y 27632 has been researched along with bisindolylmaleimide i in 47 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (bisindolylmaleimide i) | Trials (bisindolylmaleimide i) | Recent Studies (post-2010) (bisindolylmaleimide i) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 1,198 | 1 | 174 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.13) | 18.2507 |
| 2000's | 31 (65.96) | 29.6817 |
| 2010's | 15 (31.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Cox, KJ; Gaj, A; Ghosh, I; Jester, BW; Shomin, CD | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Dobashi, K; Iizuka, K; Ishizuka, T; Mori, M; Nakazawa, T; Samizo, K; Tsukagoshi, H; Yoshii, A | 1 |
| Brautigan, DL; Eto, M; Kitazawa, T; Woodsome, TP | 1 |
| Hayashi, H; Honjo, H; Ito, S; Katoh, H; Kodama, I; Kume, H; Yamaki, K | 1 |
| Brautigan, DL; Eto, M; Kitazawa, T; Mukai, H; Ono, Y; Yazawa, M | 1 |
| Eddinger, TJ; Meehl, JT; Ratz, PH | 1 |
| Barros, F; de la Pena, P; Dupuy, SG; Garcia-Manso, D; Giraldez, T; Gomez-Varela, D | 1 |
| Eto, M; Khalequzzaman, M; Kitazawa, T; Woodsome, TP | 1 |
| Hartshorne, DJ; Isaka, N; Ito, M; Kureishi, Y; Moriki, N; Nakano, T; Okamoto, R; Onishi, K; Seko, T | 1 |
| Abe, K; Misawa, M | 1 |
| Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Takahashi, R | 1 |
| Bauer, N; Casanova, N; Gebb, S; McMurtry, I; Morio, Y; Nagaoka, T; Oka, M | 1 |
| Echizen, H; Oishi, K; Uchida, M; Yamaguchi, T | 1 |
| Asaumi, S; Fujimoto, M; Kawamura, H; Kobayashi, K; Maezawa, Y; Mori, S; Saito, Y; Yokote, K | 1 |
| Larsson, C; Ling, M; Lundberg, C; Trollér, U; Zeidman, R | 1 |
| Hirano, K; Kanaide, H; Maeda, Y; Nishimura, J; Sasaki, T | 1 |
| Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Seki, N; Takahashi, R | 1 |
| Eto, M; Gong, MC; Guo, Z; Pang, H; Su, W; Xie, Z | 1 |
| Brooks, JD; Cleator, JH; Earls, L; Hamm, HE; Mazzoni, MR; McLaughlin, JN; Muldowney, JA; Perdigoto, AL; Vaughan, DE | 1 |
| Bae, YM; Cho, S; Choi, WH; Kim, B; Kim, J; Lee, CH; Lee, CK; Lee, YR | 1 |
| Jarajapu, YP; Knot, HJ | 1 |
| Brozovich, FV; Cochard, A; El-Touhky, A; Given, AM | 1 |
| Shimoda, LA; Sylvester, JT; Weigand, L | 1 |
| Mustafa, S; Oriowo, M | 1 |
| Gong, MC; Guo, Z; Pang, H; Post, SR; Su, W; Xie, Z | 1 |
| Patel, CA; Rattan, S | 1 |
| Ihara, E; MacDonald, JA; Moffat, L; Ostrander, J; Walsh, MP | 1 |
| Andersson, KE; Camello, PJ; Gomez, MF; Gomez-Pinilla, PJ; Hedlund, P; Hellstrand, P; Pozo, MJ; Swärd, K | 1 |
| Charoenphandhu, N; Krishnamra, N; Nakkrasae, LI; Thongbunchoo, J; Thongon, N | 1 |
| Fry, CH; Roosen, A; Sui, G; Wu, C | 1 |
| Honjo, H; Ito, S; Kamiya, K; Kume, H; Makino, Y; Oguma, T; Shimokata, K; Shiraki, A | 1 |
| Kajioka, S; Matsuda, M; Naito, S; Onimaru, M; Seki, N; Shahab, N; Takahashi-Yanaga, F | 1 |
| Goulopoulou, S; Hannan, JL; Matsumoto, T; Webb, RC | 1 |
| Kajioka, S; Naito, S; Seki, N; Shahab, N | 1 |
| Rattan, S; Singh, J | 2 |
| Al-Ghabkari, A; MacDonald, JA; Moffat, LD; Sutherland, C; Walsh, MP | 1 |
| Hayashi, M; Kajioka, S; Masuda, N; Naito, S; Nakayama, S; Sakamoto, K; Shahab, N; Takahashi, R; Takeda, M | 1 |
| Anjum, I; Denizalti, M; Durlu-Kandilci, NT; Kandilci, HB; Sahin-Erdemli, I | 1 |
| Bozkurt, TE; Denizalti, M; Durlu-Kandilci, NT; Sahin-Erdemli, I; Simsek, G | 1 |
