y 27632 has been researched along with carbachol in 40 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (carbachol) | Trials (carbachol) | Recent Studies (post-2010) (carbachol) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 13,918 | 81 | 968 |
| Protein | Taxonomy | y 27632 (IC50) | carbachol (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.7849 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 2.0626 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 3.4134 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 2.9961 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 2.535 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 2.9961 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 2.6638 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 4.849 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 4.99 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.50) | 18.2507 |
| 2000's | 26 (65.00) | 29.6817 |
| 2010's | 13 (32.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dobashi, K; Harada, T; Horie, T; Iizuka, K; Mori, M; Nakazawa, T; Yoshii, A | 1 |
| Hirano, K; Kanaide, H; Nishimura, J; Setoguchi, H; Takahashi, S | 1 |
| Akahane, S; Anabuki, J; Hayakawa, K; Hori, M; Karaki, H; Ozaki, H | 1 |
| Brkic-Koric, D; Pfitzer, G; Sonntag-Bensch, D | 1 |
| Azuma, M; Oka, T; Waki, M; Yoshida, Y | 1 |
| Eddinger, TJ; Meehl, JT; Ratz, PH | 1 |
| Ahn, DS; Hwang, MK; Kwon, SC; Lee, YH; Oh, JH; Taggart, MJ; You, SK | 1 |
| Büyükafşar, K; Levent, A | 2 |
| Ayman, S; Gibson, A; McFadzean, I; Wallace, P; Wayman, CP | 1 |
| Brading, AF; Hashitani, H; Suzuki, H | 1 |
| Feil, R; Feil, S; Hofmann, F; Kleppisch, T; Klugbauer, N; Koller, A; Lee, TS; Moosmang, S; Schulla, V; Wegener, JW; Welling, A | 1 |
| Fujita, A; Hata, F; Hirayama, N; Kitayama, M; Kushida, M; Takeuchi, T | 1 |
| Borgsmiller, L; Call, C; Mohr, R; Ratz, PH; Speich, JE | 1 |
| Bechrakis, NE; Choritz, L; Jaroszewski, J; Rosenthal, R; Schlott, S; Thieme, H; Wiederholt, M | 1 |
| Büyükafşar, K; Nacak, M; Sahan-Firat, S; Tiftik, RN | 1 |
| Andersson, KE; Arner, A; Ekman, M | 1 |
| Baird, AW; Feighery, R; Quinn, T | 1 |
| Akça, T; Aydin, S; Büyükafşar, K; Nalan Tiftik, R; Sahan-Firat, S | 1 |
| Janssen, LJ; Liu, C; Tazzeo, T | 1 |
| D'Aprile, A; Fernandes, L; Goldie, R; Henry, P; McGuire, M; Self, G; Sew, T | 1 |
| Azuma, YT; Hata, F; Nakajima, H; Takeuchi, T | 1 |
| Ding, H; Huang, J; Isotani, E; Kamm, KE; Mizuno, Y; Stull, JT | 1 |
| Fry, CH; Roosen, A; Sui, G; Wu, C | 1 |
| Arai, K; Kamai, T; Mizuno, T; Nakanishi, K; Yamanishi, T | 1 |
| Aikawa, K; Ishibashi, K; Kushida, N; Liu, F; Shiomi, H; Shishido, K; Takahashi, N; Yamaguchi, O; Yanagida, T | 1 |
| Frei, E; Hofmann, F; Huster, M; Schlossmann, J; Smital, P; Wegener, JW | 1 |
| Bayguinov, O; Dwyer, L; Kim, H; Koh, SD; Marklew, A; Sanders, KM | 1 |
| Antunes, E; Carvalho, FD; Claudino, MA; De Nucci, G; Franco-Penteado, CF; Grant, AD; Leiria, LO; Mónica, FZ; Schenka, A | 1 |
| Hori, M; Kishi, H; Kobayashi, S; Mori, D; Murata, T; Ohama, T; Ozaki, H | 1 |
| Kajioka, S; Matsuda, M; Naito, S; Onimaru, M; Seki, N; Shahab, N; Takahashi-Yanaga, F | 1 |
| Kajioka, S; Naito, S; Seki, N; Shahab, N | 1 |
| Balkanci, ZD; Bayrak, S; Erdem, A; Karabulut, I; Karaismailoğlu, S; Pehlivanoğlu, B | 1 |
| Bao, HF; Eaton, AF; Eaton, DC; Helms, MN; Jain, L; Ramosevac, S; Self, J; Takemura, Y | 1 |
| Alexandre, EC; Alves Junior, MJ; Antunes, E; Báu, FR; Calmasini, FB; Leiria, LO; Mónica, FZ; Silva, FH | 1 |
| Al-Qudah, M; Anderson, CD; Grider, JR; Kendig, DM; Mahavadi, S; Murthy, KS | 1 |
| Buyukafsar, K; Cevik, OS; Koyuncu, DD; Sahin, L | 1 |
| Bozkurt, TE; Denizalti, M; Durlu-Kandilci, NT; Sahin-Erdemli, I; Simsek, G | 1 |
| Eto, M; Itsumi, M; Kajioka, S; Kareman, E; Lee, K; Maki, T; Shiota, M | 1 |
| Chambers, JP; Hulls, CM; King, QM; Lentle, RG; Reynolds, GW | 1 |
40 other study(ies) available for y 27632 and carbachol
| Article | Year |
|---|---|
Relaxation of contracted rabbit tracheal and human bronchial smooth muscle by Y-27632 through inhibition of Ca2+ sensitization.
