Page last updated: 2024-09-03

y 27632 and fasudil

y 27632 has been researched along with fasudil in 139 studies

Compound Research Comparison

Studies
(y 27632)
Trials
(y 27632)
Recent Studies (post-2010)
(y 27632)
Studies
(fasudil)
Trials
(fasudil)
Recent Studies (post-2010) (fasudil)
1,924389196540552

Protein Interaction Comparison

ProteinTaxonomyy 27632 (IC50)fasudil (IC50)
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)2.28
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)2.28
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)2.28
Chain I, cAMP-dependent protein kinase inhibitor alphasynthetic construct2.28
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)2.28
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)2.28
Chain I, cAMP-dependent protein kinase inhibitor alphasynthetic construct2.28
Rho-associated protein kinase 2Homo sapiens (human)0.5296
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)5
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)1.8042
C-C motif chemokine 2Homo sapiens (human)6.9183
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)4.58
cAMP-dependent protein kinase catalytic subunit gammaHomo sapiens (human)4.58
cAMP-dependent protein kinase catalytic subunit betaHomo sapiens (human)4.58
Protein kinase C epsilon typeHomo sapiens (human)3
Rho-associated protein kinase 1Homo sapiens (human)1.1469
Myosin light chain kinase, smooth muscleHomo sapiens (human)3.6
Serine/threonine-protein kinase N1Homo sapiens (human)1.7
Serine/threonine-protein kinase N2Homo sapiens (human)1.8533
Rho-associated protein kinase 2Bos taurus (cattle)1.8042
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)1.9

Research

Studies (139)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (1.44)18.2507
2000's81 (58.27)29.6817
2010's50 (35.97)24.3611
2020's6 (4.32)2.80

