y 27632 has been researched along with endothelin-1 in 50 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (endothelin-1) | Trials (endothelin-1) | Recent Studies (post-2010) (endothelin-1) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 12,740 | 632 | 3,394 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (6.00) | 18.2507 |
| 2000's | 33 (66.00) | 29.6817 |
| 2010's | 14 (28.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dobashi, K; Harada, T; Horie, T; Iizuka, K; Mori, M; Nakazawa, T; Yoshii, A | 1 |
| Hamanaka, I; Harada, M; Izumi, T; Kajiyama, N; Kawakami, R; Kishimoto, I; Kuwahara, K; Miyamoto, Y; Nakagawa, O; Nakao, K; Ogawa, E; Ogawa, Y; Saito, Y; Takahashi, N; Tamura, N | 1 |
| Kaneda, K; Kawada, N; Kuroki, T; Seki, S | 1 |
| Melton, AC; Tran, BN; Yee, HF | 1 |
| Chitaley, K; Lewis, RW; Mills, TM; Webb, RC; Wingard, CJ | 1 |
| Kernochan, LE; Melton, AC; Tam, SP; Tangkijvanich, P; Tran, BN; Yee, HF | 1 |
| Rapoport, RM; Sherman, JD; Yoon, S; Zuccarello, M | 1 |
| Akimoto, K; Asakawa, H; Horio, T; Matsuoka, H; Minamino, N; Mori, Y; Nishikimi, T; Tadokoro, K; Wang, X; Yoshihara, F | 1 |
| Herzog, M; Scherer, EQ; Wangemann, P | 1 |
| Asahara, T; Fudaba, Y; Ito, H; Mizunuma, K; Ohdan, H; Tashiro, H | 2 |
| Eto, M; Khalequzzaman, M; Kitazawa, T; Woodsome, TP | 1 |
| Hartshorne, DJ; Isaka, N; Ito, M; Kureishi, Y; Moriki, N; Nakano, T; Okamoto, R; Onishi, K; Seko, T | 1 |
| Fujita, M; Fukai, M; Furukawa, H; Jin, MB; Nakayama, M; Sakurai, T; Shimamura, T; Suzuki, T; Takeda, K; Taniguchi, M; Todo, S | 1 |
| Jin, L; Linder, AE; Mills, TM; Webb, RC | 1 |
| Andersson, KE | 1 |
| Molenaar, P; Russell, FD | 1 |
| Arikan, O; Ark, M; Büyükafşar, K; Kubat, H; Ozveren, E | 1 |
| Kashihara, T; Nakayama, K; Nonogaki, A; Obara, K; Okamoto, Y | 1 |
| Chu, L; Endoh, M; Norota, I | 1 |
| Bechrakis, NE; Choritz, L; Jaroszewski, J; Rosenthal, R; Schlott, S; Thieme, H; Wiederholt, M | 1 |
| Chiba, Y; Misawa, M; Sakai, H | 2 |
| Chiba, Y; Misawa, M; Sakai, H; Yu, Y | 1 |
| Shimoda, LA; Sylvester, JT; Weigand, L | 1 |
| Masuda, Y | 1 |
| Akça, T; Aydin, S; Büyükafşar, K; Nalan Tiftik, R; Sahan-Firat, S | 1 |
| Barman, SA | 1 |
| Jin, L; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z | 1 |
| Lewis, SJ; Lewis, TH; Moore, JN; Noschka, E; Peroni, JF; Robertson, TP | 1 |
| Gebb, SA; Homma, N; Karoor, V; McMurtry, IF; Morio, Y; Nagaoka, T; Oka, M; Ota, H | 1 |
| Kim, SC; Lee, MY; Lee, SY; Myung, SC; Park, SH; Yum, SH | 1 |
| Choritz, L; Meissner, S; Pfeiffer, N; Renieri, G; Rosenthal, R; Thieme, H | 1 |
| Li, ZX; Luo, YL; Ren, DQ; Xu, J; Zhao, YX | 1 |
| Aoshima, D; Hori, M; Murata, T; Ozaki, H | 1 |
| Hunter, JC; Javadov, S; Karmazyn, M; Kilić, A; Rajapurohitam, V; Zeidan, A | 1 |
| Engelberts, D; Ivanovska, J; Jankov, RP; Kantores, C; Kavanagh, BP; McNamara, PJ; Xu, EZ | 1 |
| Enouri, S; Johnson, R; Monteith, G | 1 |
| Heaps, CL; Parker, JL; Robles, JC; Sturek, M | 1 |
| Hori, M; Iizuka, M; Murata, T; Ozaki, H | 1 |
| Grisk, O; Katsari, E; Löhn, M; Plettenburg, O; Reimer, N; Rettig, R; Schlüter, T; Wollert, HG; Zimmermann, U | 1 |
| Guan, YY; Li, SY; Ma, MM; Wang, M | 1 |
| Abman, SH; Gien, J; Roe, G; Seedorf, G; Tseng, N | 1 |
| Clemens, MG; Kwok, W | 1 |
| Hyun, HW; Kang, TC; Kim, JE; Ko, AR; Min, SJ | 1 |
