wb 4101 has been researched along with prazosin in 166 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (19.28) | 18.7374 |
| 1990's | 97 (58.43) | 18.2507 |
| 2000's | 30 (18.07) | 29.6817 |
| 2010's | 6 (3.61) | 24.3611 |
| 2020's | 1 (0.60) | 2.80 |
| Authors | Studies |
|---|---|
| Blaxall, HS; Bylund, DB; Caron, MG; Iversen, LJ; Lefkowitz, RJ; Lomasney, JW | 1 |
| Janssen, CG; Laduron, PM; Thijssen, JB; Van Dun, J; Wouters, W | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Timmermans, PB; van Zwieten, PA | 1 |
| Foglar, R; Horie, K; Obika, K; Ogawa, S; Sakamoto, A; Shibata, K; Tsujimoto, G | 1 |
| Bondinell, WE; Hieble, JP; Ruffolo, RR | 1 |
| Denis-Pouxviel, C; Devedjian, JC; Esclapez, F; Paris, H | 1 |
| Neubig, RR; Porter, AC; Uhlén, S | 1 |
| Ballard, S; Blagg, J; Fox, D; Kenny, B | 1 |
| Chang, DJ; Clarke, DE; Daniels, DV; Ford, AP; Gever, JR; Jasper, JR; Lesnick, JD | 1 |
| Bach, C; Bhakta, S; Chan, HW; Chang, DJ; Chang, TK; Clarke, DE; Daniels, DV; Eglen, RM; Ford, AP; Jasper, JR; Khare, R; Kosaka, AH; Lesnick, JD; Salazar, FH; Shieh, IS; Yamanishi, SS | 1 |
| Chang, DJ; Clarke, DE; Daniels, DV; Ford, AP; Gever, JR; Jasper, JR; Kava, MS; Lesnick, JD; Meloy, TD; Stepan, G; Williams, TJ | 1 |
| Beroza, P; Bradley, EK; Grootenhuis, PD; Miller, JL; Penzotti, JE; Spellmeyer, DC | 1 |
| Gaivin, RJ; Gonzalez-Cabrera, P; Perez, DM; Ross, SA; Waugh, DJ; Yun, J; Zuscik, MJ | 1 |
| Antonello, A; Bolognesi, ML; Cavalli, A; Leonardi, A; Marucci, G; Melchiorre, C; Minarini, A; Poggesi, E; Rosini, M | 1 |
| Pedretti, A; Testa, B; Villa, L; Vistoli, G | 1 |
| Bariwal, JB; Chauhan, BS; Jain, KS; Kathiravan, MK; Phoujdar, MS; Sahne, RS; Shah, AK; Yadav, MR | 1 |
| Bienkowski, P; Bucki, A; Jaśkowska, J; Kazek, G; Kowalski, P; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Mitka, K; Pawłowski, M; Siwek, A; Wasik, A; Wesołowska, A | 1 |
| Bienkowski, P; Bucki, A; Jastrzębska-Więsek, M; Kazek, G; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Siwek, A; Śniecikowska, J; Wasik, A; Wesołowska, A | 1 |
| Avery, BA; Behnke, M; Chear, NJ; Hiranita, T; Kamble, SH; León, F; McCurdy, CR; McMahon, LR; Obeng, S; Patel, A; Ramanathan, S; Reeves, ME; Restrepo, LF; Sharma, A | 1 |
| Etgen, AM; Karkanias, GB; Petitti, N | 1 |
| Kojima, C; Satoh, M; Takayanagi, I | 2 |
| Blanc, G; Glowinski, J; Hervé, D; Tassin, JP; Trovero, F; Vézina, P | 1 |
| Hiramatsu, Y; Kigoshi, S; Muramatsu, I; Muraoka, R | 2 |
| Nijkamp, FP; van Buuren, KJ; Veenstra, DM | 1 |
| Hayakawa, H; Shimizu, M; Yamawaki, S | 1 |
| Kigoshi, S; Muramatsu, I; Ohmura, T; Oshita, M | 1 |
| Abel, PW; Feng, F; Jeffries, WB; Pettinger, WA | 1 |
| García-Sáinz, JA; Torres-Márquez, ME; Villalobos-Molina, R | 1 |
| Malik, KU; Schwartz, DD | 1 |
| Piascik, MT; Pruitt, TA; Soltis, EE; Sparks, MS | 1 |
| Blendy, JA; Kellar, KJ; Pabreza, LA; Perry, DC | 1 |
| Chiang, J; Hermodsson, G; Oie, S | 1 |
| Atlas, D; Manolopoulos, VG; Pipili-Synetos, E; Synetos, D | 1 |
| Felder, CC; Kanterman, RY; McCune, SK; Voigt, MM | 1 |
| Moser, PC | 1 |
| Luchelli-Fortis, MA | 1 |
| Hashimoto, S; Kigoshi, S; Muramatsu, I; Ohmura, T; Oshita, M | 1 |
| Blendy, JA; Grimm, LJ; Kellar, KJ; Perry, DC; West-Johnsrud, L | 1 |
| Butler, BT; Kusiak, JW; Piascik, MT; Pruitt, TA | 1 |
| Terman, BI | 1 |
| Minneman, KP; Wilson, KM | 1 |
| Bevan, JA; Oriowo, MA | 1 |
| Gross, G; Hanft, G | 1 |
| Bowersox, S; Ciaranello, R; Dement, WC; Frusthofer, B; Guilleminault, C; Maddaluno, J; Mignot, E; Nishino, S | 1 |
| Klaassen, AB; Rodrigues de Miranda, JF; van Ginneken, CA; van Megen, YJ; Wentges, RT | 1 |
| Chiang, J; Oie, S | 1 |
| Mittag, TW; Podos, SM; Severin, C; Tormay, A | 1 |
| Bertini, R; Brancia, E; Brasili, L; Giardinà, D; Melchiorre, C | 1 |
| Candy, JM; Court, JA; Fowler, CJ; O'Carroll, AM | 1 |
| Gonzales, DA; Peroutka, SJ; Shapiro, M | 1 |
| Gherezghiher, T; Hey, JA; Koss, MC | 1 |
| Consolo, S; Forloni, GL; Ladinsky, H; Vinci, R; Wang, JX | 1 |
| Mittag, TW; Tormay, A | 1 |
| Battaglia, G; Creese, I; Morrow, AL; Norman, AB | 1 |
| Creese, I; Morrow, AL | 1 |
| Jhanwar-Uniyal, M; Leibowitz, SF | 1 |
| Battaglia, G; Creese, I; Loy, R; Morrow, AL; Norman, AB | 1 |
| Alexander, RW; Colucci, WS; Gimbrone, MA | 1 |
| Bhatnagar, RK; Farley, DB; Ford, SP; Reynolds, LP; Van Orden, DE | 1 |
| Lyon, TF; Randall, WC | 1 |
| Dubocovich, ML; Langer, SZ; Massingham, R; Shepperson, NB | 1 |
| Humphrey, SJ; McCall, RB | 1 |
| Daiguji, M; Meltzer, HY; U'Prichard, DC | 1 |
| Briley, MS; Langer, SZ; Wetzel, HW | 1 |
| Harris, A; Swamy, VC; Triggle, DJ; Waters, DH | 1 |
| Eckelman, WC; Francis, B; Gibson, RE; Grissom, MP; Reba, RC | 1 |
| Baldwin, JJ; Gross, D; Lundell, GF; Lyon, TF; McClure, DE; Mensler, K; Raab, AW; Randall, WC; Risley, EA; Sweet, CS; Williams, M | 1 |
| Culvenor, AJ; Jarrott, B; Louis, WJ; Summers, RJ | 1 |
| Hoffman, BB; Lefkowitz, RJ | 1 |
| Proudfit, HK; Sagen, J | 1 |
| DeGroff, V; Fishman, J; McEwen, BS; Paden, CM; Snyder, L | 1 |
| Billman, GE | 1 |
| Akino, H; Gobara, M; Kigoshi, S; Muramatsu, I; Ohmura, T; Okada, K; Oshita, M | 1 |
| Andersson, PO; Burt, RP; Chapple, CR; Greengrass, P; Marshall, I; Wyllie, M | 1 |
| Badia, A; Gascón, S; Ivorra, D; Vila, E | 1 |
| Bigg, DC; Koek, W; Sleight, AJ | 1 |
