Page last updated: 2024-09-04

xamoterol and atenolol

xamoterol has been researched along with atenolol in 16 studies

Compound Research Comparison

Studies
(xamoterol)
Trials
(xamoterol)
Recent Studies (post-2010)
(xamoterol)
Studies
(atenolol)
Trials
(atenolol)
Recent Studies (post-2010) (atenolol)
26980175,4731,950852

Protein Interaction Comparison

ProteinTaxonomyxamoterol (IC50)atenolol (IC50)
Beta-1 adrenergic receptorHomo sapiens (human)0.7468
Alpha-1D adrenergic receptorHomo sapiens (human)0.23
Alpha-1A adrenergic receptorHomo sapiens (human)0.23
Alpha-1B adrenergic receptorHomo sapiens (human)0.23

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19906 (37.50)18.7374
1990's2 (12.50)18.2507
2000's5 (31.25)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Faergeman, O; Jensen, HK; Sørensen, EV1
Lewis, RV; McDevitt, DG; McMurray, J1
Fitzgerald, DE; Harry, JD1
Folgering, HT; Lammers, JW; Müller, ME; van Herwaarden, CL1
Cuspidi, C; Fruscio, M; Gradnik, R; Leonetti, G; Rupoli, L; Sampieri, L; Terzoli, L; Zanchetti, A1
Briscoe, MG; Halliday, SE; Smith, HJ; Snow, HM1
Marlow, HF; Morton, PB; O'Neill, PA; Sharman, P; Stark, RD1
Arnold, IR; Barnett, DB; Mistry, R1
de Quervain, DJ; Hahn, EL; McGaugh, JL; Nathan, SV; Roozendaal, B1
Haynes, JM1
Hashemi-Hezaveh, SM; Sheidadoust, H; Torkaman-Boutorabi, A; Zarrindast, MR1

Trials

6 trial(s) available for xamoterol and atenolol

ArticleYear
Comparison of the effects of xamoterol, atenolol and propranolol on breathlessness, fatigue and plasma electrolytes during exercise in healthy volunteers.
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:1

    Topics: Adrenergic beta-Agonists; Adult; Atenolol; Blood Pressure; Calcium; Exercise Test; Fatigue; Heart Rate; Humans; Male; Physical Endurance; Potassium; Propanolamines; Propranolol; Xamoterol

1991
Effects of atenolol, verapamil, and xamoterol on heart rate and exercise tolerance in digitalised patients with chronic atrial fibrillation.
    Journal of cardiovascular pharmacology, 1989, Volume: 13, Issue:1

    Topics: Adrenergic beta-Agonists; Aged; Atenolol; Atrial Fibrillation; Chronic Disease; Digitalis Glycosides; Exercise Test; Female; Heart Rate; Humans; Lactates; Male; Middle Aged; Propanolamines; Verapamil; Xamoterol

1989
Effect of beta-adrenoceptor agents on the blood flow in carotid arteries in normal volunteers.
    British journal of clinical pharmacology, 1989, Volume: 28 Suppl 1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Atenolol; Blood Pressure; Carotid Arteries; Double-Blind Method; Heart Rate; Humans; Male; Propanolamines; Random Allocation; Regional Blood Flow; Xamoterol

1989
A comparative study on the ventilatory and haemodynamic effects of xamoterol and atenolol in asthmatic patients.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:5

    Topics: Adrenergic beta-Agonists; Adult; Asthma; Atenolol; Blood Pressure; Double-Blind Method; Forced Expiratory Volume; Heart Rate; Hemodynamics; Humans; Lung; Male; Middle Aged; Peak Expiratory Flow Rate; Propanolamines; Random Allocation; Terbutaline; Vital Capacity; Xamoterol

1986
Does beta 1-selective agonistic activity interfere with the antihypertensive efficacy of beta 1-selective blocking agents?
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1985, Volume: 3, Issue:3

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Benzeneacetamides; Double-Blind Method; Heart Rate; Humans; Hypertension; Propanolamines; Xamoterol

1985
In vivo regulation of human cardiac beta-adrenoceptors by a partial agonist as compared with a full antagonist: selective differences in coupling to adenylate cyclase.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:3

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Angina Pectoris; Atenolol; Double-Blind Method; Down-Regulation; Drug Tolerance; Female; Heart; Humans; Male; Middle Aged; Myocardium; Receptors, Adrenergic, beta; Xamoterol

1993

Other Studies

10 other study(ies) available for xamoterol and atenolol

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Facilitation of calcium blocking and membrane effects by intrinsic sympathomimetic activity.
    Cardiovascular research, 1984, Volume: 18, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Atenolol; Calcium; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Heart Rate; In Vitro Techniques; Myocardial Contraction; Propanolamines; Propranolol; Verapamil; Xamoterol

1984
The effects of ICI 118,587 and atenolol on the responses to exercise and on breathlessness in healthy subjects.
    British journal of clinical pharmacology, 1984, Volume: 17, Issue:1

    Topics: Adult; Atenolol; Double-Blind Method; Heart Rate; Humans; Male; Oxygen Consumption; Physical Exertion; Propanolamines; Random Allocation; Respiration; Xamoterol

1984
Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Sep-15, Volume: 24, Issue:37

    Topics: Adrenergic beta-Antagonists; Amygdala; Androstanols; Animals; Atenolol; Corticosterone; Emotions; Escape Reaction; Hippocampus; Hormone Antagonists; Male; Maze Learning; Mental Recall; Propranolol; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Glucocorticoid; Stress, Psychological; Xamoterol

2004
beta(2) and beta(3)-adrenoceptor inhibition of alpha(1)-adrenoceptor-stimulated Ca(2+) elevation in human cultured prostatic stromal cells.
    European journal of pharmacology, 2007, Sep-10, Volume: 570, Issue:1-3

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-3 Receptor Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Atenolol; Calcium; Cells, Cultured; Cyclic AMP; Ethanolamines; Humans; Isoproterenol; Male; Phenylephrine; Potassium Channel Blockers; Propanolamines; Propranolol; Prostate; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Stromal Cells; Xamoterol

2007
The possible role of medial prefrontal cortex beta-1-adrenoceptors in morphine-induced amnesia.
    Pharmacology, 2014, Volume: 93, Issue:5-6

    Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Amnesia; Animals; Atenolol; Avoidance Learning; Behavior, Animal; Male; Memory; Morphine; Prefrontal Cortex; Rats, Wistar; Receptors, Adrenergic, beta-1; Xamoterol

2014