| Alp Yildirim, Fİ; Ark, M; Aypar, E; Kaleli Durman, D; Özdemir, O; Uydeş Doğan, BS | 1 |
| Chen, C; Dong, DL; Gao, JL; Jin, J; Li, SL; Liu, MY; Shen, X; Wei, YY; Xuan, XC; Zhang, XY; Zhang, XZ; Zhen, CL | 1 |
| Berg, JO; Dreier, R; Hedin, U; Krawczyk, KK; Perisic, L; Rippe, C; Skovsted, GF; Swärd, K | 1 |
| Hu, K; Liu, P; Tang, S; Zhang, HM; Zhou, XF | 1 |
| Babaahmadi-Rezaei, H; Little, PJ; Niayesh-Mehr, R; Seif, F; Zamanpour, M | 1 |
2 review(s) available for y 27632 and endothelin-1
| Article | Year |
|---|---|
Inhibition of the tonic contraction in the treatment of erectile dysfunction.
Topics: Adrenergic Agonists; Adult; Aged; Aging; Amides; Angiotensin II; Calcium Signaling; Cyclic AMP; Endothelin-1; Erectile Dysfunction; Forecasting; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Penis; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasoactive Intestinal Peptide | 2003 |
Erectile physiological and pathophysiological pathways involved in erectile dysfunction.
Topics: Amides; Animals; Diabetes Mellitus; Endothelin-1; Erectile Dysfunction; Humans; Hypothalamus; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Nitric Oxide; Norepinephrine; Penile Erection; Phosphorylation; Pyridines; Receptors, Endothelin; rho GTP-Binding Proteins | 2003 |
48 other study(ies) available for y 27632 and endothelin-1
| Article | Year |
|---|---|
Relaxation of contracted rabbit tracheal and human bronchial smooth muscle by Y-27632 through inhibition of Ca2+ sensitization.
Topics: 1-Methyl-3-isobutylxanthine; Amides; Animals; Bronchi; Calcium; Carbachol; Cholinergic Agents; Detergents; Dose-Response Relationship, Drug; Endothelin-1; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Marine Toxins; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Octoxynol; Oxazoles; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Signal Transduction; Trachea; Type C Phospholipases | 1999 |
The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes--possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy.
Topics: Amides; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; GTP Phosphohydrolases; Heart; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Myocardium; Natriuretic Peptide, Brain; Protein Serine-Threonine Kinases; Pyridines; Rats; Recombinant Proteins; rho-Associated Kinases; Time Factors; Transfection | 1999 |
ROCK inhibitor Y-27632 attenuates stellate cell contraction and portal pressure increase induced by endothelin-1.
Topics: Actins; Amides; Animals; Antihypertensive Agents; Cell Movement; Cell Size; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Hypertension, Portal; Intracellular Signaling Peptides and Proteins; Liver; Male; Myosin Light Chains; Phosphorylation; Portal Vein; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases | 1999 |
RhoA/rho-associated kinase mediates fibroblast contractile force generation.
Topics: ADP Ribose Transferases; Amides; Animals; Botulinum Toxins; Cells, Cultured; Chick Embryo; Culture Media; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Fibroblasts; Intracellular Signaling Peptides and Proteins; Myosin Light Chains; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Time Factors | 2001 |
Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation.
