Page last updated: 2024-08-23

vx and soman

vx has been researched along with soman in 98 studies

Research

Studies (98)

TimeframeStudies, this research(%)All Research%
pre-199015 (15.31)18.7374
1990's30 (30.61)18.2507
2000's18 (18.37)29.6817
2010's27 (27.55)24.3611
2020's8 (8.16)2.80

Authors

AuthorsStudies
Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A1
Bajgar, J3
Anderson, DR; Harris, LW; Lennox, WJ; Murrow, ML; Solana, RP; Wade, JV1
Anderson, DR; Harris, LW; Lennox, WJ; Woodard, CL1
Dettbarn, WD; Gupta, RC1
Fiekers, JF; Heppner, TJ1
Bokonjić, D; Rosić, N1
Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP1
Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP; Talbot, BG1
Bide, RW; Parker, D; Sawyer, TW; Thomas, N; Weiss, MT1
Erhard, MH; Kühlmann, R; Lösch, U; Szinicz, L1
Naseem, SM1
Eldefrawi, AT; Eldefrawi, ME; Silveira, CL1
Forster, JS; Hammond, PS1
Hao, XY; Qin, BY1
Chen, SM; Chi, MG1
McDonough, JH; McLeod, CG; Nipwoda, MT1
Artursson, E; Bucht, G; Puu, G1
Andersen, RA; Fonnum, F; Malthe-Sørenssen, D; Odden, E1
Désiré, B; Saint-André, S1
Doctor, BP; Jones, D; Koplovitz, I; Rush, RS; Wolfe, AD1
Dawson, RM; Gray, PJ1
Beers, ET; Glenn, JF; Rickett, DL1
Liu, CH; Pei, SQ; Wang, ZX; Zhao, DL1
Harvey, B; Sellers, DJ; Watts, P1
Beck, HC; Benschop, HP; Van den Berg, GR1
Binenfeld, Z; Maksimović, M; Markov, V1
Bock, J; Ceulen, BI; Kienhuis, H; van Hooidonk, C1
Dettbarn, WD; Hoskin, FC; Walker, JE; Wild, JR1
Cetkovic, S; Knezevic, DL; Tadic, V1
Cetkovic, S; Kicic, Z; Knezevic, DL; Tadic, V1
Koplovitz, I; Stewart, JR1
Ashani, Y; Cohen, E; Grunwald, J; Marcus, D; Papier, Y; Raveh, L1
Degenhardt-Langelaan, CE; Kientz, CE1
Kassa, J; Vachek, J1
Ashani, Y; Cohen, E; Grauer, E; Grunwald, J; Raveh, L1
Belkin, M; Solberg, Y1
Ianno, LV; Musiĭchuk, IuI1
Holstege, CP; Kirk, M; Sidell, FR1
Broomfield, CA; Lockridge, O; Millard, CB1
Maxwell, DM; Sweeney, RE1
Burger, N; Lovrić, J; Skrinjarić-Spoljar, M1
Klein, R; Leikin, JB; Meislin, HW; Thomas, RG; Walter, FG1
Amundson, DE; Devereaux, A; Lazarus, AA; Parrish, JS1
Collins, GE; Mulchandani, A; Pumera, M; Wang, J1
Huebner, HJ; Li, Y; Lum, KT; Phillips, TD; Raushel, FM1
Cabal, J; Kassa, J; Severa, J1
Ashani, Y; Pistinner, S1
Niven, AS; Roop, SA1
Newmark, J1
Feng, C; Xie, J1
Seto, Y; Tsuge, K1
Cohen, O; Kronman, C; Mazor, O; Ordentlich, A; Raveh, L; Shafferman, A1
Bajgar, J; Jun, D; Kuca, K1
Bajgar, J; Herink, J; Koupilová, M1
Hrobak, PK1
Beck, JM; Hadad, CM1
Dabisch, PA; Horsmon, MS; Miller, DB; Mioduszewski, RJ; Muse, WT; Sommerville, DR; Taylor, JT; Thomson, S1
Kanamori-Kataoka, M; Seto, Y2
Alvaro, M; Cojocaru, B; Epure, G; Garcia, H; Neaţu, S; Pârvulescu, VI; Petrea, N; Somoghi, V1
Ditargiani, RC; Doctor, BP; Genovese, RF; Johnson, CC; Saxena, A; Sun, W1
McDonough, JH; O'Donnell, JC; Shih, TM1
Doctor, BP; Fedorko, JM; Koplovitz, I; Saxena, A; Sun, W1
Kaljurand, M; Kubáň, P; Makarõtševa, N; Seiman, A; Vaher, M1
Andrle, M; Filip, J; Machala, L; Marusak, Z; Oplustil, F; Sharma, VK; Tucek, J; Zboril, R1
Bao, Y; Chen, J; Lin, Y; Liu, Q; Wu, B; Xie, J1
Grygar, TM; Němec, T; Opluštil, F; Stengl, V1
Creasy, WR; Fry, RA; McGarvey, DJ1
Clarkson, ED; Railer, RF; Schulz, SM; Smith, KH1
Collins, JL; Lee, R; Peng, X; Pierre, Z; Sciuto, AM; Witriol, A1
Cerasoli, DM; Ditargiani, RC; Hamilton, TA; Hodgins, SM; Hughes, JH; Kauffman, MA; Otto, TC; Sarricks, EP; Saturday, GA; Scott, JR1
Bahnson, BJ; Cerasoli, DM; Kirby, SD; Norris, JR; Richard Smith, J1
Babu, UM; Condon, P; Mendez, A; Sambursky, R; VanDine, R1
Kuča, K; Misík, J; Pavliková, R1
Coleman, RM; Crow, BS; Hamelin, EI; Jakubowski, EM; Johnson, RC; Lawrence, RJ; Schulze, ND; Shaner, RL1
Chen, J; Feng, J; Guo, L; Li, C; Lin, Y; Liu, Q; Wu, B; Xie, J; Yan, L1
Breton, P; Christin, D; Daulon, S; Graziani, S; Perrier, N; Taysse, L1
Chilcott, RP; Chipman, JK; Dalton, CH; Graham, JS; Hall, CA; Lydon, HL1
Chilcott, RP; Chipman, JK; Dalton, CH; Graham, JS; Hall, CA; Jenner, J; Lydon, HL1
Blake, TA; Brewer, BN; Carter, MD; Crenshaw, MD; Crow, BS; Evans, RA; Garton, JW; Johnson, RC; Pantazides, BG; Perez, JW; Quiñones-González, J; Read, RW; Riches, JR; Stubbs, SJ; Thomas, JD; Tomcik, DJ; Watson, CM1
Antkowiak, B; Eckle, VS; Grasshoff, C; Seeger, T; Thiermann, H; Weimer, I; Worek, F1
Aas, P; Enger, S; Mariussen, E; Myhrer, T1
Dalton, C; Graham, S; Jenner, J1
Caetano, MS; da Cunha, EF; de Castro, AA; Mancini, DT; Ramalho, TC; Rocha, EP; Silva, TC1
Kim, C; Lee, JY; Lee, YH1
Chilcott, RP; Matar, H; Price, SC1
Armstrong, SJ; Cadieux, CL; Capacio, BR; Cerasoli, DM; Hodgins, SM; Kasten, SA; Lee-Stubbs, RB; Lenz, DE; Otto, TC; Reeves, TE1
Escher, B; Job, L; Köhler, A; Skerra, A; Worek, F1
Garrett, TJ; Goldberger, BA; Rubin, KM1
Bouknight, KD; Compton, JR; Guelta, MA; Harvey, SP; Jurkouich, KM; Khavrutskii, IV; Legler, PM1
Chen, J; Gao, R; Guo, L; Lin, Y; Liu, H; Liu, Q; Liu, Y; Lu, X; Wang, H; Wu, J; Xie, J; Xu, B; Zhang, M; Zhang, Y1
Myers, TM; Saxena, A; Sipos, ML1
Leif, RN; Valdez, CA1
Enright, HA; Lao, V; Lau, EY; Malfatti, MA; Mayer, BP; Valdez, CA; Williams, AM1

