warfarin and picotamide

Picotamide, a new antiplatelet drug which has only slight effects on bleeding time, could be useful, in combination with oral anticoagulants, for the prevention of thromboembolic complications in patients with heart valve prostheses. We have evaluated in a randomized, controlled, double-blind, cross-over study, the effect of picotamide on the anticoagulant activity of warfarin. Administration of 300 mg t.i.d. for 10 days to 10 patients with aortic or mitral valve prostheses did not modify significantly either the level of anticoagulation or the mean daily dosage of warfarin. We observed a trend towards a reduction of plasma levels of beta-thromboglobulin. In conclusion the results of this study show that picotamide does not interfere with the anticoagulant activity of warfarin.

Topics: Aged; Aortic Valve; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Heart Valve Prosthesis; Humans; Male; Middle Aged; Mitral Valve; Phthalic Acids; Platelet Aggregation Inhibitors; Thromboembolism; Warfarin