Topics: Amides; Animals; Blotting, Western; Electric Stimulation; Endothelin-1; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Male; Methoxamine; Penile Erection; Penis; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasoconstriction; Vasoconstrictor Agents | 2001 |
Endothelin-1 stimulates human colonic myofibroblast contraction and migration.
Topics: Amides; Cell Division; Cell Movement; Cells, Cultured; Colon; Cytosol; Dose-Response Relationship, Drug; Endothelin-1; Humans; Interleukins; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Myosins; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Tumor Necrosis Factor-alpha | 2002 |
Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of Rho kinase constrictor pathway.
Topics: Amides; Animals; Basilar Artery; Endothelin-1; Glycopeptides; Intracellular Signaling Peptides and Proteins; Male; Muscle Relaxants, Central; Protease Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Subarachnoid Hemorrhage; Vasoconstriction; Vasospasm, Intracranial | 2002 |
Cerivastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, inhibits cardiac myocyte hypertrophy induced by endothelin.
Topics: ADP Ribose Transferases; Amides; Animals; Atrial Natriuretic Factor; Botulinum Toxins; Cell Size; Cells, Cultured; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Mevalonic Acid; Myocytes, Cardiac; Phenylalanine; Polyisoprenyl Phosphates; Pravastatin; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger | 2002 |
Endothelin-1-induced vasospasms of spiral modiolar artery are mediated by rho-kinase-induced Ca(2+) sensitization of contractile apparatus and reversed by calcitonin gene-related Peptide.
Topics: Amides; Animals; Antihypertensive Agents; Arteries; Calcitonin Gene-Related Peptide; Calcium; Dansyl Compounds; Ear, Inner; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Gerbillinae; Intracellular Signaling Peptides and Proteins; Myosin-Light-Chain Phosphatase; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Pyridines; Receptor, Endothelin A; Regional Blood Flow; rho-Associated Kinases; Signal Transduction; Vascular Patency; Vasoconstriction; Vasospasm, Intracranial | 2002 |
ROCK inhibitor Y-27632 prevents primary graft non-function caused by warm ischemia/reperfusion in rat liver transplantation.
Topics: Amides; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Endothelin-1; Graft Survival; Hemoglobins; Ischemia; Liver Transplantation; Male; Oxyhemoglobins; Postoperative Complications; Pyridines; Rats; Rats, Wistar; Reperfusion; Time Factors; Transplantation, Isogeneic | 2002 |
Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle.
Topics: Amides; Animals; Calcium; Electrophysiology; Endothelin-1; Enzyme Inhibitors; Indoles; Isoenzymes; Male; Maleimides; Muscle Proteins; Muscle, Smooth; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Permeability; Phenylephrine; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Portal Vein; Pyridines; Rabbits; Type C Phospholipases; Vas Deferens; Vasoconstriction | 2003 |
Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Cells, Cultured; Cyclic GMP; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Hypertension; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; NG-Nitroarginine Methyl Ester; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Threonine | 2003 |
A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats.
Topics: Alanine Transaminase; Amides; Animals; Blood Pressure; Endothelin-1; Enzyme Inhibitors; Heart Rate; Hyaluronic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Liver; Liver Circulation; Male; Malondialdehyde; Peroxidase; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; rho-Associated Kinases; Survival Rate | 2003 |
Prevention of ischemia-reperfusion-induced hepatic microcirculatory disruption by inhibiting stellate cell contraction using rock inhibitor.
Topics: Amides; Animals; Cells, Cultured; Endothelin-1; Endothelium; Enzyme Inhibitors; Enzymes; Intracellular Signaling Peptides and Proteins; Ischemia; Liver; Liver Circulation; Liver Failure; Liver Transplantation; Male; Microcirculation; Mitochondria, Liver; Oxygen Consumption; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; Reperfusion Injury; rho-Associated Kinases | 2003 |
Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart.
Topics: Alkaloids; Amides; Androstadienes; Benzophenanthridines; Endothelin-1; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Myocardial Contraction; Myocardium; Myosin-Light-Chain Kinase; Phenanthridines; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Urotensins; Wortmannin | 2004 |
Upregulation of Rho-kinase (ROCK-2) expression and enhanced contraction to endothelin-1 in the mesenteric artery from lipopolysaccharide-treated rats.