Reviews

7 review(s) available for vx and soman

ArticleYear
The role of excitotoxicity in organophosphorous nerve agents central poisoning.
    Trends in pharmacological sciences, 1997, Volume: 18, Issue:6

    Topics: Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Excitatory Amino Acid Antagonists; Humans; Neurons; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Receptors, N-Methyl-D-Aspartate; Sarin; Seizures; Soman; Synaptic Transmission

1997
Chemical warfare. Nerve agent poisoning.
    Critical care clinics, 1997, Volume: 13, Issue:4

    Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Disaster Planning; Emergency Medical Services; Humans; Nervous System Diseases; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman

1997
A review of nerve agent exposure for the critical care physician.
    Critical care medicine, 2002, Volume: 30, Issue:10

    Topics: Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Nervous System; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman

2002
Vesicants and nerve agents in chemical warfare. Decontamination and treatment strategies for a changed world.
    Postgraduate medicine, 2002, Volume: 112, Issue:4

    Topics: Antidotes; Arsenicals; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Information Services; Internet; Irritants; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Primary Prevention; Protective Clothing; Sarin; Soman

2002
Inhalational exposure to nerve agents.
    Respiratory care clinics of North America, 2004, Volume: 10, Issue:1

    Topics: Chemical Warfare Agents; Disaster Planning; Humans; Lung Diseases; Lung Injury; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman; United States

2004
Therapy for nerve agent poisoning.
    Archives of neurology, 2004, Volume: 61, Issue:5

    Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman

2004
Analysis of Organophosphorus-Based Nerve Agent Degradation Products by Gas Chromatography-Mass Spectrometry (GC-MS): Current Derivatization Reactions in the Analytical Chemist's Toolbox.
    Molecules (Basel, Switzerland), 2021, Jul-30, Volume: 26, Issue:15

    Topics: Alkylation; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Methylation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman

2021

Other Studies

91 other study(ies) available for vx and soman

ArticleYear
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine

2008
Biological monitoring of exposure to nerve agents.
    British journal of industrial medicine, 1992, Volume: 49, Issue:9

    Topics: Acetylcholinesterase; Animals; Brain; Diaphragm; Dogs; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Salivation; Sarin; Seizures; Soman

1992
Successful pretreatment/therapy of soman, sarin and VX intoxication.
    Drug and chemical toxicology, 1992, Volume: 15, Issue:4

    Topics: Animals; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organothiophosphorus Compounds; Phenylpropionates; Physostigmine; Poisoning; Sarin; Soman; Trihexyphenidyl; Tropanes

1992
The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats.
    Drug and chemical toxicology, 1992, Volume: 15, Issue:4

