miyamoto, S | 1 |
| Kanaide, H; Naito, S; Nishimura, J; Seki, N; Takahashi, R; Tomoda, T; Yunoki, T | 1 |
| Duncker, DJ; Manintveld, OC; Verdouw, PD | 1 |
| Archer, SL; Bonnet, SN; Haromy, A; Harry, G; Hashimoto, K; Kajimoto, H; Michelakis, ED; Moudgil, R; Nakanishi, T; Rebeyka, I; Thébaud, B | 1 |
| Adams, J; Burthem, J; Lucas, GS; Mottram, R; Rees-Unwin, K; Spooncer, E; Whetton, AD | 1 |
| Jin, L; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z | 1 |
| Bähr, M; Lingor, P; Mack, H; Mueller, BK; Mueller, R; Schwarz, K; Teusch, N | 1 |
| Honda, M; Ishikawa, T; Nakayama, K; Suzuki, M | 1 |
| Kass, DA; McKinsey, TA | 1 |
| Patel, CA; Rattan, S | 1 |
| Duan, WG; Liao, H; Yan, M; Yuan, ST; Zhang, LY | 1 |
| Ark, M; Büyükafşar, K; Cnar, MG; Erol, A; Kubat, H; Tiftik, RN; Ulker, S | 1 |
| Bach, LA | 1 |
| Ichikawa, M; Sagawa, H; Saito, K; Tokita, Y; Watanabe, M; Yoshida, J | 1 |
| Chiba, Y; Hanazaki, M; Kohjitani, A; Misawa, M; Morita, K; Sakai, H; Yokoyama, M | 1 |
| Büyükafşar, K; Inan, S | 1 |
| Laschke, MW; Menger, MD; Slotta, JE; Thorlacius, H | 1 |
| Hashimoto, K; Kawagoe, J; Kurachi, H; Morishige, K; Ohta, T; Takahashi, K; Takahashi, T; Takata, K; Tsutsumi, S; Yin, L | 1 |
| Chrones, T; Preiksaitis, HG; Sims, SM | 1 |
| Asano, T; Hattori, T; Ikegaki, I; Kawasaki, K; Sasaki, Y; Satoh, S; Seto, M; Tawara, S; Toshima, Y; Yano, K | 1 |
| He, Y; Liang, L; Sun, L; Xu, H; Yang, X; Ye, Y; Yu, X; Zhan, Z | 1 |
| Bidaud, A; Grise, F; Moreau, V | 1 |
| Chan, CK; Mak, JC; Man, RY; Vanhoutte, PM | 1 |
| Dehde, S; Gatzemeier, S; Klug, P; Meyer, TN; Meyer-Schwesinger, C; Stahl, RA; Thaiss, F; von Ruffer, C; Wenzel, UO | 1 |
| Kim, JH; Kim, MG; Kim, SJ; Oh, JW; Sun, JM | 1 |
| Chen, YH; Longo, FM; Lu, Q; Massa, SM; Zhou, H | 1 |
| Ytrebo, LM | 1 |
| Adachi, S; Dohi, S; Iida, H; Kozawa, O; Matsushima-Nishiwaki, R; Takai, S; Tanabe, K; Yamaguchi, S | 1 |
| Adachi, S; Hanai, Y; Kozawa, O; Matsushima-Nishiwaki, R; Minamitani, C; Mizutani, J; Otsuka, T; Takai, S; Tokuda, H | 1 |
| Adachi, S; Kato, K; Kozawa, O; Matsushima-Nishiwaki, R; Minamitani, C; Mizutani, J; Natsume, H; Otsuka, T; Tokuda, H | 1 |
| Bagcivan, I; Berkan, O; Disli, OM; Durmus, N; Ozdemir, E; Parlak, A | 1 |
| Belcastro, R; Ivanovska, J; Jankov, RP; Kantores, C; Lau, M; McNamara, PJ; Tanswell, AK; Xu, EZ; Ziino, AJ | 1 |
| Baharvand, H; Hassani, SN; Pakzad, M; Seifinejad, A; Taei, A; Totonchi, M | 1 |
| Adachi, S; Kato, K; Kozawa, O; Matsushima-Nishiwaki, R; Minamitani, C; Mizutani, J; Natsume, H; Niida, S; Otsuka, T; Takai, S; Tokuda, H | 1 |
| Bailey, SR; Berhane, Y; Elliott, J; Woodcock, H; Zerpa, H | 1 |
| Engelberts, D; Ivanovska, J; Jankov, RP; Kantores, C; Kavanagh, BP; McNamara, PJ; Xu, EZ | 1 |
| Boergermann, C; Jakobs, KH; Lümmen, G; Rübben, H; Sanders, H; Schmidt, M; vom Dorp, F | 1 |
| Fujimura, K; Hara, Y; Hasegawa, K; Hayashi, K; Homma, K; Hosoya, K; Itoh, H; Minakuchi, H; Tokuyama, H; Tonozuka, Y; Wakino, S; Washida, N | 1 |
| Gao, H; Kobayashi, N; Li, C; Matsuda, S; Nabeka, H; Shimokawa, T; Wakisaka, H; Zhang, X | 1 |
| Belleannée, C; Breton, S; Brown, D; Da Silva, N; McKee, M; Shum, WW | 1 |
| Ishizawa, S; Kanazawa, Y; Kawanami, D; Matoba, K; Utsunomiya, K; Yokota, T | 1 |
| Asano, T; Seto, M | 1 |
| Shi, J; Surma, M; Wei, L | 1 |
| Boakes, A; Crighton, D; Heikkila, T; Kaye, SJ; Mezna, M; Olson, MF; Pang, L; Rushbrooke, M; Schroder, E; Turnbull, A; Wheatley, E | 1 |
| Jin, T; Li, L; Liu, L; Ng, DS; Tam, L | 1 |
| Campbell, WB; Nithipatikom, K; Tang, AT | 1 |
| Seto, M | 1 |
| Itoh, H; Satoh, N; Takahashi, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N; Zhang, H | 1 |
| Bailey, SR; Borer, KE; Elliott, J; Harris, PA | 1 |
| Kato, K; Kondo, A; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Mizutani, J; Otsuka, T; Tokuda, H | 1 |
| Allain, AV; Kadowitz, PJ; Lasker, GF; Murthy, SN; Pankey, EA; Stasch, JP | 1 |
| Alokam, R; Mishra, RK; Sriram, D; Yogeeswari, P | 1 |
| Shi, J; Wei, L | 1 |
| Andrews, MA; Austin, M; Ibe, BO; Lazaro, M; Lustina, J; Raj, JU; Renteria, LS | 1 |
| Bath, PM; Bayraktutan, U; Gibson, CL; Sprigg, N; Srivastava, K | 1 |
| Balakan, O; Bayraktar, R; Camci, C; Gogebakan, B; Izmirli, M; Oztuzcu, S; Suner, A; Ulasli, M | 1 |
| Funauchi, M; Hino, S; Hirooka, Y; Kinoshita, K; Kishimoto, K; Matsumura, I; Niki, K; Nozaki, Y; Yano, T | 1 |
| Chai, Z; Feng, L; Li, YH; Liu, JC; Ma, CG; Xiao, BG; Xin, YL; Yu, JZ; Zhang, GX; Zhang, HZ | 1 |
| Dzialowski, EM; Greyner, H | 1 |
| Astarci, E; Aydinoglu, F; Balli, E; Ergurhan Kiroglu, O; Ogulener, N | 1 |
| Chen, MF; Cheng, YT; Chien, CY; Jan, YJ; Ko, BS; Kuo, CC; Liang, SM; Liou, JY; Shyue, SK; Sung, LY; Wu, KK; Yeih, DF; Yet, SF; Yu, YL | 1 |
