Page last updated: 2024-09-04

xanthenone-4-acetic acid and xanthenes

xanthenone-4-acetic acid has been researched along with xanthenes in 17 studies

Compound Research Comparison

Studies
(xanthenone-4-acetic acid)
Trials
(xanthenone-4-acetic acid)
Recent Studies (post-2010)
(xanthenone-4-acetic acid)
Studies
(xanthenes)
Trials
(xanthenes)
Recent Studies (post-2010) (xanthenes)
21015,020921,325

Protein Interaction Comparison

ProteinTaxonomyxanthenone-4-acetic acid (IC50)xanthenes (IC50)
Amine oxidase [flavin-containing] BHomo sapiens (human)7.42

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's15 (88.24)18.2507
2000's1 (5.88)29.6817
2010's1 (5.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baguley, BC; Ching, LM; Gavin, JB; Thomsen, LL1
Atwell, GJ; Baguley, BC; Denny, WA; Gamage, SA; Rewcastle, GW1
Back, TT; Baguley, BC; Eader, L; Futami, H; Gruys, E; Wiltrout, RH; Young, HA1
Baguley, BC; Ching, LM; Gavin, JB; Joseph, WR; Thomsen, LL1
Baguley, BC; Ching, LM; Finlay, GJ; Joseph, WR1
Atwell, GJ; Baguley, BC; Ching, LM; Denny, WA; Joseph, WR; Rewcastle, GW; Zhuang, L1
Baguley, BC; Kestell, P; McKeage, MJ1
Atwell, GJ; Baguley, BC; Boyd, M; Denny, WA; Rewcastle, GW; Thomsen, LL; Zhuang, L1
Baguley, BC; Denny, WA; Kestell, P; McKeage, MJ1
Baguley, BC; Ching, LM; Joseph, WR; Kestell, P; McKeage, MJ; Zwi, LJ1
Baguley, BC; Ching, LM; Gavin, JB; Thomsen, LL; Zhuang, L1
Baguley, BC; Ching, LM; Thomsen, LL1
Baguley, BC; Gavin, JB; Wilson, WR; Zwi, LJ1
Baguley, BC; Kestell, P; Rewcastle, GW1
Candeias, LP; Denny, WA; Everett, SA; Wardman, P1
Barbera, M; Belluti, F; Bisi, A; Caputo, A; Carrara, M; Gobbi, S; Piazzi, L; Rampa, A; Zampiron, A1
Albelda, SM; Ching, LM; Guo, K; Henare, K; Palmer, BD; Tijono, SM; Wang, LC1

Other Studies

17 other study(ies) available for xanthenone-4-acetic acid and xanthenes

ArticleYear
Modulation of superoxide production from murine macrophages by the antitumour agent flavone acetic acid and xanthenone acetic acid analogues.
    Biochemical pharmacology, 1992, Jan-22, Volume: 43, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Flavonoids; Macrophages; Mice; Mice, Inbred C3H; Necrosis; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Xanthenes

1992
Structure-activity relationships for substituted 9-oxo-9,10-dihydroacridine-4-acetic acids: analogues of the colon tumour active agent xanthenone-4-acetic acid.
    Anti-cancer drug design, 1992, Volume: 7, Issue:5

    Topics: Animals; Colonic Neoplasms; Drug Design; Mice; Necrosis; Structure-Activity Relationship; Xanthenes

1992
Cytokine induction and therapeutic synergy with interleukin-2 against murine renal and colon cancers by xanthenone-4-acetic acid derivatives.
    Journal of immunotherapy : official journal of the Society for Biological Therapy, 1992, Volume: 12, Issue:4

    Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Cytokines; DNA; DNA Probes; Drug Screening Assays, Antitumor; Drug Synergism; Flavonoids; Gene Expression Regulation, Neoplastic; Interferon-alpha; Interferon-gamma; Interleukin-2; Kidney Neoplasms; Leukocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Recombinant Proteins; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Xanthenes

1992
Nitric oxide production in endotoxin-resistant C3H/HeJ mice stimulated with flavone-8-acetic acid and xanthenone-4-acetic acid analogues.
    Biochemical pharmacology, 1992, Jun-09, Volume: 43, Issue:11

    Topics: Animals; Cells, Cultured; Drug Resistance; Endotoxins; Flavonoids; Macrophages; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitrates; Nitric Oxide; Time Factors; Tumor Necrosis Factor-alpha; Xanthenes