    Topics: Animals; Antidotes; Cholinesterase Inhibitors; Male; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Soman

1992
Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX.
    Neurotoxicology, 1992,Fall, Volume: 13, Issue:3

    Topics: Acetylcholinesterase; Acute Disease; Animals; Atropine; Cholinesterase Inhibitors; Male; Memantine; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman; Tubocurarine

1992
The effects of irreversible acetylcholinesterase inhibitors on transmission through sympathetic ganglia of the bullfrog.
    Neuropharmacology, 1991, Volume: 30, Issue:8

    Topics: Acetylcholine; Action Potentials; Animals; Atropine; Carbachol; Cholinesterase Inhibitors; Ganglia, Sympathetic; Organothiophosphorus Compounds; Rana catesbeiana; Sarin; Soman; Synaptic Transmission

1991
The influence of inhibitors and other factors on cholinesterases.
    Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove, 1991, Volume: 34, Issue:1

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Female; Organophosphorus Compounds; Organothiophosphates; Organothiophosphorus Compounds; Rats; Sarin; Soman

1991
Anticonvulsive and protective effects of diazepam and midazolam in rats poisoned by highly toxic organophosphorus compounds.
    Arhiv za higijenu rada i toksikologiju, 1991, Volume: 42, Issue:4

    Topics: Animals; Anticonvulsants; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Male; Midazolam; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman

1991
Effects of subacute pretreatment with carbamate together with acute adjunct pretreatment against nerve agent exposure.
    Drug and chemical toxicology, 1991, Volume: 14, Issue:1-2

    Topics: Animals; Carbamates; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Mice; Organothiophosphorus Compounds; Physostigmine; Scopolamine; Soman; Trihexyphenidyl

1991
Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication.
    Drug and chemical toxicology, 1991, Volume: 14, Issue:3

    Topics: Animals; Atropine; Benztropine; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organothiophosphorus Compounds; Physostigmine; Sarin; Soman; Trihexyphenidyl

1991
Efficacy of an oximate-based skin decontaminant against organophosphate nerve agents determined in vivo and in vitro.
    Toxicology, 1991, Volume: 67, Issue:3

    Topics: Acetylcholinesterase; Animals; Brain; Chick Embryo; Cholinesterase Inhibitors; Decontamination; Diacetyl; Female; Male; Neurons; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman

1991
Detection of the organophosphorus nerve agent soman by an ELISA using monoclonal antibodies.
    Archives of toxicology, 1990, Volume: 64, Issue:7

    Topics: Alcohols; Animals; Antibodies, Monoclonal; Antibody Specificity; Buffers; Chickens; Cholinesterase Inhibitors; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Goats; Humans; Mice; Mice, Inbred Strains; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Peroxidases; Rabbits; Soman; Stereoisomerism

1990
Effect of organophosphates on dopamine and muscarinic receptor binding in rat brain.
    Biochemistry international, 1990, Volume: 20, Issue:4

    Topics: Animals; Brain; Cholinesterase Inhibitors; Female; N-Methylscopolamine; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Muscarinic; Sarin; Scopolamine Derivatives; Soman; Spiperone

1990
Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases.
    Toxicology and applied pharmacology, 1990, Volume: 103, Issue:3

    Topics: Animals; Cholinesterase Inhibitors; Dioxolanes; Dose-Response Relationship, Drug; Echothiophate Iodide; Insecticides; Male; Myocardium; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Parasympathomimetics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sarin; Soman; Tritium

1990
A microassay-based procedure for measuring low levels of toxic organophosphorus compounds through acetylcholinesterase inhibition.
    Analytical biochemistry, 1989, Aug-01, Volume: 180, Issue:2

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Isoflurophate; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Reference Standards; Soman; Spectrophotometry

1989
[Effects of soman, VX and 5-(1,3,3-trimethyl)indolinyl-N,N-dimethyl carbamate on cholinesterase isoenzymes in mouse plasma].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:4

    Topics: Animals; Carbamates; Cholinesterase Inhibitors; Cholinesterases; Indoles; Isoenzymes; Male; Mice; Organothiophosphorus Compounds; Soman

1986
[Direct effect of VX and soman on nicotinic receptors].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:5

    Topics: Animals; Binding, Competitive; Cholinesterase Inhibitors; Cobra Neurotoxin Proteins; Organothiophosphorus Compounds; Receptors, Nicotinic; Soman; Torpedo

1986
Direct microinjection of soman or VX into the amygdala produces repetitive limbic convulsions and neuropathology.
    Brain research, 1987, Dec-01, Volume: 435, Issue:1-2

    Topics: Amygdala; Animals; Brain; Convulsants; Male; Microinjections; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Seizures; Soman

1987
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
    Biochemical pharmacology, 1986, May-01, Volume: 35, Issue:9

    Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism

1986
Effects of organophosphates on presynaptic events in the vascularly perfused phrenic nerve-hemidiaphragm preparation from the rat.
    Biochemical pharmacology, 1987, Apr-01, Volume: 36, Issue:7

    Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; Female; In Vitro Techniques; Isoflurophate; Male; Muscles; Organophosphorus Compounds; Organothiophosphorus Compounds; Perfusion; Phrenic Nerve; Rats; Rats, Inbred Strains; Sarin; Soman; Synapses

1987
Inactivation of sarin and soman by cyclodextrins in vitro.
    Experientia, 1987, Apr-15, Volume: 43, Issue:4

    Topics: alpha-Cyclodextrins; beta-Cyclodextrins; Cyclodextrins; Dextrins; gamma-Cyclodextrins; Kinetics; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Starch

