xanomeline has been researched along with clozapine in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Dorsey, J; Katz, T; Lawlor, E; Messer, WS; Nagy, PI; Rieman, M; Tejada, FR; Warrier, M; Wu, C; Xu, M | 1 |
| Compton-Toth, BA; Davies, MA; Hufeisen, SJ; Meltzer, HY; Roth, BL | 1 |
| Dai, J; Li, Z; Meltzer, HY; Roseman, AS; Snigdha, S | 1 |
| Caine, SB; Fink-Jensen, A; Fulton, BS; Thomsen, M; Wess, J | 1 |
| Hikichi, H; Maehara, S; Ohta, H | 1 |
| Kinoshita, M; Odagaki, Y; Ota, T | 1 |
| Bryant, ZK; Conn, PJ; Foster, DJ | 1 |
1 review(s) available for xanomeline and clozapine
| Article | Year |
|---|---|
Targeting muscarinic receptors to treat schizophrenia.
Topics: Animals; Antipsychotic Agents; Clozapine; Cognitive Dysfunction; Humans; Muscarinic Agonists; Pyridines; Receptors, Muscarinic; Schizophrenia; Thiadiazoles | 2021 |
7 other study(ies) available for xanomeline and clozapine
| Article | Year |
|---|---|
Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the bind
Topics: Animals; Antipsychotic Agents; Cell Line; Cyclic AMP; Drug Design; Humans; Hydrolysis; Ligands; Mice; Models, Molecular; Muscarinic Agonists; Mutagenesis, Site-Directed; Mutation; Phosphatidylinositols; Piperidines; Radioligand Assay; Receptors, Muscarinic; Recombinant Fusion Proteins; Structure-Activity Relationship; Thiadiazoles | 2006 |
Advances in CNS Drugs. Recent advances and considerations in the treatment of schizophrenia.
Topics: Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Clozapine; Double-Blind Method; Drug Costs; Drugs, Investigational; Humans; Olanzapine; Pirenzepine; Placebos; Pyridines; Randomized Controlled Trials as Topic; Schizophrenia; Thiadiazoles | 1996 |
The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?
Topics: Animals; Antipsychotic Agents; CHO Cells; Clozapine; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Psychopharmacology; Pyridines; Receptors, Muscarinic; Thiadiazoles | 2005 |
Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain; comparison with effects of 4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) and N-desmethylclozapine
Topics: Acetylcholine; Animals; Antipsychotic Agents; Benzoxazines; Brain; Clozapine; Dopamine; Drug Synergism; Imines; Male; Nucleus Accumbens; Pirenzepine; Prefrontal Cortex; Pyridines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Risperidone; Thiadiazoles | 2008 |
Modulation of prepulse inhibition through both M(1) and M (4) muscarinic receptors in mice.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Female; Haloperidol; Male; Mice; Mice, Knockout; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Pyridines; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Reflex, Startle; Scopolamine; Thiadiazoles | 2010 |
Behavioral effects of N-desmethylclozapine on locomotor activity and sensorimotor gating function in mice-Possible involvement of muscarinic receptors.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Mice; Motor Activity; Muscarinic Agonists; Neural Inhibition; Oxotremorine; Psychophysics; Pyridines; Receptors, Muscarinic; Scopolamine; Sensory Gating; Thiadiazoles | 2011 |
Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes.
Topics: Animals; Antipsychotic Agents; Cerebral Cortex; Clozapine; Corpus Striatum; Hippocampus; Immunoprecipitation; Male; Muscarinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Serotonin, 5-HT1A; Thiadiazoles | 2016 |