Authors

AuthorsStudies
Caivano, M; Cohen, P; Davies, SP; Reddy, H1
McGovern, SL; Shoichet, BK1
Bellon, S; Doran, J; Fleming, M; Hayakawa, K; Jacobs, M; Swenson, L; Taslimi, P1
Bonn, S; Bossemeyer, D; Breitenlechner, CB; Engh, RA; Erlbruch, A; Gassel, M; Herrero, S; Lehmann, W1
Bamford, M; Behm, DJ; Bentley, R; Chen, Z; Doe, C; Dul, E; Grygielko, E; Hu, E; Jolivette, L; Jung, D; Khandekar, S; Kirkpatrick, R; Lafferty, R; Lee, D; Marino, JP; Panchal, T; Smith, GK; Stavenger, R; Webb, C; Willette, R; Wright, LL; Yi, T1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Herbert, JM; Hofmeister, A; Ivashchenko, Y; Janiak, P; Kadereit, D; Kannt, A; Kohlmann, M; Linz, W; Löhn, M; O'Connor, SE; Plettenburg, O; Ruetten, H; Schaefer, M1
Büttner, FH; Cywin, CL; Dahmann, G; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Mao, W; Marshall, D; Morwick, T; Paw, Z; Shih, CK; Wu, F; Young, E1
Büttner, FH; Chen, R; Cywin, CL; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Paw, Z; Prokopowicz, A; Shih, CK; Snow, R; Wu, F; Young, E1
Adam, J; Bennett, J; Black, D; Boucharens, S; Brown, AR; Cook, A; de Man, J; Epemolu, O; Fletcher, D; Haunso, A; Huggett, M; Jones, P; Laats, S; Lyons, A; Mestres, J; Morphy, R; Rankovic, Z; Ray, P; Sherborne, B; Sherry, L; van Straten, N; Westwood, P; Wright, J; Zaman, GZ1
Cox, KJ; Gaj, A; Ghosh, I; Jester, BW; Shomin, CD1
Alexander, B; Forinash, KD; Guida, WC; Lawrence, NJ; Martin, MP; Pireddu, R; Schönbrunn, E; Sebti, SM; Sun, NN; Sung, SS; Zhu, JY1
Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Bandarage, UK; Cao, J; Court, J; Gao, H; Green, J; Jacobs, M; Marhefka, C; Nakayama, T; Newsome, D; Rodems, S; Shah, S; Taslimi, P1
Domokos, D; Falkay, G; Fülöp, F; Gáspár, R1
Ito, M; Nakano, T; Narumiya, S; Nishikawa, M; Sasaki, Y; Shiku, H; Suzuki, Y; Wada, H; Yamamoto, M1
Daniel, JL; Kunapuli, SP; Paul, BZ1
Amano, M; Fukata, Y; Kaibuchi, K; Shimokawa, H1
Inagaki, M; Ishizaki, T; Kosako, H; Matsumura, F; Narumiya, S; Yoshida, T1
Epstein, HF; Hartshorne, DJ; Hirano, K; Ito, M; Liu, F; Murányi, A; Zhang, R1
Leopoldt, D; Lunn, JA; Rozengurt, E; Sinnett-Smith, J1
Jin, N; Li, L; Rhoades, RA; Swartz, DR; Wang, Z; Yancey, KW; Zhang, D1
Brady, JD; Jezior, JR; McCammon, KA; Miner, AS; Ratz, PH; Rosenstein, DI1
Shimokawa, H1
Hishinuma, S; Mita, M; Saito, M; Walsh, MP; Yanagihara, H1
Ishibashi, T; Maruyama, Y; Nagata, K; Ohkawara, H; Sakamoto, T; Sakurada, S; Shindo, J; Sugimoto, K; Takuwa, Y; Teramoto, T; Yokoyama, K1
Grenett, HE; Ku, DD; Urthaler, F; Wolkowicz, PE1
Eddinger, TJ; Meehl, JT; Ratz, PH1
Calvert, JW; Huang, L; Louis Harkey, H; Miao, L; Sung, JK; Zhang, JH1
Barros, F; de la Pena, P; Dupuy, SG; Garcia-Manso, D; Giraldez, T; Gomez-Varela, D1
Lan, C; Vollrath, B; Wickman, G1
Büyükafşar, K; Levent, A2
Bauer, J; Parekh, N1
Dubyak, GR; Estacion, M; Schilling, W; Verhoef, PA1
Abe, K; Misawa, M1
Büyükafşar, K; Un, I1
Gugliotta, W; Marroquin, BA; Moore, M; Tse, R; White, SR1
Ark, M; Büyükafşar, K; Levent, A1
Kikuta, K; Masamune, A; Satoh, K; Satoh, M; Shimosegawa, T1
Breslin, JW; Yuan, SY1
Bossemeyer, D; Breitenlechner, C; Engh, RA; Gassel, M; Hidaka, H; Huber, R; Kinzel, V1
Grigoriadis, AE; Harmey, D; Lax, AJ; Nobes, CD; Stenbeck, G1
Ohnaka, K; Takayanagi, R1
Amano, M; Kaibuchi, K; Kawabata, S; Nakayama, M; Takefuji, M1
Arikan, O; Ark, M; Büyükafsar, K; Korkmaz, B; Kubat, H; Ozveren, E; Songu-Mize, E; Yazici, G1
Fagan, KA; Gebb, SA; McMurtry, IF; Morris, KG; Nagaoka, T; Oka, M; Shimokawa, H; Suzuki, T1
Amano, M; Kaibuchi, K; Kaneko, T; Katsumi, A; Kawabata, S; Nakayama, M; Takefuji, M1
Fang, CX; Ren, J1
Jarajapu, YP; Knot, HJ1
Brock, JA; Yeoh, M1
Asano, T; Huang, Z; Kim, HH; Liao, JK; Moskowitz, MA; Rikitake, Y; Seto, M; Yano, K1
Shimoda, LA; Sylvester, JT; Weigand, L1
Hayashi, K; Kanda, T; Wakino, S1
Amobi, NI; Chung, IP; Smith, IC1
Jeppsson, B; Laschke, MW; Menger, MD; Slotta, JE; Thorlacius, H; Thorlacius, K; Wang, Y1
Chen, S; Dul, E; Hu, E; Khandekar, SS; Kirkpatrick, RB; Lee, D; Scott, GF; Smith, GK; Wright, LL; Yi, T1
Abman, SH; Grover, TR; Parker, TA; Roe, G1
Baxter, GF; Bower, HS; Hamid, SA1
Brown, JH; Del Re, DP; Miyamoto, S1
Kanaide, H; Naito, S; Nishimura, J; Seki, N; Takahashi, R; Tomoda, T; Yunoki, T1
Duncker, DJ; Manintveld, OC; Verdouw, PD1
Archer, SL; Bonnet, SN; Haromy, A; Harry, G; Hashimoto, K; Kajimoto, H; Michelakis, ED; Moudgil, R; Nakanishi, T; Rebeyka, I; Thébaud, B1
Adams, J; Burthem, J; Lucas, GS; Mottram, R; Rees-Unwin, K; Spooncer, E; Whetton, AD1
Jin, L; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z1
Bähr, M; Lingor, P; Mack, H; Mueller, BK; Mueller, R; Schwarz, K; Teusch, N1
Honda, M; Ishikawa, T; Nakayama, K; Suzuki, M1
Kass, DA; McKinsey, TA1
Patel, CA; Rattan, S1
Duan, WG; Liao, H; Yan, M; Yuan, ST; Zhang, LY1
Ark, M; Büyükafşar, K; Cnar, MG; Erol, A; Kubat, H; Tiftik, RN; Ulker, S1
Bach, LA1
Ichikawa, M; Sagawa, H; Saito, K; Tokita, Y; Watanabe, M; Yoshida, J1
Chiba, Y; Hanazaki, M; Kohjitani, A; Misawa, M; Morita, K; Sakai, H; Yokoyama, M1
Büyükafşar, K; Inan, S1
Laschke, MW; Menger, MD; Slotta, JE; Thorlacius, H1
Hashimoto, K; Kawagoe, J; Kurachi, H; Morishige, K; Ohta, T; Takahashi, K; Takahashi, T; Takata, K; Tsutsumi, S; Yin, L1
Chrones, T; Preiksaitis, HG; Sims, SM1
Asano, T; Hattori, T; Ikegaki, I; Kawasaki, K; Sasaki, Y; Satoh, S; Seto, M; Tawara, S; Toshima, Y; Yano, K1
He, Y; Liang, L; Sun, L; Xu, H; Yang, X; Ye, Y; Yu, X; Zhan, Z1
Bidaud, A; Grise, F; Moreau, V1
Chan, CK; Mak, JC; Man, RY; Vanhoutte, PM1
Dehde, S; Gatzemeier, S; Klug, P; Meyer, TN; Meyer-Schwesinger, C; Stahl, RA; Thaiss, F; von Ruffer, C; Wenzel, UO1
Kim, JH; Kim, MG; Kim, SJ; Oh, JW; Sun, JM1
Chen, YH; Longo, FM; Lu, Q; Massa, SM; Zhou, H1
Ytrebo, LM1
Adachi, S; Dohi, S; Iida, H; Kozawa, O; Matsushima-Nishiwaki, R; Takai, S; Tanabe, K; Yamaguchi, S1
Adachi, S; Hanai, Y; Kozawa, O; Matsushima-Nishiwaki, R; Minamitani, C; Mizutani, J; Otsuka, T; Takai, S; Tokuda, H1
Adachi, S; Kato, K; Kozawa, O; Matsushima-Nishiwaki, R; Minamitani, C; Mizutani, J; Natsume, H; Otsuka, T; Tokuda, H1
Bagcivan, I; Berkan, O; Disli, OM; Durmus, N; Ozdemir, E; Parlak, A1
Belcastro, R; Ivanovska, J; Jankov, RP; Kantores, C; Lau, M; McNamara, PJ; Tanswell, AK; Xu, EZ; Ziino, AJ1
Baharvand, H; Hassani, SN; Pakzad, M; Seifinejad, A; Taei, A; Totonchi, M1
Adachi, S; Kato, K; Kozawa, O; Matsushima-Nishiwaki, R; Minamitani, C; Mizutani, J; Natsume, H; Niida, S; Otsuka, T; Takai, S; Tokuda, H1
Bailey, SR; Berhane, Y; Elliott, J; Woodcock, H; Zerpa, H1
Engelberts, D; Ivanovska, J; Jankov, RP; Kantores, C; Kavanagh, BP; McNamara, PJ; Xu, EZ1
Boergermann, C; Jakobs, KH; Lümmen, G; Rübben, H; Sanders, H; Schmidt, M; vom Dorp, F1
Fujimura, K; Hara, Y; Hasegawa, K; Hayashi, K; Homma, K; Hosoya, K; Itoh, H; Minakuchi, H; Tokuyama, H; Tonozuka, Y; Wakino, S; Washida, N1
Gao, H; Kobayashi, N; Li, C; Matsuda, S; Nabeka, H; Shimokawa, T; Wakisaka, H; Zhang, X1
Belleannée, C; Breton, S; Brown, D; Da Silva, N; McKee, M; Shum, WW1
Ishizawa, S; Kanazawa, Y; Kawanami, D; Matoba, K; Utsunomiya, K; Yokota, T1
Asano, T; Seto, M1
Shi, J; Surma, M; Wei, L1
Boakes, A; Crighton, D; Heikkila, T; Kaye, SJ; Mezna, M; Olson, MF; Pang, L; Rushbrooke, M; Schroder, E; Turnbull, A; Wheatley, E1
Jin, T; Li, L; Liu, L; Ng, DS; Tam, L1
Campbell, WB; Nithipatikom, K; Tang, AT1
Seto, M1
Itoh, H; Satoh, N; Takahashi, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N; Zhang, H1
Bailey, SR; Borer, KE; Elliott, J; Harris, PA1
Kato, K; Kondo, A; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Mizutani, J; Otsuka, T; Tokuda, H1
Allain, AV; Kadowitz, PJ; Lasker, GF; Murthy, SN; Pankey, EA; Stasch, JP1
Alokam, R; Mishra, RK; Sriram, D; Yogeeswari, P1
Shi, J; Wei, L1
Andrews, MA; Austin, M; Ibe, BO; Lazaro, M; Lustina, J; Raj, JU; Renteria, LS1
Bath, PM; Bayraktutan, U; Gibson, CL; Sprigg, N; Srivastava, K1
Balakan, O; Bayraktar, R; Camci, C; Gogebakan, B; Izmirli, M; Oztuzcu, S; Suner, A; Ulasli, M1
Funauchi, M; Hino, S; Hirooka, Y; Kinoshita, K; Kishimoto, K; Matsumura, I; Niki, K; Nozaki, Y; Yano, T1
Chai, Z; Feng, L; Li, YH; Liu, JC; Ma, CG; Xiao, BG; Xin, YL; Yu, JZ; Zhang, GX; Zhang, HZ1
Dzialowski, EM; Greyner, H1
Astarci, E; Aydinoglu, F; Balli, E; Ergurhan Kiroglu, O; Ogulener, N1
Chen, MF; Cheng, YT; Chien, CY; Jan, YJ; Ko, BS; Kuo, CC; Liang, SM; Liou, JY; Shyue, SK; Sung, LY; Wu, KK; Yeih, DF; Yet, SF; Yu, YL1
Pernis, AB; Ricker, E; Rozo, C; Weng, CH; Yi, W1
Chen, X; Fu, P; Li, C; Luo, X; Tang, R; Wang, W; Xie, M; Yu, Z1
Bähr, M; Becker, S; Dambeck, V; Eckermann, K; Fonseca-Ornelas, L; Koch, JC; Lingor, P; Lopes da Fonseca, T; Outeiro, TF; Tatenhorst, L; Tönges, L; Walle, H; Zweckstetter, M1
Bicker, G; Scheiblich, H1
Huang, W; Lai, W; Li, Y; Lou, T; Peng, H; Rao, J; Tang, H; Wang, C; Ye, Z1
Hutchinson, RC; Krabbe, LM; Margulis, V; Sanli, O; Woldu, SL1
Chun, KH; Diep, DTV; Hong, K; Jun, HS; Khun, T; Kim, YB; Ul-Haq, A; Zheng, M1
Cho, KA; Kang, HT; Lee, YS; Park, CH; Park, JT; Park, SC1
Büyükafsar, K; Çarçak, N; Eryiğit Karamahmutoğlu, T; Kurt, AH; Onat, FY; Urhan Küçük, M; Yavuz, M1
Domokos, D; Ducza, E; Gáspár, R1
Balogh, A; Benyó, Z; Dancs, PT; Fülöp, Á; Kerék, M; Móré, D; Offermanns, S; Panta, CR; Proia, RL; Ruisanchez, É; Tigyi, GJ1
Akiba, Y; Eguchi, K; Izumi, K; Kakihara, Y; Kato, H; Nakata, J; Nihara, J; Ohkura, M; Otake, M; Saeki, M; Saito, I; Thant, L1
Choi, J; Dutton, JR; Hwang, J; Kang, E; Kang, S; Kim, CJ; Lee, BH; Lee, JY; Lee, Y; Mitalipov, S; Oh, SJ; Seo, EJ; Shin, J; So, S1
Baron, C; Besson, P; Bon, E; Brisson, L; Chadet, S; Lemoine, R; Lopez-Charcas, O; Moussata, D; Ouaissi, M; Poisson, L; Roger, S1
Alzayed, Z; Büyükafşar, K; İlhan, E; Seçilmiş, MA; Tiftik, RN1
Dong, G; Kaibuchi, K; Liao, J; Liu, Y; Mizoguchi, H; Nabeshima, T; Nagai, T; Ozaki, N; Sawahata, M; Wulaer, B; Yamada, K; Zhu, W1
Dongfang, H; Fei, R; Hongli, Z; Hongmei, N; Lingli, C; Penghuan, J; Rui, W; Yaming, G; Yuye, L; Zhihong, Y1