1987
Acetylcholinesterase prophylaxis against organophosphate toxicity.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1987, Volume: 9, Issue:2

    Topics: Acetylcholinesterase; Animals; Female; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Organophosphorus Compounds; Organothiophosphorus Compounds; Soman; Species Specificity

1987
Kinetic constants for the inhibition of eel and rabbit brain acetylcholinesterase by some organophosphates and carbamates of military significance.
    Toxicology and applied pharmacology, 1987, Volume: 91, Issue:1

    Topics: Animals; Brain; Carbamates; Chemical Warfare Agents; Cholinesterase Inhibitors; Eels; Kinetics; Neostigmine; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Physostigmine; Rabbits; Sarin; Soman

1987
Central respiratory effects versus neuromuscular actions of nerve agents.
    Neurotoxicology, 1986,Spring, Volume: 7, Issue:1

    Topics: Animals; Cats; Cholinesterase Inhibitors; Diaphragm; Female; Male; Neuromuscular Junction; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Respiratory Center; Respiratory Insufficiency; Sarin; Soman

1986
[Effect of soman, sarin and VX on specific binding of 3H-quinuclidinyl benzilate in rat cerebral cortex homogenates].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1983, Volume: 4, Issue:4

    Topics: Animals; Cerebral Cortex; Cholinesterase Inhibitors; In Vitro Techniques; Male; Organophosphorus Compounds; Organothiophosphorus Compounds; Quinuclidines; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Sarin; Soman; Tritium

1983
The reactivation by oximes of phosphonylated acetylcholinesterase: the possible erroneous interpretation of reactivating potency.
    Biochemical pharmacology, 1984, Nov-01, Volume: 33, Issue:21

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Organothiophosphorus Compounds; Oximes; Sarin; Soman

1984
Stereochemical analysis of the nerve agents soman, sarin, tabun, and VX by proton NMR-spectroscopy with optically active shift reagents.
    Bulletin of environmental contamination and toxicology, 1984, Volume: 33, Issue:5

    Topics: Cholinesterase Inhibitors; Indicators and Reagents; Magnetic Resonance Spectroscopy; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Stereoisomerism

1984
[Direct reactions of pyridinium oximes with organophosphorus compounds].
    Arhiv za higijenu rada i toksikologiju, 1984, Volume: 35, Issue:3

    Topics: Chemical Phenomena; Chemical Warfare Agents; Chemistry; Drug Interactions; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Sarin; Soman

1984
Rate of skin penetration of organophosphates measured in diffusion cells.
    Developments in toxicology and environmental science, 1980, Volume: 8

    Topics: Animals; Diffusion; Female; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Male; Organophosphorus Compounds; Organothiophosphorus Compounds; Skin; Soman

1980
Treatment of nerve gas poisoning.
    The Medical letter on drugs and therapeutics, 1995, May-12, Volume: 37, Issue:948

    Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman

1995
Hydrolysis of tetriso by an enzyme derived from Pseudomonas diminuta as a model for the detoxication of O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate (VX).
    Biochemical pharmacology, 1995, Mar-01, Volume: 49, Issue:5

    Topics: Aryldialkylphosphatase; Chelating Agents; Cholinesterase Inhibitors; Esterases; Inactivation, Metabolic; Isoflurophate; Organophosphorus Compounds; Organothiophosphorus Compounds; Pseudomonas; Soman

1995
The efficacy of different decontaminants in rats and pigs percutaneously poisoned with organophosphates.
    Veterinary and human toxicology, 1993, Volume: 35, Issue:5

    Topics: Administration, Cutaneous; Aluminum Silicates; Animals; Clay; Decontamination; Ethanolamines; Female; Gas Poisoning; Male; Ointments; Organothiophosphorus Compounds; Oximes; Polyethylene Glycols; Rats; Rats, Wistar; Soman; Survival Rate; Swine; Time Factors; Treatment Outcome

1993
The efficacy of different formulations of protective-decontaminating ointments based on polyethylene glycol in rats percutaneously poisoned with highly toxic organophosphates.
    Veterinary and human toxicology, 1993, Volume: 35, Issue:5

    Topics: Administration, Cutaneous; Animals; Decontamination; Female; Gas Poisoning; Ointments; Organothiophosphorus Compounds; Oximes; Polyethylene Glycols; Rats; Rats, Wistar; Soman; Time Factors; Treatment Outcome

1993
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
    Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms

1994
Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization.
    Biochemical pharmacology, 1993, Jun-22, Volume: 45, Issue:12

    Topics: Animals; Antidotes; Butyrylcholinesterase; Cholinesterase Inhibitors; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Neutralization Tests; Organophosphates; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman

1993
Capillary gas chromatographic analysis of nerve agents using large volume injections.
    Journal of chromatography. A, 1996, Feb-02, Volume: 723, Issue:1

    Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Chromatography, Gas; Hydrogen-Ion Concentration; Isoflurophate; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Water

1996
[The effect of parasympatholytics on the therapeutic effectiveness of the oxime HI-6 against organophosphorus compounds (Soman, substance VX, Fosdrin) in mice].
    Casopis lekaru ceskych, 1997, Feb-12, Volume: 136, Issue:4

    Topics: Animals; Antidotes; Atropine; Benactyzine; Biperiden; Cholinesterase Reactivators; Male; Mevinphos; Mice; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Parasympatholytics; Pyridinium Compounds; Soman