Topics: 1-Methyl-3-isobutylxanthine; Amides; Animals; Bronchi; Calcium; Carbachol; Cholinergic Agents; Detergents; Dose-Response Relationship, Drug; Endothelin-1; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Marine Toxins; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Octoxynol; Oxazoles; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Signal Transduction; Trachea; Type C Phospholipases | 1999 |
Leukotriene C(4) enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway.
Topics: Amides; Animals; Calcium; Carbachol; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Leukotriene C4; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Swine; Trachea; Type C Phospholipases | 2001 |
Muscarinic stimulation does not induce rhoA/ROCK-mediated Ca2+ sensitization of the contractile element in chicken gizzard smooth muscle.
Topics: Amides; Animals; Calcium; Carbachol; Chickens; Enzyme Inhibitors; Female; Gene Expression; Gizzard, Avian; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Verapamil | 2000 |
Thiophosphorylation-induced Ca(2+) sensitization of guinea-pig ileum contractility is not mediated by Rho-associated kinase.
Topics: Actin Cytoskeleton; Adenosine Triphosphate; Amides; Animals; Calcium; Carbachol; Drug Synergism; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Staurosporine; Sulfhydryl Compounds; Sulfur | 2001 |
Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase.
Topics: Administration, Topical; Amides; Animals; Antihypertensive Agents; Carbachol; Ciliary Body; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Intraocular Pressure; Male; Muscle Contraction; Muscle, Smooth; Ophthalmic Solutions; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Tonometry, Ocular | 2001 |
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Stomach; Urinary Bladder | 2002 |
Inhibition of rho-associated kinase reduces MLC20 phosphorylation and contractility of intact myometrium and attenuates agonist-induced Ca2+ sensitization of force of permeabilized rat myometrium.
Topics: Amides; Animals; Calcium; Carbachol; Cholinergic Agents; Enzyme Inhibitors; Female; Intracellular Signaling Peptides and Proteins; Myometrium; Myosin Light Chains; Naphthalenes; Permeability; Phosphorylation; Pregnancy; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Uterine Contraction | 2003 |
Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Carbachol; Electric Stimulation; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2003 |
Receptor-independent activation of Rho-kinase-mediated calcium sensitisation in smooth muscle.
Topics: Amides; Anal Canal; Animals; Blotting, Western; Calcium; Carbachol; Cell Membrane; Cytosol; Dose-Response Relationship, Drug; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; Receptors, Muscarinic; rho-Associated Kinases; Thapsigargin | 2003 |
Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder.
Topics: Action Potentials; Amides; Animals; Apamin; Boron Compounds; Calcium; Calcium Signaling; Carbachol; Charybdotoxin; Colforsin; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Female; Fura-2; Guinea Pigs; Isotonic Contraction; Male; Mechanotransduction, Cellular; Microelectrodes; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyridines; Transducers; Urinary Bladder | 2004 |
An essential role of Cav1.2 L-type calcium channel for urinary bladder function.
Topics: Amides; Animals; Calcium; Calcium Channels, L-Type; Carbachol; Enzyme Inhibitors; Estrenes; Intracellular Signaling Peptides and Proteins; Ion Channel Gating; Ion Transport; Isradipine; Mice; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Protein Serine-Threonine Kinases; Pyridines; Pyrrolidinones; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; Thapsigargin; Urinary Bladder; Urination Disorders | 2004 |
Mechanisms involved in carbachol-induced Ca(2+) sensitization of contractile elements in rat proximal and distal colon.
Topics: ADP Ribose Transferases; Alkaloids; Amides; Animals; Bacterial Toxins; Benzophenanthridines; Botulinum Toxins; Calcium; Carbachol; Cell Membrane Permeability; Colon, Ascending; Colon, Descending; Escin; Guanosine Triphosphate; Hemolysin Proteins; Intracellular Signaling Peptides and Proteins; Japan; Male; Muscle Contraction; Myocytes, Smooth Muscle; Peptide Fragments; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; Receptors, Muscarinic; rho-Associated Kinases; Tritium; Type C Phospholipases | 2004 |
Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sheep; Tetrodotoxin; Ureter; Vasoconstrictor Agents; Vasodilator Agents | 2004 |
ROK-induced cross-link formation stiffens passive muscle: reversible strain-induced stress softening in rabbit detrusor.
