Page last updated: 2024-09-04

xamoterol and propranolol

xamoterol has been researched along with propranolol in 18 studies

Compound Research Comparison

Studies
(xamoterol)
Trials
(xamoterol)
Recent Studies (post-2010)
(xamoterol)
Studies
(propranolol)
Trials
(propranolol)
Recent Studies (post-2010) (propranolol)
269801733,3103,4063,218

Protein Interaction Comparison

ProteinTaxonomyxamoterol (IC50)propranolol (IC50)
Beta-1 adrenergic receptor Cavia porcellus (domestic guinea pig)0.0347
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)2.294
Cytochrome P450 1A2Homo sapiens (human)4
Beta-2 adrenergic receptorHomo sapiens (human)0.0114
Beta-1 adrenergic receptorHomo sapiens (human)0.0575
5-hydroxytryptamine receptor 1AHomo sapiens (human)3.9811
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.012
Cytochrome P450 2D6Homo sapiens (human)2.9706
Beta-3 adrenergic receptorHomo sapiens (human)0.0493
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0288
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)0.012
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0827
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0288
Beta-3 adrenergic receptorRattus norvegicus (Norway rat)0.012
5-hydroxytryptamine receptor 2AHomo sapiens (human)1.466
5-hydroxytryptamine receptor 2CHomo sapiens (human)2.294
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.243
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0288
Sodium-dependent serotonin transporterHomo sapiens (human)0.38
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.342
5-hydroxytryptamine receptor 6Homo sapiens (human)3.065
Beta-2 adrenergic receptorCanis lupus familiaris (dog)0.017
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0288
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.828
Sodium channel protein type 5 subunit alphaHomo sapiens (human)2.1
Sodium/bile acid cotransporterHomo sapiens (human)5.5
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0288
GABA theta subunitRattus norvegicus (Norway rat)0.0288
Sigma non-opioid intracellular receptor 1Homo sapiens (human)2.87
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0288

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19905 (27.78)18.7374
1990's4 (22.22)18.2507
2000's6 (33.33)29.6817
2010's2 (11.11)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Isogaya, M; Kikkawa, H; Kurose, H; Nagao, T; Sugimoto, Y; Tanaka, R; Tanimura, R1
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Faergeman, O; Jensen, HK; Sørensen, EV1
Böhm, M; Erdmann, E; Mittmann, C; Schwinger, RH1
Huttunen, J; Larsen, TA; Teräväinen, H1
Cavero, I; Hicks, PE; Langer, SZ; Lefevre-Borg, F; Manoury, P1
Fitzgerald, TC; McCormick, DJ; McKillop, D1
Briscoe, MG; Halliday, SE; Smith, HJ; Snow, HM1
Kawai, C; Kihara, Y; Lee, JD; Nakamura, Y; Ohyagi, A; Sasayama, S1
Carson, PE1
Böhm, M; Dabew, E; Engelhardt, S; Lohse, MJ; Lorenz, K; Maack, C; Schäfers, HJ; Vlaskin, L1
de Quervain, DJ; Hahn, EL; McGaugh, JL; Nathan, SV; Roozendaal, B1
Haynes, JM1
Ali, A; Emran, TB; Imran, M; Ismail, ISB; Latif, Z; Muhammad, N; Saeed, L; Safi, SZ; Shah, H; Subramaniyan, V1

Reviews

1 review(s) available for xamoterol and propranolol

ArticleYear
Beta-blocker therapy in heart failure: pathophysiology and clinical results.
    Current problems in cardiology, 1999, Volume: 24, Issue:7

    Topics: Adrenergic beta-Antagonists; Aged; Bisoprolol; Carbazoles; Carvedilol; Clinical Trials as Topic; Exercise; Heart Failure; Heart Rate; Hemodynamics; Humans; Imidazoles; Male; Metoprolol; Middle Aged; Propanolamines; Propranolol; Quality of Life; Stroke Volume; Time Factors; Vasodilator Agents; Xamoterol

1999

Trials

2 trial(s) available for xamoterol and propranolol

ArticleYear
Comparison of the effects of xamoterol, atenolol and propranolol on breathlessness, fatigue and plasma electrolytes during exercise in healthy volunteers.
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:1

    Topics: Adrenergic beta-Agonists; Adult; Atenolol; Blood Pressure; Calcium; Exercise Test; Fatigue; Heart Rate; Humans; Male; Physical Endurance; Potassium; Propanolamines; Propranolol; Xamoterol