Topics: Acetylcholine; Amides; Angiotensin II; Animals; Blotting, Western; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Female; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Mesenteric Arteries; Nitrates; Nitrites; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; Sodium Chloride; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2004 |
Differential interplay between protein kinase C and Rho-kinase in the endothelin-1-induced and pressure-induced contractions of rat posterior cerebral artery.
Topics: Amides; Animals; Benzophenanthridines; Blood Pressure; Calcium Signaling; Cytosol; Endothelin-1; In Vitro Techniques; Mechanotransduction, Cellular; Posterior Cerebral Artery; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Rats; rho-Associated Kinases; Vasoconstriction | 2004 |
Differential inhibition by the Rho kinase inhibitor Y-27632 of the increases in contractility and Ca2+ transients induced by endothelin-1 in rabbit ventricular myocytes.
Topics: Adrenergic beta-Agonists; Amides; Animals; Calcium; Cell Size; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Fluorescent Dyes; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Isoproterenol; Male; Myocardial Contraction; Myocytes, Cardiac; Papillary Muscles; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases | 2005 |
Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork.
Topics: Amides; Animals; Azepines; Carbachol; Cattle; Cells, Cultured; Cholinergic Agonists; Endothelin-1; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Naphthalenes; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Serine; Tissue Culture Techniques; Trabecular Meshwork | 2005 |
Endothelin-1-induced translocation of RhoA is mediated by endothelin ET(A) receptors in rat bronchial smooth muscle.
Topics: Amides; Animals; Atropine; Blotting, Western; Bronchi; Cell Membrane; Cytosol; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Oligopeptides; Peptides, Cyclic; Piperidines; Protein Transport; Pyridines; Rats; Rats, Wistar; Receptor, Endothelin A; rhoA GTP-Binding Protein; Time Factors | 2005 |
Effects of repeated antigen exposure on endothelin-1-induced bronchial smooth muscle contraction and activation of RhoA in sensitized rats.
Topics: Amides; Animals; Antigens; Bronchi; Bronchial Hyperreactivity; Calcium; Dose-Response Relationship, Drug; Endothelin-1; Male; Muscle Contraction; Muscle, Smooth; Pyridines; Rats; Rats, Wistar; rhoA GTP-Binding Protein; Time Factors | 2005 |
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction | 2006 |
Intrahepatic flow disturbance: possibility of a hidden cause of drug toxicity.
Topics: Amides; Anesthetics; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Endothelin-1; Enzyme Inhibitors; Ethanolamines; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Liver; Liver Circulation; Portal Vein; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; Staining and Labeling; Vasoconstriction; Vasoconstrictor Agents | 2006 |
Contribution of Rho-kinase in human gallbladder contractions.
Topics: Aged; Amides; Blotting, Western; Carbachol; Cholecystokinin; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Female; Gallbladder; Histamine; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Muscle Contraction; Neurokinin A; Peptide Fragments; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Serotonin | 2006 |
Role of Rho kinase in endothelin-1-induced phosphorylation of CPI-17 in rat bronchial smooth muscle.
Topics: Amides; Animals; Bronchi; Endothelin-1; Enzyme Inhibitors; Male; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Myosin Light Chains; Phosphoproteins; Phosphorylation; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases | 2007 |
Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C.
Topics: Amides; Animals; Blotting, Western; Carbazoles; Endothelin-1; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle, Smooth, Vascular; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Species Specificity; Vasoconstriction | 2007 |
Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Atropine; Blotting, Western; Calcium Signaling; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Enzyme Inhibitors; Guanine Nucleotide Dissociation Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rho-Specific Guanine Nucleotide Dissociation Inhibitors; rhoA GTP-Binding Protein; Urethra; Urinary Bladder | 2007 |
Effects of Rho-kinase and Src protein tyrosine kinase inhibition on agonist-induced vasoconstriction of arteries and veins of the equine laminar dermis.
