Compounds > xanomeline
Page last updated: 2024-08-24

xanomeline and carbachol

xanomeline has been researched along with carbachol in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (38.46)18.2507
2000's12 (46.15)29.6817
2010's4 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abuh, YF; Dunbar, PG; Edgar, MA; El-Assadi, AA; Fang, Z; Huzl, JJ; Liu, Y; Messer, WS; Nagy, PI; Ngur, DO; Ojo, B; Periyasamy, S; Rho, T; Roknich, S; Sbeih, S; Zhang, H1
Bymaster, FP; Calligaro, DO; DeLapp, NW; Fink-Jensen, A; Jeppesen, L; Olesen, PH; Rasmussen, T; Rimvall, K; Sauerberg, P; Shannon, HE; Sheardown, MJ; Thomsen, C; Ward, JS; Whitesitt, CA1
Bymaster, FP; Calligaro, DO; Christensen, MS; Delapp, NW; Felder, CC; Hansen, L; Jensen, AF; Jeppesen, L; Olesen, PH; Rasmussen, T; Rimvall, K; Sauerberg, P; Shannon, HE; Sheardown, MJ; Thomsen, C; Ward, JS; Whitesitt, C1
Cao, Y; Colclough, T; Ellis, J; Huang, XP; Lee, S; Levine, BA; Liu, F; Messer, WS; Nagy, PI; Nocka, KH; Rajeswaran, WG; Wroblewski, ME1
Balázs, A; Cao, Y; Lee, S; Messer, WS; Nagy, PI; Takács-Novák, K; Torös, S; Whipple, T; Wroblewski, ME; Wu, C; Zhang, M1
Dorsey, J; Katz, T; Lawlor, E; Messer, WS; Nagy, PI; Rieman, M; Tejada, FR; Warrier, M; Wu, C; Xu, M1
Dei, S; Marconi, C; Pedretti, A; Romanelli, MN; Scapecchi, S; Vistoli, G1
Bymaster, FP; DeLapp, NW; Eckols, K; Mitch, CH; Shannon, HE; Ward, JS1
Christopoulos, A; El-Fakahany, EE1
Belagaje, R; Bymaster, F; Calligaro, D; DeLapp, N; Fink-Jensen, A; Jeppesen, L; Johnstone, E; Little, S; Mitch, C; Sauerberg, P; Shannon, H; Sheardown, M; Thomsen, C; Ward, J; Whitesitt, C; Wu, S1
Christopoulos, A; El-Fakahany, EE; Pierce, TL; Sorman, JL1
Christopoulos, A; El-Fakahany, EE; Parsons, AM1
Abou-Gharbia, M; Boast, CA; Husbands, GM; Moyer, JA; Sabb, AL; Stein, RP; Tasse, RP; Tokolics, J1
Christopoulos, A; El-Fakahany, EE; Lew, MJ; Parsons, AM1
Anderton, BH; Dayanandan, R; Forlenza, OV; Lovestone, S; Olesen, OF; Spink, JM1
Cohen, ML; Stengel, PW1
Goodhead, LH; Mitchell, SN; Moss, S; Sharott, A1
El-Fakahany, EE; Grant, MK1
Dolezal, V; El-Fakahany, EE; Jakubík, J1
De Lorme, KC; El-Fakahany, EE; Grant, MK; Noetzel, MJ; Polson, SB1
Dolezal, V; Jakubík, J; Machová, E; Michal, P1
El-Fakahany, EE; Grant, MK; Noetzel, MJ1
De Lorme, KC; Doležal, V; El-Fakahany, EE; Grant, MK; Jakubík, J; Noetzel, MJ1
Dehnicke, C; Deisz, RA; Gigout, S; Horn, P; Lehmann, TN; Wierschke, S1
Dolejší, E; Doležal, V; El-Fakahany, EE; Jakubík, J; Randáková, A; Rudajev, V; Zimčík, P1
Gmeiner, P; Hu, Y; Hübner, H; Jin, C; Kaindl, J; Kobilka, BK; Li, H; Maeda, S; Niu, X; Risel, P; Xu, J1

Reviews

1 review(s) available for xanomeline and carbachol

ArticleYear
Importance and prospects for design of selective muscarinic agonists.
    Physiological research, 2008, Volume: 57 Suppl 3

    Topics: Acetylcholine; Animals; Brain; Carbachol; Drug Design; Guanosine Triphosphate; Humans; Muscarinic Agonists; Protein Binding; Pyridines; Receptor, Muscarinic M1; Thiadiazoles

2008

Other Studies

25 other study(ies) available for xanomeline and carbachol

ArticleYear
Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.
    Journal of medicinal chemistry, 1997, Apr-11, Volume: 40, Issue:8

    Topics: Animals; Arecoline; Brain; Carbachol; Cell Line; Models, Molecular; Muscarinic Agonists; Phosphatidylinositols; Pyrimidines; Quinuclidinyl Benzilate; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Structure-Activity Relationship