1997
The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase.
    Toxicology and applied pharmacology, 1997, Volume: 145, Issue:1

    Topics: Animals; Behavior, Animal; Biological Availability; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Injections, Intramuscular; Injections, Intravenous; Lethal Dose 50; Macaca mulatta; Models, Biological; Organothiophosphorus Compounds; Poisoning; Random Allocation; Soman; Spatial Behavior; Statistics as Topic

1997
[Acute poisoning by neuroparalytic agents and its long-term effects].
    Meditsina truda i promyshlennaia ekologiia, 1997, Issue:6

    Topics: Acute Disease; Adult; Chemical Industry; Chemical Warfare Agents; Cholinesterase Inhibitors; Female; Follow-Up Studies; Humans; Male; Middle Aged; Occupational Diseases; Occupations; Organothiophosphorus Compounds; Sarin; Soman; Time Factors

1997
Differential inhibition of the brain acetylcholinesterase molecular forms following sarin, soman and VX intoxication in laboratory rats.
    Acta medica (Hradec Kralove), 1997, Volume: 40, Issue:4

    Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Female; Organothiophosphorus Compounds; Rats; Rats, Wistar; Sarin; Soman

1997
Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization.
    Chemico-biological interactions, 1999, May-14, Volume: 119-120

    Topics: Animals; Benzoylcholine; Binding Sites; Butyrylcholinesterase; Butyrylthiocholine; Cephamycins; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Design; Echothiophate Iodide; Humans; Hydrolysis; Inactivation, Metabolic; Kinetics; Mutagenesis, Site-Directed; Organophosphates; Organothiophosphorus Compounds; Protein Engineering; Sarin; Soman; Torpedo

1999
A theoretical model of the competition between hydrolase and carboxylesterase in protection against organophosphorus poisoning.
    Mathematical biosciences, 1999, Volume: 160, Issue:2

    Topics: Acetylcholinesterase; Animals; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Dichlorvos; Esterases; Isoflurophate; Lethal Dose 50; Models, Biological; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Sarin; Soman

1999
Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphonylation of the enzyme.
    Journal of enzyme inhibition, 1999, Volume: 14, Issue:5

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Ferric Compounds; Ferricyanides; Humans; Organophosphonates; Organothiophosphorus Compounds; Oximes; Phosphorylation; Protein Binding; Pyridinium Compounds; Soman

1999
Measurements of chemical warfare agent degradation products using an electrophoresis microchip with contactless conductivity detector.
    Analytical chemistry, 2002, Dec-01, Volume: 74, Issue:23

    Topics: Chemical Warfare Agents; Electric Conductivity; Electrophoresis; Microchemistry; Miniaturization; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Sensitivity and Specificity; Soman

2002
Organophosphate nerve agent toxicity in Hydra attenuata.
    Chemical research in toxicology, 2003, Volume: 16, Issue:8

    Topics: Administration, Oral; Animals; Artemia; Biological Assay; Chemical Warfare Agents; Hydra; Models, Molecular; Organothiophosphorus Compounds; Sarin; Soman; Stereoisomerism; Structure-Activity Relationship; Time Factors; Toxicity Tests

2003
A comparison of the decontamination efficacy of foam-making blends based on cationic and nonionic tensides against organophosphorus compounds determined in vitro and in vivo.
    Human & experimental toxicology, 2003, Volume: 22, Issue:9

    Topics: Administration, Cutaneous; Animals; Cations; Chemical Warfare Agents; Decontamination; Dose-Response Relationship, Drug; Hydrogen Peroxide; In Vitro Techniques; Lethal Dose 50; Male; Organothiophosphorus Compounds; Rats; Rats, Wistar; Soman; Surface-Active Agents

2003
Estimation of the upper limit of human butyrylcholinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 77, Issue:2

    Topics: Acetylcholinesterase; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Erythrocytes; Esterases; Humans; In Vitro Techniques; Inactivation, Metabolic; Models, Biological; Nervous System Diseases; Neuroprotective Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Soman

2004
[Determination of five nerve agents in contaminated serum by gas chromatography].
    Se pu = Chinese journal of chromatography, 2005, Volume: 23, Issue:1

    Topics: Chemical Warfare Agents; Chromatography, Gas; Humans; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Serum; Soman

2005
Detection of human butyrylcholinesterase-nerve gas adducts by liquid chromatography-mass spectrometric analysis after in gel chymotryptic digestion.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Jun-21, Volume: 838, Issue:1

    Topics: Amino Acid Sequence; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Humans; Molecular Sequence Data; Molecular Structure; Organothiophosphorus Compounds; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization

2006
Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds.
    Molecular pharmacology, 2006, Volume: 70, Issue:3

    Topics: Acetylcholinesterase; Animals; Binding Sites; Butyrylcholinesterase; Humans; Lethal Dose 50; Male; Mice; Organophosphorus Compounds; Organothiophosphorus Compounds; Polyethylene Glycols; Recombinant Proteins; Sarin; Soman; Survival Analysis; Tissue Distribution

2006
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
    Drug and chemical toxicology, 2007, Volume: 30, Issue:1

    Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime

2007
The effect of sublethal doses of cholinesterase inhibitors on spontaneous motor activity in laboratory rats.
    Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems, 1991, Volume: 33, Issue:5-6