| Adachi, M; Manita, S; Matsuda, T; Shigenobu, K; Tanaka, H | 1 |
| Kocić, I | 1 |
| Aston, N; Chess-Williams, R; Couldwell, C | 1 |
| Bowdish, DM; Gaspar, V; Low, AM; Prashad, TR | 1 |
| John, GW; Le Grand, B; Marty, A; Talmant, JM; Vieu, S | 1 |
| Kigoshi, S; Muramatsu, I; Muraoka, R; Noguchi, H | 1 |
| Kokubu, N; Satoh, M; Takayanagi, I | 1 |
| Edwards, FR; Hill, CE; Hirst, GD; Klemm, M | 1 |
| Badia, A; Dierssen, M; Gascón, S; Màrmol, F; Vivas, NM | 1 |
| Kennedy, RH; Lindemann, JP; Seifen, E; Williamson, AP | 1 |
| Badia, A; Sallés, J | 1 |
| Daniel, EE; Hoo, KH; Kwan, CY | 1 |
| Blanc, G; Glowinski, J; Godeheu, AM; Hervé, D; Tassin, JP; Trovero, F; Vezina, P | 1 |
| Oriowo, MA | 1 |
| Kigoshi, S; Kohno, Y; Muramatsu, I; Saito, H; Takita, M | 1 |
| Kennedy, RH; Lindemann, JP; Seifen, E; Stimers, JR; Williamson, AP | 1 |
| Hayashi, H; Kigoshi, S; Muramatsu, I; Ohmura, T; Sakamoto, S | 1 |
| Hagino, Y; Hasegawa, S; Kondo, H; Nomura, H; Nomura, T; Sumi-Ichinose, C; Tachibana, M; Ukai, K; Watanabe, T; Yokoyama, R | 1 |
| Mironneau, C; Mironneau, J; Neuilly, G; Rakotoarisoa, L; Sayet, I | 1 |
| Hatano, A; Koizumi, T; Komeyama, T; Takahashi, H; Takeda, M; Tamaki, M; Tsutsui, T | 1 |
| Chen, BH; Chen, GT; Creveling, CR; Daly, JW; Gusovsky, F; King, M; Kirk, KL; Nie, JY | 1 |
| Docherty, JR; Kearns, S; O'Rourke, M | 1 |
| Hayashi, H; Hiraoka, Y; Muramatsu, I; Ohmura, T; Sakamoto, S | 1 |
| Kiem, DT; Makara, GB; Vizi, ES | 1 |
| Giannella, M; Leonardi, A; Melchiorre, C; Piergentili, A; Pigini, M; Quaglia, W; Taddei, C; Tayebati, SK | 1 |
| Aghajanian, GK; Marek, GJ | 1 |
| Bencsics, A; Elenkov, IJ; Vizi, ES | 1 |
| Akaishi, Y; Hattori, Y; Kanno, M; Nagashima, M | 1 |
| Badia, A; Gascón, S; Sallés, J | 1 |
| Chapple, CR; Chess-Williams, R; Couldwell, CJ; Michel, MC; Noble, AJ; Verfurth, F | 1 |
| Dóda, M | 1 |
| Cassels, BK; D'Ocon, P; Elorriaga, M; Ivorra, MD; Madrero, Y; Martinez, S; Noguera, MA | 1 |
| Bremner, JB; Coban, B; Griffith, R | 1 |
| Homuth, V; Luther, HP; Wallukat, G | 1 |
| Dyer, DC; Hu, XQ | 1 |
| Bricola, A; Jurkiewicz, A; Jurkiewicz, NH | 1 |
| Badia, A; Giraldo, J; Tabernero, A; Vila, E; Vivas, NM | 1 |
| Chiba, T; Fukutomi, J; Hattori, K; Maruyama, K; Nagatomo, T; Takeda, M; Yamaguchi, M | 1 |
| Macmillan, JB; McGrath, JC; Smith, KM | 1 |
| Hussain, MB; Marshall, I | 2 |
| Endoh, M; Yang, HT | 1 |
| Hasegawa, Y; Ono, H; Wada, T | 1 |
| Kadavil, EA; Oriowo, MA; Yousif, M | 1 |
| Brown, RD; Daniel, EE; Kwan, CY; Low, AM; Lu-Chao, H; Wang, YF | 1 |
| Fang, F; Proudfit, HK | 1 |
| Avkiran, M; Yasutake, M; Yokoyama, H | 1 |
| Foster, HE; Latifpour, J; Nishi, K; Saito, M; Weiss, RM; Yoshida, M | 1 |
| Bolognesi, ML; Budriesi, R; Chiarini, A; Giardinà, D; Leonardi, A; Melchiorre, C; Minarini, A; Quaglia, W | 1 |
| Hattori, K; Makara, Y; Maruyama, K; Nagatomo, T; Ohnuki, T; Suzuki, M; Tsuchiya, M; Watanabe, K | 1 |
| Caramona, MM; Figueiredo, IV; Guimarães, S; Moura, D; Paiva, MQ | 1 |
| Du, XJ; Han, C; Yan, M; Zhang, Y | 1 |
| Hiraoka, Y; Kato, H; Morikawa, K; Muramatsu, I; Nagata, O; Ohmura, T; Oshita, M; Taniguchi, T; Watanabe, Y | 1 |
| Barna, I; Kiem, DT; Makara, GB; Zelena, D | 1 |
| Davies, MG; Hagen, PO; Huynh, TT | 1 |
| Avellar, MC; Megale, A; Porto, CS; Silva, MA | 1 |
| Arias-Montaño, JA; Berger, VA; Soria-Jasso, LE; Young, JM | 1 |
| Chin, C; Lau, WA; Pennefather, JN; Story, ME; Ventura, S | 1 |
| Antzelevitch, C; Burashnikov, A | 1 |
| Sasa, M; Tanimitsu, N; Tsuru, H; Yajin, K | 1 |
| Adya, HV; Faisal, M; Mallick, BN | 1 |
| Angeli, P; Bolognesi, ML; Chiarini, A; Giardinà, D; Gulini, U; Leonardi, A; Marucci, G; Melchiorre, C; Minarini, A; Pigini, M; Quaglia, W; Rosini, M; Tumiatti, V | 1 |
| Eckert, RE; Karsten, AJ; Utz, J; Ziegler, M | 1 |
| Daly, CJ; Heeley, RP; MacKenzie, JF; McGrath, JC; Pediani, JD | 1 |
| Chen, PC; Cheng, JT; Liu, IM; Yen, ST | 1 |
| Hillier, C; Jarajapu, YP; MacDonald, A | 1 |
| Koike, K; Yamamoto, Y | 2 |
| Chiba, S; Taguchi, Y; Yang, XP | 1 |
| Katus, HA; Kemken, D; Kurz, T; Mier, K; Richardt, G | 1 |
| Dyer, DC; Ioudina, MV | 1 |
| Horinouchi, T; Koike, K; Shibano, M; Tanaka, Y; Yamamoto, Y | 1 |
| Bonnal, JL; Dewailly, E; Lemonnier, L; Mauroy, B; Prevarskaya, N; Roudbaraki, M; Shuba, Y; Skryma, R; Slomianny, C; Sydorenko, V; Thebault, S | 1 |
| Koss, MC; Yu, Y | 1 |
| Campos, M; Morais, Pde L; Pupo, AS | 1 |
| Capello, SA; Chou, EC; Levin, RM; Longhurst, PA | 1 |
| Cheng, JT; Tang, LM; Tong, YC | 1 |
| Chen, K; Chen, M; Han, C; Lu, Z; Song, Y; Yan, J; Zhang, Y | 1 |
| Gray, KT; Ventura, S | 1 |
| Avellar, MC; Caricati-Neto, A; Jurkiewicz, A; Jurkiewicz, NH; Reuter, HR; Verde, LF | 1 |
| Doze, VA; Hillman, KL; Porter, JE | 1 |
| Centurión, D; Görnemann, T; Jähnichen, S; Kleuser, B; Pertz, HH; Villalón, CM; von Wenckstern, H | 1 |
| Clair, DK; García-Cazarín, ML; Piascik, MT; Smith, JL | 1 |
| Ehara, T; Ichishima, K; Iwamoto, T; Yamamoto, S | 1 |
| Centurión, D; Hofmann, RA; Jantschak, F; Pertz, HH; Popp, AM; Villalón, CM | 1 |
| Bockman, CS; Dang, HK; Gruber, DD; Scofield, MA; Wangemann, P; Witt, KM | 1 |
| Bielawski, A; Coccurello, R; D'Amato, FR; Kowalska, M; Nalepa, I; Vetulani, J; Zelek-Molik, A | 1 |
6 review(s) available for wb 4101 and prazosin
| Article | Year |
|---|---|
alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.
