y 27632 has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 23 studies
| Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) | Studies (2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one) | Trials (2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one) | Recent Studies (post-2010) (2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one) |
|---|---|---|---|---|---|
| 1,924 | 3 | 891 | 4,823 | 5 | 1,810 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (65.22) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Baker, RC; Farley, JM; Mamoon, AM | 1 |
| Helfman, DM; Pawlak, G | 1 |
| Bauer, N; Casanova, N; Gebb, S; McMurtry, I; Morio, Y; Nagaoka, T; Oka, M | 1 |
| Loberg, RD; Northcott, CA; Watts, SW; Wehrwein, EA | 1 |
| Hirata Terra, J; Millward, TA; Montaño, I; Schilb, A | 1 |
| Hirano, K; Kanaide, H; Maeda, Y; Nishimura, J; Sasaki, T | 1 |
| Boettiger, D; Guvakova, MA; Lynch, L; Vodyanik, PI | 1 |
| Gouëffic, Y; Guérin, P; Guilluy, C; Loirand, G; Pacaud, P; Patra, P | 1 |
| Hetman, M; Kalita, K; Kharebava, G; Zheng, JJ | 1 |
| Baarsma, HA; Dekkers, BG; Ens, KM; Frohwerk, E; Gosens, R; Halayko, AJ; McNeill, KD; Meurs, H; Nelemans, SA; Penninks, JM; Schaafsma, D; Sharma, P; Stelmack, GL; Zaagsma, J | 1 |
| Ishibashi, F | 1 |
| Jarroll, EL; Khan, NA; Siddiqui, R | 1 |
| Gahtan, V; Lawler, J; Maier, KG; Sadowitz, B; Seymour, KA; Stein, JJ | 1 |
| Bredow, M; Brünnert, D; Ehrhardt, J; Goyal, P; Piccenini, S; Zygmunt, M | 1 |
| Cheng, R; Hu, T; Pan, HY; Shao, MY; Xu, J; Yang, H; Zhang, P | 1 |
| Huang, S; Qi, F; Wang, Z; Wu, Q; Yang, S | 1 |
| Idiris, A; Kumagai, H; Miyagi, Y; Miyazaki, K; Okamoto, R; Togo, S | 1 |
| Huang, S; Jin, F; Liu, Y; Qi, F; Yang, S | 1 |
23 other study(ies) available for y 27632 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Activation of phospholipase D in porcine tracheal smooth muscle: role of phosphatidylinositol 3-kinase and RhoA activation.
Topics: Acetylcholine; Amides; Androstadienes; Animals; Calcium; Chromones; Enzyme Activation; In Vitro Techniques; Male; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phospholipase D; Pyridines; rhoA GTP-Binding Protein; Swine; Tetradecanoylphorbol Acetate; Trachea; Wortmannin | 2001 |
Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts.
Topics: Actin Cytoskeleton; Amides; Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; Chromones; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Oncogene Protein p21(ras); Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; Transcription, Genetic; Transfection | 2002 |
Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats.
Topics: Amides; Animals; Blood Pressure; Chromones; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Indoles; Injections, Intravenous; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Morpholines; Nifedipine; Potassium Chloride; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilator Agents | 2004 |
Rho/Rho kinase and phosphoinositide 3-kinase are parallel pathways in the development of spontaneous arterial tone in deoxycorticosterone acetate-salt hypertension.
Topics: Amides; Animals; Arteries; Calcium; Chromones; Desoxycorticosterone; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasoconstriction | 2004 |
Development of a microplate bioassay for monocyte chemoattractant protein-1 based on activation of p44/42 mitogen-activated protein kinase.
Topics: Amides; Animals; Antibodies, Monoclonal; Biological Assay; Carbazoles; Cell Line; Chemokine CCL2; Chromones; Cricetinae; DNA, Complementary; Enzyme Inhibitors; Indoles; Microchemistry; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphorylation; Promoter Regions, Genetic; Pyridines; Receptors, CCR2; Receptors, Chemokine; Transfection | 2004 |
Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Ascorbic Acid; Bradykinin; Cattle; Cerebral Arteries; Chromones; Culture Media; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; Imidazoles; In Vitro Techniques; Indoles; Maleimides; Morpholines; Oxidative Stress; Potassium; Protein Kinase Inhibitors; Pyridines; Serum; Superoxide Dismutase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2004 |
Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells.
Topics: Actins; Amides; Blotting, Western; Breast Neoplasms; Butadienes; Carcinoma; Catalysis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; CSK Tyrosine-Protein Kinase; Culture Media, Serum-Free; Depsipeptides; Down-Regulation; Fibronectins; Flow Cytometry; Humans; Immunoprecipitation; Insulin-Like Growth Factor I; Integrin alpha5beta1; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Microscopy, Phase-Contrast; Models, Biological; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; src-Family Kinases; Time Factors | 2005 |
Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation.