    Topics: Animals; Cholinesterase Inhibitors; Depression, Chemical; Dose-Response Relationship, Drug; Motor Activity; Organothiophosphorus Compounds; Rats; Soman

1991
Nerve agents: implications for anesthesia providers.
    AANA journal, 2008, Volume: 76, Issue:2

    Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors

2008
Hydrolysis of nerve agents by model nucleophiles: a computational study.
    Chemico-biological interactions, 2008, Sep-25, Volume: 175, Issue:1-3

    Topics: Chemical Warfare Agents; Hydrolysis; Organothiophosphorus Compounds; Sarin; Soman

2008
Gender difference in the miotic potency of soman vapor in rats.
    Cutaneous and ocular toxicology, 2008, Volume: 27, Issue:2

    Topics: Acetylcholinesterase; Analysis of Variance; Animals; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Eye; Female; Infrared Rays; Male; Miosis; Models, Animal; Organophosphorus Compounds; Organothiophosphorus Compounds; Pupil; Rats; Rats, Sprague-Dawley; Sex Characteristics; Soman

2008
Paraoxonase activity against nerve gases measured by capillary electrophoresis and characterization of human serum paraoxonase (PON1) polymorphism in the coding region (Q192R).
    Analytical biochemistry, 2009, Feb-01, Volume: 385, Issue:1

    Topics: Aryldialkylphosphatase; Electrophoresis, Capillary; Genotype; Humans; Hydrolysis; Molecular Structure; Open Reading Frames; Organothiophosphorus Compounds; Polymerase Chain Reaction; Polymorphism, Genetic; Sarin; Soman

2009
Synergism of activated carbon and undoped and nitrogen-doped TiO2 in the photocatalytic degradation of the chemical warfare agents soman, VX, and yperite.
    ChemSusChem, 2009, Volume: 2, Issue:5

    Topics: Adsorption; Catalysis; Charcoal; Chemical Warfare Agents; Mustard Gas; Nitrogen; Organothiophosphorus Compounds; Photochemical Processes; Soman; Spectrophotometry, Ultraviolet; Titanium

2009
Safety of administration of human butyrylcholinesterase and its conjugates with soman or VX in rats.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 106, Issue:5

    Topics: Animals; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Motor Activity; Organothiophosphorus Compounds; Oxotremorine; Rats; Soman

2010
Changes in extracellular striatal acetylcholine and brain seizure activity following acute exposure to nerve agents in freely moving guinea pigs.
    Toxicology mechanisms and methods, 2010, Volume: 20, Issue:3

    Topics: Acetylcholine; Animals; Brain; Chemical Warfare Agents; Choline; Cholinesterase Inhibitors; Corpus Striatum; Electroencephalography; Guinea Pigs; Male; Organothiophosphorus Compounds; Sarin; Seizures; Soman

2010
Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX.
    Biochemical pharmacology, 2011, Jan-01, Volume: 81, Issue:1

    Topics: Animals; Antidotes; Butyrylcholinesterase; Chemical Warfare Agents; Dose-Response Relationship, Drug; Female; Guinea Pigs; Half-Life; Humans; Male; Organothiophosphorus Compounds; Soman

2011
In situ determination of nerve agents in various matrices by portable capillary electropherograph with contactless conductivity detection.
    Journal of chromatography. A, 2011, May-06, Volume: 1218, Issue:18

    Topics: Chemical Warfare Agents; Chromatography, High Pressure Liquid; Drug Stability; Electric Conductivity; Electrophoresis, Capillary; Gas Chromatography-Mass Spectrometry; Linear Models; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Sensitivity and Specificity; Soil; Soman; Specimen Handling

2011
Treatment of chemical warfare agents by zero-valent iron nanoparticles and ferrate(VI)/(III) composite.
    Journal of hazardous materials, 2012, Apr-15, Volume: 211-212

    Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Iron; Microscopy, Electron, Scanning; Mustard Gas; Nanoparticles; Organothiophosphorus Compounds; Oxidation-Reduction; Powder Diffraction; Soman; Water Pollutants, Chemical; Water Purification; X-Ray Diffraction

2012
Quantification of nerve agent adducts with albumin in rat plasma using liquid chromatography-isotope dilution tandem mass spectrometry.
    Journal of chromatography. A, 2012, Mar-16, Volume: 1229

    Topics: Animals; Biomarkers; Butyrylcholinesterase; Chromatography, Liquid; Limit of Detection; Male; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sarin; Serum Albumin; Soman; Tandem Mass Spectrometry; Tyrosine

2012
Ge4+ doped TiO2 for stoichiometric degradation of warfare agents.
    Journal of hazardous materials, 2012, Aug-15, Volume: 227-228

    Topics: Chemical Warfare Agents; Decontamination; Germanium; Metal Nanoparticles; Mustard Gas; Organothiophosphorus Compounds; Soman; Titanium

2012
Reaction of nerve agents with phosphate buffer at pH 7.
    The journal of physical chemistry. A, 2012, Jul-12, Volume: 116, Issue:27

    Topics: Buffers; Chemical Warfare Agents; Half-Life; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Organophosphonates; Organothiophosphorus Compounds; Phosphates; Sarin; Soman; Water

2012
Median lethal dose determination for percutaneous exposure to soman and VX in guinea pigs and the effectiveness of decontamination with M291 SDK or SANDIA foam.
    Toxicology letters, 2012, Aug-03, Volume: 212, Issue:3