| Pernis, AB; Ricker, E; Rozo, C; Weng, CH; Yi, W | 1 |
| Chen, X; Fu, P; Li, C; Luo, X; Tang, R; Wang, W; Xie, M; Yu, Z | 1 |
| Bähr, M; Becker, S; Dambeck, V; Eckermann, K; Fonseca-Ornelas, L; Koch, JC; Lingor, P; Lopes da Fonseca, T; Outeiro, TF; Tatenhorst, L; Tönges, L; Walle, H; Zweckstetter, M | 1 |
| Bicker, G; Scheiblich, H | 1 |
| Huang, W; Lai, W; Li, Y; Lou, T; Peng, H; Rao, J; Tang, H; Wang, C; Ye, Z | 1 |
| Hutchinson, RC; Krabbe, LM; Margulis, V; Sanli, O; Woldu, SL | 1 |
| Chun, KH; Diep, DTV; Hong, K; Jun, HS; Khun, T; Kim, YB; Ul-Haq, A; Zheng, M | 1 |
| Cho, KA; Kang, HT; Lee, YS; Park, CH; Park, JT; Park, SC | 1 |
| Büyükafsar, K; Çarçak, N; Eryiğit Karamahmutoğlu, T; Kurt, AH; Onat, FY; Urhan Küçük, M; Yavuz, M | 1 |
| Domokos, D; Ducza, E; Gáspár, R | 1 |
| Balogh, A; Benyó, Z; Dancs, PT; Fülöp, Á; Kerék, M; Móré, D; Offermanns, S; Panta, CR; Proia, RL; Ruisanchez, É; Tigyi, GJ | 1 |
| Akiba, Y; Eguchi, K; Izumi, K; Kakihara, Y; Kato, H; Nakata, J; Nihara, J; Ohkura, M; Otake, M; Saeki, M; Saito, I; Thant, L | 1 |
| Choi, J; Dutton, JR; Hwang, J; Kang, E; Kang, S; Kim, CJ; Lee, BH; Lee, JY; Lee, Y; Mitalipov, S; Oh, SJ; Seo, EJ; Shin, J; So, S | 1 |
| Baron, C; Besson, P; Bon, E; Brisson, L; Chadet, S; Lemoine, R; Lopez-Charcas, O; Moussata, D; Ouaissi, M; Poisson, L; Roger, S | 1 |
| Alzayed, Z; Büyükafşar, K; İlhan, E; Seçilmiş, MA; Tiftik, RN | 1 |
| Dong, G; Kaibuchi, K; Liao, J; Liu, Y; Mizoguchi, H; Nabeshima, T; Nagai, T; Ozaki, N; Sawahata, M; Wulaer, B; Yamada, K; Zhu, W | 1 |
| Dongfang, H; Fei, R; Hongli, Z; Hongmei, N; Lingli, C; Penghuan, J; Rui, W; Yaming, G; Yuye, L; Zhihong, Y | 1 |
15 review(s) available for y 27632 and fasudil
| Article | Year |
|---|---|
Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiovascular Diseases; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vasodilator Agents | 2002 |
[Rho-kinase inhibitor].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Drug Design; Humans; Intracellular Signaling Peptides and Proteins; Osteogenesis; Osteoporosis; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases | 2004 |
[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Angina Pectoris; Animals; Arteriosclerosis; Calcium; Enzyme Inhibitors; Humans; Hypertension; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases | 2004 |
Small guanine nucleotide-binding protein Rho and myocardial function.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Heart Failure; Humans; Intracellular Signaling Peptides and Proteins; Myocardial Contraction; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2005 |
Rho/Rho kinase as a potential target for the treatment of renal disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Disease Models, Animal; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Kidney Diseases; Kidney Tubules; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rats; rho GTP-Binding Proteins; rho-Associated Kinases | 2005 |
Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiomegaly; Cardiovascular Agents; Humans; Models, Biological; Molecular Structure; Pyridines; Receptors, Cell Surface; Signal Transduction | 2007 |
[Advances in the study of Rho kinase and its inhibitors].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Antihypertensive Agents; Cardiovascular Diseases; Humans; Pyridines; rho-Associated Kinases; Signal Transduction; Subarachnoid Hemorrhage; Vasodilator Agents | 2007 |
Rho GTPases in hepatocellular carcinoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Carcinoma, Hepatocellular; Disease Progression; Farnesyltranstransferase; Humans; Liver Neoplasms; Neoplasm Metastasis; Pyridines; rho GTP-Binding Proteins; Signal Transduction | 2009 |
[Rho-kinase inhibitors].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Clinical Trials as Topic; Coronary Artery Disease; Drug Design; Glaucoma; Humans; Hypertension, Pulmonary; Mice; Molecular Targeted Therapy; Pyridines; Rats; rho-Associated Kinases; Vasospasm, Intracranial | 2011 |
Rho kinase as a therapeutic target in cardiovascular disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Apoptosis; Cardiovascular Diseases; Coronary Artery Disease; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Heart Failure; Humans; Male; Myocytes, Cardiac; Protein Isoforms; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Vasodilation | 2011 |
[Development of Rho kinase inhibitors for pulmonary arterial hypertension].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Drug Design; Humans; Hypertension, Pulmonary; Molecular Targeted Therapy; Pyridines; rho-Associated Kinases | 2012 |
