vx has been researched along with soman in 98 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 15 (15.31) | 18.7374 |
1990's | 30 (30.61) | 18.2507 |
2000's | 18 (18.37) | 29.6817 |
2010's | 27 (27.55) | 24.3611 |
2020's | 8 (8.16) | 2.80 |
Authors | Studies |
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Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A | 1 |
Bajgar, J | 3 |
Anderson, DR; Harris, LW; Lennox, WJ; Murrow, ML; Solana, RP; Wade, JV | 1 |
Anderson, DR; Harris, LW; Lennox, WJ; Woodard, CL | 1 |
Dettbarn, WD; Gupta, RC | 1 |
Fiekers, JF; Heppner, TJ | 1 |
Bokonjić, D; Rosić, N | 1 |
Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP | 1 |
Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP; Talbot, BG | 1 |
Bide, RW; Parker, D; Sawyer, TW; Thomas, N; Weiss, MT | 1 |
Erhard, MH; Kühlmann, R; Lösch, U; Szinicz, L | 1 |
Naseem, SM | 1 |
Eldefrawi, AT; Eldefrawi, ME; Silveira, CL | 1 |
Forster, JS; Hammond, PS | 1 |
Hao, XY; Qin, BY | 1 |
Chen, SM; Chi, MG | 1 |
McDonough, JH; McLeod, CG; Nipwoda, MT | 1 |
Artursson, E; Bucht, G; Puu, G | 1 |
Andersen, RA; Fonnum, F; Malthe-Sørenssen, D; Odden, E | 1 |
Désiré, B; Saint-André, S | 1 |
Doctor, BP; Jones, D; Koplovitz, I; Rush, RS; Wolfe, AD | 1 |
Dawson, RM; Gray, PJ | 1 |
Beers, ET; Glenn, JF; Rickett, DL | 1 |
Liu, CH; Pei, SQ; Wang, ZX; Zhao, DL | 1 |
Harvey, B; Sellers, DJ; Watts, P | 1 |
Beck, HC; Benschop, HP; Van den Berg, GR | 1 |
Binenfeld, Z; Maksimović, M; Markov, V | 1 |
Bock, J; Ceulen, BI; Kienhuis, H; van Hooidonk, C | 1 |
Dettbarn, WD; Hoskin, FC; Walker, JE; Wild, JR | 1 |
Cetkovic, S; Knezevic, DL; Tadic, V | 1 |
Cetkovic, S; Kicic, Z; Knezevic, DL; Tadic, V | 1 |
Koplovitz, I; Stewart, JR | 1 |
Ashani, Y; Cohen, E; Grunwald, J; Marcus, D; Papier, Y; Raveh, L | 1 |
Degenhardt-Langelaan, CE; Kientz, CE | 1 |
Kassa, J; Vachek, J | 1 |
Ashani, Y; Cohen, E; Grauer, E; Grunwald, J; Raveh, L | 1 |
Belkin, M; Solberg, Y | 1 |
Ianno, LV; Musiĭchuk, IuI | 1 |
Holstege, CP; Kirk, M; Sidell, FR | 1 |
Broomfield, CA; Lockridge, O; Millard, CB | 1 |
Maxwell, DM; Sweeney, RE | 1 |
Burger, N; Lovrić, J; Skrinjarić-Spoljar, M | 1 |
Klein, R; Leikin, JB; Meislin, HW; Thomas, RG; Walter, FG | 1 |
Amundson, DE; Devereaux, A; Lazarus, AA; Parrish, JS | 1 |
Collins, GE; Mulchandani, A; Pumera, M; Wang, J | 1 |
Huebner, HJ; Li, Y; Lum, KT; Phillips, TD; Raushel, FM | 1 |
Cabal, J; Kassa, J; Severa, J | 1 |
Ashani, Y; Pistinner, S | 1 |
Niven, AS; Roop, SA | 1 |
Newmark, J | 1 |
Feng, C; Xie, J | 1 |
Seto, Y; Tsuge, K | 1 |
Cohen, O; Kronman, C; Mazor, O; Ordentlich, A; Raveh, L; Shafferman, A | 1 |
Bajgar, J; Jun, D; Kuca, K | 1 |
Bajgar, J; Herink, J; Koupilová, M | 1 |
Hrobak, PK | 1 |
Beck, JM; Hadad, CM | 1 |
Dabisch, PA; Horsmon, MS; Miller, DB; Mioduszewski, RJ; Muse, WT; Sommerville, DR; Taylor, JT; Thomson, S | 1 |