    Topics: Administration, Cutaneous; Animals; Chemical Warfare Agents; Decontamination; Dosage Forms; Emollients; Guinea Pigs; Lethal Dose 50; Male; Ointments; Organothiophosphorus Compounds; Skin; Skin Absorption; Skin Care; Soman; Toxicity Tests, Acute

2012
Determination of LCt(50)s in anesthetized rats exposed to aerosolized nerve agents.
    Toxicology mechanisms and methods, 2013, Volume: 23, Issue:2

    Topics: Administration, Inhalation; Aerosols; Anesthesia; Animals; Chemical Warfare Agents; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Neurotoxins; Organothiophosphorus Compounds; Rats; Sarin; Soman

2013
Identification and characterization of novel catalytic bioscavengers of organophosphorus nerve agents.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Antidotes; Aryldialkylphosphatase; Bacillales; Bacterial Proteins; Chemical Warfare Agents; Drug Discovery; Drug Evaluation, Preclinical; Haloarcula; Hydrolysis; Micromonospora; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Soman

2013
Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Amino Acid Substitution; Antidotes; Aryldialkylphosphatase; Catalytic Domain; Chemical Warfare Agents; Humans; Hydrolysis; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Protein Engineering; Recombinant Proteins; Sarin; Soman; Substrate Specificity

2013
A 10-minute point-of-care assay for detection of blood protein adducts resulting from low level exposure to organophosphate nerve agents.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Adult; Blood Chemical Analysis; Blood Proteins; Chemical Warfare Agents; Cholinesterase Inhibitors; Cross Reactions; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Point-of-Care Systems; Sarin; Soman

2013
Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detergents.
    Arhiv za higijenu rada i toksikologiju, 2013, Volume: 64, Issue:2

    Topics: Administration, Cutaneous; Animals; Chemical Warfare Agents; Decontamination; Detergents; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Organothiophosphorus Compounds; Paraoxon; Pesticides; Protective Agents; Rats; Rats, Wistar; Soman; Survival Rate

2013
Quantitation of five organophosphorus nerve agent metabolites in serum using hydrophilic interaction liquid chromatography and tandem mass spectrometry.
    Analytical and bioanalytical chemistry, 2014, Volume: 406, Issue:21

    Topics: Ammonium Compounds; Biotransformation; Buffers; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Fluorides; Humans; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Limit of Detection; Organophosphorus Compounds; Organothiophosphorus Compounds; Quaternary Ammonium Compounds; Sarin; Solid Phase Extraction; Soman; Tandem Mass Spectrometry

2014
Determination of nerve agent metabolites in human urine by isotope-dilution gas chromatography-tandem mass spectrometry after solid phase supported derivatization.
    Analytical and bioanalytical chemistry, 2014, Volume: 406, Issue:21

    Topics: Biotransformation; Chemical Warfare Agents; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Indicator Dilution Techniques; Limit of Detection; Liquid-Liquid Extraction; Organophosphonates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman

2014
Effects of repeated low-dose exposure of the nerve agent VX on monoamine levels in different brain structures in mice.
    Neurochemical research, 2014, Volume: 39, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cholinesterase Inhibitors; Cholinesterases; Dopamine; Male; Mice, Inbred BALB C; Organothiophosphorus Compounds; Serotonin; Soman

2014
Development of haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents. 1: evaluation of in vitro clotting efficacy in the presence of certain contaminants.
    Journal of applied toxicology : JAT, 2015, Volume: 35, Issue:5

    Topics: Animals; Blood Coagulation; Chemical Warfare Agents; Decontamination; Female; Hemostatics; Mustard Gas; Organothiophosphorus Compounds; Petrolatum; Soman; Swine; Wounds and Injuries

2015
Development of haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents. 2: evaluation of in vitro topical decontamination efficacy using undamaged skin.
    Journal of applied toxicology : JAT, 2015, Volume: 35, Issue:5

    Topics: Aluminum Compounds; Animals; Chemical Warfare Agents; Decontamination; Hemostatics; Magnesium Compounds; Mustard Gas; Organothiophosphorus Compounds; Silicates; Skin; Skin Absorption; Soman; Swine; Wounds and Injuries

2015
Simultaneous measurement of tabun, sarin, soman, cyclosarin, VR, VX, and VM adducts to tyrosine in blood products by isotope dilution UHPLC-MS/MS.
    Analytical chemistry, 2014, Oct-21, Volume: 86, Issue:20

    Topics: Blood Chemical Analysis; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Humans; Organophosphorus Compounds; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization; Time Factors; Tyrosine

2014
Measurement of breakthrough volumes of volatile chemical warfare agents on a poly(2,6-diphenylphenylene oxide)-based adsorbent and application to thermal desorption-gas chromatography/mass spectrometric analysis.
    Journal of chromatography. A, 2015, Sep-04, Volume: 1410

    Topics: Adsorption; Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Phenols; Polymers; Sarin; Soman; Volatilization

2015
Self-regeneration of neuromuscular function following soman and VX poisoning in spinal cord-skeletal muscle cocultures.
    Toxicology letters, 2016, Feb-26, Volume: 244

    Topics: Animals; Cell Survival; Chemical Warfare Agents; Coculture Techniques; Mice, Inbred C57BL; Microscopy, Video; Muscle Contraction; Muscle, Skeletal; Neuromuscular Junction; Organothiophosphorus Compounds; Recovery of Function; Regeneration; Soman; Spinal Cord; Time Factors; Tissue Culture Techniques

