xav939 and magnolol
xav939 has been researched along with magnolol* in 1 studies
Other Studies
1 other study(ies) available for xav939 and magnolol
| Article | Year |
|---|---|
Identification by Inverse Virtual Screening of magnolol-based scaffold as new tankyrase-2 inhibitors.
The natural product magnolol (1) and a selection of its bioinspired derivatives 2-5, were investigated by Inverse Virtual Screening in order to identify putative biological targets from a panel of 308 proteins involved in cancer processes. By this in silico analysis we selected tankyrase-2 (TNKS2), casein kinase 2 (CK2) and bromodomain 9 (Brd9) as potential targets for experimental evaluations. The Surface Plasmon Resonance assay revealed that 3-5 present a good affinity for tankyrase-2, and, in particular, 3 showed an antiproliferative activity on A549 cells higher than the well-known tankyrase-2 inhibitor XAV939 used as reference compound. Topics: Algorithms; Antineoplastic Agents; Biphenyl Compounds; Cell Proliferation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Lignans; Molecular Structure; Recombinant Proteins; Structure-Activity Relationship; Surface Plasmon Resonance; Tankyrases; Thermodynamics; Tumor Cells, Cultured | 2018 |