| Bujang, SNB; Kennedy, C; Syed, NI; Talip, STA; Tengah, A | 1 |
| Eto, M; Itsumi, M; Kajioka, S; Kareman, E; Lee, K; Maki, T; Shiota, M | 1 |
| Hata, T; Himi, T; Hosaka, Y; Kakiuchi, A; Kakuki, T; Kaneko, Y; Kikuchi, S; Kohno, T; Kojima, T; Konno, T; Ninomiya, T; Takano, K | 1 |
| Al-Jarallah, A; Chacko Verghese, L; Oommen, E; Oriowo, MA | 1 |
47 other study(ies) available for y 27632 and bisindolylmaleimide i
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.
Topics: Animals; Binding, Competitive; Catalytic Domain; Cell-Free System; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Databases, Factual; Genes, Reporter; Luciferases; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Recombinant Fusion Proteins; Structure-Activity Relationship | 2012 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea.
Topics: Amides; Animals; Calcium; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Myosin-Light-Chain Phosphatase; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Trachea | 1999 |
Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility.
Topics: Amides; Animals; Cell Membrane Permeability; Enzyme Inhibitors; Femoral Artery; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Histamine; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phenylephrine; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Type C Phospholipases | 2000 |
Possible involvement of Rho kinase in Ca2+ sensitization and mobilization by MCh in tracheal smooth muscle.
Topics: Amides; Animals; Bronchoconstriction; Bronchoconstrictor Agents; Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Guinea Pigs; In Vitro Techniques; Indoles; Intracellular Fluid; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Methacholine Chloride; Muscle, Smooth; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Spectrometry, Fluorescence; Trachea | 2001 |
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms.
Topics: Amides; Amino Acid Sequence; Animals; Aorta; Carbazoles; Chromatography; Chromatography, Affinity; Chromatography, Ion Exchange; Durapatite; Enzyme Activation; Enzyme Inhibitors; Histamine; In Vitro Techniques; Indoles; Isoenzymes; Kinetics; Maleimides; Molecular Sequence Data; Muscle Contraction; Muscle Proteins; Muscle Relaxants, Central; Muscle, Smooth, Vascular; Myelin Basic Protein; Myosin-Light-Chain Phosphatase; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Pyridines; Recombinant Proteins; Substrate Specificity; Swine; Vasoconstriction | 2001 |
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Stomach; Urinary Bladder | 2002 |
Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cells, Cultured; Enzyme Inhibitors; ERG1 Potassium Channel; Estrenes; Ether-A-Go-Go Potassium Channels; Hydrolysis; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Maleimides; Membrane Potentials; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphoprotein Phosphatases; Phosphorylation; Pituitary Gland, Anterior; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Pyridines; Pyrrolidinones; Rats; rho-Associated Kinases; Signal Transduction; Thyrotropin-Releasing Hormone | 2003 |
Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle.
