warfarin and 9-10-anthraquinone

warfarin has been researched along with 9-10-anthraquinone* in 1 studies

Other Studies

1 other study(ies) available for warfarin and 9-10-anthraquinone

Article	Year
Protein-ligand structure and electronic coupling of photoinduced charge-separated state: 9,10-anthraquinone-1-sulfonate bound to human serum albumin. Journal of the American Chemical Society, 2011, Oct-26, Volume: 133, Issue:42 To elucidate how the protein-ligand docking structure affects electronic interactions in the electron-transfer process, we have analyzed time-resolved electron paramagnetic resonance spectra of photoinduced charge-separated (CS) states generated by light excitation of 9,10-anthraquinone-1-sulfonate (AQ1S(-)) bound to human serum albumin at a hydrophobic drug-binding region. The spectra have been explained in terms of the triplet-triplet electron spin polarization transfer model to determine both the geometries and the exchange couplings of the CS states of AQ1S(2-•)-histidine-242 radical cation (H242(+•)) and AQ1S(2-•)-tryptophan-214 radical cation (W214(+•)). For the CS state of the former, it has been revealed that, due to the orthogonal relationship between the singly occupied molecular orbitals of AQ1S(2-•) and H242(+•), the electronic coupling (5.4 cm(-1)) is very weak, contributing to the prevention of energy-wasting charge recombination, even at a contact edge-to-edge separation. Topics: Anthraquinones; Crystallography, X-Ray; Electrons; Humans; Ligands; Light; Molecular Structure; Serum Albumin; Warfarin	2011

Article

Year

Protein-ligand structure and electronic coupling of photoinduced charge-separated state: 9,10-anthraquinone-1-sulfonate bound to human serum albumin.

Journal of the American Chemical Society, 2011, Oct-26, Volume: 133, Issue:42

To elucidate how the protein-ligand docking structure affects electronic interactions in the electron-transfer process, we have analyzed time-resolved electron paramagnetic resonance spectra of photoinduced charge-separated (CS) states generated by light excitation of 9,10-anthraquinone-1-sulfonate (AQ1S(-)) bound to human serum albumin at a hydrophobic drug-binding region. The spectra have been explained in terms of the triplet-triplet electron spin polarization transfer model to determine both the geometries and the exchange couplings of the CS states of AQ1S(2-•)-histidine-242 radical cation (H242(+•)) and AQ1S(2-•)-tryptophan-214 radical cation (W214(+•)). For the CS state of the former, it has been revealed that, due to the orthogonal relationship between the singly occupied molecular orbitals of AQ1S(2-•) and H242(+•), the electronic coupling (5.4 cm(-1)) is very weak, contributing to the prevention of energy-wasting charge recombination, even at a contact edge-to-edge separation.

Topics: Anthraquinones; Crystallography, X-Ray; Electrons; Humans; Ligands; Light; Molecular Structure; Serum Albumin; Warfarin

2011