Potential role of Rho kinase inhibitors in combating diabetes-related complications including diabetic neuropathy--a review.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiomyopathies; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Humans; Mice; Oxidative Stress; Pyridines; Rats; rho-Associated Kinases; Sexual Dysfunction, Physiological; Signal Transduction; Vasodilator Agents | 2013 |
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Drug Design; Humans; Molecular Targeted Therapy; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction | 2013 |
Rho Kinases in Autoimmune Diseases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arthritis, Rheumatoid; Autoimmune Diseases; B-Lymphocytes; Cell Movement; Cell Proliferation; Cell Survival; Cytoskeleton; Gene Expression; Giant Cell Arteritis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lupus Erythematosus, Systemic; Myeloid Cells; Osteoarthritis; Protein Kinase Inhibitors; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Scleroderma, Systemic; T-Lymphocytes | 2016 |
The Rho GTPase signalling pathway in urothelial carcinoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Camellia sinensis; Carcinoma, Transitional Cell; Enzyme Inhibitors; Humans; Neoplasm Metastasis; Plant Extracts; Protein Kinase Inhibitors; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Urinary Bladder Neoplasms | 2018 |
124 other study(ies) available for y 27632 and fasudil
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Kinase inhibitors: not just for kinases anymore.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation | 2003 |
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Amino Acid Sequence; Binding Sites; Binding, Competitive; Cyclic AMP-Dependent Protein Kinases; Dimerization; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Molecular Sequence Data; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyridines; rho-Associated Kinases; Structure-Activity Relationship | 2006 |
Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity.
Topics: Animals; Benzamides; Cattle; Cyclic AMP-Dependent Protein Kinases; Erlotinib Hydrochloride; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Models, Molecular; Mutagenesis, Site-Directed; Piperazines; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Quinazolines; Recombinant Fusion Proteins; rho-Associated Kinases; Structure-Activity Relationship; Substrate Specificity | 2006 |
Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Cells, Cultured; Cytokines; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Macrophages; Male; Oxadiazoles; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Vasodilator Agents | 2007 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor.
Topics: Animals; Arteries; Blood Pressure; Catalysis; Cell Line; Cell Proliferation; Chemotaxis; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Immunoblotting; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Myosin-Light-Chain Phosphatase; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; rho-Associated Kinases; Stress Fibers; Vasoconstriction | 2009 |
Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.
Topics: Animals; Aorta; Bisbenzimidazole; Drug Discovery; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Protein Kinase Inhibitors; Rats; rho-Associated Kinases; Structure-Activity Relationship; Urea | 2010 |
Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Crystallography, X-Ray; Drug Discovery; Isoquinolines; Models, Molecular; Protein Kinase Inhibitors; Rats; rho-Associated Kinases | 2010 |
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Topics: Amines; Animals; Binding Sites; Computer Simulation; Crystallography, X-Ray; Drug Evaluation, Preclinical; Isoquinolines; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; rho-Associated Kinases; Structure-Activity Relationship | 2011 |
Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.
Topics: Animals; Binding, Competitive; Catalytic Domain; Cell-Free System; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Databases, Factual; Genes, Reporter; Luciferases; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Recombinant Fusion Proteins; Structure-Activity Relationship | 2012 |
Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).
Topics: | 2012 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
Topics: Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Structure-Activity Relationship | 2015 |
Effects of newly synthetized isoquinoline derivatives on rat uterine contractility and ROCK II activity.
