Page last updated: 2024-09-04

xamoterol and captopril

xamoterol has been researched along with captopril in 7 studies

Compound Research Comparison

Studies (xamoterol)	Trials (xamoterol)	Recent Studies (post-2010) (xamoterol)	Studies (captopril)	Trials (captopril)	Recent Studies (post-2010) (captopril)
269	80	17	10,320	1,514	890

Protein Interaction Comparison

Protein	Taxonomy	captopril (IC50)
Leukotriene A-4 hydrolase	Homo sapiens (human)	3.6
Angiotensin-converting enzyme	Homo sapiens (human)	0.084
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	0.0173
Succinyl-diaminopimelate desuccinylase	Haemophilus influenzae Rd KW20	3.3
Angiotensin-converting enzyme	Rattus norvegicus (Norway rat)	0.1004
Beta-lactamase	Pseudomonas aeruginosa	5
Angiotensin-converting enzyme 2	Homo sapiens (human)	0.011
Beta-lactamase class B VIM-2	Pseudomonas aeruginosa	3.5

Research

Studies (7)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (28.57)	18.2507
2000's	3 (42.86)	29.6817
2010's	2 (28.57)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Oakley, C; Pouleur, H; Rousseau, MF; Rydén, L	1
Bayliss, J; Darasz, KH; Keegan, J; Poole-Wilson, PA; Sutton, GC; Underwood, SR	1

Trials

2 trial(s) available for xamoterol and captopril

Article	Year
Difference in mortality between patients treated with captopril or enalapril in the Xamoterol in Severe Heart Failure Study. The American journal of cardiology, 1991, Jul-01, Volume: 68, Issue:1 Topics: Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Captopril; Cardiomyopathy, Dilated; Cause of Death; Double-Blind Method; Drug Interactions; Enalapril; Female; Follow-Up Studies; Humans; Life Tables; Male; Middle Aged; Probability; Propanolamines; Xamoterol	1991
Left ventricular volume in thrombolysed patients with acute anterior myocardial infarction: the effect of captopril and xamoterol. International journal of cardiology, 1995, Volume: 51, Issue:2 Topics: Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Cardiac Volume; Cardiotonic Agents; Dilatation, Pathologic; Double-Blind Method; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Infarction; Placebos; Prospective Studies; Stroke Volume; Thrombolytic Therapy; Ventricular Dysfunction, Left; Ventricular Function, Left; Xamoterol	1995

Article

Year

Difference in mortality between patients treated with captopril or enalapril in the Xamoterol in Severe Heart Failure Study.

The American journal of cardiology, 1991, Jul-01, Volume: 68, Issue:1

Topics: Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Captopril; Cardiomyopathy, Dilated; Cause of Death; Double-Blind Method; Drug Interactions; Enalapril; Female; Follow-Up Studies; Humans; Life Tables; Male; Middle Aged; Probability; Propanolamines; Xamoterol

1991

Left ventricular volume in thrombolysed patients with acute anterior myocardial infarction: the effect of captopril and xamoterol.

International journal of cardiology, 1995, Volume: 51, Issue:2

Topics: Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Cardiac Volume; Cardiotonic Agents; Dilatation, Pathologic; Double-Blind Method; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Infarction; Placebos; Prospective Studies; Stroke Volume; Thrombolytic Therapy; Ventricular Dysfunction, Left; Ventricular Function, Left; Xamoterol

1995

Other Studies

5 other study(ies) available for xamoterol and captopril

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013