1992
In vitro methods for screening agents with an indirect mechanism of antitumour activity: xanthenone analogues of flavone acetic acid.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:12

    Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Evaluation, Preclinical; Macrophage Activation; Macrophages; Mice; Mice, Inbred Strains; Tumor Cells, Cultured; Xanthenes; Xanthones

1991
Induction of natural killer activity by xanthenone analogues of flavone acetic acid: relation with antitumour activity.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:1

    Topics: Animals; Colonic Neoplasms; Cytotoxicity, Immunologic; Dose-Response Relationship, Immunologic; Immunologic Factors; Killer Cells, Natural; Mice; Mice, Inbred Strains; Xanthenes

1991
Determination of xanthenone-4-acetic acid in mouse plasma by high-performance liquid chromatography.
    Journal of chromatography, 1991, Mar-08, Volume: 564, Issue:1

    Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Colonic Neoplasms; Male; Mice; Xanthenes

1991
Potential antitumor agents. 63. Structure-activity relationships for side-chain analogues of the colon 38 active agent 9-oxo-9H-xanthene-4-acetic acid.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:9

    Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Macrophages; Methylation; Mice; Nitrates; Nitrites; Structure-Activity Relationship; Xanthenes

1991
Plasma pharmacokinetics of the antitumour agents 5,6-dimethylxanthenone-4-acetic acid, xanthenone-4-acetic acid and flavone-8-acetic acid in mice.
    Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:6

    Topics: Animals; Antineoplastic Agents; Blood Proteins; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Flavonoids; Male; Mice; Mice, Inbred Strains; Protein Binding; Xanthenes; Xanthones

1991
Haematological effects in mice of the antitumour agents xanthenone-4-acetic acid, 5,6-dimethyl-xanthenone-4-acetic acid [correction of 5,6-methyl-] and flavone acetic acid.
    Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:6

    Topics: Animals; Antineoplastic Agents; Blood; Blood Cells; Bone Marrow; Bone Marrow Cells; Colony-Forming Units Assay; Flavonoids; Lymphocytes; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Xanthenes; Xanthones

1991
Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice.
    Cancer research, 1991, Jan-01, Volume: 51, Issue:1

    Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Flavonoids; Methylation; Mice; Mice, Inbred Strains; Nitrates; Nitrites; Xanthenes; Xanthones

1991
Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid.
    Cancer research, 1990, Nov-01, Volume: 50, Issue:21

    Topics: Animals; Antineoplastic Agents; Arginine; Cell Survival; Colonic Neoplasms; Dexamethasone; Flavonoids; Macrophages; Mice; Neoplasm Transplantation; Nitrates; Nitric Acid; Nitric Oxide; omega-N-Methylarginine; Xanthenes

1990
Correlation between immune and vascular activities of xanthenone acetic acid antitumor agents.
    Oncology research, 1994, Volume: 6, Issue:2

    Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Flavonoids; Immunity, Cellular; Male; Mice; Mice, Inbred Strains; Necrosis; Structure-Activity Relationship; Tumor Cells, Cultured; Xanthenes

1994
Disposition of the novel antitumour agent xanthenone-4-acetic acid in the mouse: identification of metabolites and routes of elimination.
    Xenobiotica; the fate of foreign compounds in biological systems, 1994, Volume: 24, Issue:7

    Topics: Animals; Antineoplastic Agents; Bile; Biliary Tract; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glucuronidase; Hydrolysis; Male; Mice; Mice, Inbred Strains; Sulfatases; Xanthenes

1994
Decarboxylation of the antitumour drugs flavone-8-acetic acid and xanthenone-4-acetic acid by nitrogen dioxide.
    Anti-cancer drug design, 1994, Volume: 9, Issue:1

    Topics: Antineoplastic Agents; Decarboxylation; Flavonoids; Nitrogen Dioxide; Xanthenes

1994
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells.
    Bioorganic & medicinal chemistry, 2006, Jun-15, Volume: 14, Issue:12

    Topics: Cell Proliferation; Humans; Leukocytes, Mononuclear; Molecular Structure; Nitric Oxide; Stereoisomerism; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones

2006
Identification of human-selective analogues of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).
    British journal of cancer, 2013, Apr-02, Volume: 108, Issue:6

    Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Collagen; Drug Combinations; Human Umbilical Vein Endothelial Cells; Humans; Interleukin-6; Interleukin-8; Laminin; Leukocytes; Mice; Mice, Nude; Neovascularization, Physiologic; Proteoglycans; Xanthenes; Xanthones

2013