Topics: Amides; Animals; Calcium; Electrophysiology; Endothelin-1; Enzyme Inhibitors; Indoles; Isoenzymes; Male; Maleimides; Muscle Proteins; Muscle, Smooth; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Permeability; Phenylephrine; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Portal Vein; Pyridines; Rabbits; Type C Phospholipases; Vas Deferens; Vasoconstriction | 2003 |
Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Cells, Cultured; Cyclic GMP; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Hypertension; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; NG-Nitroarginine Methyl Ester; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Threonine | 2003 |
Astrocyte stellation induced by Rho kinase inhibitors in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Astrocytes; Carbazoles; Cell Size; Cells, Cultured; Cerebral Cortex; Colchicine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gout Suppressants; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Phalloidine; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; rho-Associated Kinases | 2003 |
Modulation of Ca2+ sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle.
Topics: Adrenergic alpha-Agonists; Amides; Animals; Calcium; Enzyme Inhibitors; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Penis; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Type C Phospholipases | 2003 |
Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats.
Topics: Amides; Animals; Blood Pressure; Chromones; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Indoles; Injections, Intravenous; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Morpholines; Nifedipine; Potassium Chloride; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilator Agents | 2004 |
Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells.
Topics: Amides; Amlodipine; Animals; Antipyrine; Arteriosclerosis; Basilar Artery; Cell Division; Cell Survival; Cells, Cultured; Drug Synergism; Drug Therapy, Combination; Edaravone; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Free Radical Scavengers; Indoles; Maleimides; Methacrylates; Muscle, Smooth, Vascular; Pyridines; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles | 2003 |
High glucose-induced upregulation of osteopontin is mediated via Rho/Rho kinase pathway in cultured rat aortic smooth muscle cells.
Topics: Amides; Animals; Aorta; Enzyme Inhibitors; Glucose; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Osteopontin; Protein Kinase C; Protein Prenylation; Protein Serine-Threonine Kinases; Pyridines; Quinolines; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Sialoglycoproteins; Up-Regulation | 2004 |
Induction of neurites by the regulatory domains of PKCdelta and epsilon is counteracted by PKC catalytic activity and by the RhoA pathway.
Topics: Actins; Amides; Catalysis; Cell Line; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Indoles; Isoenzymes; Luminescent Proteins; Maleimides; Models, Biological; Neurites; Neuroblastoma; Neurons; Phorbol Esters; Protein Kinase C; Protein Structure, Tertiary; Pyridines; Recombinant Fusion Proteins; rhoA GTP-Binding Protein; Stress Fibers; Time Factors; Transfection; Tumor Cells, Cultured | 2004 |
Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Ascorbic Acid; Bradykinin; Cattle; Cerebral Arteries; Chromones; Culture Media; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; Imidazoles; In Vitro Techniques; Indoles; Maleimides; Morpholines; Oxidative Stress; Potassium; Protein Kinase Inhibitors; Pyridines; Serum; Superoxide Dismutase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2004 |
Ca2+ sensitization in contraction of human bladder smooth muscle.
Topics: Aged; Amides; Calcium; Female; Humans; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Urinary Bladder | 2004 |
RhoA-Rho kinase pathway mediates thrombin- and U-46619-induced phosphorylation of a myosin phosphatase inhibitor, CPI-17, in vascular smooth muscle cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Immunoblotting; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Thrombin; Vasoconstrictor Agents | 2005 |
Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells.
Topics: Adenosine Diphosphate; Algorithms; Amides; Apoptosis; Cells, Cultured; Cluster Analysis; Culture Media; DNA Primers; DNA, Complementary; Dose-Response Relationship, Drug; Electric Impedance; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Indoles; Maleimides; Microcirculation; Models, Biological; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Peptides; Pertussis Toxin; Promoter Regions, Genetic; Protein Binding; Pyridines; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Thrombin; Thrombospondin 1; Time Factors; Umbilical Veins; Up-Regulation | 2005 |
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.
Topics: Amides; Animals; Aorta, Thoracic; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Hypertension; In Vitro Techniques; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Vasoconstriction; Vasodilator Agents; Verapamil | 2005 |
Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amides; Animals; Benzophenanthridines; Blood Pressure; Calcium; Calcium Signaling; Cerebral Arteries; Enzyme Inhibitors; Hypertension; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Tonus; Muscle, Smooth, Vascular; Phenanthridines; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases | 2005 |
PHI-1 induced enhancement of myosin phosphorylation in chicken smooth muscle.