Topics: Animals; Dose-Response Relationship, Drug; Female; Isoquinolines; Molecular Structure; Pregnancy; Protein Kinase Inhibitors; Rats; rho-Associated Kinases; Structure-Activity Relationship; Uterine Contraction | 2018 |
Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Blood Platelets; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Myosin-Light-Chain Phosphatase; Myosins; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein | 1999 |
Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape change.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Blood Platelets; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Egtazic Acid; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Myosins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction | 1999 |
Purification and in vitro activity of Rho-associated kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Baculoviridae; Catalytic Domain; Cattle; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Pyridines; Recombinant Fusion Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Staurosporine | 2000 |
Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Blood Proteins; Carrier Proteins; Cell Division; Cell Line; Cytoskeletal Proteins; Fluorescent Antibody Technique; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microfilament Proteins; Myosin Light Chains; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Stress Fibers | 2000 |
Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Base Sequence; Binding Sites; DNA Primers; Enzyme Inhibitors; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Myosin-Light-Chain Phosphatase; Myotonic Dystrophy; Myotonin-Protein Kinase; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Subunits; Pyridines; Recombinant Proteins; rho-Associated Kinases | 2001 |
Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Amides; Animals; Bombesin; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Pyridines; Retinoblastoma-Like Protein p130; rho-Associated Kinases; Stress Fibers | 2001 |
Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antineoplastic Agents; Aorta; Azepines; Calcium; Colchicine; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Male; Microtubules; Muscle Contraction; Muscle, Smooth, Vascular; Nocodazole; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstrictor Agents | 2001 |
Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetamides; Amides; Animals; Bethanechol; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Imidazoles; In Vitro Techniques; Indoles; Ion Channels; Isoquinolines; Muscle Contraction; Myosin Light Chains; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rabbits; Time Factors; Urinary Bladder; Verapamil | 2001 |
Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arteries; Enzyme Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Potassium; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2002 |
Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amides; Arteriosclerosis; Base Sequence; Botulinum Toxins; Cells, Cultured; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Monocytes; Plasminogen Activator Inhibitor 1; Polyisoprenyl Phosphates; Pravastatin; Protein Prenylation; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Signal Transduction | 2002 |
Occupation of the prostaglandin E2-type 1 receptor increases rat atrial contractility via a Y-27632-sensitive pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic Antagonists; Amides; Animals; Atrial Function, Left; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Myocardial Contraction; Perfusion; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; rho-Associated Kinases | 2002 |
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Stomach; Urinary Bladder | 2002 |
A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amides; Animals; Blotting, Western; Botulinum Toxins; Enzyme Inhibitors; Female; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Motor Activity; Protein Serine-Threonine Kinases; Proteins; Pyridines; Rats; Rats, Sprague-Dawley; Recovery of Function; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Spinal Cord Injuries | 2003 |
Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cells, Cultured; Enzyme Inhibitors; ERG1 Potassium Channel; Estrenes; Ether-A-Go-Go Potassium Channels; Hydrolysis; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Maleimides; Membrane Potentials; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphoprotein Phosphatases; Phosphorylation; Pituitary Gland, Anterior; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Pyridines; Pyrrolidinones; Rats; rho-Associated Kinases; Signal Transduction; Thyrotropin-Releasing Hormone | 2003 |
Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Basilar Artery; Benzamides; Biological Transport; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Muscle, Smooth, Vascular; Oxyhemoglobins; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rabbits; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Vasoconstriction | 2003 |
Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Carbachol; Electric Stimulation; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2003 |
Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Calcium Channel Blockers; Enzyme Inhibitors; Female; Gallic Acid; Indoles; Nifedipine; Norepinephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; Signal Transduction; Staurosporine; Vasoconstrictor Agents | 2003 |
P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Caspase Inhibitors; Caspases; Cell Line; Enzyme Activation; Extracellular Space; Humans; Interleukin-1; Intracellular Signaling Peptides and Proteins; Macrophages; Mice; Protein Serine-Threonine Kinases; Pseudopodia; Pyridines; Receptors, Purinergic P2; Receptors, Purinergic P2X7; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2003 |
Astrocyte stellation induced by Rho kinase inhibitors in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Astrocytes; Carbazoles; Cell Size; Cells, Cultured; Cerebral Cortex; Colchicine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gout Suppressants; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Phalloidine; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; rho-Associated Kinases | 2003 |
Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Muscle Relaxation; Penis; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases | 2003 |
Rho kinase inhibition initiates apoptosis in human airway epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Actins; Amides; Animals; Apoptosis; Caspase Inhibitors; Cell Membrane; Cells, Cultured; Cytochalasin D; Cytoskeleton; Enzyme Inhibitors; Epithelial Cells; Humans; Intracellular Signaling Peptides and Proteins; Mice; Protein Serine-Threonine Kinases; Pyridines; Respiratory Mucosa; rho-Associated Kinases; Stress Fibers | 2004 |
Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Blotting, Western; Electric Stimulation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanethidine; Intracellular Signaling Peptides and Proteins; Male; Mice; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vas Deferens | 2003 |
