Compounds > wr 1065
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wr 1065 and wr 33278

wr 1065 has been researched along with wr 33278 in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19903 (17.65)18.7374
1990's10 (58.82)18.2507
2000's4 (23.53)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fichtinger-Schepman, AM; Nijtmans, LG; Treskes, M; van der Vijgh, WJ1
Holwerda, U; Nijtmans, LG; Pinedo, HM; Treskes, M; van der Vijgh, WJ1
Holwerda, U; Klein, I; Pinedo, HM; Treskes, M; van der Vijgh, WJ1
Fahey, RC; Newton, GL1
Fahey, RC; Smoluk, GD; Ward, JF1
Bonner, HS; Glover, DJ; Kligerman, MM; Norfleet, AL; Shaw, LM; Turrisi, AT; Weiler, C1
Choe, CY; Diveley, RR; Judd, GG; Leyser, A; Mitchell, JL1
Aguilera, JA; Fahey, RC; Kim, T; Newton, GL; Ward, JF1
Aguilera, JA; Fahey, RC; Newton, GL; Ward, JF1
Bonner, H; Lieberman, R; Shaw, LM1
Charlier, M; Hugot, S; Sabattier, R; Savoye, C; Spotheim-Maurizot, M; Swenberg, C; Sy, D1
Capizzi, RL1
List, AF1
Booth, VK; Lepock, JR; Roberts, JC; Warters, RL; Wilmore, BH1
Gerner, EW; List, AF1
Grdina, DJ; Hallahan, DE; Kataoka, Y; Murley, JS; Roberts, JC1
Gerner, EW; List, AF; Quiñones, HI1

Reviews

3 review(s) available for wr 1065 and wr 33278

ArticleYear
Pharmacokinetic profile of amifostine.
    Seminars in oncology, 1996, Volume: 23, Issue:4 Suppl 8

    Topics: Amifostine; Animals; Humans; Mercaptoethylamines; Radiation-Protective Agents

1996
The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine.
    Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 7

    Topics: Amifostine; Animals; Antineoplastic Agents; Cytoprotection; Drug Evaluation, Preclinical; Humans; Mercaptoethylamines; Neoplasms; Neoplasms, Experimental; Prodrugs; Protective Agents; Radiation-Protective Agents; Tumor Cells, Cultured

1999
Use of amifostine in hematologic malignancies, myelodysplastic syndrome, and acute leukemia.
    Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 7

    Topics: Acute Disease; Amifostine; Animals; Apoptosis; Cytoprotection; Hematologic Neoplasms; Hematopoietic Stem Cells; Humans; Leukemia; Mercaptoethylamines; Molecular Structure; Myelodysplastic Syndromes; Protective Agents; Spermidine; Spermine

1999

Other Studies

14 other study(ies) available for wr 1065 and wr 33278

ArticleYear
Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethyldithiocarbamate.
    Biochemical pharmacology, 1992, Mar-03, Volume: 43, Issue:5

    Topics: Amifostine; Animals; Buffers; Cisplatin; Ditiocarb; DNA; DNA Adducts; Hydrogen-Ion Concentration; Mercaptoethylamines; Salmon; Thiosulfates

1992
The reversal of cisplatin-protein interactions by the modulating agent WR2721 and its metabolites WR1065 and WR33278.
    Cancer chemotherapy and pharmacology, 1992, Volume: 29, Issue:6

    Topics: Amifostine; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cisplatin; Ditiocarb; Drug Interactions; Drug Stability; Fumarate Hydratase; Glutathione; Kinetics; Mercaptoethylamines; Radiation-Protective Agents; Spectrophotometry, Ultraviolet

1992
The chemical reactivity of the modulating agent WR2721 (ethiofos) and its main metabolites with the antitumor agents cisplatin and carboplatin.
    Biochemical pharmacology, 1991, Nov-06, Volume: 42, Issue:11

    Topics: Amifostine; Carboplatin; Cisplatin; Drug Administration Schedule; Drug Interactions; Kinetics; Mercaptoethylamines; Radiation-Protective Agents

