y 27632 has been researched along with chir 99021 in 16 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (chir 99021) | Trials (chir 99021) | Recent Studies (post-2010) (chir 99021) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 272 | 1 | 258 |
| Protein | Taxonomy | y 27632 (IC50) | chir 99021 (IC50) |
|---|---|---|---|
| G2/mitotic-specific cyclin-B2 | Homo sapiens (human) | 8.8 | |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | 8.8 | |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | 8.8 | |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | 0.0089 | |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | 0.0133 | |
| G2/mitotic-specific cyclin-B3 | Homo sapiens (human) | 8.8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 11 (68.75) | 24.3611 |
| 2020's | 4 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
| Cao, N; Cui, C; Liao, J; Liu, L; Liu, Z; Wang, J; Xiao, L; Xu, P; Yang, HT; Yu, L; Zhu, W | 1 |
| Hashimoto, Y; Nakada, A; Nakamura, T; Shigeno, K; Shimada, H | 1 |
| Gao, H; Jiang, L; Jin, H; Li, L; Liu, T; Peng, X; Qian, Q; Sun, Y; Wang, Y; Wu, M; Yang, B | 1 |
| Baharvand, H; Eftekhari-Yazdi, P; Gourabi, H; Hassani, SN; Masoudi, NS; Nokhbatolfoghahai, M; Pakzad, M; Rezazadeh Valojerdi, M; Taei, A | 1 |
| Fang, Y; Hu, WT; Qiu, ZD; Yan, QY; Zhang, SM | 1 |
| Sheikh, F; Zanella, F | 1 |
| Di Pasquale, E; Nakahama, H | 1 |
| Lai, KW; Lau, VY; Lee, YK; Ran, X; Siu, DC; Tse, HF | 1 |
| Camargo, FD; Hagiwara, K; Katsuda, T; Kawamata, M; Ochiya, T; Takahashi, RU; Yamamoto, Y | 1 |
| Choi, SY; Hahn, S; Jee, J; Jeong, S; Jeong, SY; Kim, HK; Kim, HS; Kim, MS; Park, JS; Shin, H; Yoo, J | 1 |
| Abe, M; Inoue, A; Katsuda, T; Kawamata, M; Ochiya, T; Yamaguchi, T | 1 |
| Anand, M; Bontovics, B; Chrenek, P; Fábián, R; Gócza, E; Lázár, B; Makarevich, AV; Maraghechi, P; Németh, K; Vašíček, J | 1 |
| Cao, H; Chen, Z; Chi, S; Guo, S; Hu, Q; Sun, T; Tao, H; Yang, J; Zhang, L; Zhu, H | 1 |
| Ding, M; Fu, GB; Gao, Y; Huang, WJ; Wang, HY; Wu, HP; Xu, LY; Yan, HX; Zeng, M; Zhang, HD; Zhou, X | 1 |
16 other study(ies) available for y 27632 and chir 99021
| Article | Year |
|---|---|
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes.
Topics: Action Potentials; Amides; Animals; Benzamides; Calcium; Cell Differentiation; Culture Media, Serum-Free; Diphenylamine; Embryonic Stem Cells; Glycogen Synthase Kinase 3; MAP Kinase Kinase Kinases; Myocytes, Cardiac; Phenotype; Pyridines; Pyrimidines; Rats; rho-Associated Kinases | 2011 |
Accelerated generation of human induced pluripotent stem cells with retroviral transduction and chemical inhibitors under physiological hypoxia.
Topics: Amides; Animals; Benzamides; Butyrates; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Cell Line; Diphenylamine; DNA Methylation; Enzyme Inhibitors; Gene Silencing; Genes, myc; Humans; Induced Pluripotent Stem Cells; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; Mice, SCID; Octamer Transcription Factor-3; Pyrazoles; Pyridines; Pyrimidines; Retroviridae; SOXB1 Transcription Factors; Thiocarbamates; Thiosemicarbazones; Transduction, Genetic; Transgenes | 2012 |
Conversion of rat embryonic stem cells into neural precursors in chemical-defined medium.
Topics: Amides; Animals; Bone Morphogenetic Protein 4; Cells, Cultured; Culture Media; Embryonic Stem Cells; Glycogen Synthase Kinase 3; Neural Stem Cells; Neurogenesis; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Rats | 2013 |
Enhanced generation of human embryonic stem cells from single blastomeres of fair and poor-quality cleavage embryos via inhibition of glycogen synthase kinase β and Rho-associated kinase signaling.
Topics: Amides; Benzazepines; Blastomeres; Cell Differentiation; Cell Line; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; Embryonic Stem Cells; Fibroblast Growth Factor 2; Glycogen Synthase Kinases; Humans; Indoles; Karyotyping; Pyridines; Pyrimidines; rho-Associated Kinases; Signal Transduction | 2013 |
Transient folate deprivation in combination with small-molecule compounds facilitates the generation of somatic cell-derived pluripotent stem cells in mice.