1991
Selective adrenergic beta-2-receptor blocking drug, ICI-118.551, is effective in essential tremor.
    Acta neurologica Scandinavica, 1986, Volume: 74, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Propanolamines; Propranolol; Random Allocation; Tremor; Xamoterol

1986

Other Studies

15 other study(ies) available for xamoterol and propranolol

ArticleYear
Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists.
    Molecular pharmacology, 1999, Volume: 56, Issue:5

    Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alanine; Albuterol; Amino Acid Substitution; Animals; Binding Sites; Computer Simulation; COS Cells; Ethanolamines; Formoterol Fumarate; Humans; Models, Molecular; Norepinephrine; Procaterol; Propanolamines; Propranolol; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Recombinant Fusion Proteins; Xamoterol

1999
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Effects of xamoterol on inotropic and lusitropic properties of the human myocardium and on adenylate cyclase activity.
    American heart journal, 1990, Volume: 120, Issue:6 Pt 1

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Dose-Response Relationship, Drug; Heart Atria; Heart Failure; Humans; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Myocardium; Pindolol; Propanolamines; Propranolol; Radioligand Assay; Receptors, Adrenergic, beta; Xamoterol

1990
Comparative analysis of beta-1 adrenoceptor agonist and antagonist potency and selectivity of cicloprolol, xamoterol and pindolol.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:3

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Pindolol; Propanolamines; Propranolol; Rats; Receptors, Adrenergic, beta; Trachea; Xamoterol

1987
The metabolism of propranolol (ICI 45,520, Inderal) and xamoterol (ICI 118,587, Corwin) by isolated rat hepatocytes: in vivo-in vitro correlations.
    Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:12

    Topics: Animals; Biotransformation; Glucuronates; In Vitro Techniques; Kinetics; Liver; Male; Models, Biological; Propanolamines; Propranolol; Rats; Sulfates; Xamoterol

1988
Facilitation of calcium blocking and membrane effects by intrinsic sympathomimetic activity.
    Cardiovascular research, 1984, Volume: 18, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Atenolol; Calcium; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Heart Rate; In Vitro Techniques; Myocardial Contraction; Propanolamines; Propranolol; Verapamil; Xamoterol

1984
Effect of ICI 118,587 on left ventricular function during graded treadmill exercise in conscious dogs.
    The American journal of cardiology, 1984, Nov-01, Volume: 54, Issue:8

    Topics: Adrenergic beta-Agonists; Animals; Dogs; Heart; Heart Rate; Isoproterenol; Myocardial Contraction; Physical Exertion; Propanolamines; Propranolol; Xamoterol

1984
Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor.
    Circulation, 2003, Jul-22, Volume: 108, Issue:3

    Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atrial Function; Heart Atria; Heart Failure; Heart Rate; Humans; In Vitro Techniques; Male; Metoprolol; Mice; Mice, Transgenic; Middle Aged; Myocardial Contraction; Organ Specificity; Propanolamines; Propranolol; Receptors, Adrenergic, beta-1; Species Specificity; Xamoterol

2003
Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Sep-15, Volume: 24, Issue:37

    Topics: Adrenergic beta-Antagonists; Amygdala; Androstanols; Animals; Atenolol; Corticosterone; Emotions; Escape Reaction; Hippocampus; Hormone Antagonists; Male; Maze Learning; Mental Recall; Propranolol; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Glucocorticoid; Stress, Psychological; Xamoterol

2004
beta(2) and beta(3)-adrenoceptor inhibition of alpha(1)-adrenoceptor-stimulated Ca(2+) elevation in human cultured prostatic stromal cells.
    European journal of pharmacology, 2007, Sep-10, Volume: 570, Issue:1-3

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-3 Receptor Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Atenolol; Calcium; Cells, Cultured; Cyclic AMP; Ethanolamines; Humans; Isoproterenol; Male; Phenylephrine; Potassium Channel Blockers; Propanolamines; Propranolol; Prostate; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Stromal Cells; Xamoterol

2007
Mechanisms of β-adrenergic receptors agonists in mediating pro and anti-apoptotic pathways in hyperglycemic Müller cells.
    Molecular biology reports, 2022, Volume: 49, Issue:10

    Topics: Adrenergic beta-Agonists; Brain-Derived Neurotrophic Factor; Caspase 3; Caspase 8; Cyclic AMP Response Element-Binding Protein; Cytochromes c; Ependymoglial Cells; Glucose; Humans; Isoproterenol; Propranolol; Reactive Oxygen Species; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-2; Salmeterol Xinafoate; Xamoterol

2022