wl 19 and losartan
wl 19 has been researched along with losartan in 10 studies
Compound Research Comparison
| Studies (wl 19) | Trials (wl 19) | Recent Studies (post-2010) (wl 19) | Studies (losartan) | Trials (losartan) | Recent Studies (post-2010) (losartan) |
|---|---|---|---|---|---|
| 13 | 0 | 2 | 7,231 | 1,245 | 2,118 |
Protein Interaction Comparison
| Protein | Taxonomy | wl 19 (IC50) | losartan (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 9.01 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2.882 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.019 | |
| Atrial natriuretic peptide receptor 3 | Homo sapiens (human) | 0.0018 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.019 | |
| Type-1A angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0247 | |
| Type-1B angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0234 | |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | 0.0032 | |
| Type-1 angiotensin II receptor | Homo sapiens (human) | 0.047 | |
| Type-1 angiotensin II receptor | Oryctolagus cuniculus (rabbit) | 0.025 | |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0118 | |
| Type-2 angiotensin II receptor | Homo sapiens (human) | 0.019 | |
| Platelet glycoprotein VI | Homo sapiens (human) | 4 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 1.1481 | |
| Type-1 angiotensin II receptor | Cavia porcellus (domestic guinea pig) | 0.018 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 0.2884 |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Aiyar, N; Edwards, RM; Hill, DT; Keenan, RM; Stack, EJ; Weidley, EF; Weinstock, J | 1 |
| Chang, RS; Lotti, VJ; Scott, AL; Siegl, PK | 1 |
| Banks, RJ; Dourish, CT; Duggan, JA | 1 |
| Chakravarty, PK; Chang, RS; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Ondeyka, DL; Patchett, AA; Siegl, PK; Sweet, CS | 1 |
| Rampersaud, A; Steinberg, MI; Wiest, SA; Zimmerman, K | 1 |
| Gackenheimer, SL; Gehlert, DR; Schober, DA | 2 |
| Gackenheimer, SL; Gehlert, DR; Lin, HS; Reel, JK; Steinberg, MI | 1 |
| Chang, RS; Lotti, VJ | 1 |
| Hong, KW; Rhim, BY; Shin, YW; Yoo, SE | 1 |
Other Studies
10 other study(ies) available for wl 19 and losartan
| Article | Year |
|---|---|
Characterization of renal angiotensin II receptors using subtype selective antagonists.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Dithiothreitol; Guanylyl Imidodiphosphate; Imidazoles; In Vitro Techniques; Kidney; Losartan; Oligopeptides; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Thiophenes | 1992 |
Cardiac angiotensin receptors: effects of selective angiotensin II receptor antagonists, DUP 753 and PD 121981, in rabbit heart.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Biphenyl Compounds; Imidazoles; Losartan; Myocardial Contraction; Myocardium; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles | 1992 |
Drinking induced by subcutaneous injection of angiotensin II in the rat is blocked by the selective AT1 receptor antagonist DuP 753 but not by the selective AT2 receptor antagonist WL 19.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Drinking; Imidazoles; Injections, Subcutaneous; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Tetrazoles | 1992 |
In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Imidazoles; Injections, Intravenous; Losartan; Macaca mulatta; Male; Pressoreceptors; Pyridines; Rats; Rats, Inbred Strains; Tetrazoles | 1992 |
Characterization of distinct angiotensin II binding sites in rat adrenal gland and bovine cerebellum using selective nonpeptide antagonists.
Topics: Adrenal Glands; Adrenal Medulla; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Cattle; Cerebellum; Imidazoles; In Vitro Techniques; Kinetics; Losartan; Male; Peptides; Pyridines; Rabbits; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Vasoconstriction; Zona Glomerulosa | 1991 |
Angiotensin II receptor subtypes in rat brain: dithiothreitol inhibits ligand binding to AII-1 and enhances binding to AII-2.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Brain Chemistry; Dithiothreitol; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Saralasin; Tetrazoles | 1991 |
Autoradiographic localization of subtypes of angiotensin II antagonist binding in the rat brain.
Topics: Angiotensin II; Animals; Autoradiography; Binding Sites; Biphenyl Compounds; Brain; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Saralasin; Tetrazoles; Tissue Distribution | 1991 |
Non-peptide angiotensin II receptor antagonists discriminate subtypes of 125I-angiotensin II binding sites in the rat brain.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Hypothalamus; Imidazoles; Iodine Radioisotopes; Losartan; Male; Medulla Oblongata; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1990 |
Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Azoles; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Dithiothreitol; Imidazoles; In Vitro Techniques; Ligands; Losartan; Pyridines; Rats; Receptors, Angiotensin; Saralasin | 1990 |
Characterization of PD 121981- and CGP 42112-induced unmasking of low concentration effects of angiotensin II in rabbit abdominal aorta.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Abdominal; Biphenyl Compounds; Calcium; Dithiothreitol; Female; Gallic Acid; Imidazoles; Losartan; Male; Nifedipine; Oligopeptides; Pyridines; Rabbits; Tetrazoles; Vasoconstriction | 1994 |