Topics: Actins; Amides; Animals; Antibodies, Monoclonal; Aorta; Bacterial Toxins; Cell Movement; Cells, Cultured; Chromones; Complement C3; Cytoskeleton; Dose-Response Relationship, Drug; Enterotoxins; Escherichia coli Proteins; Extracellular Matrix Proteins; Genes, tat; Hyaluronan Receptors; Hyaluronic Acid; Intracellular Signaling Peptides and Proteins; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; rac GTP-Binding Proteins; Rats; Recombinant Fusion Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Signal Transduction; Simvastatin; Stimulation, Chemical | 2006 |
Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity.
Topics: 4-Aminopyridine; Amides; Animals; Animals, Newborn; Bicuculline; Brain-Derived Neurotrophic Factor; Butadienes; Cells, Cultured; Cerebral Cortex; Chlorocebus aethiops; Chromones; COS Cells; Cysteine-Rich Protein 61; Gene Expression Regulation; Genes, fos; Hippocampus; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; N-Methylaspartate; Neurons; Nitriles; Potassium Chloride; Prosencephalon; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; RNA Interference; Serum Response Factor; Signal Transduction; Synaptic Transmission; Transcription Factors; Transcription, Genetic; Transfection | 2006 |
Insulin increases the expression of contractile phenotypic markers in airway smooth muscle.
Topics: Amides; Animals; Calcium-Binding Proteins; Calponins; Cattle; Cell Shape; Cells, Cultured; Chromones; Contractile Proteins; Hypoglycemic Agents; Insulin; Intracellular Signaling Peptides and Proteins; Microfilament Proteins; Morpholines; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Organ Culture Techniques; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Receptor, IGF Type 1; Receptor, IGF Type 2; Receptor, Insulin; rho-Associated Kinases; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Signal Transduction; Smooth Muscle Myosins; Time Factors; Trachea; Transcription, Genetic | 2007 |
High glucose increases phosphocofilin via phosphorylation of LIM kinase due to Rho/Rho kinase activation in cultured pig proximal tubular epithelial cells.
Topics: Amides; Androstadienes; Animals; Chromones; Cofilin 1; Enzyme Activation; Enzyme Inhibitors; Glucose; Kidney Tubules, Proximal; Lim Kinases; LLC-PK1 Cells; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction; Swine; Wortmannin | 2008 |
Balamuthia mandrillaris: role of galactose in encystment and identification of potential inhibitory targets.
Topics: Amides; Amoebozoa; Brain; Calcium-Binding Proteins; Cells, Cultured; Chromones; Cytochalasin D; Cytoskeleton; Endothelial Cells; Enzyme Inhibitors; Galactose; Genistein; Humans; Monosaccharide Transport Proteins; Morpholines; Periplasmic Binding Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vanadates | 2010 |
Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated.
Topics: Amides; Cell Movement; Cells, Cultured; Chemotaxis; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organophosphonates; Protein Folding; Pyridines; Pyrimidines; Signal Transduction; Thrombospondin 1 | 2011 |
Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways.
Topics: Amides; Aminoquinolines; Cell Line; Chromones; Cycloheximide; Dactinomycin; Female; Humans; Interleukin-6; Lysophospholipids; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Pregnancy; Pyrazoles; Pyridines; Pyrimidines; rac1 GTP-Binding Protein; Receptors, Lysosphingolipid; rho GTP-Binding Proteins; rho-Associated Kinases; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Trophoblasts | 2013 |
Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.
Topics: Adolescent; Adult; Amides; Apoptosis; Blotting, Western; Butadienes; Cell Culture Techniques; Cell Proliferation; Chromones; Dental Pulp; Homeostasis; Humans; In Vitro Techniques; Lysophospholipids; Membrane Potential, Mitochondrial; Molar, Third; Morpholines; Nitriles; Pyridines; Signal Transduction; Sphingosine | 2015 |
Sevoflurane and isoflurane inhibit KCl-induced Class II phosphoinositide 3-kinase α subunit mediated vasoconstriction in rat aorta.
Topics: Amides; Anesthetics, Inhalation; Animals; Aorta; Blotting, Western; Chromones; Class II Phosphatidylinositol 3-Kinases; Dose-Response Relationship, Drug; Isoflurane; Male; Methyl Ethers; Morpholines; Myosin Light Chains; Phosphorylation; Potassium Chloride; Protein Phosphatase 1; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Sevoflurane; Vasoconstriction; Vasodilation | 2016 |
Collective cancer cell invasion in contact with fibroblasts through integrin-α5β1/fibronectin interaction in collagen matrix.
Topics: A549 Cells; Adenocarcinoma; Amides; Benzamides; Cancer-Associated Fibroblasts; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Collagen; Colonic Neoplasms; Connective Tissue; Dioxoles; Epidermal Growth Factor; Fibroblasts; Fibronectins; Humans; Immunohistochemistry; Integrin alpha5beta1; MCF-7 Cells; Morpholines; Neoplasm Invasiveness; Pyridines; Spheroids, Cellular; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2020 |
Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas.
Topics: Aging; Amides; Anesthetics, Inhalation; Animals; Aorta; Chromones; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Isoflurane; Morpholines; Phosphatidylinositol 3-Kinases; Potassium Chloride; Pyridines; Rats, Inbred OLETF; Rats, Wistar; rho-Associated Kinases; Sevoflurane; Vasoconstriction | 2021 |