Topics: Amides; Animals; Calcium; Carbachol; Elasticity; Enzyme Activation; Enzyme Inhibitors; Female; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscarinic Agonists; Muscle, Smooth; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Solutions; Stress, Mechanical; Urinary Bladder; Viscosity | 2005 |
Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork.
Topics: Amides; Animals; Azepines; Carbachol; Cattle; Cells, Cultured; Cholinergic Agonists; Endothelin-1; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Naphthalenes; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Serine; Tissue Culture Techniques; Trabecular Meshwork | 2005 |
Rho kinase expression and its central role in ovine gallbladder contractions elicited by a variety of excitatory stimuli.
Topics: Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Gallbladder; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoenzymes; Muscle Contraction; Muscle, Smooth; Neurokinin A; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Serotonin; Sheep; Signal Transduction | 2005 |
Developmental regulation of nerve and receptor mediated contractions of mammalian urinary bladder smooth muscle.
Topics: Adenosine Triphosphate; Age Factors; Amides; Animals; Animals, Newborn; Carbachol; Cholinergic Agonists; Cholinergic Fibers; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Stimulation; Female; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Nifedipine; Pyridines; Receptors, Muscarinic; Scopolamine; Tetrodotoxin; Urinary Bladder; Vasodilator Agents | 2006 |
Role of Rho-kinase in guinea-pig gallbladder smooth muscle contraction.
Topics: Amides; Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Carbachol; Cholecystokinin; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Gallbladder; Guinea Pigs; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Thapsigargin | 2006 |
Contribution of Rho-kinase in human gallbladder contractions.
Topics: Aged; Amides; Blotting, Western; Carbachol; Cholecystokinin; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Female; Gallbladder; Histamine; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Muscle Contraction; Neurokinin A; Peptide Fragments; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Serotonin | 2006 |
Isoprostane-induced airway hyperresponsiveness is dependent on internal Ca2+ handling and Rho/ROCK signaling.
Topics: Amides; Animals; Bronchial Hyperreactivity; Calcium; Carbachol; Cattle; Dinoprostone; Enzyme Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoprostanes; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; Respiratory System; rho-Associated Kinases; Signal Transduction; Trachea | 2006 |
A Rho-kinase inhibitor, Y-27632, reduces cholinergic contraction but not neurotransmitter release.
Topics: Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred CBA; Muscle Contraction; Muscle, Smooth, Vascular; Neurotransmitter Agents; Parasympathetic Nervous System; Parasympathomimetics; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Trachea | 2006 |
A minor role for Ca2+ sensitization in sustained contraction through activation of muscarinic receptor in circular muscle of rat distal colon.
Topics: Alkaloids; Amides; Animals; Benzophenanthridines; Calcium; Carbachol; Carcinogens; Cholinergic Agonists; Colon; Dose-Response Relationship, Drug; Guanosine Triphosphate; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Pyridines; Rats; Rats, Wistar; Receptors, Muscarinic | 2007 |
Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo.
Topics: Amides; Animals; Calcium; Calcium Signaling; Calmodulin; Carbachol; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Mice; Mice, Transgenic; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Naphthalenes; Phosphoproteins; Phosphorylation; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Urinary Bladder | 2008 |
Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms.
Topics: Amides; Animals; Calcium Signaling; Carbachol; Guinea Pigs; Indoles; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Phenylephrine; Protein Kinase C; Pyridines; Receptor Cross-Talk; Receptors, Adrenergic; Receptors, Muscarinic; rho-Associated Kinases; Signal Transduction; Urinary Bladder | 2009 |
Expression of RhoA mRNA and activated RhoA in urothelium and smooth muscle, and effects of a Rho-kinase inhibitor on contraction of the porcine urinary bladder.
Topics: Amides; Animals; Blotting, Western; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Female; Immunohistochemistry; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Swine; Urinary Bladder; Urothelium | 2009 |
Obstruction alters muscarinic receptor-coupled RhoA/Rho-kinase pathway in the urinary bladder of the rat.
Topics: Amides; Animals; Blotting, Western; Carbachol; Electric Stimulation; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; In Vitro Techniques; Male; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Organ Size; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; rho GTP-Binding Proteins; rho-Associated Kinases; Urinary Bladder; Urinary Bladder Neck Obstruction | 2009 |
Calcium-dependent and calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle.
Topics: Amides; Animals; Calcium Signaling; Carbachol; Cholinergic Agonists; Colon; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Jejunum; Marine Toxins; Membrane Proteins; Mice; Mice, Knockout; Muscle Relaxation; Muscle, Smooth; Mutation; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Pyridines; rho-Associated Kinases; Time Factors | 2009 |
Contribution of Rho-kinase to membrane excitability of murine colonic smooth muscle.