Reviews

15 review(s) available for y 27632 and fasudil

ArticleYear
Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.
    Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiovascular Diseases; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vasodilator Agents

2002
[Rho-kinase inhibitor].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Drug Design; Humans; Intracellular Signaling Peptides and Proteins; Osteogenesis; Osteoporosis; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases

2004
[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Angina Pectoris; Animals; Arteriosclerosis; Calcium; Enzyme Inhibitors; Humans; Hypertension; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases

2004
Small guanine nucleotide-binding protein Rho and myocardial function.
    Acta pharmacologica Sinica, 2005, Volume: 26, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Heart Failure; Humans; Intracellular Signaling Peptides and Proteins; Myocardial Contraction; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

2005
Rho/Rho kinase as a potential target for the treatment of renal disease.
    Drug news & perspectives, 2005, Volume: 18, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Disease Models, Animal; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Kidney Diseases; Kidney Tubules; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rats; rho GTP-Binding Proteins; rho-Associated Kinases

2005
Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.
    Nature reviews. Drug discovery, 2007, Volume: 6, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiomegaly; Cardiovascular Agents; Humans; Models, Biological; Molecular Structure; Pyridines; Receptors, Cell Surface; Signal Transduction

2007
[Advances in the study of Rho kinase and its inhibitors].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Antihypertensive Agents; Cardiovascular Diseases; Humans; Pyridines; rho-Associated Kinases; Signal Transduction; Subarachnoid Hemorrhage; Vasodilator Agents

2007
Rho GTPases in hepatocellular carcinoma.
    Biochimica et biophysica acta, 2009, Volume: 1795, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Carcinoma, Hepatocellular; Disease Progression; Farnesyltranstransferase; Humans; Liver Neoplasms; Neoplasm Metastasis; Pyridines; rho GTP-Binding Proteins; Signal Transduction

2009
[Rho-kinase inhibitors].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2011, Volume: 138, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Clinical Trials as Topic; Coronary Artery Disease; Drug Design; Glaucoma; Humans; Hypertension, Pulmonary; Mice; Molecular Targeted Therapy; Pyridines; Rats; rho-Associated Kinases; Vasospasm, Intracranial

2011
Rho kinase as a therapeutic target in cardiovascular disease.
    Future cardiology, 2011, Volume: 7, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Apoptosis; Cardiovascular Diseases; Coronary Artery Disease; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Heart Failure; Humans; Male; Myocytes, Cardiac; Protein Isoforms; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Vasodilation

2011
[Development of Rho kinase inhibitors for pulmonary arterial hypertension].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2012, Volume: 139, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Drug Design; Humans; Hypertension, Pulmonary; Molecular Targeted Therapy; Pyridines; rho-Associated Kinases

2012
Potential role of Rho kinase inhibitors in combating diabetes-related complications including diabetic neuropathy--a review.
    Current diabetes reviews, 2013, Volume: 9, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiomyopathies; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Humans; Mice; Oxidative Stress; Pyridines; Rats; rho-Associated Kinases; Sexual Dysfunction, Physiological; Signal Transduction; Vasodilator Agents

2013
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil.
    Journal of cardiovascular pharmacology, 2013, Volume: 62, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Drug Design; Humans; Molecular Targeted Therapy; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction

2013
Rho Kinases in Autoimmune Diseases.
    Annual review of medicine, 2016, Volume: 67

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arthritis, Rheumatoid; Autoimmune Diseases; B-Lymphocytes; Cell Movement; Cell Proliferation; Cell Survival; Cytoskeleton; Gene Expression; Giant Cell Arteritis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lupus Erythematosus, Systemic; Myeloid Cells; Osteoarthritis; Protein Kinase Inhibitors; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Scleroderma, Systemic; T-Lymphocytes

2016
The Rho GTPase signalling pathway in urothelial carcinoma.
    Nature reviews. Urology, 2018, Volume: 15, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Camellia sinensis; Carcinoma, Transitional Cell; Enzyme Inhibitors; Humans; Neoplasm Metastasis; Plant Extracts; Protein Kinase Inhibitors; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Urinary Bladder Neoplasms

2018

Other Studies

124 other study(ies) available for y 27632 and fasudil

ArticleYear
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

2000
Kinase inhibitors: not just for kinases anymore.
    Journal of medicinal chemistry, 2003, Apr-10, Volume: 46, Issue:8

    Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation

2003
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
    The Journal of biological chemistry, 2006, Jan-06, Volume: 281, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Amino Acid Sequence; Binding Sites; Binding, Competitive; Cyclic AMP-Dependent Protein Kinases; Dimerization; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Molecular Sequence Data; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyridines; rho-Associated Kinases; Structure-Activity Relationship

2006
Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity.
    The Journal of biological chemistry, 2006, Aug-25, Volume: 281, Issue:34

    Topics: Animals; Benzamides; Cattle; Cyclic AMP-Dependent Protein Kinases; Erlotinib Hydrochloride; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Models, Molecular; Mutagenesis, Site-Directed; Piperazines; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Quinazolines; Recombinant Fusion Proteins; rho-Associated Kinases; Structure-Activity Relationship; Substrate Specificity

2006
Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Cells, Cultured; Cytokines; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Macrophages; Male; Oxadiazoles; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Vasodilator Agents

2007
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor.
    Hypertension (Dallas, Tex. : 1979), 2009, Volume: 54, Issue:3

    Topics: Animals; Arteries; Blood Pressure; Catalysis; Cell Line; Cell Proliferation; Chemotaxis; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Immunoblotting; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Myosin-Light-Chain Phosphatase; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; rho-Associated Kinases; Stress Fibers; Vasoconstriction

2009
Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.
    Journal of medicinal chemistry, 2010, Jan-28, Volume: 53, Issue:2

    Topics: Animals; Aorta; Bisbenzimidazole; Drug Discovery; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Protein Kinase Inhibitors; Rats; rho-Associated Kinases; Structure-Activity Relationship; Urea

2010
Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account.
    Bioorganic & medicinal chemistry letters, 2010, Jun-01, Volume: 20, Issue:11

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Crystallography, X-Ray; Drug Discovery; Isoquinolines; Models, Molecular; Protein Kinase Inhibitors; Rats; rho-Associated Kinases

2010
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
    Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

    Topics: Amines; Animals; Binding Sites; Computer Simulation; Crystallography, X-Ray; Drug Evaluation, Preclinical; Isoquinolines; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; rho-Associated Kinases; Structure-Activity Relationship

2011
Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.
    Journal of medicinal chemistry, 2012, Feb-23, Volume: 55, Issue:4

    Topics: Animals; Binding, Competitive; Catalytic Domain; Cell-Free System; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Databases, Factual; Genes, Reporter; Luciferases; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Recombinant Fusion Proteins; Structure-Activity Relationship

2012
Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).
    MedChemComm, 2012, Jun-01, Volume: 3, Issue:6

    Topics:

2012
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
    The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2

    Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

2013
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
    Journal of medicinal chemistry, 2015, Jun-25, Volume: 58, Issue:12

    Topics: Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Structure-Activity Relationship

2015
Effects of newly synthetized isoquinoline derivatives on rat uterine contractility and ROCK II activity.
    Bioorganic & medicinal chemistry letters, 2018, 02-01, Volume: 28, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Female; Isoquinolines; Molecular Structure; Pregnancy; Protein Kinase Inhibitors; Rats; rho-Associated Kinases; Structure-Activity Relationship; Uterine Contraction

2018
Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase.
    Blood, 1999, May-15, Volume: 93, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Blood Platelets; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Myosin-Light-Chain Phosphatase; Myosins; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein

1999
Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape change.
    The Journal of biological chemistry, 1999, Oct-01, Volume: 274, Issue:40

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Blood Platelets; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Egtazic Acid; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Myosins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction

1999
Purification and in vitro activity of Rho-associated kinase.
    Methods in enzymology, 2000, Volume: 325

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Baculoviridae; Catalytic Domain; Cattle; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Pyridines; Recombinant Fusion Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Staurosporine

2000
Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow.
    Oncogene, 2000, Dec-07, Volume: 19, Issue:52

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Blood Proteins; Carrier Proteins; Cell Division; Cell Line; Cytoskeletal Proteins; Fluorescent Antibody Technique; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microfilament Proteins; Myosin Light Chains; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Stress Fibers

2000
Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity.
    FEBS letters, 2001, Mar-30, Volume: 493, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Base Sequence; Binding Sites; DNA Primers; Enzyme Inhibitors; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Myosin-Light-Chain Phosphatase; Myotonic Dystrophy; Myotonin-Protein Kinase; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Subunits; Pyridines; Recombinant Proteins; rho-Associated Kinases

2001
Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).
    Experimental cell research, 2001, Jun-10, Volume: 266, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Amides; Animals; Bombesin; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Pyridines; Retinoblastoma-Like Protein p130; rho-Associated Kinases; Stress Fibers

2001
Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.
    Journal of muscle research and cell motility, 2001, Volume: 22, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antineoplastic Agents; Aorta; Azepines; Calcium; Colchicine; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Male; Microtubules; Muscle Contraction; Muscle, Smooth, Vascular; Nocodazole; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstrictor Agents

2001
Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.
    British journal of pharmacology, 2001, Volume: 134, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetamides; Amides; Animals; Bethanechol; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Imidazoles; In Vitro Techniques; Indoles; Ion Channels; Isoquinolines; Muscle Contraction; Myosin Light Chains; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rabbits; Time Factors; Urinary Bladder; Verapamil

2001
Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.
    The Biochemical journal, 2002, Jun-01, Volume: 364, Issue:Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arteries; Enzyme Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Potassium; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases

2002
Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes.
    Biochimica et biophysica acta, 2002, Jun-12, Volume: 1590, Issue:1-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amides; Arteriosclerosis; Base Sequence; Botulinum Toxins; Cells, Cultured; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Monocytes; Plasminogen Activator Inhibitor 1; Polyisoprenyl Phosphates; Pravastatin; Protein Prenylation; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Signal Transduction

2002
Occupation of the prostaglandin E2-type 1 receptor increases rat atrial contractility via a Y-27632-sensitive pathway.
    Prostaglandins & other lipid mediators, 2002, Volume: 70, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic Antagonists; Amides; Animals; Atrial Function, Left; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Myocardial Contraction; Perfusion; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; rho-Associated Kinases

2002
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.
    British journal of pharmacology, 2002, Volume: 137, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Stomach; Urinary Bladder

2002
A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.
    Brain research, 2003, Jan-03, Volume: 959, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amides; Animals; Blotting, Western; Botulinum Toxins; Enzyme Inhibitors; Female; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Motor Activity; Protein Serine-Threonine Kinases; Proteins; Pyridines; Rats; Rats, Sprague-Dawley; Recovery of Function; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Spinal Cord Injuries

2003
Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells.
    The Journal of physiology, 2003, Mar-15, Volume: 547, Issue:Pt 3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cells, Cultured; Enzyme Inhibitors; ERG1 Potassium Channel; Estrenes; Ether-A-Go-Go Potassium Channels; Hydrolysis; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Maleimides; Membrane Potentials; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphoprotein Phosphatases; Phosphorylation; Pituitary Gland, Anterior; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Pyridines; Pyrrolidinones; Rats; rho-Associated Kinases; Signal Transduction; Thyrotropin-Releasing Hormone

2003
Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.
    Circulation research, 2003, Apr-18, Volume: 92, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Basilar Artery; Benzamides; Biological Transport; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Muscle, Smooth, Vascular; Oxyhemoglobins; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rabbits; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Vasoconstriction

2003
Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.
    Biochemical and biophysical research communications, 2003, Apr-11, Volume: 303, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Carbachol; Electric Stimulation; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction

