xenon-129-atom and cucurbit(6)uril

Here, a novel method was developed for suppressing 129Xe signals in cucurbit[6]uril (CB6) until the trigger is activated by a specific enzyme. Due to its noncovalent interactions with amino-groups and CB6, putrescine dihydrochloride (Put) was chosen for blocking interactions between 129Xe and CB6. Upon adding diamine oxidase (DAO), Put was released from CB6 and a 129Xe@CB6 Hyper-CEST signal emerged. This proposed 129Xe biosensor was then tested in small intestinal villus epithelial cells.

Topics: Amine Oxidase (Copper-Containing); Biosensing Techniques; Bridged-Ring Compounds; Epithelial Cells; Humans; Imidazoles; Intestine, Small; Magnetic Resonance Spectroscopy; Microvilli; Xenon Isotopes

Molecular imaging holds considerable promise for elucidating biological processes in normal physiology as well as disease states, by determining the location and relative concentration of specific molecules of interest. Proton-based magnetic resonance imaging (

Topics: beta-Lactamases; Biosensing Techniques; Bridged-Ring Compounds; Humans; Imidazoles; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Imaging; Molecular Structure; Polycyclic Compounds; Xenon Isotopes