Page last updated: 2024-09-04

willardiine and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

willardiine has been researched along with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid in 11 studies

Compound Research Comparison

Studies
(willardiine)
Trials
(willardiine)
Recent Studies (post-2010)
(willardiine)
Studies
(alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)
Trials
(alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)
Recent Studies (post-2010) (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)
430102,89911609
430102403

Protein Interaction Comparison

ProteinTaxonomywillardiine (IC50)alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (IC50)
Glutamate receptor 1Rattus norvegicus (Norway rat)0.157
Glutamate receptor 2Rattus norvegicus (Norway rat)0.1765
Glutamate receptor 3Rattus norvegicus (Norway rat)0.1765
Glutamate receptor 4Rattus norvegicus (Norway rat)0.1765
Glutamate receptor 1Mus musculus (house mouse)0.04
Glutamate receptor 2Mus musculus (house mouse)0.04
Glutamate receptor 1Homo sapiens (human)0.1353
Glutamate receptor 2Homo sapiens (human)0.1353
Glutamate receptor 3Homo sapiens (human)0.1353
Glutamate receptor 4Homo sapiens (human)0.1353
Glutamate receptor 4Mus musculus (house mouse)0.04
Glutamate receptor 3Mus musculus (house mouse)0.04

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (54.55)18.2507
2000's5 (45.45)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Butini, S; Campiani, G; Christensen, JK; Coccone, SS; De Angelis, M; Fiorini, I; Gemma, S; Guarino, E; Morelli, E; Novellino, E; Pickering, DS; Schousboe, A; Trotta, F1
Jane, DE; Mayer, ML; Patneau, DK; Watkins, JC1
Jane, DE; Mayer, ML; Watkins, JC; Wong, LA1
Beaver, KM; Hawkins, LM; Jane, DE; Roberts, PJ; Sunter, DC; Taylor, PM1
Bowie, D; Smart, TG1
Beart, PM; Ganakas, AM; Lawrence, AJ; Lunn, ML; Mercer, LD1
Gouaux, E; Jin, R1
Alt, A; Bleakman, D; Collingridge, GL; Dolman, NP; Jane, DE; Knauss, JL; More, JC; Troop, HM1
Jayaraman, V; Mankiewicz, KA; Rambhadran, A; Wathen, L1
Bleakman, D; Deverill, M; Hoo, K; Jane, DE; Kamboj, R; Mandelzys, A1
Barinka, C; Hlouchová, K; Konvalinka, J; Lubkowski, J; Majer, P; Mlcochová, P; Plechanovová, A; Rovenská, M; Slusher, BS; Tsukamoto, T1

Other Studies

11 other study(ies) available for willardiine and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

ArticleYear
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
    Journal of medicinal chemistry, 2008, Oct-23, Volume: 51, Issue:20

    Topics: Animals; Cell Line; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Humans; Ligands; Molecular Structure; Oocytes; Pyrimidinones; Rats; Receptors, Glutamate; Spodoptera; Structure-Activity Relationship; Thiophenes; Xenopus laevis

2008
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:2

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Ibotenic Acid; Isomerism; Kainic Acid; Kinetics; Mathematics; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Pyrimidinones; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Structure-Activity Relationship; Uracil

1992
Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:6

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Dose-Response Relationship, Drug; Ganglia, Spinal; Hippocampus; Kainic Acid; Kinetics; Neurons; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Time Factors; Uracil

1994
Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine.
    Neuropharmacology, 1995, Volume: 34, Issue:4

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Male; Pyrimidinones; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Stereoisomerism; Synaptic Membranes; Tritium; Uracil

1995
Thiocyanate ions selectively antagonize AMPA-evoked responses in Xenopus laevis oocytes microinjected with rat brain mRNA.
    British journal of pharmacology, 1993, Volume: 109, Issue:3

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Cell Membrane; Cerebellum; Electrophysiology; Female; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Microinjections; Neurons; Oocytes; Pregnancy; Pyrimidinones; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thiocyanates; Uracil; Xenopus laevis

1993
Localisation and properties of AMPA-insensitive kainate sites: receptor autoradiography and gene expression in rat brain.
    Neuroscience letters, 1996, Feb-02, Volume: 204, Issue:1-2

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Base Sequence; Brain; Brain Chemistry; Excitatory Amino Acid Agonists; Gene Expression Regulation; In Vitro Techniques; Male; Molecular Sequence Data; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Uracil

1996
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.
    Biochemistry, 2003, May-13, Volume: 42, Issue:18

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Uracil

2003
Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.
    Journal of medicinal chemistry, 2006, Apr-20, Volume: 49, Issue:8

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cell Line; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Molecular Structure; Pyrimidinones; Rats; Receptors, Kainic Acid; Recombinant Proteins; Structure-Activity Relationship; Time Factors; Uracil

2006
Chemical interplay in the mechanism of partial agonist activation in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
    Biochemistry, 2008, Jan-08, Volume: 47, Issue:1

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cell Line; Fluorescence Resonance Energy Transfer; Humans; Protein Binding; Protein Conformation; Protein Structure, Secondary; Pyrimidinones; Receptors, AMPA; Spectroscopy, Fourier Transform Infrared; Uracil

2008
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
    Journal of medicinal chemistry, 1997, Oct-24, Volume: 40, Issue:22

    Topics: Alanine; Cell Line; Excitatory Amino Acid Agonists; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidinones; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Triazines; Uracil

1997
Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.
    Journal of medicinal chemistry, 2007, Jul-12, Volume: 50, Issue:14

    Topics: Crystallography, X-Ray; Glutamate Carboxypeptidase II; Humans; Models, Molecular; Molecular Mimicry; Protein Conformation; Recombinant Proteins

2007