Topics: Amides; Animals; Calcium; Chickens; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Maleimides; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proteins; Pyridines; Threonine | 2005 |
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction | 2006 |
Cooling-induced contraction of the rat gastric fundus: mediation via transient receptor potential (TRP) cation channel TRPM8 receptor and Rho-kinase activation.
Topics: Amides; Animals; Calcium; Calcium Channel Blockers; Capsaicin; Cold Temperature; Enzyme Activation; Enzyme Inhibitors; Gastric Fundus; Gene Expression; Genistein; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Contraction; Nifedipine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA, Messenger; TRPM Cation Channels | 2005 |
Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucose; Immunoblotting; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Up-Regulation | 2006 |
Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK.
Topics: ADP Ribose Transferases; Amides; Anal Canal; Animals; Botulinum Toxins; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Guanine Nucleotide Dissociation Inhibitors; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myocytes, Smooth Muscle; Myosin Light Chains; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Rectum; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2007 |
Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle.
Topics: Amides; Animals; Apoptosis Regulatory Proteins; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Death-Associated Protein Kinases; Ileum; Indoles; Maleimides; Microcystins; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphoproteins; Protein Kinase C; Protein Phosphatase 1; Pyridines; Rats | 2007 |
Melatonin restores impaired contractility in aged guinea pig urinary bladder.
Topics: Aging; Amides; Animals; Antioxidants; Calcium; Calcium Signaling; Enzyme Inhibitors; Female; Gene Expression Regulation; Guinea Pigs; Indoles; Isometric Contraction; Maleimides; Melatonin; Myosin-Light-Chain Phosphatase; Phosphorylation; Protein Kinase C; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Urinary Bladder; Urinary Bladder Diseases | 2008 |
Prolactin stimulates transepithelial calcium transport and modulates paracellular permselectivity in Caco-2 monolayer: mediation by PKC and ROCK pathways.
Topics: Amides; Animals; Biological Transport; Calcium; Cell Line, Tumor; Cell Membrane Permeability; Colonic Neoplasms; Culture Media; Epithelial Cells; Humans; Indoles; Maleimides; Prolactin; Protein Kinase C; Pyridines; Rats; rho-Associated Kinases | 2008 |
Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms.
Topics: Amides; Animals; Calcium Signaling; Carbachol; Guinea Pigs; Indoles; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Phenylephrine; Protein Kinase C; Pyridines; Receptor Cross-Talk; Receptors, Adrenergic; Receptors, Muscarinic; rho-Associated Kinases; Signal Transduction; Urinary Bladder | 2009 |
Role of Ca2+ mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Bridged-Ring Compounds; Calcium Channel Blockers; Calcium Signaling; Diltiazem; Dinoprost; Dioxanes; Enzyme Inhibitors; Estrenes; Guinea Pigs; Imidazoles; In Vitro Techniques; Indoles; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Norbornanes; Pyridines; Pyrrolidinones; Receptors, Thromboxane A2, Prostaglandin H2; rho-Associated Kinases; Signal Transduction; Thiocarbamates; Thiones; Trachea; Type C Phospholipases; Vasoconstrictor Agents; Verapamil | 2009 |
Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle.
Topics: Amides; Animals; Calcium; Carbachol; Enzyme Inhibitors; Guinea Pigs; Indoles; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Protein Kinase C; Pyridines; rho-Associated Kinases; Signal Transduction; Urinary Bladder Neck Obstruction | 2012 |
Pregnancy reduces RhoA/Rho kinase and protein kinase C signaling pathways downstream of thromboxane receptor activation in the rat uterine artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Enzyme Inhibitors; Female; Indoles; Maleimides; Mesenteric Arteries; Pregnancy; Pregnancy, Animal; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; rho-Associated Kinases; Signal Transduction; Uterine Artery; Uterus; Vasoconstrictor Agents | 2012 |
Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle.