Rho kinase inhibitors block activation of pancreatic stellate cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Blotting, Western; Cell Division; Cell Size; Cells, Cultured; Chemotaxis; Collagen Type I; Enzyme Inhibitors; Fluorescent Dyes; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Microscopy, Confocal; Pancreas; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Rhodamines | 2003 |
Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Capillary Permeability; Cattle; Cells, Cultured; Complement C5a; Endothelium, Vascular; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Neutrophils; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Swine | 2004 |
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Amino Acid Sequence; Animals; Binding Sites; Cattle; Cell Adhesion; Crystallography, X-Ray; Cyclic AMP-Dependent Protein Kinases; Electrons; Enzyme Inhibitors; Escherichia coli; Glycine; Kinetics; Models, Chemical; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Pyridines; Recombinant Proteins; Sequence Homology, Amino Acid | 2003 |
Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amides; Animals; Bacterial Proteins; Bacterial Toxins; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Botulinum Toxins; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Mice; Osteoblasts; Osteogenesis; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Skull; Transforming Growth Factor beta | 2004 |
Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sheep; Tetrodotoxin; Ureter; Vasoconstrictor Agents; Vasodilator Agents | 2004 |
Effects of HA-1077 and Y-27632, two rho-kinase inhibitors, in the human umbilical artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Biophysics; Calcium; Dose-Response Relationship, Drug; Humans; Models, Biological; Nifedipine; Potassium Chloride; Protein Isoforms; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Serotonin; Umbilical Arteries | 2004 |
Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Inhalation; Administration, Oral; Amides; Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Intracellular Signaling Peptides and Proteins; Male; Nitric Oxide; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Treatment Outcome; Vasodilator Agents | 2005 |
Rho-kinase and myosin II activities are required for cell type and environment specific migration.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Culture Techniques; Cell Movement; Cell Nucleus; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Epithelial Cells; Fibroblasts; Heterocyclic Compounds, 4 or More Rings; Humans; Intracellular Signaling Peptides and Proteins; Macrophages; Monomeric GTP-Binding Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Type II; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases | 2005 |
Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amides; Animals; Benzophenanthridines; Blood Pressure; Calcium; Calcium Signaling; Cerebral Arteries; Enzyme Inhibitors; Hypertension; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Tonus; Muscle, Smooth, Vascular; Phenanthridines; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases | 2005 |
Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amides; Animals; Arteries; Clonidine; Electric Stimulation; Electrophysiology; Female; Idazoxan; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Phenylephrine; Prazosin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Suramin; Tail; Vasoconstriction | 2005 |
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Analysis of Variance; Animals; Antihypertensive Agents; Aorta; Blotting, Northern; Blotting, Western; Brain Ischemia; Cattle; Cell Line; Cells, Cultured; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypoxia; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Serine-Threonine Kinases; Pyridines; Regional Blood Flow; rho-Associated Kinases; RNA, Messenger; Stroke; Time Factors; Umbilical Veins; Up-Regulation | 2005 |
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction | 2006 |
Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Azepines; Calcium; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Norepinephrine; Potassium; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X; rho-Associated Kinases; Vas Deferens | 2006 |
Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Apoptosis; Cell Communication; Chemokines, CXC; Chemotaxis, Leukocyte; Disease Models, Animal; Endothelial Cells; Endotoxemia; Hepatic Artery; Hepatocytes; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Regional Blood Flow; rho-Associated Kinases; Tumor Necrosis Factor-alpha | 2006 |
Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Amino Acid Sequence; Animals; Humans; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Molecular Weight; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyridines; rho-Associated Kinases; Spodoptera; Staurosporine | 2006 |
Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Intracellular Signaling Peptides and Proteins; Lung; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pregnancy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyridines; rho-Associated Kinases; Sheep; Signal Transduction; Vascular Resistance | 2006 |
Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Androstadienes; Animals; Apoptosis; Cardiotonic Agents; Coronary Circulation; Cytoskeletal Proteins; Enzyme Activation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Microfilament Proteins; Multiprotein Complexes; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Wortmannin | 2007 |
RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 8; Caspase 9; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Mitochondria; Myocytes, Cardiac; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Up-Regulation | 2007 |
RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Blotting, Western; Calcium; Cells, Cultured; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Prostate; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; Type C Phospholipases | 2007 |
The RISK of ROCK.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Apoptosis; Cardiotonic Agents; Coronary Circulation; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Research Design; rho-Associated Kinases; Signal Transduction | 2007 |
Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Ductus Arteriosus; Enzyme Activation; Enzyme Induction; Feedback, Physiological; Female; Fetal Heart; Gestational Age; Humans; Hydrogen Peroxide; Hypoplastic Left Heart Syndrome; Infant, Newborn; Intracellular Signaling Peptides and Proteins; Male; Mitochondria, Heart; Nifedipine; Organ Culture Techniques; Oxidation-Reduction; Oxygen; Partial Pressure; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rabbits; Reactive Oxygen Species; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Superoxides; Vasoconstriction | 2007 |
The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Antigens, CD34; Benzamides; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; rho-Associated Kinases; Stem Cells; Tumor Cells, Cultured | 2007 |
Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Atropine; Blotting, Western; Calcium Signaling; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Enzyme Inhibitors; Guanine Nucleotide Dissociation Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rho-Specific Guanine Nucleotide Dissociation Inhibitors; rhoA GTP-Binding Protein; Urethra; Urinary Bladder | 2007 |
Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Axons; Cell Line; Chondroitin Sulfate Proteoglycans; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Intracellular Signaling Peptides and Proteins; Nerve Crush; Nerve Regeneration; Neurites; Neurons; Optic Nerve; Optic Nerve Injuries; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases | 2007 |
Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenalectomy; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amides; Anesthetics, Local; Animals; Blood Pressure; Blood Vessels; Body Temperature Regulation; Clonidine; Cold Temperature; Heart Rate; Intracellular Signaling Peptides and Proteins; Isoquinolines; Laser-Doppler Flowmetry; Male; Mice; Naphthyridines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Quinolizines; Receptors, Adrenergic, alpha-2; Reflex; Regional Blood Flow; rho-Associated Kinases; Skin; Skin Temperature; Sympathetic Nervous System; Tetrodotoxin; Vasoconstriction | 2007 |
Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isometric Contraction; Male; Muscle Tonus; Muscle, Smooth; Myosin-Light-Chain Kinase; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2008 |
Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcimycin; Cells, Cultured; Coronary Vessels; Down-Regulation; Endothelial Cells; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Nitroprusside; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Sodium Nitrite; Triazenes | 2008 |
Rho kinase inhibition: a new approach for treating diabetic nephropathy?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Diabetic Nephropathies; Humans; Mice; Protein Kinase Inhibitors; Pyridines; Rats; rho-Associated Kinases | 2008 |
Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Axons; Cats; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Male; Nerve Crush; Nerve Regeneration; Optic Nerve; Optic Nerve Injuries; Organ Culture Techniques; Protein Kinase Inhibitors; Pyridines; Retina; rho-Associated Kinases; Treatment Outcome; Wallerian Degeneration | 2008 |
Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Bronchi; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Propofol; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases | 2008 |
Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Anticonvulsants; Blotting, Western; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Kindling, Neurologic; Male; Mice; Motor Activity; Pentylenetetrazole; Protein Kinase Inhibitors; Protein Transport; Pyridines; Reflex; rho-Associated Kinases; Seizures | 2008 |
Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alanine Transaminase; Amides; Analysis of Variance; Animals; Cytokines; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Hepatectomy; Hepatitis; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction | 2008 |
Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Autocrine Communication; Cell Hypoxia; Cell Movement; Cell Nucleus; Drug Screening Assays, Antitumor; Endothelial Cells; Enzyme Activation; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Myosin Light Chains; Neovascularization, Pathologic; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Pyridines; rho-Associated Kinases; Ubiquitination; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2008 |
Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Benzophenanthridines; Calcium; Electric Stimulation; Esophageal Sphincter, Lower; Humans; In Vitro Techniques; Muscle Contraction; Naphthalenes; Protein Kinase C; Pyridines; rhoA GTP-Binding Protein | 2008 |
Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Activating Transcription Factor 3; Amides; Animals; Blotting, Western; Brain; Cerebral Cortex; Cerebral Infarction; Enzyme Inhibitors; Hippocampus; Immunohistochemistry; Male; Myosin Light Chains; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Tissue Extracts | 2008 |
Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Amides; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Enzyme Activation; Female; Humans; Interleukin-1beta; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Middle Aged; NF-kappa B; Pyridines; Rats; rho-Associated Kinases; Signal Transduction; Synovial Membrane; Tumor Necrosis Factor-alpha | 2008 |
Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antihypertensive Agents; Aorta, Thoracic; Blotting, Western; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; In Vitro Techniques; Isometric Contraction; Male; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Species Specificity; Vasoconstriction | 2009 |
Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Nucleus; Chemokines; Enzyme Inhibitors; Female; Kidney; Leukocytes; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nephritis; NF-kappa B p50 Subunit; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Renal Insufficiency; rho-Associated Kinases; Signal Transduction; Transcription Factor RelA | 2009 |
Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Cell Line; DNA-Directed RNA Polymerases; Hepacivirus; Hepatocytes; Humans; Interferon-alpha; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Viral Proteins; Virus Replication | 2009 |
Signaling through Rho GTPase pathway as viable drug target.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aminoquinolines; Anilides; Animals; Benzamides; Cardiovascular Diseases; Humans; Lung Diseases; Neoplasms; Nervous System Diseases; Protein Kinase Inhibitors; Pyridines; Pyrimidines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2009 |
Vascular dysfunction in septic shock--any ROCKing news?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Disease Models, Animal; Endothelium, Vascular; Muscle, Smooth; Nitric Oxide; Pyridines; Rats; rho-Associated Kinases; Sensitivity and Specificity; Shock, Septic; Vasoconstriction; Vasodilation | 2009 |
Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Brain; Cell Line, Tumor; Encephalitis; I-kappa B Proteins; Interleukin-6; MAP Kinase Signaling System; Neurons; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; rho-Associated Kinases; Signal Transduction; Tumor Necrosis Factor-alpha | 2009 |
Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Line; HSP27 Heat-Shock Proteins; Lysophospholipids; Mice; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; Sphingosine | 2009 |
Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alprostadil; Amides; Animals; Cell Line; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; Vascular Endothelial Growth Factor A | 2009 |
Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Amides; Constriction, Pathologic; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nitroarginine; Nitroprusside; Oxadiazoles; Protein Kinase Inhibitors; Pyridines; Quinoxalines; Radial Artery; Receptors, Calcium-Sensing; rho-Associated Kinases; Vasoconstriction; Vasodilation | 2009 |
Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Airway Remodeling; Amides; Animals; Animals, Newborn; Antihypertensive Agents; Becaplermin; Body Weight; Chronic Disease; Disease Models, Animal; DNA Replication; Dose-Response Relationship, Drug; Hyperoxia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Muscle, Smooth, Vascular; Organ Size; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyridines; Rats; Receptor, Platelet-Derived Growth Factor beta; rho-Associated Kinases; Vascular Resistance | 2010 |
Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Apoptosis; Biomarkers; Cell Differentiation; Cell Line; Cell Proliferation; Cell Shape; Collagen; Drug Carriers; Drug Combinations; Embryonic Stem Cells; Extracellular Matrix; Gene Expression Regulation, Developmental; Humans; Induced Pluripotent Stem Cells; Integrin alpha6; Integrin alphaV; Integrin beta1; Karyotyping; Laminin; Protein Kinase Inhibitors; Proteoglycans; Pyridines; rho-Associated Kinases; RNA, Messenger | 2010 |
Rho-kinase limits FGF-2-stimulated VEGF release in osteoblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Analysis of Variance; Animals; Blotting, Western; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Humans; Immunoenzyme Techniques; JNK Mitogen-Activated Protein Kinases; Mice; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; Vascular Endothelial Growth Factor A | 2010 |
Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Amides; Animals; Antioxidants; Benzophenanthridines; Body Temperature Regulation; Brimonidine Tartrate; Cold Temperature; Cyclic N-Oxides; Cytoskeletal Proteins; Female; Horses; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Quinoxalines; Reactive Oxygen Species; rho-Associated Kinases; Rotenone; Spin Labels; Vasoconstriction; Vasodilator Agents; Veins | 2010 |
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aging; Amides; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Injections, Subcutaneous; Muscle, Smooth, Vascular; Myocardium; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Rats; Receptor, Endothelin A; rho-Associated Kinases; RNA Interference; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2010 |
Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Bacterial Proteins; Bacterial Toxins; Calcium; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Movement; Fura-2; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Lysophospholipids; Mutation; Pertussis Toxin; Phalloidine; Protein Kinase Inhibitors; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Type C Phospholipases | 2011 |
Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Anti-Infective Agents, Local; Cells, Cultured; Chlorhexidine; Disease Models, Animal; Enzyme Inhibitors; Epithelium; Humans; Immunoenzyme Techniques; Male; Neovascularization, Pathologic; Peritoneal Fibrosis; Pleural Cavity; Pyridines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; RNA, Messenger; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2011 |
Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actomyosin; Amides; Cell Movement; Cells, Cultured; Focal Adhesions; Humans; Myosin Light Chains; Osteoblasts; Phosphorylation; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Stress Fibers | 2011 |
Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; ADP Ribose Transferases; Amides; Animals; Blotting, Western; Botulinum Toxins; Cytoskeleton; Enzyme Inhibitors; Epididymis; Epithelial Cells; Flow Cytometry; Green Fluorescent Proteins; Male; Mice; Mice, Transgenic; Microvilli; Proton Pumps; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Vacuolar Proton-Translocating ATPases | 2011 |
Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Cell Movement; Cells, Cultured; Chemokine CCL2; Endothelium, Vascular; Gene Expression; Humans; Mice; Mice, Inbred Strains; Monocytes; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Thrombin | 2011 |
Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Catalytic Domain; Cell Line, Tumor; Collagen; Crystallography, X-Ray; Drug Combinations; Extracellular Matrix; Humans; Inhibitory Concentration 50; Laminin; Models, Molecular; Myotonin-Protein Kinase; Neoplasm Invasiveness; Protein Kinase Inhibitors; Protein Multimerization; Protein-Tyrosine Kinases; Proteoglycans; Pyridines; rho-Associated Kinases; Thiophenes | 2011 |
Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Adipogenesis; Amides; Animals; beta Catenin; Gene Expression Regulation; Lysophospholipids; Mice; PPAR gamma; Pyridines; Receptor Cross-Talk; rho-Associated Kinases; RNA, Messenger; Time Factors; Transcriptional Activation; Wnt Proteins; Wnt Signaling Pathway | 2011 |
ROCK1 feedback regulation of the upstream small GTPase RhoA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; ADP Ribose Transferases; Amides; Aminoquinolines; Botulinum Toxins; Cell Line, Tumor; Gene Expression Regulation; Guanine Nucleotide Exchange Factors; Humans; Male; Prostatic Neoplasms; Pyridines; Pyrimidines; rac1 GTP-Binding Protein; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; T-Lymphoma Invasion and Metastasis-inducing Protein 1 | 2012 |
Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Amides; Animals; Calcium; Cattle; Cells, Cultured; Cytochalasin D; Dose-Response Relationship, Drug; Nocodazole; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Time Factors; Up-Regulation | 2012 |
Contractile responses of isolated equine digital arteries under hypoxic or hyperoxic conditions in vitro: role of reactive oxygen species and Rho kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arteries; Cadaver; Hindlimb; Horses; NADPH Oxidases; Oxygen; Phenylephrine; Pyridines; Reactive Oxygen Species; rho-Associated Kinases; Vasoconstriction | 2013 |
Rho-kinase negatively regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Line; Gene Expression Regulation; Mice; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Osteoblasts; Osteocalcin; Phosphorylation; Pyridines; rho-Associated Kinases; RNA, Messenger; Triiodothyronine | 2013 |
The selective Rho-kinase inhibitor azaindole-1 has long-lasting erectile activity in the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Area Under Curve; Atropine; Blood Pressure; Diamines; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Male; Muscarinic Antagonists; Nitric Oxide; Oxadiazoles; Penile Erection; Penis; Peripheral Nerve Injuries; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; rho-Associated Kinases; Signal Transduction; Time Factors | 2013 |
RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Flavonoids; Imidazoles; Lung; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Mutation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, G-Protein-Coupled; rho-Associated Kinases; rhoA GTP-Binding Protein; Sheep | 2013 |
Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Astrocytes; Blood-Brain Barrier; Blotting, Western; Brain Chemistry; Brain Ischemia; Cells, Cultured; Cerebral Infarction; Endothelial Cells; Functional Laterality; Male; Mice; Mice, Inbred C57BL; NADPH Oxidases; Nerve Tissue Proteins; Oxidative Stress; Protein Kinase Inhibitors; Psychomotor Performance; Pyridines; Reactive Oxygen Species; rho-Associated Kinases; Tight Junctions | 2014 |
Do fasudil and Y-27632 affect the level of transient receptor potential (TRP) gene expressions in breast cancer cell lines?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Pyridines; rho-Associated Kinases; Transient Receptor Potential Channels; TRPC Cation Channels; TRPM Cation Channels | 2014 |
