Page last updated: 2024-09-04

withanolide d and withaferin a

withanolide d has been researched along with withaferin a in 9 studies

Compound Research Comparison

Studies
(withanolide d)
Trials
(withanolide d)
Recent Studies (post-2010)
(withanolide d)
Studies
(withaferin a)
Trials
(withaferin a)
Recent Studies (post-2010) (withaferin a)
2501159022454

Protein Interaction Comparison

ProteinTaxonomywithanolide d (IC50)withaferin a (IC50)
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 20.585
Nuclear factor NF-kappa-B p105 subunitHomo sapiens (human)0.047
Nuclear factor NF-kappa-B p100 subunit Homo sapiens (human)0.047
Transcription factor p65Homo sapiens (human)0.047

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's2 (22.22)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Batista, PHJ; Gunatilaka, AAL; Mafezoli, J; Minguzzi, S; Oliveira, MCF; Pessoa, ODL; Whitesell, L; Wijeratne, EMK; Xu, YM1
Cuendet, M; Freitas Misakyan, MF; Gunatilaka, AAL; Issa, ME; Monteillier, A; Wijeratne, EMK; Xu, YM1
Chowdhury, K; Neogy, RK1
Chakraborti, SK; Chatterjee, S1
Jha, S; Ray, S1
Choudhary, MI; Ganzera, M; Khan, IA1
Bargagna-Mohan, P; Mohan, R; Ravindranath, PP1
Kumar, G; Patnaik, R1
Choi, SM; Dash, R; Hannan, MA; Haque, MN; Moon, IS1

Other Studies

9 other study(ies) available for withanolide d and withaferin a

ArticleYear
Withaferin A and Withanolide D Analogues with Dual Heat-Shock-Inducing and Cytotoxic Activities: Semisynthesis and Biological Evaluation.
    Journal of natural products, 2018, 04-27, Volume: 81, Issue:4

    Topics: Biological Products; Cell Line; Cell Line, Tumor; Cytotoxins; Heat-Shock Response; HEK293 Cells; Humans; Iodine; Organophosphorus Compounds; Sarcoma, Ewing; Structure-Activity Relationship; Withanolides

2018
Structure-Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model.
    Journal of natural products, 2021, 08-27, Volume: 84, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Coculture Techniques; Humans; Molecular Structure; Multiple Myeloma; Structure-Activity Relationship; Withania; Withanolides

2021
Mode of action of Withaferin A and Withanolide D.
    Biochemical pharmacology, 1975, Apr-15, Volume: 24, Issue:8

    Topics: Animals; Antineoplastic Agents; Cholestenes; Cholestenones; Depression, Chemical; Ethers, Cyclic; Lactones; Male; Mice; Neoplasm Transplantation; Phenylalanine; RNA, Neoplasm; Sarcoma 180; Transplantation, Homologous; Uracil; Withanolides

1975
Antimicrobial activities of some antineoplastic and other withanolides.
    Antonie van Leeuwenhoek, 1980, Volume: 46, Issue:1

    Topics: Antineoplastic Agents; Aspergillus niger; Bacillus; Bacteria; Candida albicans; Enterobacteriaceae; Ergosterol; Fungi; Lactones; Saccharomyces cerevisiae; Staphylococcus aureus; Structure-Activity Relationship; Withanolides

1980
Production of withaferin A in shoot cultures of Withania somnifera.
    Planta medica, 2001, Volume: 67, Issue:5

    Topics: Adenine; Agar; Antineoplastic Agents, Phytogenic; Benzyl Compounds; Carbon; Culture Media; Culture Techniques; Ergosterol; Kinetin; Plant Extracts; Plant Growth Regulators; Plant Shoots; Purines; Solanaceae; Withanolides

2001
Quantitative HPLC analysis of withanolides in Withania somnifera.
    Fitoterapia, 2003, Volume: 74, Issue:1-2

    Topics: Chromatography, High Pressure Liquid; Ergosterol; Humans; Phytotherapy; Plant Extracts; Plant Leaves; Plant Roots; Plant Stems; Reproducibility of Results; Withania; Withanolides

2003
Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: potential application to choroidal neovascularization.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:9

    Topics: Angiogenesis Inhibitors; Blotting, Western; Cells, Cultured; Choroid; Choroidal Neovascularization; Endothelium, Vascular; Ergosterol; Growth Substances; Heme Oxygenase-1; Humans; I-kappa B Proteins; Neovascularization, Physiologic; NF-KappaB Inhibitor alpha; Plant Extracts; Plants, Medicinal; Proteasome Endopeptidase Complex; Ubiquitin; Umbilical Veins; Withanolides

2006
Exploring neuroprotective potential of Withania somnifera phytochemicals by inhibition of GluN2B-containing NMDA receptors: An in silico study.
    Medical hypotheses, 2016, Volume: 92

    Topics: Allosteric Site; Blood-Brain Barrier; Humans; Ligands; Molecular Conformation; Molecular Docking Simulation; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuroprotection; Phytochemicals; Receptors, N-Methyl-D-Aspartate; Sitosterols; Withania; Withanolides

2016
Integrated System Pharmacology and
    CNS & neurological disorders drug targets, 2020, Volume: 19, Issue:7

    Topics: Alzheimer Disease; Computer Simulation; Glycogen Synthase Kinase 3 beta; Humans; Phosphatidylinositol 3-Kinases; Plant Extracts; Sitosterols; Withania; Withanolides

2020