Kanamori-Kataoka, M; Seto, Y | 2 |
Alvaro, M; Cojocaru, B; Epure, G; Garcia, H; Neaţu, S; Pârvulescu, VI; Petrea, N; Somoghi, V | 1 |
Ditargiani, RC; Doctor, BP; Genovese, RF; Johnson, CC; Saxena, A; Sun, W | 1 |
McDonough, JH; O'Donnell, JC; Shih, TM | 1 |
Doctor, BP; Fedorko, JM; Koplovitz, I; Saxena, A; Sun, W | 1 |
Kaljurand, M; Kubáň, P; Makarõtševa, N; Seiman, A; Vaher, M | 1 |
Andrle, M; Filip, J; Machala, L; Marusak, Z; Oplustil, F; Sharma, VK; Tucek, J; Zboril, R | 1 |
Bao, Y; Chen, J; Lin, Y; Liu, Q; Wu, B; Xie, J | 1 |
Grygar, TM; Němec, T; Opluštil, F; Stengl, V | 1 |
Creasy, WR; Fry, RA; McGarvey, DJ | 1 |
Clarkson, ED; Railer, RF; Schulz, SM; Smith, KH | 1 |
Collins, JL; Lee, R; Peng, X; Pierre, Z; Sciuto, AM; Witriol, A | 1 |
Cerasoli, DM; Ditargiani, RC; Hamilton, TA; Hodgins, SM; Hughes, JH; Kauffman, MA; Otto, TC; Sarricks, EP; Saturday, GA; Scott, JR | 1 |
Bahnson, BJ; Cerasoli, DM; Kirby, SD; Norris, JR; Richard Smith, J | 1 |
Babu, UM; Condon, P; Mendez, A; Sambursky, R; VanDine, R | 1 |
Kuča, K; Misík, J; Pavliková, R | 1 |
Coleman, RM; Crow, BS; Hamelin, EI; Jakubowski, EM; Johnson, RC; Lawrence, RJ; Schulze, ND; Shaner, RL | 1 |
Chen, J; Feng, J; Guo, L; Li, C; Lin, Y; Liu, Q; Wu, B; Xie, J; Yan, L | 1 |
Breton, P; Christin, D; Daulon, S; Graziani, S; Perrier, N; Taysse, L | 1 |
Chilcott, RP; Chipman, JK; Dalton, CH; Graham, JS; Hall, CA; Lydon, HL | 1 |
Chilcott, RP; Chipman, JK; Dalton, CH; Graham, JS; Hall, CA; Jenner, J; Lydon, HL | 1 |
Blake, TA; Brewer, BN; Carter, MD; Crenshaw, MD; Crow, BS; Evans, RA; Garton, JW; Johnson, RC; Pantazides, BG; Perez, JW; Quiñones-González, J; Read, RW; Riches, JR; Stubbs, SJ; Thomas, JD; Tomcik, DJ; Watson, CM | 1 |
Antkowiak, B; Eckle, VS; Grasshoff, C; Seeger, T; Thiermann, H; Weimer, I; Worek, F | 1 |
Aas, P; Enger, S; Mariussen, E; Myhrer, T | 1 |
Dalton, C; Graham, S; Jenner, J | 1 |
Caetano, MS; da Cunha, EF; de Castro, AA; Mancini, DT; Ramalho, TC; Rocha, EP; Silva, TC | 1 |
Kim, C; Lee, JY; Lee, YH | 1 |
Chilcott, RP; Matar, H; Price, SC | 1 |
Armstrong, SJ; Cadieux, CL; Capacio, BR; Cerasoli, DM; Hodgins, SM; Kasten, SA; Lee-Stubbs, RB; Lenz, DE; Otto, TC; Reeves, TE | 1 |
Escher, B; Job, L; Köhler, A; Skerra, A; Worek, F | 1 |
Garrett, TJ; Goldberger, BA; Rubin, KM | 1 |
Bouknight, KD; Compton, JR; Guelta, MA; Harvey, SP; Jurkouich, KM; Khavrutskii, IV; Legler, PM | 1 |
Chen, J; Gao, R; Guo, L; Lin, Y; Liu, H; Liu, Q; Liu, Y; Lu, X; Wang, H; Wu, J; Xie, J; Xu, B; Zhang, M; Zhang, Y | 1 |
Myers, TM; Saxena, A; Sipos, ML | 1 |
Leif, RN; Valdez, CA | 1 |
Enright, HA; Lao, V; Lau, EY; Malfatti, MA; Mayer, BP; Valdez, CA; Williams, AM | 1 |
7 review(s) available for vx and soman
Article | Year |
---|---|
The role of excitotoxicity in organophosphorous nerve agents central poisoning.