2016
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats.
    Neurotoxicology, 2015, Volume: 50

    Topics: Animals; Anticonvulsants; Antidotes; Body Weight; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Lethal Dose 50; Levetiracetam; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Piracetam; Procyclidine; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman

2015
Effect of exposure area on nerve agent absorption through skin in vitro.
    Toxicology in vitro : an international journal published in association with BIBRA, 2015, Dec-25, Volume: 30, Issue:1 Pt B

    Topics: Animals; Diffusion; Guinea Pigs; In Vitro Techniques; Nerve Agents; Organothiophosphorus Compounds; Skin Absorption; Soman; Swine

2015
Molecular Docking, Metal Substitution and Hydrolysis Reaction of Chiral Substrates of Phosphotriesterase.
    Combinatorial chemistry & high throughput screening, 2016, Volume: 19, Issue:4

    Topics: Aluminum; Catalytic Domain; Cholinesterase Inhibitors; Hydrolysis; Kinetics; Metals; Molecular Docking Simulation; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Phosphoric Triester Hydrolases; Sarin; Soman; Stereoisomerism

2016
Simultaneous Time-concentration Analysis of Soman and VX Adducts to Butyrylcholinesterase and Albumin by LC-MS-MS.
    Journal of analytical toxicology, 2018, Jun-01, Volume: 42, Issue:5

    Topics: Animals; Biomarkers, Pharmacological; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromatography, Affinity; Chromatography, High Pressure Liquid; Immunomagnetic Separation; Injections, Intravenous; Limit of Detection; Macaca mulatta; Male; Molecular Structure; Nerve Agents; Oligopeptides; Organothiophosphorus Compounds; Peptide Fragments; Reproducibility of Results; Serum Albumin; Soman; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Toxicokinetics; Tyrosine

2018
Further studies of the efficacy of military, commercial and novel skin decontaminants against the chemical warfare agents sulphur Mustard, Soman and VX.
    Toxicology in vitro : an international journal published in association with BIBRA, 2019, Volume: 54

    Topics: Animals; Chemical Warfare Agents; Decontamination; Female; Mustard Gas; Organothiophosphorus Compounds; Skin; Skin Absorption; Soman; Swine

2019
Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication.
    Biochemical pharmacology, 2020, Volume: 171

    Topics: Animals; Area Under Curve; Butyrylcholinesterase; Chemical Warfare Agents; Guinea Pigs; Humans; Injections, Intramuscular; Injections, Intravenous; Lethal Dose 50; Male; Metabolic Clearance Rate; Nerve Agents; Neuroprotective Agents; Organothiophosphorus Compounds; Poisoning; Soman; Stereoisomerism

2020
A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds.
    Toxicology letters, 2020, Mar-15, Volume: 321

    Topics: Antidotes; Bacterial Proteins; Caulobacteraceae; Drug Stability; Enzyme Stability; Hot Temperature; Mutation; Nerve Agents; Organophosphate Poisoning; Organophosphorus Compounds; Organothiophosphorus Compounds; Oxidation-Reduction; Phosphoric Triester Hydrolases; Protein Denaturation; Recombinant Proteins; Sarin; Soman

2020
Detection of Chemical Weapon Nerve Agents in Bone by Liquid Chromatography-Mass Spectrometry.
    Journal of analytical toxicology, 2020, May-18, Volume: 44, Issue:4

    Topics: Animals; Bone and Bones; Chemical Warfare Agents; Chromatography, Liquid; Humans; Limit of Detection; Nerve Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Swine

2020
Structural and kinetic evidence of aging after organophosphate inhibition of human Cathepsin A.
    Biochemical pharmacology, 2020, Volume: 177

    Topics: Acetylcholinesterase; Binding Sites; Cathepsin A; Cell Line; Chemical Warfare Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Gene Expression; GPI-Linked Proteins; HEK293 Cells; Humans; Isoflurophate; Kinetics; Models, Molecular; Organophosphorus Compounds; Organothiophosphorus Compounds; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Proteins; Sarin; Soman; Substrate Specificity; Time Factors

2020
Sensitive Untargeted Screening of Nerve Agents and Their Degradation Products Using Liquid Chromatography-High Resolution Mass Spectrometry.
    Analytical chemistry, 2020, 08-04, Volume: 92, Issue:15

    Topics: Chemical Warfare Agents; Chromatography, Liquid; Databases, Chemical; Mass Spectrometry; Organothiophosphorus Compounds; Sarin; Sensitivity and Specificity; Small Molecule Libraries; Soman

2020
Conjugates of human serum butyrylcholinesterase and nerve agents are behaviorally safe in rhesus macaques.
    Chemico-biological interactions, 2021, Aug-01, Volume: 344

    Topics: Animals; Butyrylcholinesterase; Diazepam; Female; Humans; Macaca mulatta; Male; Memory; Nerve Agents; Organothiophosphorus Compounds; Soman

2021
Evaluation of 6-OxP-CD, an Oxime-based cyclodextrin as a viable medical countermeasure against nerve agent poisoning: Experimental and molecular dynamic simulation studies on its inclusion complexes with cyclosarin, soman and VX.
    PloS one, 2023, Volume: 18, Issue:3

    Topics: Chemical Warfare Agents; Cyclodextrins; Medical Countermeasures; Molecular Dynamics Simulation; Nerve Agents; Organophosphorus Compounds; Oximes; Phosphorus; Soman

2023