1991
Measurement of WR-2721, WR-1065, and WR-33278 in plasma.
    International journal of radiation oncology, biology, physics, 1985, Volume: 11, Issue:6

    Topics: Adult; Amifostine; Animals; Female; Humans; Male; Mercaptoethylamines; Methods; Organothiophosphorus Compounds; Radiation-Protective Agents; Rats; Rats, Inbred F344

1985
Equilibrium dialysis studies of the binding of radioprotector compounds to DNA.
    Radiation research, 1986, Volume: 107, Issue:2

    Topics: Amifostine; DNA; Mercaptoethylamines; Radiation-Protective Agents

1986
Human pharmacokinetics of WR-2721.
    International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:8

    Topics: Amifostine; Humans; Kinetics; Mercaptoethylamines; Neoplasms; Organothiophosphorus Compounds; Radiation-Protective Agents; Tissue Distribution

1986
Involvement of the polyamine transport system in cellular uptake of the radioprotectants WR-1065 and WR-33278.
    Carcinogenesis, 1995, Volume: 16, Issue:12

    Topics: Antimutagenic Agents; Biological Transport; Cell Line; Homeostasis; Kinetics; Mercaptoethylamines; Oxidation-Reduction; Polyamines; Radiation-Protective Agents

1995
Transport of aminothiol radioprotectors into mammalian cells: passive diffusion versus mediated uptake.
    Radiation research, 1996, Volume: 146, Issue:2

    Topics: Animals; Biological Transport; Cricetinae; Cricetulus; Diffusion; Dithiothreitol; Mercaptoethylamines; Radiation-Protective Agents

1996
Binding of radioprotective thiols and disulfides in Chinese hamster V79 cell nuclei.
    Radiation research, 1996, Volume: 146, Issue:3

    Topics: Animals; Cell Line; Cell Nucleus; Chromatin; Cricetinae; Cricetulus; Cysteamine; Cysteine; Disulfides; Glutathione; Histones; Magnesium Chloride; Mercaptoethylamines; Radiation-Protective Agents; Spermine; Structure-Activity Relationship; Sulfhydryl Compounds

1996
Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage.
    International journal of radiation biology, 1997, Volume: 71, Issue:2

    Topics: Amifostine; Base Sequence; Circular Dichroism; Computer Simulation; DNA Damage; DNA, Bacterial; Fast Neutrons; Mercaptoethylamines; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Plasmids; Radiation-Protective Agents

1997
Radioprotective thiolamines WR-1065 and WR-33278 selectively denature nonhistone nuclear proteins.
    Radiation research, 2000, Volume: 153, Issue:6

    Topics: Animals; Calorimetry, Differential Scanning; Cell Line; Cell Nucleus; Chromosomal Proteins, Non-Histone; Cricetinae; Cricetulus; Mercaptoethylamines; Polyamines; Protein Denaturation; Radiation-Protective Agents

2000
Amifostine: a tonic or toxin to myeloid progenitors.
    Leukemia research, 2000, Volume: 24, Issue:12

    Topics: Amifostine; Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Humans; Leukemia, Myeloid; Mercaptoethylamines; Myeloid Progenitor Cells; Radiation-Protective Agents

2000
Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells.
    Free radical biology & medicine, 2001, Jun-15, Volume: 30, Issue:12

    Topics: Acetylcysteine; Blotting, Northern; Catalase; Cell Line, Transformed; Dimerization; Endothelium, Vascular; Enzyme Induction; Free Radical Scavengers; Gene Expression Regulation; Humans; Hydrogen Peroxide; Intercellular Adhesion Molecule-1; Mercaptoethylamines; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Prodrugs; Pyruvates; Radiation-Protective Agents; RNA, Messenger; Skin; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2001
Selective exclusion by the polyamine transporter as a mechanism for differential radioprotection of amifostine derivatives.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:5

    Topics: Amifostine; Biological Transport; Cell Survival; Dose-Response Relationship, Drug; Eflornithine; Gene Expression; Humans; Mercaptoethylamines; Ornithine Decarboxylase Inhibitors; Polyamines; Proteins; Radiation-Protective Agents; Transfection; Tumor Cells, Cultured

2002