wr 159412 has been researched along with wr 158122 in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elslager, EF; Hutt, MP; Jacob, P; Johnson, J; Rane, L; Temporelli, B; Werbel, LM; Worth, DF | 1 |
| Fukunaga, JY; Hansch, C; Jow, PY | 1 |
| Fukunaga, JY; Hansch, C; Steller, EE | 1 |
| Degnan, MJ; Werbel, LM | 1 |
| Crippen, GM; Ghose, AK | 3 |
| Battershell, C; Hopfinger, AJ; Malhotra, D | 1 |
| Crippen, GM | 1 |
| Schmidt, LH | 1 |
10 other study(ies) available for wr 159412 and wr 158122
| Article | Year |
|---|---|
Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity.
Topics: Animals; Antimalarials; Bacteria; Chemical Phenomena; Chemistry; Chickens; Drug Resistance; Folic Acid Antagonists; Haplorhini; Malaria; Mice; Plasmodium; Quinazolines | 1979 |
Quantitative structure-activity relationships of antimalarial and dihydrofolate reductase inhibition by quinazolines and 5-substituted benzyl-2,4-diaminopyrimidines.
Topics: Animals; Antimalarials; Escherichia coli; Folic Acid Antagonists; Mathematics; Mice; Microbial Sensitivity Tests; Pyrimidines; Quinazolines; Streptococcus; Structure-Activity Relationship | 1977 |
Inhibition of dihydrofolate reductase. Structure-activity correlations of quinazolines.
Topics: Binding Sites; Folic Acid Antagonists; Liver; Molecular Conformation; Quinazolines; Structure-Activity Relationship | 1976 |
Synthesis and antimalarial and antitumor effects of 2-amino-4-(hydrazino and hydroxyamino)-6-[(aryl)thio]quinazolines.
Topics: Animals; Antimalarials; Antineoplastic Agents; Hydrazines; Hydroxylamines; Mice; Quinazolines; Structure-Activity Relationship | 1987 |
General distance geometry three-dimensional receptor model for diverse dihydrofolate reductase inhibitors.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Crystallography; Folic Acid Antagonists; Liver; Models, Chemical; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Rats; Structure-Activity Relationship; Triazines | 1984 |
Combined distance geometry analysis of dihydrofolate reductase inhibition by quinazolines and triazines.
Topics: Chemical Phenomena; Chemistry; Folic Acid Antagonists; Molecular Conformation; Quinazolines; Streptococcus; Structure-Activity Relationship; Triazines | 1983 |
Quantitative structure-activity relationship by distance geometry: quinazolines as dihydrofolate reductase inhibitors.
Topics: Chemical Phenomena; Chemistry, Physical; Energy Metabolism; Folic Acid Antagonists; Molecular Conformation; Quinazolines; Receptors, Drug; Structure-Activity Relationship | 1982 |
Inhibition of dihydrofolate reductase: structure-activity correlations of quinazolines based upon molecular shape analysis.
Topics: Chemical Phenomena; Chemistry, Physical; Folic Acid Antagonists; Models, Molecular; Molecular Conformation; Quinazolines; Structure-Activity Relationship | 1981 |
Quantitative structure-activity relationships by distance geometry: systematic analysis of dihydrofolate reductase inhibitors.
Topics: Binding Sites; Folic Acid Antagonists; Ligands; Models, Biological; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Thermodynamics | 1980 |
Studies on the 2,4-diamino-6-substituted quinazolines. III. The capacity of sulfadiazine to enhance the activities of WR-158,122 and WR-159,412 against infections with various drug-susceptible and drug-resistant strains of Plasmodium falciparum and Plasmo
Topics: Animals; Aotus trivirgatus; Drug Combinations; Drug Resistance, Microbial; Female; Haplorhini; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Quinazolines; Sulfadiazine | 1979 |