2003
Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.
    Kidney international, 2003, Volume: 63, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Calcium Channel Blockers; Enzyme Inhibitors; Female; Gallic Acid; Indoles; Nifedipine; Norepinephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; Signal Transduction; Staurosporine; Vasoconstrictor Agents

2003
P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Jun-01, Volume: 170, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Caspase Inhibitors; Caspases; Cell Line; Enzyme Activation; Extracellular Space; Humans; Interleukin-1; Intracellular Signaling Peptides and Proteins; Macrophages; Mice; Protein Serine-Threonine Kinases; Pseudopodia; Pyridines; Receptors, Purinergic P2; Receptors, Purinergic P2X7; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

2003
Astrocyte stellation induced by Rho kinase inhibitors in culture.
    Brain research. Developmental brain research, 2003, Jun-12, Volume: 143, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Astrocytes; Carbazoles; Cell Size; Cells, Cultured; Cerebral Cortex; Colchicine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gout Suppressants; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Phalloidine; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; rho-Associated Kinases

2003
Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice.
    European journal of pharmacology, 2003, Jul-11, Volume: 472, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Muscle Relaxation; Penis; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases

2003
Rho kinase inhibition initiates apoptosis in human airway epithelial cells.
    American journal of respiratory cell and molecular biology, 2004, Volume: 30, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Actins; Amides; Animals; Apoptosis; Caspase Inhibitors; Cell Membrane; Cells, Cultured; Cytochalasin D; Cytoskeleton; Enzyme Inhibitors; Epithelial Cells; Humans; Intracellular Signaling Peptides and Proteins; Mice; Protein Serine-Threonine Kinases; Pyridines; Respiratory Mucosa; rho-Associated Kinases; Stress Fibers

2004
Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens.
    British journal of pharmacology, 2003, Volume: 140, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Blotting, Western; Electric Stimulation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanethidine; Intracellular Signaling Peptides and Proteins; Male; Mice; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vas Deferens

2003
Rho kinase inhibitors block activation of pancreatic stellate cells.
    British journal of pharmacology, 2003, Volume: 140, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Blotting, Western; Cell Division; Cell Size; Cells, Cultured; Chemotaxis; Collagen Type I; Enzyme Inhibitors; Fluorescent Dyes; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Microscopy, Confocal; Pancreas; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Rhodamines

2003
Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 286, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Capillary Permeability; Cattle; Cells, Cultured; Complement C5a; Endothelium, Vascular; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Neutrophils; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Swine

2004
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
    Structure (London, England : 1993), 2003, Volume: 11, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Amino Acid Sequence; Animals; Binding Sites; Cattle; Cell Adhesion; Crystallography, X-Ray; Cyclic AMP-Dependent Protein Kinases; Electrons; Enzyme Inhibitors; Escherichia coli; Glycine; Kinetics; Models, Chemical; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Pyridines; Recombinant Proteins; Sequence Homology, Amino Acid

2003
Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2004, Volume: 19, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amides; Animals; Bacterial Proteins; Bacterial Toxins; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Botulinum Toxins; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Mice; Osteoblasts; Osteogenesis; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Skull; Transforming Growth Factor beta

2004
Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
    British journal of pharmacology, 2004, Volume: 143, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sheep; Tetrodotoxin; Ureter; Vasoconstrictor Agents; Vasodilator Agents

2004
Effects of HA-1077 and Y-27632, two rho-kinase inhibitors, in the human umbilical artery.
    Cell biochemistry and biophysics, 2004, Volume: 41, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Biophysics; Calcium; Dose-Response Relationship, Drug; Humans; Models, Biological; Nifedipine; Potassium Chloride; Protein Isoforms; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Serotonin; Umbilical Arteries

2004
Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.
    American journal of respiratory and critical care medicine, 2005, Mar-01, Volume: 171, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Inhalation; Administration, Oral; Amides; Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Intracellular Signaling Peptides and Proteins; Male; Nitric Oxide; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Treatment Outcome; Vasodilator Agents

2005
Rho-kinase and myosin II activities are required for cell type and environment specific migration.
    Genes to cells : devoted to molecular & cellular mechanisms, 2005, Volume: 10, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Culture Techniques; Cell Movement; Cell Nucleus; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Epithelial Cells; Fibroblasts; Heterocyclic Compounds, 4 or More Rings; Humans; Intracellular Signaling Peptides and Proteins; Macrophages; Monomeric GTP-Binding Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Type II; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases

2005
Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amides; Animals; Benzophenanthridines; Blood Pressure; Calcium; Calcium Signaling; Cerebral Arteries; Enzyme Inhibitors; Hypertension; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Tonus; Muscle, Smooth, Vascular; Phenanthridines; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases

2005
Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.
    British journal of pharmacology, 2005, Volume: 146, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amides; Animals; Arteries; Clonidine; Electric Stimulation; Electrophysiology; Female; Idazoxan; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Phenylephrine; Prazosin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Suramin; Tail; Vasoconstriction

2005
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
    Stroke, 2005, Volume: 36, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Analysis of Variance; Animals; Antihypertensive Agents; Aorta; Blotting, Northern; Blotting, Western; Brain Ischemia; Cattle; Cell Line; Cells, Cultured; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypoxia; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Serine-Threonine Kinases; Pyridines; Regional Blood Flow; rho-Associated Kinases; RNA, Messenger; Stroke; Time Factors; Umbilical Veins; Up-Regulation

2005
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 290, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction

2006
Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.
    Autonomic & autacoid pharmacology, 2006, Volume: 26, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Azepines; Calcium; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Norepinephrine; Potassium; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X; rho-Associated Kinases; Vas Deferens

2006
Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury.
    Journal of leukocyte biology, 2006, Volume: 79, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Apoptosis; Cell Communication; Chemokines, CXC; Chemotaxis, Leukocyte; Disease Models, Animal; Endothelial Cells; Endotoxemia; Hepatic Artery; Hepatocytes; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Regional Blood Flow; rho-Associated Kinases; Tumor Necrosis Factor-alpha

2006
Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.
    Protein and peptide letters, 2006, Volume: 13, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Amino Acid Sequence; Animals; Humans; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Molecular Weight; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyridines; rho-Associated Kinases; Spodoptera; Staurosporine

2006
Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 291, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Intracellular Signaling Peptides and Proteins; Lung; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pregnancy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyridines; rho-Associated Kinases; Sheep; Signal Transduction; Vascular Resistance

2006
Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Androstadienes; Animals; Apoptosis; Cardiotonic Agents; Coronary Circulation; Cytoskeletal Proteins; Enzyme Activation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Microfilament Proteins; Multiprotein Complexes; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Wortmannin

2007
RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis.
    The Journal of biological chemistry, 2007, Mar-16, Volume: 282, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 8; Caspase 9; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Mitochondria; Myocytes, Cardiac; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Up-Regulation

2007
RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.
    Neurourology and urodynamics, 2007, Volume: 26, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Blotting, Western; Calcium; Cells, Cultured; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Prostate; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; Type C Phospholipases

2007
The RISK of ROCK.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Apoptosis; Cardiotonic Agents; Coronary Circulation; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Research Design; rho-Associated Kinases; Signal Transduction

2007
Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.
    Circulation, 2007, Apr-03, Volume: 115, Issue:13

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Ductus Arteriosus; Enzyme Activation; Enzyme Induction; Feedback, Physiological; Female; Fetal Heart; Gestational Age; Humans; Hydrogen Peroxide; Hypoplastic Left Heart Syndrome; Infant, Newborn; Intracellular Signaling Peptides and Proteins; Male; Mitochondria, Heart; Nifedipine; Organ Culture Techniques; Oxidation-Reduction; Oxygen; Partial Pressure; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rabbits; Reactive Oxygen Species; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Superoxides; Vasoconstriction