Topics: Adipose Tissue; Animals; Blood Platelets; Central Nervous System; Humans; Islets of Langerhans; Melanocytes; Muscle, Smooth, Vascular; Nerve Endings; Norepinephrine; Parasympathetic Nervous System; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Serotonin; Synapses | 1982 |
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Topics: Animals; Humans; Molecular Biology; Molecular Structure; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1995 |
Pharmacological options in the treatment of benign prostatic hyperplasia.
Topics: 5-alpha Reductase Inhibitors; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Controlled Clinical Trials as Topic; Endothelins; Enzyme Inhibitors; Humans; Male; Prostate; Prostatic Hyperplasia; Receptors, Adrenergic, alpha; Structure-Activity Relationship | 1997 |
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Humans; Hypertension; Molecular Structure; Receptors, Adrenergic, alpha-1; Risk Factors; Stereoisomerism; Structure-Activity Relationship | 2008 |
Search for selective antagonists at alpha 1-adrenoreceptors: neutral or negative antagonism?
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Humans; Prazosin; Receptors, Adrenergic, alpha-1; Structure-Activity Relationship | 1998 |
Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Humans; Prazosin; Quinazolines | 2000 |
160 other study(ies) available for wb 4101 and prazosin
| Article | Year |
|---|---|
Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning.
Topics: Adrenergic alpha-Antagonists; Animals; Cell Line; Cell Membrane; Cloning, Molecular; DNA; Humans; Lung; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tumor Cells, Cultured | 1992 |
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.
Topics: Animals; Binding, Competitive; Brain; Chemical Phenomena; Chemistry; Frontal Lobe; Guinea Pigs; Ketanserin; Kinetics; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1986 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Calcium; Cell Line; CHO Cells; Clonidine; Cloning, Molecular; Cricetinae; Humans; Indoles; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Sulfonamides; Tamsulosin | 1995 |
Further characterization of human alpha 2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Line; Dioxanes; Humans; Idazoxan; Plasmids; Radioligand Assay; Receptors, Adrenergic, alpha; Transfection | 1994 |
The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; CHO Cells; Cricetinae; Dibenzazepines; Humans; Imidazoles; Indoles; Isoindoles; Quinolizines; Radioligand Assay; Receptors, Adrenergic, alpha-2 | 1994 |
Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications for alpha1-adrenoceptor classification.
Topics: Adrenergic Agents; Animals; CHO Cells; Cloning, Molecular; Cricetinae; Humans; Inositol Phosphates; Radioligand Assay; Receptors, Adrenergic, alpha-1; Recombinant Proteins | 1997 |
Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms.
Topics: Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Cloning, Molecular; Cricetinae; Gene Library; Humans; Inositol Phosphates; Male; Molecular Sequence Data; Polymerase Chain Reaction; Prostate; Radioligand Assay; Receptors, Adrenergic, alpha-1; Recombinant Proteins; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Transfection | 1998 |
Human cloned alpha1A-adrenoceptor isoforms display alpha1L-adrenoceptor pharmacology in functional studies.
Topics: Adrenergic alpha-Agonists; Animals; CHO Cells; Cloning, Organism; Cricetinae; Humans; In Vitro Techniques; Inositol Phosphates; Protein Isoforms; Receptors, Adrenergic, alpha-1; Recombinant Proteins | 1999 |
A rapid computational method for lead evolution: description and application to alpha(1)-adrenergic antagonists.
Topics: Adrenergic alpha-Antagonists; Databases, Factual; Drug Design; Glycine; Heterocyclic Compounds; Ligands; Models, Molecular; Molecular Conformation; Receptors, Adrenergic, alpha-1 | 2000 |
Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Cell Membrane; Clonidine; Conserved Sequence; Cricetinae; Dihydropyridines; Dioxanes; Humans; Imidazoles; Models, Molecular; Molecular Sequence Data; Oxymetazoline; Phenylalanine; Piperazines; Prazosin; Protein Structure, Secondary; Rats; Receptors, Adrenergic, alpha-1; Structure-Activity Relationship | 2001 |
Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors.
Topics: Acetylcholinesterase; Adrenergic alpha-Antagonists; Aminoacridines; Animals; Aorta, Thoracic; CHO Cells; Cholinesterase Inhibitors; Cricetinae; Dioxanes; Humans; In Vitro Techniques; Male; Models, Molecular; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Piperazines; Prazosin; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Structure-Activity Relationship; Vas Deferens | 2003 |
Range and sensitivity as descriptors of molecular property spaces in dynamic QSAR analyses.
Topics: Chemical Phenomena; Chemistry, Physical; Ligands; Models, Molecular; Molecular Conformation; Monte Carlo Method; Quantitative Structure-Activity Relationship; Receptors, Adrenergic, alpha-1; Solvents | 2005 |
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; CHO Cells; Cricetulus; Dementia; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Male; Models, Molecular; Motor Activity; Radioligand Assay; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides | 2014 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indoles; Ligands; Male; Models, Molecular; Molecular Structure; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship; Swimming | 2015 |
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Topics: Adrenergic Agents; Analgesics; Animals; Blood Proteins; CHO Cells; Cricetulus; Dopamine Agents; Guinea Pigs; Humans; Microsomes, Liver; Rats; Receptors, Adrenergic; Receptors, Opioid; Secologanin Tryptamine Alkaloids | 2020 |
Estradiol selectively regulates alpha 1B-noradrenergic receptors in the hypothalamus and preoptic area.
Topics: Animals; Clonidine; Cyclic AMP; Dioxanes; Estradiol; Female; Hypothalamus; Ovariectomy; Piperazines; Prazosin; Preoptic Area; Rats; Receptors, Adrenergic | 1992 |
Characterization of alpha 1-adrenoceptor subtypes labeled by [3H]prazosin in single cells prepared from rabbit thoracic aorta.
Topics: Animals; Aorta, Thoracic; Binding Sites; Calcium; Clonidine; Dioxanes; In Vitro Techniques; Methoxamine; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Spiperone | 1992 |
Contribution of an alpha 1-adrenergic receptor subtype to the expression of the "ventral tegmental area syndrome".
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Denervation; Dioxanes; Dopamine; Male; Motor Activity; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Synaptic Transmission; Tegmentum Mesencephali | 1992 |
5-Methylurapidil may discriminate between alpha 1-adrenoceptors with a high affinity for WB4101 in rat lung.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; In Vitro Techniques; Lung; Male; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1992 |
Determination of alpha 1-adrenoceptor subtype selectivity by [3H]-prazosin displacement studies in guinea-pig cerebral cortex and rat spleen membranes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Cerebral Cortex; Dioxanes; Guinea Pigs; Male; Phentolamine; Prazosin; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Spleen | 1992 |
The effects of electroconvulsive shock or imipramine on subtypes of alpha 1-adrenoceptors in the frontal cortex of the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Clonidine; Dioxanes; Electroshock; Hippocampus; Imipramine; In Vitro Techniques; Kinetics; Male; Prazosin; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1992 |
Identification of alpha 1-adrenoceptor subtypes in the rat vas deferens: binding and functional studies.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Electric Stimulation; Epididymis; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Nifedipine; Norepinephrine; Oxathiins; Prazosin; Prostate; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Vas Deferens | 1992 |
Pharmacological characterization of contractile responses induced by alpha 1-agonists, norepinephrine and clonidine, by selective antagonists of their subtypes in rabbit thoracic aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Dioxanes; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Piperazines; Prazosin; Rabbits | 1992 |
Regional distribution of alpha 1-adrenoceptor subtypes in rat kidney.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Cell Membrane; Clonidine; Dioxanes; Kidney; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1991 |
Alpha 1-adrenoceptor subtypes in aorta (alpha 1A) and liver (alpha 1B).
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Epinephrine; In Vitro Techniques; Liver; Membranes; Muscle, Smooth, Vascular; Phosphatidylinositols; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha | 1991 |
Mechanism of neurotransmitter release elicited by the preferential alpha 1-adrenergic receptor agonist phenylephrine in superfused superior cervical ganglion cells in culture.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atenolol; Cells, Cultured; Cocaine; Cyclic AMP; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Ethanolamines; Ganglia, Sympathetic; Kidney; Methoxamine; Neurotransmitter Agents; Norepinephrine; Phenylephrine; Potassium Chloride; Prazosin; Propranolol; Rats; Tritium | 1991 |
Evidence for a complex interaction between the subtypes of the alpha 1-adrenoceptor.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Dioxanes; In Vitro Techniques; Kinetics; Male; Methoxamine; Muscle, Smooth, Vascular; Phenoxybenzamine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1991 |
Electroconvulsive shock increases alpha 1b- but not alpha 1a-adrenoceptor binding sites in rat cerebral cortex.
Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Cerebral Cortex; Dioxanes; Electroshock; Inositol; Kinetics; Male; Norepinephrine; Phenylephrine; Phosphatidylinositols; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reference Values | 1991 |
The effect of alpha 1-acid glycoprotein on the pharmacological activity of alpha 1-adrenergic antagonists in rabbit aortic strips.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; Drug Interactions; Male; Muscle, Smooth, Vascular; Orosomucoid; Phenylephrine; Prazosin; Proteins; Rabbits; Vasodilator Agents | 1991 |
Human plasma-derived material with clonidine displacing substance (CDS)-like properties contracts the isolated rat aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Blood; Brain; Clonidine; Dioxanes; Female; In Vitro Techniques; Male; Methoxamine; Muscle Contraction; Prazosin; Rats; Rats, Inbred WKY; Yohimbine | 1991 |
The rat alpha 2-C4 adrenergic receptor gene encodes a novel pharmacological subtype.
Topics: Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Blotting, Northern; Colforsin; Cyclic AMP; Dioxanes; DNA; Gene Expression; Humans; Molecular Sequence Data; Prazosin; Radioligand Assay; Rats; Receptors, Adrenergic, alpha; RNA; Sequence Homology, Nucleic Acid; Transfection; Yohimbine | 1991 |
The effect of putative 5-HT1A receptor antagonists on 8-OH-DPAT-induced hypothermia in rats and mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Dioxanes; Dose-Response Relationship, Drug; Hypothermia, Induced; Male; Mice; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1991 |
Rat salivary glands as a model for the study of adrenergic receptor modulation.
Topics: Animals; Autonomic Nervous System; Denervation; Dioxanes; Disease Models, Animal; Prazosin; Rats; Receptors, Adrenergic, alpha; Reserpine; Submandibular Gland | 1990 |
Pharmacological subclassification of alpha 1-adrenoceptors in vascular smooth muscle.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Animals; Blood Vessels; Clonidine; Dioxanes; Dogs; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Phentolamine; Prazosin; Rabbits; Rats; Receptors, Adrenergic, alpha; Species Specificity; Yohimbine | 1990 |
Electroconvulsive shock differentially increases binding to alpha-1 adrenergic receptor subtypes in discrete regions of rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Autoradiography; Brain; Dioxanes; Electroshock; Male; Osmolar Concentration; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reference Values; Tissue Distribution | 1990 |
Agonist interaction with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Clonidine; Diltiazem; Dioxanes; Drug Interactions; Heart; Inositol Phosphates; Male; Muscle, Smooth, Vascular; Myocardium; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1990 |
[The identification and characteristics of subpopulations of alpha 1-adrenergic receptors].
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain Chemistry; Calcium; Clonidine; Dioxanes; GTP-Binding Proteins; Liver; Microsomes; Phentolamine; Prazosin; Rats; Receptors, Adrenergic, alpha | 1990 |
Pertussis toxin inhibits norepinephrine-stimulated inositol phosphate formation in primary brain cell cultures.
Topics: Animals; Brain; Calcium; Carbachol; Cells, Cultured; Clonidine; Cyclic AMP; Dioxanes; GTP-Binding Proteins; Inositol Phosphates; Norepinephrine; Pertussis Toxin; Phenethylamines; Prazosin; Rats; Receptors, Adrenergic, alpha; Tetralones; Virulence Factors, Bordetella; Yohimbine | 1990 |
Chloroethylclonidine unmasks a non-alpha-adrenoceptor noradrenaline binding site in the rat aorta.
Topics: Animals; Aorta, Thoracic; Clonidine; Dioxanes; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Phenoxybenzamine; Prazosin; Rats; Receptors, Adrenergic; Yohimbine | 1990 |
Subclassification of alpha 1-adrenoceptor recognition sites by urapidil derivatives and other selective antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Dioxanes; Heart; In Vitro Techniques; Male; Myocardium; Phenethylamines; Phentolamine; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetralones; Yohimbine | 1989 |
Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cataplexy; Clonidine; Dioxanes; Dogs; Narcolepsy; Phenoxybenzamine; Prazosin; Receptors, Adrenergic, alpha; Sleep, REM | 1989 |
Demonstration of alpha 1-adrenoceptors in rat nasal mucosa.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; Nasal Mucosa; Prazosin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1989 |
Alteration in the pharmacologic activity of alpha 1 adrenergic antagonists by alpha-1-acid glycoprotein.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Orosomucoid; Prazosin | 1989 |
Alpha-adrenergic antagonists: correlation of the effect on intraocular pressure and on alpha 2-adrenergic receptor binding specificity in the rabbit eye.
Topics: Adrenergic alpha-Antagonists; Animals; Ciliary Body; Dioxanes; Intraocular Pressure; Iris; Membranes; Moxisylyte; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Time Factors; Yohimbine | 1985 |
Structure-activity relationships for prazosin and WB 4101 analogues as alpha 1-adrenoreceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Dioxanes; Dioxins; Male; Methylation; Prazosin; Quinazolines; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Vas Deferens | 1985 |
Stimulation by noradrenaline of inositol phospholipid breakdown in the rat hippocampus: effect of the ambient potassium concentration.
Topics: Animals; Biotransformation; Carbachol; Cerebellum; Cerebral Cortex; Dioxanes; Hippocampus; Hypothalamus; In Vitro Techniques; Male; Norepinephrine; Pargyline; Phenylephrine; Phosphatidylinositols; Potassium; Prazosin; Rats; Rats, Inbred Strains | 1986 |
Modulation of postdecapitation convulsions in rats by alpha-adrenergic and 5-hydroxytryptamine1A agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Animals; Buspirone; Death; Dioxanes; Male; Prazosin; Pyrimidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Seizures; Serotonin; Tetrahydronaphthalenes; Yohimbine | 1987 |
Atypical alpha-adrenoceptor mediates phenylephrine-induced mydriasis in anesthetized cats.
Topics: Adrenergic alpha-Antagonists; Animals; Cats; Dioxanes; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Male; Mydriatics; Nictitating Membrane; Phenoxybenzamine; Phenylephrine; Prazosin; Pupil; Receptors, Adrenergic, alpha | 1988 |
Characterization of the alpha adrenergic receptor population in hippocampus up regulated by serotonergic raphe deafferentiation.
Topics: Animals; Clonidine; Dioxanes; Female; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Norepinephrine; Prazosin; Propranolol; Raphe Nuclei; Rats; Receptors, Adrenergic, alpha; Serotonin; Sodium; Yohimbine | 1985 |
Adrenergic receptor subtypes in rabbit iris-ciliary body membranes: classification by radioligand studies.
Topics: Animals; Binding, Competitive; Ciliary Body; Dihydroalprenolol; Dioxanes; In Vitro Techniques; Iris; Prazosin; Rabbits; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Yohimbine | 1985 |
Identification of subtypes of [3H]prazosin-labelled alpha 1 receptor binding sites in rat brain.
Topics: Animals; Binding Sites; Brain Chemistry; Dioxanes; In Vitro Techniques; Male; Phentolamine; Prazosin; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tritium | 1985 |
Characterization of alpha 1-adrenergic receptor subtypes in rat brain: a reevaluation of [3H]WB4104 and [3H]prazosin binding.
Topics: Animals; Binding, Competitive; Brain; Dioxanes; Dioxins; Epinephrine; Kinetics; Mathematics; Norepinephrine; Phentolamine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1986 |
Impact of food deprivation on alpha 1- and alpha 2-noradrenergic receptors in the paraventricular nucleus and other hypothalamic areas.
Topics: Animals; Clonidine; Dioxanes; Food Deprivation; Hypothalamus; Male; Paraventricular Hypothalamic Nucleus; Prazosin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Satiety Response | 1986 |
Up-regulation of serotonergic binding sites labeled by [3H]WB4101 following fimbrial transection and 5,7-dihydroxytryptamine-induced lesions.