Topics: Amides; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Carbachol; Cell Membrane; Colon; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membrane Potentials; Mice; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Pyridines; rho-Associated Kinases | 2011 |
Functional, morphological and molecular characterization of bladder dysfunction in streptozotocin-induced diabetic mice: evidence of a role for L-type voltage-operated Ca2+ channels.
Topics: Amides; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Chloride; Carbachol; Cholinergic Agonists; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Nifedipine; Pyridines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Purinergic P2X1; rho-Associated Kinases; RNA, Messenger; Urinary Bladder Diseases | 2011 |
Synchronous phosphorylation of CPI-17 and MYPT1 is essential for inducing Ca(2+) sensitization in intestinal smooth muscle.
Topics: Amides; Animals; Calcium; Carbachol; Carbazoles; Cholinergic Agonists; Guanosine Triphosphate; Intestines; Male; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Phosphoproteins; Phosphorylation; Potassium; Protein Kinase C; Protein Phosphatase 1; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2011 |
Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle.
Topics: Amides; Animals; Calcium; Carbachol; Enzyme Inhibitors; Guinea Pigs; Indoles; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Protein Kinase C; Pyridines; rho-Associated Kinases; Signal Transduction; Urinary Bladder Neck Obstruction | 2012 |
Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle.
Topics: Amides; Calcium; Carbachol; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Maleimides; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Protein Kinase C; Pyridines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; rho-Associated Kinases; Signal Transduction; Urinary Bladder | 2012 |
The effect of hypercholesterolemia on carbachol-induced contractions of the detrusor smooth muscle in rats: increased role of L-type Ca2+ channels.
Topics: Amides; Animals; Calcium Channels, L-Type; Carbachol; Cholinergic Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Hypercholesterolemia; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium Chloride; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Urinary Bladder | 2012 |
Cholinergic regulation of epithelial sodium channels in rat alveolar type 2 epithelial cells.
Topics: Alveolar Epithelial Cells; Amides; Animals; Atropine; Carbachol; Cells, Cultured; Enzyme Activation; Epithelial Sodium Channel Agonists; Epithelial Sodium Channels; Membrane Potentials; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Oxotremorine; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; rho-Associated Kinases; rhoA GTP-Binding Protein | 2013 |
Increased Rho-kinase-mediated prostate contractions associated with impairment of β-adrenergic-cAMP-signaling pathway by chronic nitric oxide deficiency.
Topics: Adenosine Triphosphate; Amides; Animals; Carbachol; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phenylephrine; Prostate; Pyridines; Rats; rho-Associated Kinases; Signal Transduction | 2015 |
Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Benzimidazoles; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carbachol; Cholinergic Neurons; Colon; Enzyme Inhibitors; In Vitro Techniques; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Myosin-Light-Chain Kinase; Naphthalimides; Peptide Fragments; Pyridines; Rats, Sprague-Dawley; Receptor, Muscarinic M3; rho-Associated Kinases | 2014 |
Role of rho-kinase (ROCK) in tonic but not phasic contraction in the frog stomach smooth muscle.
Topics: Amides; Animals; Atropine; Carbachol; Gastric Mucosa; Muscle Contraction; Muscle, Smooth; Nifedipine; Organ Culture Techniques; Pirenzepine; Pyridines; Ranidae; rho-Associated Kinases | 2018 |
Rho Kinase and Protein Kinase C Pathways are Responsible for Enhanced Carbachol Contraction in Permeabilized Detrusor in a Rat Model of Cystitis.
Topics: Amides; Animals; Carbachol; Cholinergic Agonists; Cystitis, Interstitial; Enzyme Inhibitors; Heparin; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Protein Kinase C; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Signal Transduction; Urinary Bladder | 2018 |
Mirabegron induces relaxant effects via cAMP signaling-dependent and -independent pathways in detrusor smooth muscle.
Topics: Acetanilides; Adenylyl Cyclase Inhibitors; Aged; Amides; Animals; Carbachol; Cyclic AMP; Female; Humans; Indoles; Isoquinolines; Male; Maleimides; Muscle Relaxation; Muscle, Smooth; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction; Sulfonamides; Swine; Thiazoles; Urinary Bladder; Urological Agents | 2019 |
Pharmacological modulation of the spatiotemporal disposition of micromotions in the intact resting urinary bladder of the rabbit; their pattern is under both myogenic and autonomic control.
Topics: Adrenergic beta-Agonists; Amides; Animals; Carbachol; Carbenoxolone; Cholinergic Agonists; Isoproterenol; Muscle Contraction; Muscle Relaxants, Central; Pyridines; Rabbits; rho-Associated Kinases; Urinary Bladder | 2019 |