2007
The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.
    Leukemia, 2007, Volume: 21, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Antigens, CD34; Benzamides; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; rho-Associated Kinases; Stem Cells; Tumor Cells, Cultured

2007
Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.
    Biochemical pharmacology, 2007, Aug-15, Volume: 74, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Atropine; Blotting, Western; Calcium Signaling; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Enzyme Inhibitors; Guanine Nucleotide Dissociation Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rho-Specific Guanine Nucleotide Dissociation Inhibitors; rhoA GTP-Binding Protein; Urethra; Urinary Bladder

2007
Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo.
    Journal of neurochemistry, 2007, Volume: 103, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Axons; Cell Line; Chondroitin Sulfate Proteoglycans; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Intracellular Signaling Peptides and Proteins; Nerve Crush; Nerve Regeneration; Neurites; Neurons; Optic Nerve; Optic Nerve Injuries; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases

2007
Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.
    British journal of pharmacology, 2007, Volume: 152, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenalectomy; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amides; Anesthetics, Local; Animals; Blood Pressure; Blood Vessels; Body Temperature Regulation; Clonidine; Cold Temperature; Heart Rate; Intracellular Signaling Peptides and Proteins; Isoquinolines; Laser-Doppler Flowmetry; Male; Mice; Naphthyridines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Quinolizines; Receptors, Adrenergic, alpha-2; Reflex; Regional Blood Flow; rho-Associated Kinases; Skin; Skin Temperature; Sympathetic Nervous System; Tetrodotoxin; Vasoconstriction

2007
Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle.
    American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 294, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isometric Contraction; Male; Muscle Tonus; Muscle, Smooth; Myosin-Light-Chain Kinase; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases

2008
Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells.
    Journal of cardiovascular pharmacology, 2008, Volume: 51, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcimycin; Cells, Cultured; Coronary Vessels; Down-Regulation; Endothelial Cells; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Nitroprusside; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Sodium Nitrite; Triazenes

2008
Rho kinase inhibition: a new approach for treating diabetic nephropathy?
    Diabetes, 2008, Volume: 57, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Diabetic Nephropathies; Humans; Mice; Protein Kinase Inhibitors; Pyridines; Rats; rho-Associated Kinases

2008
Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats.
    Brain research, 2008, Mar-27, Volume: 1201

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Axons; Cats; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Male; Nerve Crush; Nerve Regeneration; Optic Nerve; Optic Nerve Injuries; Organ Culture Techniques; Protein Kinase Inhibitors; Pyridines; Retina; rho-Associated Kinases; Treatment Outcome; Wallerian Degeneration

2008
Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Bronchi; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Propofol; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases

2008
Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.
    British journal of pharmacology, 2008, Volume: 155, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Anticonvulsants; Blotting, Western; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Kindling, Neurologic; Male; Mice; Motor Activity; Pentylenetetrazole; Protein Kinase Inhibitors; Protein Transport; Pyridines; Reflex; rho-Associated Kinases; Seizures

2008
Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy.
    The British journal of surgery, 2008, Volume: 95, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alanine Transaminase; Amides; Analysis of Variance; Animals; Cytokines; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Hepatectomy; Hepatitis; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction

2008
Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Autocrine Communication; Cell Hypoxia; Cell Movement; Cell Nucleus; Drug Screening Assays, Antitumor; Endothelial Cells; Enzyme Activation; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Myosin Light Chains; Neovascularization, Pathologic; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Pyridines; rho-Associated Kinases; Ubiquitination; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2008
Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Benzophenanthridines; Calcium; Electric Stimulation; Esophageal Sphincter, Lower; Humans; In Vitro Techniques; Muscle Contraction; Naphthalenes; Protein Kinase C; Pyridines; rhoA GTP-Binding Protein

2008
Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction.
    European journal of pharmacology, 2008, Oct-10, Volume: 594, Issue:1-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Activating Transcription Factor 3; Amides; Animals; Blotting, Western; Brain; Cerebral Cortex; Cerebral Infarction; Enzyme Inhibitors; Hippocampus; Immunohistochemistry; Male; Myosin Light Chains; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Tissue Extracts

2008
Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis.
    Arthritis and rheumatism, 2008, Volume: 58, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Amides; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Enzyme Activation; Female; Humans; Interleukin-1beta; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Middle Aged; NF-kappa B; Pyridines; Rats; rho-Associated Kinases; Signal Transduction; Synovial Membrane; Tumor Necrosis Factor-alpha

2008
Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antihypertensive Agents; Aorta, Thoracic; Blotting, Western; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; In Vitro Techniques; Isometric Contraction; Male; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Species Specificity; Vasoconstriction

2009
Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling.
    American journal of physiology. Renal physiology, 2009, Volume: 296, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Nucleus; Chemokines; Enzyme Inhibitors; Female; Kidney; Leukocytes; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nephritis; NF-kappa B p50 Subunit; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Renal Insufficiency; rho-Associated Kinases; Signal Transduction; Transcription Factor RelA

2009
Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase.
    Journal of viral hepatitis, 2009, Volume: 16, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Cell Line; DNA-Directed RNA Polymerases; Hepacivirus; Hepatocytes; Humans; Interferon-alpha; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Viral Proteins; Virus Replication

2009
Signaling through Rho GTPase pathway as viable drug target.
    Current medicinal chemistry, 2009, Volume: 16, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aminoquinolines; Anilides; Animals; Benzamides; Cardiovascular Diseases; Humans; Lung Diseases; Neoplasms; Nervous System Diseases; Protein Kinase Inhibitors; Pyridines; Pyrimidines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction

2009
Vascular dysfunction in septic shock--any ROCKing news?
    Critical care medicine, 2009, Volume: 37, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Disease Models, Animal; Endothelium, Vascular; Muscle, Smooth; Nitric Oxide; Pyridines; Rats; rho-Associated Kinases; Sensitivity and Specificity; Shock, Septic; Vasoconstriction; Vasodilation

2009
Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.
    Neurochemistry international, 2009, Volume: 55, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Brain; Cell Line, Tumor; Encephalitis; I-kappa B Proteins; Interleukin-6; MAP Kinase Signaling System; Neurons; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; rho-Associated Kinases; Signal Transduction; Tumor Necrosis Factor-alpha

2009
Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
    International journal of molecular medicine, 2009, Volume: 24, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Line; HSP27 Heat-Shock Proteins; Lysophospholipids; Mice; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; Sphingosine

2009
Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells.
    Prostaglandins & other lipid mediators, 2009, Volume: 90, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alprostadil; Amides; Animals; Cell Line; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; Vascular Endothelial Growth Factor A

2009
Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery.
    Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Amides; Constriction, Pathologic; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nitroarginine; Nitroprusside; Oxadiazoles; Protein Kinase Inhibitors; Pyridines; Quinoxalines; Radial Artery; Receptors, Calcium-Sensing; rho-Associated Kinases; Vasoconstriction; Vasodilation

2009
Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia.
    Pediatric research, 2010, Volume: 67, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Airway Remodeling; Amides; Animals; Animals, Newborn; Antihypertensive Agents; Becaplermin; Body Weight; Chronic Disease; Disease Models, Animal; DNA Replication; Dose-Response Relationship, Drug; Hyperoxia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Muscle, Smooth, Vascular; Organ Size; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyridines; Rats; Receptor, Platelet-Derived Growth Factor beta; rho-Associated Kinases; Vascular Resistance