Topics: Amides; Calcium; Carbachol; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Maleimides; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Protein Kinase C; Pyridines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; rho-Associated Kinases; Signal Transduction; Urinary Bladder | 2012 |
Bioengineered human IAS reconstructs with functional and molecular properties similar to intact IAS.
Topics: Adrenergic beta-Agonists; Amides; Anal Canal; Bethanechol; Gene Expression Regulation, Enzymologic; Humans; Indoles; Isoproterenol; Maleimides; Muscarinic Agonists; Muscle Tonus; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Pyridines; rho-Associated Kinases; Tissue Engineering | 2012 |
Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle.
Topics: Amides; Animals; Apoptosis Regulatory Proteins; Arteries; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Death-Associated Protein Kinases; Immunoprecipitation; Indoles; Male; Maleimides; Microcystins; Muscle Contraction; Muscle, Smooth, Vascular; Octoxynol; Phosphorylation; Protein Binding; Protein Phosphatase 1; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; rho-Associated Kinases; Staurosporine; Threonine; Time Factors | 2013 |
Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle.
Topics: Amides; Animals; Carcinogens; Enzyme Inhibitors; Fecal Incontinence; Indoles; Maleimides; Muscle Contraction; Muscle, Smooth; Naphthalenes; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Rectum; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2013 |
Novel effect of 2-aminoethoxydiphenylborate through inhibition of calcium sensitization induced by Rho kinase activation in human detrusor smooth muscle.
Topics: Aged; Amides; Bacterial Toxins; Boron Compounds; Calcium; Hemolysin Proteins; Humans; In Vitro Techniques; Indoles; Maleimides; Muscle, Smooth; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases | 2013 |
Enhancement of S1P-induced contractile response in detrusor smooth muscle of rats having cystitis.
Topics: Amides; Animals; Calcium; Cystitis; Female; Gene Expression Regulation; Indoles; Lysophospholipids; Maleimides; Muscle Contraction; Muscle, Smooth; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Urinary Bladder | 2017 |
Rho Kinase and Protein Kinase C Pathways are Responsible for Enhanced Carbachol Contraction in Permeabilized Detrusor in a Rat Model of Cystitis.
Topics: Amides; Animals; Carbachol; Cholinergic Agonists; Cystitis, Interstitial; Enzyme Inhibitors; Heparin; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Protein Kinase C; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Signal Transduction; Urinary Bladder | 2018 |
Comparison of signalling mechanisms underlying UTP-evoked vasoconstriction of rat pulmonary and tail arteries.
Topics: Amides; Animals; Calcium; Indoles; Male; Maleimides; Nifedipine; Protein Kinase C; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Ryanodine; Signal Transduction; Thapsigargin; Uridine Triphosphate; Vasoconstriction | 2018 |
Mirabegron induces relaxant effects via cAMP signaling-dependent and -independent pathways in detrusor smooth muscle.
Topics: Acetanilides; Adenylyl Cyclase Inhibitors; Aged; Amides; Animals; Carbachol; Cyclic AMP; Female; Humans; Indoles; Isoquinolines; Male; Maleimides; Muscle Relaxation; Muscle, Smooth; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction; Sulfonamides; Swine; Thiazoles; Urinary Bladder; Urological Agents | 2019 |
Rho-kinase and PKCα Inhibition Induces Primary Cilia Elongation and Alters the Behavior of Undifferentiated and Differentiated Temperature-sensitive Mouse Cochlear Cells.
Topics: Amides; Animals; Cell Differentiation; Cell Line; Cilia; Cochlea; Hair Cells, Auditory; Indoles; Maleimides; Mice; Protein Kinase C-alpha; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Temperature | 2019 |
Role of Extracellular Calcium and Calcium Sensitization in the Anti-Contractile Effect of Perivascular Adipose Tissue in Pregnant Rat Aorta.
Topics: Adipose Tissue; Amides; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Female; Indoles; Maleimides; Nifedipine; Pregnancy; Pyridines; Rats, Sprague-Dawley; Serotonin; Vasoconstriction | 2019 |