xanthohumol-c and xanthohumol

xanthohumol-c has been researched along with xanthohumol* in 2 studies

Other Studies

2 other study(ies) available for xanthohumol-c and xanthohumol

ArticleYear
Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv. "Cascade").
    Journal of natural products, 2016, Mar-25, Volume: 79, Issue:3

    Humulus lupulus (hop plant) has long been used in traditional medicine as a sedative and antimicrobial agent. More recently, attention has been devoted to the phytoestrogenic activity of the plant extracts as well as to the anti-inflammatory and chemopreventive properties of the prenylated chalcones present. In this study, an Italian sample of H. lupulus cv. "Cascade" has been investigated and three new compounds [4-hydroxycolupulone (6), humudifucol (7) and cascadone (8)] have been purified and identified by means of NMR spectroscopy along with four known metabolites. Notably, humudifucol (7) is the first prenylated dimeric phlorotannin discovered in nature. Because structurally related phloroglucinols from natural sources were found previously to inhibit microsomal prostaglandin E2 synthase (mPGES)-1 and 5-lipoxygenase (5-LO), the isolated compounds were evaluated for their bioactivity against these pro-inflammatory target proteins. The prenylated chalcone xanthohumol inhibited both enzymes at low μM concentrations.

    Topics: Arachidonate 5-Lipoxygenase; Chalcones; Flavonoids; Humulus; Intramolecular Oxidoreductases; Italy; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phytoestrogens; Plant Extracts; Plants, Medicinal; Polyphenols; Prenylation; Propiophenones; Prostaglandin-E Synthases

2016
Synthesis, cytotoxicity, and antioxidative activity of minor prenylated chalcones from Humulus lupulus.
    Journal of natural products, 2008, Volume: 71, Issue:7

    The minor hop ( Humulus lupulus) chalcones 3'-geranylchalconaringenin (3), 5'-prenylxanthohumol (4), flavokawin (5), xanthohumol H (8), xanthohumol C (9), and 1'',2''-dihydroxanthohumol C (10) were synthesized. The non-natural chalcones 3'-geranyl-6'-O-methylchalconaringenin (2), 3'-methylflavokawin (6), and 2'-O-methyl-3'-prenylchalconaringenin (7) were also synthesized. Cytotoxicity was investigated in HeLa cells, and these compounds all had IC 50 values comparable to xanthohumol (8.2-19.2 microM). The ORAC-fluorescein assay revealed potent antioxidative activity for 7 and 8 with 5.2 and 4.8 Trolox equivalents, respectively.

    Topics: Antioxidants; Chalcones; Flavonoids; HeLa Cells; Humans; Humulus; Inhibitory Concentration 50; Molecular Structure; Propiophenones

2008