1997
Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation.
    Bioorganic & medicinal chemistry letters, 1998, Oct-20, Volume: 8, Issue:20

    Topics: Animals; Cells, Cultured; CHO Cells; Cricetinae; Humans; Inhibitory Concentration 50; Muscarinic Agonists; Pyridines; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Structure-Activity Relationship; Thiadiazoles; Transfection

1998
1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives.
    Journal of medicinal chemistry, 1999, Jun-03, Volume: 42, Issue:11

    Topics: Animals; Aza Compounds; Binding, Competitive; Biological Availability; Cell Line; Cerebral Cortex; CHO Cells; Cricetinae; Cyclic AMP; Heptanes; Humans; Hydrolysis; In Vitro Techniques; Mice; Muscarinic Agonists; Phosphatidylinositols; Radioligand Assay; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic; Structure-Activity Relationship; Thiadiazoles; Transfection

1999
Design, synthesis, and biological characterization of bivalent 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as selective muscarinic agonists.
    Journal of medicinal chemistry, 2001, Dec-20, Volume: 44, Issue:26

    Topics: Binding, Competitive; Cell Line; Drug Design; Humans; Ligands; Models, Molecular; Muscarinic Agonists; Phosphatidylinositols; Protein Structure, Tertiary; Pyridines; Radioligand Assay; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptor, Muscarinic M5; Receptors, Muscarinic; Solubility; Structure-Activity Relationship; Thiadiazoles; Transfection

2001
Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders.
    Journal of medicinal chemistry, 2003, Sep-25, Volume: 46, Issue:20

    Topics: Animals; Benzilates; Binding, Competitive; Carbachol; Cell Line; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Humans; Hypothermia; Male; Mice; Models, Molecular; Muscarinic Agonists; Nervous System Diseases; Pyridines; Radioligand Assay; Rats; Rats, Long-Evans; Receptors, Muscarinic; Thiadiazoles

2003
Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the bind
    Journal of medicinal chemistry, 2006, Dec-14, Volume: 49, Issue:25

    Topics: Animals; Antipsychotic Agents; Cell Line; Cyclic AMP; Drug Design; Humans; Hydrolysis; Ligands; Mice; Models, Molecular; Muscarinic Agonists; Mutagenesis, Site-Directed; Mutation; Phosphatidylinositols; Piperidines; Radioligand Assay; Receptors, Muscarinic; Recombinant Fusion Proteins; Structure-Activity Relationship; Thiadiazoles

2006
Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding.
    Bioorganic & medicinal chemistry, 2008, Mar-15, Volume: 16, Issue:6

    Topics: Binding Sites; Computer Simulation; Humans; Ligands; Muscarinic Agonists; Protein Binding; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M5; Receptors, Muscarinic

2008
The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from Chinese hamster ovary-m1 cells.
    Life sciences, 1995, Volume: 57, Issue:12

    Topics: Amyloid beta-Protein Precursor; Animals; Carbachol; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Electrophoresis; Humans; Immunoblotting; Muscarinic Agonists; Phorbols; Pyridines; Thiadiazoles

1995
Novel persistent activation of muscarinic M1 receptors by xanomeline.
    European journal of pharmacology, 1997, Sep-03, Volume: 334, Issue:1

    Topics: Animals; Carbachol; CHO Cells; Cricetinae; Enzyme Activation; Muscarinic Agonists; Nitric Oxide Synthase; Pyridines; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiadiazoles; Transfection

1997
Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells.
    Biochemical and biophysical research communications, 1998, Mar-06, Volume: 244, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Blotting, Western; Carbachol; CHO Cells; Cloning, Molecular; Cricetinae; Humans; Muscarinic Agonists; Mutation; Peptide Fragments; Protein Processing, Post-Translational; Pyridines; Receptor, Muscarinic M1; Receptors, Muscarinic; Sweden; Thiadiazoles; Transfection

1998
On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor.
    Molecular pharmacology, 1998, Volume: 53, Issue:6

    Topics: Animals; Atropine; Carbachol; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Muscarinic Agonists; N-Methylscopolamine; Nitric Oxide Synthase; Phosphatidylinositols; Pyridines; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiadiazoles; Time Factors

1998
Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3

    Topics: Animals; Atropine; Binding, Competitive; Carbachol; CHO Cells; Citrulline; Cricetinae; Humans; Kinetics; Muscarinic Agonists; N-Methylscopolamine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pirenzepine; Pyridines; Radioligand Assay; Receptor, Muscarinic M1; Receptors, Muscarinic; Recombinant Proteins; Thiadiazoles; Transfection; Tritium

1999
Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling.
    Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14

    Topics: Administration, Oral; Animals; Bridged-Ring Compounds; Carbachol; Cerebral Cortex; CHO Cells; Cognition Disorders; Computer Simulation; Cricetinae; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Humans; Macaca mulatta; Maze Learning; Models, Molecular; Muscarinic Agonists; Phosphatidylinositols; Protein Conformation; Pyrazines; Pyridines; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Salivation; Structure-Activity Relationship; Thiadiazoles