Topics: 5,7-Dihydroxytryptamine; Afferent Pathways; Animals; Binding, Competitive; Dioxanes; Dioxins; Female; Hippocampus; Prazosin; Rats; Receptors, Serotonin; Serotonin | 1985 |
Regulation of myocardial and vascular alpha-adrenergic receptor affinity. Effects of guanine nucleotides, cations, estrogen, and catecholamine depletion.
Topics: Animals; Dioxanes; Epinephrine; Estrogens; Guanine Nucleotides; Heart; Male; Muscle, Smooth, Vascular; Prazosin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sodium; Yohimbine | 1984 |
Quantitation of alpha 1-adrenergic receptors in porcine uterine and mesenteric arteries.
Topics: Animals; Arteries; Binding Sites; Dioxanes; Female; Membranes; Mesenteric Arteries; Prazosin; Radioligand Assay; Receptors, Adrenergic, alpha; Regional Blood Flow; Swine; Tritium; Uterus | 1984 |
Multiple central WB-4101 binding sites and the selectivity of prazosin.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Cattle; Clonidine; Dioxanes; Dioxins; In Vitro Techniques; Kinetics; Membranes; Norepinephrine; Prazosin; Quinazolines; Receptors, Adrenergic, alpha | 1980 |
In vivo selectivity of prazosin but not of WB4101 for postsynaptic alpha-1 adrenoceptors.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Cats; Dioxanes; Dioxins; Dogs; Female; Heart Rate; Male; Nictitating Membrane; Norepinephrine; Phentolamine; Prazosin; Quinazolines; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Spleen; Synapses | 1981 |
Evidence for a central depressor action of postsynaptic alpha 1-adrenergic receptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Depression, Chemical; Dioxanes; Hemodynamics; Phentolamine; Piperoxan; Prazosin; Pressoreceptors; Receptors, Adrenergic; Sympathetic Nervous System | 1981 |
Human platelet alpha 2-adrenergic receptors: labeling with 3H-yohimbine, a selective antagonist ligand.
Topics: Adrenergic alpha-Antagonists; Blood Platelets; Catecholamines; Dihydroergotoxine; Dioxanes; Humans; Imidazoles; Kinetics; Magnesium; Prazosin; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Yohimbine | 1981 |
3H-WB 4101 binding in the rat vas deferens. Effects of chronic treatments with desipramine and prazosin.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Desipramine; Dioxanes; Dioxins; Male; Prazosin; Quinazolines; Rats; Rats, Inbred Strains; Vas Deferens | 1981 |
Responses to noradrenaline of portal vein strips from normotensive and spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Blood Pressure; Dioxanes; Gallopamil; Hypertension; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Prazosin; Rats; Rats, Inbred Strains | 1980 |
The use of tritium labeled compounds to develop gamma-emitting receptor-binding radiotracers.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Dihydroalprenolol; Dioxanes; Dogs; Guinea Pigs; Heart; Humans; Male; N-Methylscopolamine; Parasympatholytics; Pindolol; Prazosin; Propanolamines; Quinuclidinyl Benzilate; Rabbits; Radionuclide Imaging; Rats; Scopolamine Derivatives; Tritium | 1982 |
Antihypertensive beta-adrenergic blocking agents: N-aralkyl analogues of 2-[3-(tert-butylamino)-2-hydroxypropoxy]-3-cyanopyridine.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Cerebral Cortex; Dihydroalprenolol; Dioxanes; Prazosin; Pyridines; Rats; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1983 |
Characterization of alpha-adrenoceptors in rat and guinea pig tissues using radiolabeled agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Clonidine; Dioxanes; Dioxins; Guinea Pigs; Male; Prazosin; Quinazolines; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1980 |
[3H]WB4101--caution about its role as an alpha-adrenergic subtype selective radioligand.
Topics: Animals; Brain; Dihydroergotoxine; Dioxanes; Dioxins; Female; In Vitro Techniques; Prazosin; Rabbits; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Uterus; Yohimbine | 1980 |
Effect of intrathecally administered noradrenergic antagonists on nociception in the rat.
Topics: Animals; Brain Mapping; Brain Stem; Dioxanes; Efferent Pathways; Injections, Spinal; Male; Norepinephrine; Pain; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Spinal Cord; Yohimbine | 1984 |
Competition by estrogens for catecholamine receptor binding in vitro.
Topics: Animals; Binding, Competitive; Brain; Cerebral Cortex; Corpus Striatum; Dioxanes; Estradiol; Estrogens; Female; Hydroxyestrones; Pituitary Gland, Anterior; Prazosin; Rats; Receptors, Adrenergic; Spiperone; Tetrahydronaphthalenes | 1982 |
Effect of alpha 1-adrenergic receptor antagonists on susceptibility to malignant arrhythmias: protection from ventricular fibrillation.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Dioxanes; Disease Models, Animal; Dogs; Electrophysiology; Exercise Test; Heart Rate; Injections, Intravenous; Myocardial Infarction; Myocardial Ischemia; Prazosin; Ventricular Fibrillation | 1994 |
Pharmacological characterization of alpha 1-adrenoceptor subtypes in the human prostate: functional and binding studies.
Topics: Adrenergic alpha-Antagonists; Binding, Competitive; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Humans; Male; Muscle Contraction; Muscles; Norepinephrine; Phenylephrine; Prazosin; Prostatic Hyperplasia; Receptors, Adrenergic, alpha-1 | 1994 |
Alpha 1-adrenoceptor subtypes in the human prostate.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Aminoquinolines; Dioxanes; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Muscle Contraction; Muscles; Norepinephrine; Prazosin; Prostate; Prostatic Hyperplasia; Receptors, Adrenergic, alpha-1; Tetrahydroisoquinolines | 1994 |
Alpha 1-adrenoceptor subtypes and inositol phosphates production in heart ventricles of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Heart Ventricles; Hypertension; Inositol Phosphates; Male; Myocardium; Norepinephrine; Prazosin; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha | 1993 |
Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Binding Sites; Dioxanes; Hippocampus; In Vitro Techniques; Isoxazoles; Male; Phentolamine; Piperazines; Piperidines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Risperidone; Spleen | 1993 |
Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Atropine; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Mice; Myocardial Contraction; Myocardium; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Yohimbine | 1995 |
Direct inotropic action of WB-4101 and prazosin in the guinea pig papillary muscle. Comparison with HOE-234, the new activator of ATP-sensitive K+ channels.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Chromans; Depression, Chemical; Dioxanes; Female; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Male; Myocardial Contraction; Papillary Muscles; Potassium Channels; Prazosin; Pyrrolidines | 1994 |
Alpha 1A-adrenoceptor subtype mediates contraction of the rat urethra.
Topics: Aminoquinolines; Animals; Calcium; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tetrahydroisoquinolines; Urethra | 1994 |
Interactions of chloroethylclonidine with rauwolscine- and prazosin-sensitive adrenoceptors in dog saphenous vein.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Calcium; Calcium Channel Blockers; Clonidine; Dioxanes; Dogs; Extracellular Space; In Vitro Techniques; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Saphenous Vein; Yohimbine | 1994 |
Veratrine-induced tetanic contracture of the rat isolated left atrium. Evidence for novel direct protective effects of prazosin and WB4101.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channels; Dioxanes; Electric Stimulation; Heart Atria; Isometric Contraction; Male; Myocardial Contraction; Prazosin; Rats; Rats, Wistar; Sodium Channels; Veratrine | 1993 |
Alpha 1-adrenoceptor subtype involved in the positive inotropic response to phenylephrine in rat atria.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1993 |
Chloroethylclonidine discriminates between alpha 1A- and alpha 1B-adrenoceptors in the presence of guanosine 5'-triphosphate in rabbit thoracic aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding Sites; Clonidine; Dioxanes; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Phenylephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha | 1993 |
Sympathetic transmission to the dilator muscle of the rat iris.
Topics: Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Clonidine; Dioxanes; Iris; Membrane Potentials; Neuroeffector Junction; Norepinephrine; Parasympathetic Nervous System; Prazosin; Rats; Receptors, Adrenergic, alpha-1; Sympathetic Nervous System; Synaptic Transmission; Synaptic Vesicles; Yohimbine | 1993 |
Effects of age on alpha 1-adrenoceptor subtypes in the heart ventricular muscle of the rat.
Topics: Adrenergic alpha-Antagonists; Aging; Alkylating Agents; Animals; Binding, Competitive; Clonidine; Dioxanes; In Vitro Techniques; Myocardium; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 1993 |
Effects of WB4101 and chloroethylclonidine on the positive and negative inotropic actions of phenylephrine in rat cardiac muscle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Drug Antagonism; In Vitro Techniques; Male; Myocardial Contraction; Phenylephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 1994 |
Selective enrichment with alpha 1A- and alpha 1B-adrenoceptor subtypes in rat brain cortical membranes.