Signaling Rho-kinase mediates inflammation and apoptosis in T cells and renal tubules in cisplatin nephrotoxicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Amides; Animals; Anti-Inflammatory Agents; Apoptosis; Cells, Cultured; Chemotaxis; Cisplatin; Coculture Techniques; Cytoprotection; Disease Models, Animal; Hepatitis A Virus Cellular Receptor 1; Inflammation Mediators; Kidney Tubules; Macrophages; Membrane Proteins; Mice, Inbred C57BL; Nephritis; Neutrophil Infiltration; NF-kappa B; Phosphorylation; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction; T-Lymphocytes; Time Factors | 2015 |
Protective effect of a novel Rho kinase inhibitor WAR-5 in experimental autoimmune encephalomyelitis by modulating inflammatory response and neurotrophic factors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aminopyridines; Animals; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Immunoblotting; Immunoenzyme Techniques; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Nerve Growth Factors; Piperidines; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; T-Lymphocytes, Regulatory | 2015 |
In vitro oxygen exposure promotes maturation of the oxygen sensitive contraction in pre-term chicken ductus arteriosus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Chick Embryo; Chickens; Dinoprostone; Dose-Response Relationship, Drug; Ductus Arteriosus; Enzyme Inhibitors; Nifedipine; Nitric Oxide; Oxygen; Pyridines; rho-Associated Kinases; Time Factors; Vasoconstriction | 2015 |
Effects of ethanol on RhoA/Rho-kinase-mediated calcium sensitization in mouse lung parenchymal tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Ethanol; Lung; Male; Mice; Microscopy, Electron; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2015 |
Rho-associated kinase inhibitors promote the cardiac differentiation of embryonic and induced pluripotent stem cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Cell Differentiation; Echocardiography; Embryonic Stem Cells; Gene Expression; Hematopoietic Stem Cells; Induced Pluripotent Stem Cells; Male; Mice; Myocardial Infarction; Myocytes, Cardiac; Platelet Membrane Glycoprotein IIb; Pluripotent Stem Cells; Protein Kinase Inhibitors; Pyridines; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; Stem Cell Transplantation | 2015 |
Rho-Associated Kinase Inhibitors Promote Microglial Uptake Via the ERK Signaling Pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Blotting, Western; Cell Line; Flow Cytometry; Immunohistochemistry; MAP Kinase Signaling System; Mice; Microglia; Phagocytosis; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2016 |
Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Synuclein; Amides; Animals; Brain; Carrier Proteins; Cell Line, Tumor; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Humans; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Aggregates; Protein Kinase Inhibitors; Psychomotor Performance; Pyridines; Recognition, Psychology; Time Factors; Tyrosine 3-Monooxygenase | 2016 |
Regulation of Microglial Phagocytosis by RhoA/ROCK-Inhibiting Drugs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Biological Assay; Cell Line; Down-Regulation; Humans; Ibuprofen; Lysophospholipids; Mice; Microglia; Nitric Oxide; Phagocytosis; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2017 |
The RhoA/ROCK Pathway Ameliorates Adhesion and Inflammatory Infiltration Induced by AGEs in Glomerular Endothelial Cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Chemokine CCL2; Diabetic Nephropathies; Disease Models, Animal; Endothelial Cells; Glycation End Products, Advanced; Inflammation; Intercellular Adhesion Molecule-1; Kidney Glomerulus; Mice; Mice, Mutant Strains; Protein Kinase Inhibitors; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction | 2017 |
Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Actin Cytoskeleton; Adipocytes; Adipogenesis; Amides; Animals; Anti-Obesity Agents; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Fatty Acid-Binding Proteins; Gene Expression Regulation; Glucose Transporter Type 4; Heterocyclic Compounds, 4 or More Rings; Mice; PPAR gamma; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction | 2018 |
A crucial role of ROCK for alleviation of senescence-associated phenotype.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Proliferation; Cellular Senescence; Child; Chromatin; Fibroblasts; Humans; Male; Mice; Mice, Inbred C57BL; Phenotype; Progeria; Pyridines; rho-Associated Kinases; Wound Healing | 2018 |
Suppressive effect of Rho-kinase inhibitors Y-27632 and fasudil on spike-and-wave discharges in genetic absence epilepsy rats from Strasbourg (GAERS).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Brain; Electroencephalography; Epilepsy, Absence; Male; Protein Kinase Inhibitors; Pyridines; Rats, Wistar; rho GTP-Binding Proteins | 2018 |
RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cervical Ripening; Cervix Uteri; Female; In Vitro Techniques; Muscle Contraction; Pregnancy; Pyridines; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Simvastatin | 2019 |
Sphingosine-1-Phosphate Enhances α
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Drug Synergism; Lysophospholipids; Mice, Inbred C57BL; Mice, Knockout; Phenylephrine; Pyridines; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2019 |
ROCK inhibitors enhance bone healing by promoting osteoclastic and osteoblastic differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Differentiation; Cell Line; Fracture Healing; Male; Mice; Osteoblasts; Osteoclasts; Osteogenesis; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; rho-Associated Kinases; Skull; Small Molecule Libraries | 2020 |
The Rho-associated kinase inhibitor fasudil can replace Y-27632 for use in human pluripotent stem cell research.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Embryonic Stem Cells; Humans; Induced Pluripotent Stem Cells; Neural Crest; Pluripotent Stem Cells; Protein Kinase Inhibitors; Pyridines; Retinal Pigment Epithelium; rho-Associated Kinases; Stem Cell Research | 2020 |
Rock inhibition promotes Na
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Humans; NAV1.5 Voltage-Gated Sodium Channel; Neoplasm Invasiveness; Protein Serine-Threonine Kinases; Pyridines; Signal Transduction | 2020 |
Effects of the Rho/Rho-Kinase Pathway on Perfusion Pressure in the Isolated-Perfused Rat Hind Limb Vascular Bed.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Atorvastatin; Muscle Relaxants, Central; Perfusion; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasodilation; Vasodilator Agents | 2021 |
Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia.
Topics: Animals; Clozapine; Cognitive Dysfunction; Haloperidol; Male; Methamphetamine; Mice; Monomeric GTP-Binding Proteins; Protein Kinase Inhibitors; rho-Associated Kinases; Schizophrenia | 2023 |
Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model.
Topics: Animals; Cognition; Cognitive Dysfunction; Fluorides; Humans; Mice; Mice, Inbred ICR; Neurodegenerative Diseases; rho-Associated Kinases | 2023 |