Topics: Amides; Animals; Arteries; Calcium; Dose-Response Relationship, Drug; Endothelin-1; Foot; Intracellular Signaling Peptides and Proteins; Phenylephrine; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; Pyrimidines; rho-Associated Kinases; Serotonin; Signal Transduction; src-Family Kinases; Vasoconstriction; Vasoconstrictor Agents; Veins | 2007 |
Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation.
Topics: Amides; Animals; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Enzyme Activation; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; Peptides, Cyclic; Perfusion; Potassium Chloride; Pulmonary Artery; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Serotonin; Signal Transduction; Vasoconstriction | 2007 |
Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladder.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Adrenergic alpha-Agonists; Amides; Animals; Antihypertensive Agents; Calcium Channel Agonists; Clitoris; Dose-Response Relationship, Drug; Endothelin-1; Female; Isometric Contraction; Models, Animal; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Oligopeptides; Peptides, Cyclic; Phenylephrine; Piperidines; Potassium; Pyridines; Rabbits; Urinary Bladder, Overactive; Vasodilator Agents | 2008 |
Effects of endothelin-1 on calcium-independent contraction of bovine trabecular meshwork.
Topics: Amides; Animals; Blotting, Western; Calcium; Cattle; Cell Culture Techniques; Egtazic Acid; Endothelin-1; Enzyme Inhibitors; Isometric Contraction; Muscle Contraction; Muscle, Smooth; Pyridines; Receptor, Endothelin A; Receptor, Endothelin B; rho-Associated Kinases; rhoA GTP-Binding Protein; Trabecular Meshwork | 2008 |
[Rho-kinase signaling pathway participates in endothelin-1-induced human airway smooth muscle cell migration and cytoskeletal reorganization].
Topics: Amides; Bronchi; Cell Movement; Cells, Cultured; Cytoskeleton; Endothelin-1; Enzyme Inhibitors; Humans; Microscopy, Confocal; Muscle, Smooth; Pyridines; rho-Associated Kinases; Signal Transduction | 2008 |
Time-dependent phenotypic and contractile changes of pulmonary artery in chronic hypoxia-induced pulmonary hypertension.
Topics: Actins; Amides; Animals; Cell Proliferation; Endothelin-1; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Nicardipine; Phenotype; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Thiazines; Time Factors | 2009 |
Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway.
Topics: Actins; Amides; Animals; Animals, Newborn; Cardiomegaly; Cofilin 2; Cyclic GMP; Endothelin-1; Isoenzymes; Models, Biological; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Protein Transport; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Time Factors; Transcription Factors | 2009 |
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aging; Amides; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Injections, Subcutaneous; Muscle, Smooth, Vascular; Myocardium; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Rats; Receptor, Endothelin A; rho-Associated Kinases; RNA Interference; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2010 |
Characteristics of myogenic reactivity in isolated rat mesenteric veins.
Topics: Amides; Animals; Benzophenanthridines; Calcium; Calcium Channels, L-Type; Compliance; Endothelin-1; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Veins; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide Synthase Type III; Nitroarginine; Norepinephrine; Pressure; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2011 |
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Collateral Circulation; Coronary Vessels; Endothelin-1; Enzyme Inhibitors; Female; Muscle Contraction; Naphthalenes; Phorbol 12,13-Dibutyrate; Physical Conditioning, Animal; Protein Kinase C; Pyridines; rho-Associated Kinases; Swine; Vasodilator Agents | 2011 |
Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways.
Topics: Actins; Amides; Animals; Blotting, Western; Calcium; Calcium Signaling; Cell Shape; Cells, Cultured; Endothelin-1; Hepatic Stellate Cells; Indoles; Liver; Liver Cirrhosis, Experimental; Male; Maleimides; Muscle Proteins; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Phosphatase 1; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; Time Factors | 2011 |
The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries.
Topics: Amides; Animals; Blood Glucose; Blood Pressure; Endothelin-1; Enzyme Inhibitors; Humans; Protein Isoforms; Pyridines; Rats; Rats, Zucker; Renal Artery; rho-Associated Kinases; RNA, Messenger; Species Specificity; Vascular Resistance; Vasoconstrictor Agents | 2012 |
Simvastatin attenuated cerebrovascular cell proliferation in the development of hypertension through Rho/Rho-kinase pathway.