2010
Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging.
    Stem cell reviews and reports, 2010, Volume: 6, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Apoptosis; Biomarkers; Cell Differentiation; Cell Line; Cell Proliferation; Cell Shape; Collagen; Drug Carriers; Drug Combinations; Embryonic Stem Cells; Extracellular Matrix; Gene Expression Regulation, Developmental; Humans; Induced Pluripotent Stem Cells; Integrin alpha6; Integrin alphaV; Integrin beta1; Karyotyping; Laminin; Protein Kinase Inhibitors; Proteoglycans; Pyridines; rho-Associated Kinases; RNA, Messenger

2010
Rho-kinase limits FGF-2-stimulated VEGF release in osteoblasts.
    Bone, 2010, Volume: 46, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Analysis of Variance; Animals; Blotting, Western; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Humans; Immunoenzyme Techniques; JNK Mitogen-Activated Protein Kinases; Mice; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; Vascular Endothelial Growth Factor A

2010
Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins.
    Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Amides; Animals; Antioxidants; Benzophenanthridines; Body Temperature Regulation; Brimonidine Tartrate; Cold Temperature; Cyclic N-Oxides; Cytoskeletal Proteins; Female; Horses; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Quinoxalines; Reactive Oxygen Species; rho-Associated Kinases; Rotenone; Spin Labels; Vasoconstriction; Vasodilator Agents; Veins

2010
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aging; Amides; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Injections, Subcutaneous; Muscle, Smooth, Vascular; Myocardium; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Rats; Receptor, Endothelin A; rho-Associated Kinases; RNA Interference; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling

2010
Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.
    Urologia internationalis, 2011, Volume: 86, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Bacterial Proteins; Bacterial Toxins; Calcium; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Movement; Fura-2; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Lysophospholipids; Mutation; Pertussis Toxin; Phalloidine; Protein Kinase Inhibitors; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Type C Phospholipases

2011
Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Anti-Infective Agents, Local; Cells, Cultured; Chlorhexidine; Disease Models, Animal; Enzyme Inhibitors; Epithelium; Humans; Immunoenzyme Techniques; Male; Neovascularization, Pathologic; Peritoneal Fibrosis; Pleural Cavity; Pyridines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; RNA, Messenger; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A

2011
Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity.
    Cellular & molecular biology letters, 2011, Volume: 16, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actomyosin; Amides; Cell Movement; Cells, Cultured; Focal Adhesions; Humans; Myosin Light Chains; Osteoblasts; Phosphorylation; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Stress Fibers

2011
Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells.
    American journal of physiology. Cell physiology, 2011, Volume: 301, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; ADP Ribose Transferases; Amides; Animals; Blotting, Western; Botulinum Toxins; Cytoskeleton; Enzyme Inhibitors; Epididymis; Epithelial Cells; Flow Cytometry; Green Fluorescent Proteins; Male; Mice; Mice, Transgenic; Microvilli; Proton Pumps; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Vacuolar Proton-Translocating ATPases

2011
Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells.
    Biochemical and biophysical research communications, 2011, Aug-12, Volume: 411, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Cell Movement; Cells, Cultured; Chemokine CCL2; Endothelium, Vascular; Gene Expression; Humans; Mice; Mice, Inbred Strains; Monocytes; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Thrombin

2011
Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Catalytic Domain; Cell Line, Tumor; Collagen; Crystallography, X-Ray; Drug Combinations; Extracellular Matrix; Humans; Inhibitory Concentration 50; Laminin; Models, Molecular; Myotonin-Protein Kinase; Neoplasm Invasiveness; Protein Kinase Inhibitors; Protein Multimerization; Protein-Tyrosine Kinases; Proteoglycans; Pyridines; rho-Associated Kinases; Thiophenes

2011
Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2011, Volume: 89, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Adipogenesis; Amides; Animals; beta Catenin; Gene Expression Regulation; Lysophospholipids; Mice; PPAR gamma; Pyridines; Receptor Cross-Talk; rho-Associated Kinases; RNA, Messenger; Time Factors; Transcriptional Activation; Wnt Proteins; Wnt Signaling Pathway

2011
ROCK1 feedback regulation of the upstream small GTPase RhoA.
    Cellular signalling, 2012, Volume: 24, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; ADP Ribose Transferases; Amides; Aminoquinolines; Botulinum Toxins; Cell Line, Tumor; Gene Expression Regulation; Guanine Nucleotide Exchange Factors; Humans; Male; Prostatic Neoplasms; Pyridines; Pyrimidines; rac1 GTP-Binding Protein; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; T-Lymphoma Invasion and Metastasis-inducing Protein 1

2012
Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Amides; Animals; Calcium; Cattle; Cells, Cultured; Cytochalasin D; Dose-Response Relationship, Drug; Nocodazole; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Time Factors; Up-Regulation

2012
Contractile responses of isolated equine digital arteries under hypoxic or hyperoxic conditions in vitro: role of reactive oxygen species and Rho kinase.
    Journal of veterinary pharmacology and therapeutics, 2013, Volume: 36, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arteries; Cadaver; Hindlimb; Horses; NADPH Oxidases; Oxygen; Phenylephrine; Pyridines; Reactive Oxygen Species; rho-Associated Kinases; Vasoconstriction

2013
Rho-kinase negatively regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.
    Biochimie, 2013, Volume: 95, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Line; Gene Expression Regulation; Mice; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Osteoblasts; Osteocalcin; Phosphorylation; Pyridines; rho-Associated Kinases; RNA, Messenger; Triiodothyronine

2013
The selective Rho-kinase inhibitor azaindole-1 has long-lasting erectile activity in the rat.
    Urology, 2013, Volume: 81, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Area Under Curve; Atropine; Blood Pressure; Diamines; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Male; Muscarinic Antagonists; Nitric Oxide; Oxadiazoles; Penile Erection; Penis; Peripheral Nerve Injuries; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; rho-Associated Kinases; Signal Transduction; Time Factors

2013
RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation.
    Cell proliferation, 2013, Volume: 46, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Flavonoids; Imidazoles; Lung; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Mutation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, G-Protein-Coupled; rho-Associated Kinases; rhoA GTP-Binding Protein; Sheep

2013
Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions.
    Journal of neurochemistry, 2014, Volume: 129, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Astrocytes; Blood-Brain Barrier; Blotting, Western; Brain Chemistry; Brain Ischemia; Cells, Cultured; Cerebral Infarction; Endothelial Cells; Functional Laterality; Male; Mice; Mice, Inbred C57BL; NADPH Oxidases; Nerve Tissue Proteins; Oxidative Stress; Protein Kinase Inhibitors; Psychomotor Performance; Pyridines; Reactive Oxygen Species; rho-Associated Kinases; Tight Junctions

2014
Do fasudil and Y-27632 affect the level of transient receptor potential (TRP) gene expressions in breast cancer cell lines?
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Pyridines; rho-Associated Kinases; Transient Receptor Potential Channels; TRPC Cation Channels; TRPM Cation Channels