Topics: Adrenergic alpha-Antagonists; Alkylating Agents; Alkylation; Animals; Binding Sites; Cerebral Cortex; Clonidine; Cystamine; Dihydropyridines; Dioxanes; Phenoxybenzamine; Phentolamine; Prazosin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1994 |
Identification of alpha 1-adrenoceptor subtypes in rat lung by binding of [3H]-prazosin and [3H]-WB4101.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Dioxanes; Lung; Male; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 1994 |
Investigation of alpha 1-adrenoceptor subtypes in canine aorta, using alkylating agents.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Aorta; Binding, Competitive; Clonidine; Dioxanes; Dogs; Female; In Vitro Techniques; Male; Mesenteric Veins; Muscle, Smooth, Vascular; Oxymetazoline; Prazosin; Radioligand Assay; Receptors, Adrenergic, alpha-1 | 1994 |
Blockade of prefronto-cortical alpha 1-adrenergic receptors prevents locomotor hyperactivity induced by subcortical D-amphetamine injection.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Dextroamphetamine; Dioxanes; Hyperkinesis; Male; Microinjections; Nucleus Accumbens; Prazosin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reaction Time; Scopolamine | 1994 |
Alpha 1-adrenoceptor subtype(s) mediating noradrenaline-induced contractions of the guinea-pig aorta.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Clonidine; Dioxanes; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Oxazines; Prazosin; Receptors, Adrenergic, alpha-1 | 1994 |
Heterogeneity of alpha 1-adrenoceptor subtypes involved in adrenergic contractions of dog blood vessels.
Topics: Acetonitriles; Animals; Dioxanes; Dogs; Electric Stimulation; Female; In Vitro Techniques; Male; Nifedipine; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha-1; Vasoconstriction | 1994 |
Alpha 1b-adrenoceptor-mediated stimulation of Na-K pump current in adult rat ventricular myocytes.
Topics: Adrenergic alpha-Antagonists; Animals; Cells, Cultured; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Heart; Heart Ventricles; Male; Myocardium; Ouabain; Phenoxybenzamine; Phenylephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sodium-Potassium-Exchanging ATPase; Ventricular Function, Left | 1993 |
Identification of alpha 1-adrenoceptor subtypes in the dog prostate.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dogs; Male; Norepinephrine; Prazosin; Prostate; Receptors, Adrenergic, alpha | 1993 |
Alpha 1B-adrenoceptor-mediated stimulation of Ca2+ mobilization and cAMP accumulation in isolated rat hepatocytes.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Clonidine; Cyclic AMP; Dioxanes; In Vitro Techniques; Liver; Male; Methoxamine; Norepinephrine; Pertussis Toxin; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Vasopressins; Virulence Factors, Bordetella | 1993 |
Relation between alpha 1-adrenoceptor subtypes and noradrenaline-induced contraction in rat portal vein smooth muscle.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Clonidine; Dioxanes; Horses; In Vitro Techniques; Isometric Contraction; Kinetics; Microsomes; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Prazosin; Rats; Receptors, Adrenergic, alpha-1 | 1993 |
Alpha 1-adrenoceptors in the human prostatic urethra are different from those of the human peripheral arteries.
Topics: Arteries; Atropine; Clonidine; Dioxanes; Humans; Iliac Artery; Isometric Contraction; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Phenylephrine; Piperazines; Prazosin; Propranolol; Receptors, Adrenergic, alpha-1; Urethra; Yohimbine | 1993 |
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.
Topics: Animals; Cell Membrane; Cerebral Cortex; Dioxanes; Epinephrine; Fluorine Compounds; Guinea Pigs; Inositol Phosphates; Norepinephrine; Phenylephrine; Prazosin; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Structure-Activity Relationship; Synaptosomes | 1993 |
Investigation of the actions of chloroethylclonidine in rat aorta.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Aorta; Clonidine; Cystamine; Dioxanes; Dose-Response Relationship, Drug; Drug Synergism; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxathiins; Phenoxybenzamine; Phentolamine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spiperone; Xylazine; Yohimbine | 1995 |
Identification of alpha 1-adrenoceptor subtypes in the rabbit prostate.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; Male; Muscle Contraction; Norepinephrine; Piperazines; Prazosin; Prostate; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha-1 | 1995 |
Hypothalamic alpha 2A-adrenoceptors stimulate growth hormone release in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Berberine; Clonidine; Dioxanes; Growth Hormone-Releasing Hormone; Hypothalamus; Injections, Intraventricular; Male; Oxymetazoline; Prazosin; Rats; Rats, Wistar; Somatostatin | 1995 |
Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Line; Cerebral Cortex; Chlorocebus aethiops; Circular Dichroism; Cloning, Molecular; Dioxanes; Dioxins; Kinetics; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Muscle, Smooth; Prazosin; Radioligand Assay; Rats; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Transfection; Vas Deferens | 1996 |
Alpha 1B-adrenoceptor-mediated excitation of piriform cortical interneurons.
Topics: Action Potentials; Adrenergic alpha-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Dioxanes; In Vitro Techniques; Interneurons; Male; Norepinephrine; Oxathiins; Phentolamine; Piperazines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Risperidone; Spiperone | 1996 |
alpha 2-, alpha 2A-, alpha 2B/2C-Adrenoceptor subtype antagonists prevent lipopolysaccharide-induced fever response in rabbits.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Body Temperature; Dioxanes; Fever; Imidazoles; Indoles; Injections, Intravenous; Isoindoles; Isoquinolines; Lipopolysaccharides; Male; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha-2; Skin Physiological Phenomena | 1995 |
Alpha 1-adrenoceptor subtype distribution and the coupling to phosphoinositide hydrolysis in rat and rabbit ventricular myocardium.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Female; Heart Ventricles; Hydrolysis; Kinetics; Lithium Chloride; Male; Myocardium; Phosphatidylinositols; Prazosin; Rabbits; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tritium | 1996 |
Sustained increase in rat myocardial alpha 1A-adrenoceptors induced by 6-hydroxydopamine treatment involves a decelerated receptor turnover.
Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Body Weight; Dioxanes; Male; Myocardium; Norepinephrine; Organ Size; Oxidopamine; Phenoxybenzamine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Up-Regulation | 1996 |
The effects of SB 216469, an antagonist which discriminates between the alpha 1A-adrenoceptor and the human prostatic alpha 1-adrenoceptor.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Cattle; Chromones; Dihydropyridines; Dioxanes; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Male; Prazosin; Prostate; Radioligand Assay; Rats; Rats, Wistar | 1996 |
Role of different subtypes of adrenoceptors in pressor responses to catecholamines released from sympathetic nerve endings.
Topics: Adrenergic alpha-Antagonists; Animals; Berberine; Blood Pressure; Cats; Dimethylphenylpiperazinium Iodide; Dioxanes; Female; Ganglionic Stimulants; Imidazoles; Indoles; Isoindoles; Male; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System | 1997 |
A possible structural determinant of selectivity of boldine and derivatives for the alpha 1A-adrenoceptor subtype.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antioxidants; Aporphines; Binding, Competitive; Cerebral Cortex; Dioxanes; Female; Oxathiins; Prazosin; Rats; Rats, Wistar | 1996 |
Pharmacophore development for antagonists at alpha 1 adrenergic receptor subtypes.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Computer-Aided Design; Dioxanes; Drug Design; Models, Molecular; Molecular Conformation; Prazosin; Protein Conformation; Receptors, Adrenergic, alpha-1; Software; Structure-Activity Relationship | 1996 |
Alpha 1-adrenergic receptor antibodies in patients with primary hypertension.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Aged; Amino Acid Sequence; Animals; Animals, Newborn; Autoantibodies; Blood Proteins; Cells, Cultured; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Heart; Humans; Hypertension; Male; Middle Aged; Molecular Sequence Data; Peptides; Phenylephrine; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Vascular Resistance | 1997 |
Heterogeneity and complexity of alpha 1-adrenoceptors in the ovine uterine artery and umbilical vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Binding, Competitive; Calcium Channel Blockers; Clonidine; Dioxanes; Drug Interactions; Drug Synergism; Female; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Prazosin; Pregnancy; Receptors, Adrenergic, alpha-1; Sheep; Umbilical Veins; Uterus; Vasoconstriction | 1997 |
Functional study of the excitatory alpha-adrenoceptor in guinea pig ileum, in relation to the hypothesis of an atypical receptor.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Epinephrine; Guinea Pigs; Ileum; Indoramin; Models, Biological; Muscle Contraction; Norepinephrine; Phenylephrine; Piperoxan; Prazosin; Receptors, Adrenergic, alpha | 1997 |
Use of the operational model of agonism and [3H]prazosin binding to assess altered responsiveness of alpha1-adrenoceptors in the vas deferens of spontaneously hypertensive rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Piperazines; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-1; Vas Deferens | 1997 |
Two district alpha(1)-adrenoceptor subtypes in the human prostate: assessment by radioligand binding assay using 3H-prazosin.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Binding, Competitive; Dioxanes; Humans; In Vitro Techniques; Kinetics; Male; Nifedipine; Phentolamine; Piperazines; Prazosin; Prostate; Protein Binding; Radioligand Assay; Receptors, Adrenergic, alpha-1; Sulfonamides; Tamsulosin; Tritium | 1996 |
Investigation of alpha1-adrenoceptor subtypes mediating vasoconstriction in rabbit cutaneous resistance arteries.