Topics: Amides; Animals; Butyric Acid; Cell Differentiation; Cell Line; Cell Proliferation; Extraembryonic Membranes; Folic Acid; Induced Pluripotent Stem Cells; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; Octamer Transcription Factor-3; Proto-Oncogene Proteins c-myc; Pyrazoles; Pyridines; Pyrimidines; SOXB1 Transcription Factors; Thiocarbamates; Thiosemicarbazones | 2014 |
Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization of Cardiac Cells.
Topics: Actinin; Amides; Biomarkers; Calcium; Cardiomyopathy, Dilated; Cell Culture Techniques; Cell Differentiation; Cellular Reprogramming; Collagen; Drug Combinations; Enzyme Inhibitors; Gene Expression; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Humans; Induced Pluripotent Stem Cells; Insulin; Intercellular Signaling Peptides and Proteins; Laminin; Models, Biological; Molecular Imaging; Myocytes, Cardiac; Primary Cell Culture; Proteoglycans; Pyridines; Pyrimidines; Transcription Factors | 2016 |
Generation of Cardiomyocytes from Pluripotent Stem Cells.
Topics: Amides; Cell Culture Techniques; Cell Differentiation; Cellular Reprogramming; Collagen; Drug Combinations; Embryoid Bodies; Enzyme Inhibitors; Humans; Intercellular Signaling Peptides and Proteins; Laminin; Myocytes, Cardiac; Pluripotent Stem Cells; Primary Cell Culture; Proteoglycans; Pyridines; Pyrimidines; Wnt Signaling Pathway | 2016 |
Generation and Characterization of Patient-Specific iPSC Model for Cardiovascular Disease.
Topics: Amides; Animals; beta Catenin; Biomarkers; Cell Culture Techniques; Cell Differentiation; Cellular Reprogramming; Collagen; Drug Combinations; Embryo, Mammalian; Embryoid Bodies; Enzyme Inhibitors; Feeder Cells; Fibroblasts; Gene Expression; Genetic Vectors; Humans; Induced Pluripotent Stem Cells; Intercellular Signaling Peptides and Proteins; Laminin; Mice; Myocytes, Cardiac; Primary Cell Culture; Proteoglycans; Pyridines; Pyrimidines; Retroviridae; Teratoma; Wnt Signaling Pathway | 2016 |
Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity.
Topics: Amides; Animals; Cell Differentiation; Cell Lineage; Cell Proliferation; Cells, Cultured; Cellular Reprogramming; Chimera; Diploidy; Epithelial Cells; Hepatocytes; Liver; Liver Regeneration; Mice; Pyrazoles; Pyridines; Pyrimidines; Rats; Regeneration; Reproducibility of Results; Small Molecule Libraries; Stem Cells; Thiosemicarbazones; Time Factors | 2017 |
Leucine-rich repeat-containing G-protein coupled receptor 5 enriched organoids under chemically-defined growth conditions.
Topics: Adult Stem Cells; Amides; Animals; Cell Self Renewal; Culture Media, Serum-Free; Flavonoids; Gene Expression; Humans; Intestinal Mucosa; Mice; Mice, Transgenic; Organoids; Pyrazoles; Pyridines; Pyrimidines; Receptors, G-Protein-Coupled; RNA, Messenger; Thiosemicarbazones; Valproic Acid | 2019 |
Long-term maintenance of functional primary human hepatocytes using small molecules.
Topics: Amides; Cell Proliferation; Cells, Cultured; Cytochrome P-450 Enzyme System; Glycogen; Hepatocytes; Humans; Phenobarbital; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Rifampin; Urea | 2020 |
The effect of dual inhibition of Ras-MEK-ERK and GSK3β pathways on development of
Topics: Amides; Animals; Benzamides; Diphenylamine; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; Enzyme Inhibitors; Female; Germ Layers; Glycogen Synthase Kinase 3 beta; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Pyrazoles; Pyridines; Pyrimidines; Rabbits; ras Proteins; Thiosemicarbazones | 2020 |
Small molecular compounds efficiently convert human fibroblasts directly into neurons.
Topics: Amides; Anthracenes; Cell Differentiation; Cells, Cultured; Cellular Reprogramming; Cellular Reprogramming Techniques; Colforsin; Culture Media, Conditioned; Fibroblasts; Foreskin; Humans; Indoles; Male; Maleimides; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Pyrazoles; Pyridines; Pyrimidines; Transcription Factors | 2020 |
The combined induction of liver progenitor cells and the suppression of stellate cells by small molecules reverts chronic hepatic dysfunction.
Topics: Amides; Animals; Carbon Tetrachloride; CD24 Antigen; Cells, Cultured; Gene Expression; Hepatic Stellate Cells; Hepatocytes; Humans; Liver; Liver Cirrhosis; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Pyridines; Pyrimidines; Small Molecule Libraries; Stem Cells | 2021 |