2014
Signaling Rho-kinase mediates inflammation and apoptosis in T cells and renal tubules in cisplatin nephrotoxicity.
    American journal of physiology. Renal physiology, 2015, Apr-15, Volume: 308, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Amides; Animals; Anti-Inflammatory Agents; Apoptosis; Cells, Cultured; Chemotaxis; Cisplatin; Coculture Techniques; Cytoprotection; Disease Models, Animal; Hepatitis A Virus Cellular Receptor 1; Inflammation Mediators; Kidney Tubules; Macrophages; Membrane Proteins; Mice, Inbred C57BL; Nephritis; Neutrophil Infiltration; NF-kappa B; Phosphorylation; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction; T-Lymphocytes; Time Factors

2015
Protective effect of a novel Rho kinase inhibitor WAR-5 in experimental autoimmune encephalomyelitis by modulating inflammatory response and neurotrophic factors.
    Experimental and molecular pathology, 2015, Volume: 99, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aminopyridines; Animals; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Immunoblotting; Immunoenzyme Techniques; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Nerve Growth Factors; Piperidines; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; T-Lymphocytes, Regulatory

2015
In vitro oxygen exposure promotes maturation of the oxygen sensitive contraction in pre-term chicken ductus arteriosus.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2015, Volume: 188

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Chick Embryo; Chickens; Dinoprostone; Dose-Response Relationship, Drug; Ductus Arteriosus; Enzyme Inhibitors; Nifedipine; Nitric Oxide; Oxygen; Pyridines; rho-Associated Kinases; Time Factors; Vasoconstriction

2015
Effects of ethanol on RhoA/Rho-kinase-mediated calcium sensitization in mouse lung parenchymal tissue.
    European journal of pharmacology, 2015, Oct-05, Volume: 764

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Ethanol; Lung; Male; Mice; Microscopy, Electron; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

2015
Rho-associated kinase inhibitors promote the cardiac differentiation of embryonic and induced pluripotent stem cells.
    International journal of cardiology, 2015, Dec-15, Volume: 201

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Cell Differentiation; Echocardiography; Embryonic Stem Cells; Gene Expression; Hematopoietic Stem Cells; Induced Pluripotent Stem Cells; Male; Mice; Myocardial Infarction; Myocytes, Cardiac; Platelet Membrane Glycoprotein IIb; Pluripotent Stem Cells; Protein Kinase Inhibitors; Pyridines; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; Stem Cell Transplantation

2015
Rho-Associated Kinase Inhibitors Promote Microglial Uptake Via the ERK Signaling Pathway.
    Neuroscience bulletin, 2016, Volume: 32, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Blotting, Western; Cell Line; Flow Cytometry; Immunohistochemistry; MAP Kinase Signaling System; Mice; Microglia; Phagocytosis; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases

2016
Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.
    Acta neuropathologica communications, 2016, Apr-22, Volume: 4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Synuclein; Amides; Animals; Brain; Carrier Proteins; Cell Line, Tumor; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Humans; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Aggregates; Protein Kinase Inhibitors; Psychomotor Performance; Pyridines; Recognition, Psychology; Time Factors; Tyrosine 3-Monooxygenase

2016
Regulation of Microglial Phagocytosis by RhoA/ROCK-Inhibiting Drugs.
    Cellular and molecular neurobiology, 2017, Volume: 37, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Biological Assay; Cell Line; Down-Regulation; Humans; Ibuprofen; Lysophospholipids; Mice; Microglia; Nitric Oxide; Phagocytosis; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

2017
The RhoA/ROCK Pathway Ameliorates Adhesion and Inflammatory Infiltration Induced by AGEs in Glomerular Endothelial Cells.
    Scientific reports, 2017, 01-05, Volume: 7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Chemokine CCL2; Diabetic Nephropathies; Disease Models, Animal; Endothelial Cells; Glycation End Products, Advanced; Inflammation; Intercellular Adhesion Molecule-1; Kidney Glomerulus; Mice; Mice, Mutant Strains; Protein Kinase Inhibitors; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction

2017
Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells.
    Scientific reports, 2018, 02-06, Volume: 8, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Actin Cytoskeleton; Adipocytes; Adipogenesis; Amides; Animals; Anti-Obesity Agents; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Fatty Acid-Binding Proteins; Gene Expression Regulation; Glucose Transporter Type 4; Heterocyclic Compounds, 4 or More Rings; Mice; PPAR gamma; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction

2018
A crucial role of ROCK for alleviation of senescence-associated phenotype.
    Experimental gerontology, 2018, Volume: 106

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Proliferation; Cellular Senescence; Child; Chromatin; Fibroblasts; Humans; Male; Mice; Mice, Inbred C57BL; Phenotype; Progeria; Pyridines; rho-Associated Kinases; Wound Healing

2018
Suppressive effect of Rho-kinase inhibitors Y-27632 and fasudil on spike-and-wave discharges in genetic absence epilepsy rats from Strasbourg (GAERS).
    Naunyn-Schmiedeberg's archives of pharmacology, 2018, Volume: 391, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Brain; Electroencephalography; Epilepsy, Absence; Male; Protein Kinase Inhibitors; Pyridines; Rats, Wistar; rho GTP-Binding Proteins

2018
RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility.
    European journal of pharmacology, 2019, Jan-15, Volume: 843

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cervical Ripening; Cervix Uteri; Female; In Vitro Techniques; Muscle Contraction; Pregnancy; Pyridines; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Simvastatin

2019
Sphingosine-1-Phosphate Enhances α
    International journal of molecular sciences, 2019, Dec-17, Volume: 20, Issue:24

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Drug Synergism; Lysophospholipids; Mice, Inbred C57BL; Mice, Knockout; Phenylephrine; Pyridines; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

2019
ROCK inhibitors enhance bone healing by promoting osteoclastic and osteoblastic differentiation.
    Biochemical and biophysical research communications, 2020, 06-04, Volume: 526, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Differentiation; Cell Line; Fracture Healing; Male; Mice; Osteoblasts; Osteoclasts; Osteogenesis; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; rho-Associated Kinases; Skull; Small Molecule Libraries

2020
The Rho-associated kinase inhibitor fasudil can replace Y-27632 for use in human pluripotent stem cell research.
    PloS one, 2020, Volume: 15, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Embryonic Stem Cells; Humans; Induced Pluripotent Stem Cells; Neural Crest; Pluripotent Stem Cells; Protein Kinase Inhibitors; Pyridines; Retinal Pigment Epithelium; rho-Associated Kinases; Stem Cell Research

2020
Rock inhibition promotes Na
    Scientific reports, 2020, 08-07, Volume: 10, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Humans; NAV1.5 Voltage-Gated Sodium Channel; Neoplasm Invasiveness; Protein Serine-Threonine Kinases; Pyridines; Signal Transduction

2020
Effects of the Rho/Rho-Kinase Pathway on Perfusion Pressure in the Isolated-Perfused Rat Hind Limb Vascular Bed.
    Balkan medical journal, 2021, Volume: 38, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Atorvastatin; Muscle Relaxants, Central; Perfusion; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasodilation; Vasodilator Agents

2021
Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia.
    Pharmacological research, 2023, Volume: 194

    Topics: Animals; Clozapine; Cognitive Dysfunction; Haloperidol; Male; Methamphetamine; Mice; Monomeric GTP-Binding Proteins; Protein Kinase Inhibitors; rho-Associated Kinases; Schizophrenia

2023
Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model.
    Ecotoxicology and environmental safety, 2023, Nov-01, Volume: 266

    Topics: Animals; Cognition; Cognitive Dysfunction; Fluorides; Humans; Mice; Mice, Inbred ICR; Neurodegenerative Diseases; rho-Associated Kinases

2023