Topics: Acetonitriles; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Male; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha-1; Skin; Tetrahydronaphthalenes; Vascular Resistance; Vasoconstriction | 1997 |
Characterization of alpha1-adrenoceptor subtypes mediating contractions to phenylephrine in rat thoracic aorta, mesenteric artery and pulmonary artery.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Dioxanes; Dioxins; Dose-Response Relationship, Drug; In Vitro Techniques; Indoles; Indoramin; Isometric Contraction; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Oxathiins; Phenylephrine; Piperazines; Prazosin; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Spiro Compounds; Vasoconstrictor Agents | 1997 |
Pharmacological evidence for alpha(1D)-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Calcium Channel Blockers; Dihydropyridines; Dioxanes; Dose-Response Relationship, Drug; Heart; Heart Ventricles; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha-1 | 1997 |
Characterization of alpha1-adrenoceptor subtypes in facilitation of rat spinal motoneuron activity.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Bridged-Ring Compounds; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Epinephrine; Male; Methoxamine; Motor Neurons; Norepinephrine; Oxazines; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Wistar; Spinal Cord | 1997 |
Heterogeneity of alpha 1-adrenoceptor subtypes mediating noradrenaline-induced contractions of the rat superior mesenteric artery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Mesenteric Artery, Superior; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spiperone; Vasoconstriction; Vasoconstrictor Agents | 1998 |
Pharmacological and immunocytochemical characterization of subtypes of alpha-1 adrenoceptors in dog aorta.
Topics: Animals; Aorta; Clonidine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Immunohistochemistry; Indoles; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Spiro Compounds | 1998 |
Antinociception produced by microinjection of morphine in the rat periaqueductal gray is enhanced in the foot, but not the tail, by intrathecal injection of alpha1-adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Behavior, Animal; Dioxanes; Female; Foot; Idazoxan; Injections, Spinal; Microinjections; Morphine; Narcotics; Nociceptors; Pain; Periaqueductal Gray; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Spinal Cord; Tail | 1998 |
Alpha1-adrenergic stimulation of sarcolemmal Na+-H+ exchanger activity in rat ventricular myocytes: evidence for selective mediation by the alpha1A-adrenoceptor subtype.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Clonidine; Dioxanes; Heart Ventricles; Humans; Imidazoles; Kinetics; Myocardium; Phenylephrine; Piperazines; Prazosin; Rats; Receptors, Adrenergic, alpha-1; Sarcolemma; Sodium-Hydrogen Exchangers; Tetrahydronaphthalenes | 1998 |
Characterization, localization and distribution of alpha1 adrenoceptor subtype in male rabbit urethra.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Autoradiography; Dioxanes; Immunohistochemistry; Male; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha-1; Spiperone; Urethra | 1998 |
Discrimination of alpha1-adrenoceptor subtypes in rat aorta and prostate.
Topics: Acetonitriles; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Piperazines; Prazosin; Prostate; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Sulfonamides; Tamsulosin; Vasoconstriction; Vasodilator Agents | 1998 |
Prejunctional alpha2A-autoreceptors in the human gastric and ileocolic arteries.
Topics: Adrenergic alpha-Antagonists; Aged; Arteries; Autoreceptors; Colon; Dioxanes; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gastric Mucosa; Humans; Idazoxan; Ileum; In Vitro Techniques; Male; Middle Aged; Neuromuscular Junction; Norepinephrine; Phentolamine; Prazosin; Receptors, Adrenergic, alpha-2; Spiro Compounds; Stomach; Tritium; Yohimbine | 1998 |
Functional assessment of alpha 1-adrenoceptor subtypes in porcine coronary artery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Coronary Vessels; Dioxanes; Humans; In Vitro Techniques; Kinetics; Male; Norepinephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Swine; Vasoconstriction | 1998 |
Binding and functional characterization of alpha1-adrenoceptor subtypes in the rat prostate.
Topics: Acetonitriles; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Norepinephrine; Oxymetazoline; Piperazines; Prazosin; Prostate; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Sulfonamides; Tamsulosin; Tritium | 1999 |
Alpha 2-adrenoreceptor subtypes regulate ACTH and beta-endorphin secretions during stress in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Animals; beta-Endorphin; Clonidine; Dioxanes; Ether; Kinetics; Male; Methoxamine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Stress, Physiological | 1999 |
Functional characterization of alpha1-adrenergic receptors in experimental vein grafts.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carotid Arteries; Carotid Artery, Common; Dioxanes; GTP-Binding Proteins; Jugular Veins; Male; Osmolar Concentration; Pertussis Toxin; Phenylephrine; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Vasoconstriction; Virulence Factors, Bordetella | 1999 |
Expression and pharmacological characterization of alpha1-adrenoceptors in rat seminal vesicle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Clonidine; Dioxanes; Epinephrine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Phenoxybenzamine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seminal Vesicles | 1999 |
Characterisation of alpha1B-adrenoceptors linked to inositol phosphate formation and calcium mobilisation in human astrocytoma U373 MG cells.
Topics: Adrenergic alpha-Antagonists; Astrocytoma; Calcium; Cell Membrane; Clonidine; Dihydropyridines; Dioxanes; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Thymidine; Tumor Cells, Cultured | 1999 |
alpha(1L)-adrenoceptors mediate noradrenaline-induced contractions of the guinea-pig prostate stroma.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Prazosin; Prostate; Receptors, Adrenergic, alpha-1; Sulfonamides; Tamsulosin | 1999 |
Differences in the electrophysiologic response of four canine ventricular cell types to alpha 1-adrenergic agonists.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Clonidine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Endocardium; Heart Ventricles; In Vitro Techniques; Methoxamine; Microelectrodes; Pericardium; Phenylephrine; Prazosin; Propranolol; Purkinje Fibers | 1999 |
alpha(1)-adrenoceptor subtypes and effect of alpha(1A)-adrenoceptor agonist NS-49 on guinea pig nasal mucosa vasculature.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anilides; Animals; Blood Vessels; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Male; Nasal Mucosa; Norepinephrine; Oxymetazoline; Piperazines; Prazosin; Spiperone; Vasoconstriction; Yohimbine | 2000 |
Norepinephrine-stimulated increase in Na+, K+-ATPase activity in the rat brain is mediated through alpha1A-adrenoceptor possibly by dephosphorylation of the enzyme.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anticoagulants; Brain; Calcimycin; Calcineurin; Calcium; Calmodulin; Colforsin; Cyclosporine; Dioxanes; Enzyme Activation; Enzyme Inhibitors; Heparin; Ionophores; Male; Norepinephrine; Phosphorylation; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Sulfonamides | 2000 |
Alpha(1)-adrenoceptor subtypes mediating contractions of the rat mesenteric artery.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationship, Drug; Endothelium, Vascular; Imidazoles; In Vitro Techniques; Indoles; Indoramin; Male; Mesenteric Arteries; Methoxamine; Oxathiins; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Vasoconstriction; Vasoconstrictor Agents | 2000 |
Regulation of renal artery smooth muscle tone by alpha1-adrenoceptors: role of voltage-gated calcium channels and intracellular calcium stores.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Diltiazem; Dioxanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Ischemia; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Phenoxybenzamine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Renal Artery; Renal Circulation; Swine; Thapsigargin; Verapamil | 2000 |
Single-cell recombinant pharmacology: bovine alpha(1a)-adrenoceptors in rat-1 fibroblasts release intracellular ca(2+), display subtype-characteristic agonism and antagonism, and exhibit an antagonist-reversible inverse concentration-response phase.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Calcium Signaling; Cattle; Dioxanes; Dose-Response Relationship, Drug; Imidazoles; Phenylalanine; Piperazines; Prazosin; Rats; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Tetrahydronaphthalenes | 2000 |
Role of alpha1A-adrenoceptor in the regulation of glucose uptake into white adipocyte of rats in vitro.
