willardiine has been researched along with kainic acid in 10 studies
| Studies (willardiine) | Trials (willardiine) | Recent Studies (post-2010) (willardiine) | Studies (kainic acid) | Trials (kainic acid) | Recent Studies (post-2010) (kainic acid) |
|---|---|---|---|---|---|
| 43 | 0 | 10 | 9,540 | 3 | 1,775 |
| Protein | Taxonomy | willardiine (IC50) | kainic acid (IC50) |
|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 3 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 4 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 5 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | 0.0126 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bleakman, D; Deverill, M; Hoo, K; Jane, DE; Kamboj, R; Mandelzys, A | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Butini, S; Campiani, G; Christensen, JK; Coccone, SS; De Angelis, M; Fiorini, I; Gemma, S; Guarino, E; Morelli, E; Novellino, E; Pickering, DS; Schousboe, A; Trotta, F | 1 |
| Jane, DE; Mayer, ML; Patneau, DK; Watkins, JC | 1 |
| Jane, DE; Mayer, ML; Watkins, JC; Wong, LA | 1 |
| Bowie, D; Smart, TG | 1 |
| Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P; Varga, V | 1 |
| Gouaux, E; Jin, R | 1 |
| Ahmed, AH; Fenwick, MK; Jane, DE; Maltsev, AS; Oswald, RE | 1 |
| Tobi, D | 1 |
10 other study(ies) available for willardiine and kainic acid
| Article | Year |
|---|---|
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
Topics: Alanine; Cell Line; Excitatory Amino Acid Agonists; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidinones; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Triazines; Uracil | 1997 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Topics: Animals; Cell Line; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Humans; Ligands; Molecular Structure; Oocytes; Pyrimidinones; Rats; Receptors, Glutamate; Spodoptera; Structure-Activity Relationship; Thiophenes; Xenopus laevis | 2008 |
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Ibotenic Acid; Isomerism; Kainic Acid; Kinetics; Mathematics; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Pyrimidinones; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Structure-Activity Relationship; Uracil | 1992 |
Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Dose-Response Relationship, Drug; Ganglia, Spinal; Hippocampus; Kainic Acid; Kinetics; Neurons; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Time Factors; Uracil | 1994 |
Thiocyanate ions selectively antagonize AMPA-evoked responses in Xenopus laevis oocytes microinjected with rat brain mRNA.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Cell Membrane; Cerebellum; Electrophysiology; Female; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Microinjections; Neurons; Oocytes; Pregnancy; Pyrimidinones; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thiocyanates; Uracil; Xenopus laevis | 1993 |
Interference of S-nitrosoglutathione with the binding of ligands to ionotropic glutamate receptors in pig cerebral cortical synaptic membranes.
Topics: Alanine; Animals; Binding, Competitive; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Kainic Acid; Kinetics; Ligands; Neuroprotective Agents; Nitroso Compounds; Piperazines; Pyrimidinones; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Swine; Synaptic Membranes; Uracil | 2000 |
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Uracil | 2003 |
Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution.
Topics: Alanine; Animals; Crystallography, X-Ray; Glutamic Acid; Kainic Acid; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptors, AMPA; Solutions; Uracil | 2008 |
Dynamical differences of hemoglobin and the ionotropic glutamate receptor in different states revealed by a new dynamics alignment method.
Topics: 2,3-Diphosphoglycerate; Alanine; Algorithms; Allosteric Site; Animals; Binding Sites; Excitatory Amino Acid Agonists; Halogenation; Hemoglobins; Humans; Kainic Acid; Ligands; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Rats; Receptors, AMPA; Sequence Alignment; Sequence Homology, Amino Acid; Thermodynamics; Uracil | 2017 |