Topics: Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Excitatory Amino Acid Antagonists; Humans; Neurons; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Receptors, N-Methyl-D-Aspartate; Sarin; Seizures; Soman; Synaptic Transmission | 1997 |
Chemical warfare. Nerve agent poisoning.
Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Disaster Planning; Emergency Medical Services; Humans; Nervous System Diseases; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman | 1997 |
A review of nerve agent exposure for the critical care physician.
Topics: Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Nervous System; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman | 2002 |
Vesicants and nerve agents in chemical warfare. Decontamination and treatment strategies for a changed world.
Topics: Antidotes; Arsenicals; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Information Services; Internet; Irritants; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Primary Prevention; Protective Clothing; Sarin; Soman | 2002 |
Inhalational exposure to nerve agents.
Topics: Chemical Warfare Agents; Disaster Planning; Humans; Lung Diseases; Lung Injury; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman; United States | 2004 |
Therapy for nerve agent poisoning.
Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman | 2004 |
Analysis of Organophosphorus-Based Nerve Agent Degradation Products by Gas Chromatography-Mass Spectrometry (GC-MS): Current Derivatization Reactions in the Analytical Chemist's Toolbox.
Topics: Alkylation; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Methylation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman | 2021 |
91 other study(ies) available for vx and soman
Article | Year |
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Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine | 2008 |
Biological monitoring of exposure to nerve agents.
Topics: Acetylcholinesterase; Animals; Brain; Diaphragm; Dogs; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Salivation; Sarin; Seizures; Soman | 1992 |
Successful pretreatment/therapy of soman, sarin and VX intoxication.
Topics: Animals; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organothiophosphorus Compounds; Phenylpropionates; Physostigmine; Poisoning; Sarin; Soman; Trihexyphenidyl; Tropanes | 1992 |
The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Male; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Soman | 1992 |
Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX.
Topics: Acetylcholinesterase; Acute Disease; Animals; Atropine; Cholinesterase Inhibitors; Male; Memantine; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman; Tubocurarine | 1992 |
The effects of irreversible acetylcholinesterase inhibitors on transmission through sympathetic ganglia of the bullfrog.
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Carbachol; Cholinesterase Inhibitors; Ganglia, Sympathetic; Organothiophosphorus Compounds; Rana catesbeiana; Sarin; Soman; Synaptic Transmission | 1991 |
The influence of inhibitors and other factors on cholinesterases.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Female; Organophosphorus Compounds; Organothiophosphates; Organothiophosphorus Compounds; Rats; Sarin; Soman | 1991 |
Anticonvulsive and protective effects of diazepam and midazolam in rats poisoned by highly toxic organophosphorus compounds.
Topics: Animals; Anticonvulsants; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Male; Midazolam; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1991 |
Effects of subacute pretreatment with carbamate together with acute adjunct pretreatment against nerve agent exposure.
Topics: Animals; Carbamates; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Mice; Organothiophosphorus Compounds; Physostigmine; Scopolamine; Soman; Trihexyphenidyl | 1991 |
Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication.
Topics: Animals; Atropine; Benztropine; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organothiophosphorus Compounds; Physostigmine; Sarin; Soman; Trihexyphenidyl | 1991 |
Efficacy of an oximate-based skin decontaminant against organophosphate nerve agents determined in vivo and in vitro.
Topics: Acetylcholinesterase; Animals; Brain; Chick Embryo; Cholinesterase Inhibitors; Decontamination; Diacetyl; Female; Male; Neurons; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1991 |
Detection of the organophosphorus nerve agent soman by an ELISA using monoclonal antibodies.
Topics: Alcohols; Animals; Antibodies, Monoclonal; Antibody Specificity; Buffers; Chickens; Cholinesterase Inhibitors; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Goats; Humans; Mice; Mice, Inbred Strains; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Peroxidases; Rabbits; Soman; Stereoisomerism | 1990 |
Effect of organophosphates on dopamine and muscarinic receptor binding in rat brain.
Topics: Animals; Brain; Cholinesterase Inhibitors; Female; N-Methylscopolamine; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Muscarinic; Sarin; Scopolamine Derivatives; Soman; Spiperone | 1990 |
Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases.