1999
The assessment of antagonist potency under conditions of transient response kinetics.
    European journal of pharmacology, 1999, Oct-15, Volume: 382, Issue:3

    Topics: Animals; Artifacts; Atropine; Binding, Competitive; Calcium; Carbachol; CHO Cells; Cricetinae; Drug Antagonism; Humans; Intracellular Fluid; Kinetics; Models, Biological; Monte Carlo Method; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Pyridines; Radioligand Assay; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiadiazoles; Time Factors

1999
Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3beta inhibition and in neurons.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:10

    Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cells, Cultured; Fetus; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Lithium Chloride; Microtubules; Muscarinic Agonists; Neurons; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; tau Proteins; Tetrazoles; Thiadiazoles

2000
Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:3

    Topics: Animals; Atropine; Bradycardia; Carbachol; Drug Interactions; Heart; Heart Rate; Imines; In Vitro Techniques; Mice; Muscarinic Agonists; Pyridines; Quinuclidines; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic; Thiadiazoles

2001
Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens.
    European journal of pharmacology, 2003, Jan-24, Volume: 460, Issue:2-3

    Topics: Animals; Atropine; Bicuculline; Bridged-Ring Compounds; Carbachol; Cholinergic Agonists; Diamines; Dopamine; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nucleus Accumbens; Oxotremorine; Pilocarpine; Pyridines; Rats; Receptors, Muscarinic; Spiro Compounds; Thiadiazoles; Tropanes

2003
Persistent binding and functional antagonism by xanomeline at the muscarinic M5 receptor.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:1

    Topics: Animals; Carbachol; CHO Cells; Cricetinae; Inositol Phosphates; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Pilocarpine; Pyridines; Receptor, Muscarinic M5; Thiadiazoles

2005
Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors.
    Molecular pharmacology, 2006, Volume: 70, Issue:2

    Topics: Animals; Carbachol; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Muscarinic Agonists; N-Methylscopolamine; Pyridines; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Thiadiazoles

2006
Long-term changes in the muscarinic M1 receptor induced by instantaneous formation of wash-resistant xanomeline-receptor complex.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:3

    Topics: Allosteric Site; Animals; Binding, Competitive; Carbachol; Cells, Cultured; Cricetinae; Cricetulus; Female; Humans; Inositol Phosphates; Ligands; Muscarinic Agonists; N-Methylscopolamine; Ovary; Protein Binding; Pyridines; Radioligand Assay; Receptor, Muscarinic M1; Thiadiazoles; Time Factors; Transfection

2007
Mechanisms of M3 muscarinic receptor regulation by wash-resistant xanomeline binding.
    Pharmacology, 2009, Volume: 83, Issue:5

    Topics: Animals; Atropine; Binding Sites; Carbachol; Cell Line, Transformed; Cricetinae; Drug Interactions; Female; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Muscarinic Agonists; N-Methylscopolamine; Phosphatidylinositols; Pilocarpine; Pyridines; Quinuclidinyl Benzilate; Receptor, Muscarinic M3; Thiadiazoles; Time Factors; Transfection

2009
Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor.
    PloS one, 2010, Dec-23, Volume: 5, Issue:12

    Topics: Animals; Atropine; Binding Sites; Carbachol; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Down-Regulation; Humans; Hydrolysis; Muscarinic Agonists; Protein Binding; Pyridines; Receptor, Muscarinic M1; Thiadiazoles

2010
Muscarinic acetylcholine receptor-mediated effects in slices from human epileptogenic cortex.
    Neuroscience, 2012, Oct-25, Volume: 223

    Topics: Action Potentials; Adult; Biophysics; Carbachol; Cerebral Cortex; Cholinergic Agonists; Drug Combinations; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Female; Humans; In Vitro Techniques; Male; Muscarinic Antagonists; Patch-Clamp Techniques; Pirenzepine; Pyridines; Receptors, Muscarinic; Thiadiazoles

2012
Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms.
    Pharmacological research, 2015, Volume: 97

    Topics: Animals; Binding Sites; Calcium; Carbachol; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Inositol Phosphates; Models, Molecular; Muscarinic Agonists; Mutation; Oxotremorine; Pyridines; Receptor, Muscarinic M1; Receptors, G-Protein-Coupled; Thiadiazoles

2015
Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy.
    Molecular cell, 2019, 07-11, Volume: 75, Issue:1

    Topics: Acetylcholine; Animals; Baculoviridae; Binding Sites; Carbachol; Cloning, Molecular; Gene Expression; Genetic Vectors; Humans; Isoxazoles; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Pilocarpine; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Pyridines; Quaternary Ammonium Compounds; Receptor, Muscarinic M2; Recombinant Proteins; Sf9 Cells; Spodoptera; Thermodynamics; Thiadiazoles

2019