Topics: Adipocytes; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkaloids; Animals; Benzophenanthridines; Biological Transport, Active; Chromones; Clonidine; Deoxyglucose; Dioxanes; Enzyme Inhibitors; Estrenes; Glucose; Glucose Transporter Type 4; Indoles; Male; Maleimides; Methoxamine; Monosaccharide Transport Proteins; Morpholines; Muscle Proteins; Phenanthridines; Phosphoinositide-3 Kinase Inhibitors; Prazosin; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Sulfonamides; Tamsulosin; Type C Phospholipases | 2000 |
The alpha(1A)-adrenoceptor subtype mediates contraction in rat femoral resistance arteries.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Femoral Artery; Imidazoles; In Vitro Techniques; Isoquinolines; Male; Naphthyridines; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tetrahydronaphthalenes; Vascular Resistance; Vasoconstriction | 2001 |
Characterization of alpha1-adrenoceptor-mediated contraction in the mouse thoracic aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Buspirone; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; In Vitro Techniques; Male; Methoxamine; Mice; Models, Biological; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Serotonin Receptor Agonists; Statistics as Topic; Vasoconstriction | 2001 |
Existence of alpha(1A)- and alpha(1B)-adrenoceptor subtypes in canine mandibular alveolar arteries.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alveolar Process; Animals; Arteries; Clonidine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Mandible; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Vasoconstriction; Xylazine; Yohimbine | 2001 |
alpha(1)-Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Abdominal; Dioxanes; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mesenteric Arteries; Mice; Norepinephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Vasoconstriction | 2001 |
Adrenergic activation of cardiac phospholipase D: role of alpha(1)-adrenoceptor subtypes.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Clonidine; Dioxanes; Male; Myocardium; Norepinephrine; Perfusion; Phospholipase D; Piperazines; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Signal Transduction; Stimulation, Chemical | 2002 |
Pharmacological characterization of alpha1-adrenoceptor subtypes in the bovine tail artery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Cattle; Dioxanes; Dose-Response Relationship, Drug; Imidazoles; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Tail; Tetrahydronaphthalenes; Vasoconstriction | 2002 |
Pharmacological characterization of alpha1-adrenoceptor in mouse iliac artery.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationship, Drug; Iliac Artery; In Vitro Techniques; Male; Mice; Norepinephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Vasoconstriction | 2002 |
Alpha1-adrenergic receptors activate Ca(2+)-permeable cationic channels in prostate cancer epithelial cells.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Blotting, Western; Boron Compounds; Calcium; Calcium Channel Blockers; Cations; Cell Division; Diglycerides; Dioxanes; Electrophysiology; Epithelial Cells; Humans; Imidazoles; Male; Microscopy, Fluorescence; Prazosin; Prostatic Neoplasms; Receptors, Adrenergic, alpha-1; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tumor Cells, Cultured | 2003 |
Functional characterization of alpha-adrenoceptors mediating pupillary dilation in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Fibers; Animals; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Injections, Intravenous; Male; Mydriasis; Norepinephrine; Phenoxybenzamine; Phentolamine; Piperazines; Prazosin; Pupil; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Yohimbine | 2003 |
Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens.
Topics: Animals; Castration; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Male; Muscle Contraction; Neuronal Plasticity; Norepinephrine; Phentolamine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Testosterone; Time Factors; Vas Deferens; Yohimbine | 2003 |
Excitatory alpha1-adrenergic receptors predominate over inhibitory beta-receptors in rabbit dorsal detrusor.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Urinary Bladder | 2003 |
Inhibitory effect of buflomedil on prostate alpha1A adrenoceptor in the Wistar rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Blood Pressure; Cell Line; Deoxyglucose; Dioxanes; Dose-Response Relationship, Drug; Glucose; Heart Rate; In Vitro Techniques; Male; Phenylephrine; Prazosin; Prostate; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Time Factors; Tritium; Vasoconstriction | 2004 |
Different roles of alpha1-adrenoceptor subtypes in mediating cardiomyocyte protein synthesis in neonatal rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Cell Enlargement; Cells, Cultured; Dioxanes; Indoles; Leucine; Muscle Proteins; Myocytes, Cardiac; Norepinephrine; Piperazines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 2004 |
Alpha1L-adrenoceptors mediate contractions of the isolated mouse prostate.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Analysis of Variance; Animals; Clonidine; Dioxanes; Dopamine; Dose-Response Relationship, Drug; Epinephrine; In Vitro Techniques; Indoles; Isoproterenol; Male; Mice; Muscle Contraction; Norepinephrine; Phenylephrine; Prazosin; Prostate; Receptors, Adrenergic, alpha-1; Yohimbine | 2006 |
Sympathetic neurotransmission in the rat testicular capsule: functional characterization and identification of mRNA encoding alpha1-adrenoceptor subtypes.
Topics: Acetyl-CoA C-Acyltransferase; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Calcium Channel Blockers; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Male; Muscle Contraction; Nifedipine; Norepinephrine; Prazosin; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Purinergic P2; Reserpine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spiperone; Suramin; Sympathetic Nervous System; Synaptic Transmission; Testis | 2006 |
Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electrophysiology; Hippocampus; In Vitro Techniques; Interneurons; Isoproterenol; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 2007 |
Characterization of the postjunctional alpha 2C-adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Gene Expression; Imidazoles; In Vitro Techniques; Indoles; Isoindoles; Isoquinolines; Neuromuscular Junction; Norepinephrine; Piperazines; Prazosin; Pulmonary Veins; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Vasoconstriction; Yohimbine | 2007 |
The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.
Topics: Acetophenones; Adrenergic alpha-1 Receptor Antagonists; Anthracenes; Aorta; Apoptosis; Benzothiazoles; Cells, Cultured; Culture Media, Serum-Free; Dioxanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitochondria; Muscle, Smooth, Vascular; Phenylephrine; Piperazines; Prazosin; Pyridines; Reactive Oxygen Species; Receptors, Adrenergic, alpha-1; Time Factors; Toluene; Tumor Suppressor Protein p53 | 2008 |
alpha-Adrenoceptor-mediated depletion of phosphatidylinositol 4, 5-bisphosphate inhibits activation of volume-regulated anion channels in mouse ventricular myocytes.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Antibodies; Dioxanes; Estrenes; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Phenylephrine; Phosphatidylinositol 4,5-Diphosphate; Prazosin; Pyrrolidinones; Receptors, Adrenergic, alpha; Voltage-Dependent Anion Channels | 2010 |
Postjunctional α2C-adrenoceptors mediate vasoconstriction in rat tail artery: influence of precontraction and temperature on vasoreactivity.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Brimonidine Tartrate; Dioxanes; Imidazoles; In Vitro Techniques; Isoindoles; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Piperazines; Prazosin; Quinolizines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Serotonin; Tail; Temperature; Vasoconstriction; Yohimbine | 2010 |
Molecular and pharmacological characteristics of the gerbil α(1a)-adrenergic receptor.
Topics: Adrenergic alpha-1 Receptor Antagonists; Amino Acid Sequence; Animals; Arteries; Chlorocebus aethiops; Clonidine; Cloning, Molecular; Cochlea; Conserved Sequence; COS Cells; Dioxanes; Dose-Response Relationship, Drug; Gerbillinae; Humans; Mice; Molecular Sequence Data; Piperazines; Prazosin; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Sequence Analysis, Protein; Transfection; Vasoconstriction | 2012 |
Brief maternal separation affects brain α1-adrenoceptors and apoptotic signaling in adult mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Aging; Animals; Apoptosis; Brain; Cyclin D1; Dioxanes; Female; Food Preferences; Heat-Shock Proteins; Hippocampus; Male; Maternal Deprivation; Mice; Prazosin; Receptors, Adrenergic, alpha-1; Saccharin; Signal Transduction; Sweetening Agents; Time Factors | 2014 |