Topics: Amides; Animals; Basilar Artery; Blood Pressure; Cell Proliferation; Cerebrovascular Circulation; Disease Models, Animal; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocytes, Smooth Muscle; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin | 2012 |
Endothelin-1 impairs angiogenesis in vitro through Rho-kinase activation after chronic intrauterine pulmonary hypertension in fetal sheep.
Topics: Amides; Analysis of Variance; Animals; Blotting, Western; DNA Primers; Ductus Arteriosus; Endothelial Cells; Endothelin-1; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Fetus; Humans; In Vitro Techniques; Infant, Newborn; Ligation; Lung; Neovascularization, Physiologic; Persistent Fetal Circulation Syndrome; Pyridines; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; RNA Interference; Sheep | 2013 |
Rho-kinase activation contributes to Lps-induced impairment of endothelial nitric oxide synthase activation by endothelin-1 in cultured hepatic sinusoidal endothelial cells.
Topics: Actins; Amides; Animals; Caveolin 1; Cells, Cultured; Cofilin 1; Endothelial Cells; Endothelin-1; Enzyme Activation; Inflammation; Lipopolysaccharides; Liver; Male; Microcirculation; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Sepsis; Serine | 2014 |
Endothelin-1 induces LIMK2-mediated programmed necrotic neuronal death independent of NOS activity.
Topics: Amides; Animals; Apoptosis; Blood-Brain Barrier; Caveolin 1; Endothelin-1; Hippocampus; Lim Kinases; Male; Mitochondrial Dynamics; Models, Biological; Necrosis; Neurons; Nitric Oxide Synthase Type I; Oligopeptides; Peptides; Piperidines; Pyridines; Rats, Sprague-Dawley; Receptors, Endothelin; rho-Associated Kinases; RNA, Messenger; Status Epilepticus | 2015 |
Atorvastatin acutely reduces the reactivity to spasmogens in rat aorta: implication of the inhibition of geranylgeranylation and MYPT-1 phosphorylation.
Topics: Amides; Animals; Aorta, Thoracic; Atorvastatin; Endothelin-1; Endothelium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Norepinephrine; Phosphorylation; Polyisoprenyl Phosphates; Potassium Chloride; Prenylation; Protein Phosphatase 1; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Sesquiterpenes | 2016 |
Mitochondrial Fission Inhibitors Suppress Endothelin-1-Induced Artery Constriction.
Topics: Amides; Animals; Aorta, Thoracic; Dynamins; Endothelin-1; Hydrazones; Male; Mesenteric Arteries; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Dynamics; Myocytes, Smooth Muscle; Pyridines; Quinazolinones; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vasoconstriction | 2017 |
Expression of endothelin type B receptors (EDNRB) on smooth muscle cells is controlled by MKL2, ternary complex factors, and actin dynamics.
Topics: Actin Cytoskeleton; Actin Depolymerizing Factors; Amides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Carotid Artery Injuries; Endothelin-1; Gene Expression Regulation, Developmental; Humans; Myocytes, Smooth Muscle; Nuclear Proteins; Proto-Oncogene Protein c-fli-1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Pyridines; Rats; Receptor, Endothelin B; rho-Associated Kinases; Ternary Complex Factors; Thiazolidines; Trans-Activators; Transcription Factors | 2018 |
Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia.
Topics: Amides; Animals; Apoptosis; Blood Pressure; Carotid Body; Disease Models, Animal; Endothelin-1; Enzyme Inhibitors; Hypertension; Hypoxia; Male; NADPH Oxidases; Neuronal Plasticity; Onium Compounds; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; rho-Associated Kinases; Signal Transduction | 2019 |
Endothelin-1 increases CHSY-1 expression in aortic endothelial cells via transactivation of transforming growth factor β type I receptor induced by type B receptor endothelin-1.
Topics: Amides; Animals; Aorta; Blotting, Western; Cattle; Cells, Cultured; Cytochalasin D; Endothelial Cells; Endothelin-1; N-Acetylgalactosaminyltransferases; Oligopeptides; Phosphorylation; Piperidines; Pyridines; Receptor, Endothelin B; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; rho-Associated Kinases; Time Factors; Transcriptional Activation; Transforming Growth Factor beta | 2019 |