Topics: Animals; Cholinesterase Inhibitors; Dioxolanes; Dose-Response Relationship, Drug; Echothiophate Iodide; Insecticides; Male; Myocardium; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Parasympathomimetics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sarin; Soman; Tritium | 1990 |
A microassay-based procedure for measuring low levels of toxic organophosphorus compounds through acetylcholinesterase inhibition.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Isoflurophate; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Reference Standards; Soman; Spectrophotometry | 1989 |
[Effects of soman, VX and 5-(1,3,3-trimethyl)indolinyl-N,N-dimethyl carbamate on cholinesterase isoenzymes in mouse plasma].
Topics: Animals; Carbamates; Cholinesterase Inhibitors; Cholinesterases; Indoles; Isoenzymes; Male; Mice; Organothiophosphorus Compounds; Soman | 1986 |
[Direct effect of VX and soman on nicotinic receptors].
Topics: Animals; Binding, Competitive; Cholinesterase Inhibitors; Cobra Neurotoxin Proteins; Organothiophosphorus Compounds; Receptors, Nicotinic; Soman; Torpedo | 1986 |
Direct microinjection of soman or VX into the amygdala produces repetitive limbic convulsions and neuropathology.
Topics: Amygdala; Animals; Brain; Convulsants; Male; Microinjections; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Seizures; Soman | 1987 |
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism | 1986 |
Effects of organophosphates on presynaptic events in the vascularly perfused phrenic nerve-hemidiaphragm preparation from the rat.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; Female; In Vitro Techniques; Isoflurophate; Male; Muscles; Organophosphorus Compounds; Organothiophosphorus Compounds; Perfusion; Phrenic Nerve; Rats; Rats, Inbred Strains; Sarin; Soman; Synapses | 1987 |
Inactivation of sarin and soman by cyclodextrins in vitro.
Topics: alpha-Cyclodextrins; beta-Cyclodextrins; Cyclodextrins; Dextrins; gamma-Cyclodextrins; Kinetics; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Starch | 1987 |
Acetylcholinesterase prophylaxis against organophosphate toxicity.
Topics: Acetylcholinesterase; Animals; Female; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Organophosphorus Compounds; Organothiophosphorus Compounds; Soman; Species Specificity | 1987 |
Kinetic constants for the inhibition of eel and rabbit brain acetylcholinesterase by some organophosphates and carbamates of military significance.
Topics: Animals; Brain; Carbamates; Chemical Warfare Agents; Cholinesterase Inhibitors; Eels; Kinetics; Neostigmine; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Physostigmine; Rabbits; Sarin; Soman | 1987 |
Central respiratory effects versus neuromuscular actions of nerve agents.
Topics: Animals; Cats; Cholinesterase Inhibitors; Diaphragm; Female; Male; Neuromuscular Junction; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Respiratory Center; Respiratory Insufficiency; Sarin; Soman | 1986 |
[Effect of soman, sarin and VX on specific binding of 3H-quinuclidinyl benzilate in rat cerebral cortex homogenates].
Topics: Animals; Cerebral Cortex; Cholinesterase Inhibitors; In Vitro Techniques; Male; Organophosphorus Compounds; Organothiophosphorus Compounds; Quinuclidines; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Sarin; Soman; Tritium | 1983 |
The reactivation by oximes of phosphonylated acetylcholinesterase: the possible erroneous interpretation of reactivating potency.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Organothiophosphorus Compounds; Oximes; Sarin; Soman | 1984 |
Stereochemical analysis of the nerve agents soman, sarin, tabun, and VX by proton NMR-spectroscopy with optically active shift reagents.
Topics: Cholinesterase Inhibitors; Indicators and Reagents; Magnetic Resonance Spectroscopy; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Stereoisomerism | 1984 |
[Direct reactions of pyridinium oximes with organophosphorus compounds].
Topics: Chemical Phenomena; Chemical Warfare Agents; Chemistry; Drug Interactions; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Sarin; Soman | 1984 |
Rate of skin penetration of organophosphates measured in diffusion cells.
Topics: Animals; Diffusion; Female; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Male; Organophosphorus Compounds; Organothiophosphorus Compounds; Skin; Soman | 1980 |
Treatment of nerve gas poisoning.
Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman | 1995 |
Hydrolysis of tetriso by an enzyme derived from Pseudomonas diminuta as a model for the detoxication of O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate (VX).
Topics: Aryldialkylphosphatase; Chelating Agents; Cholinesterase Inhibitors; Esterases; Inactivation, Metabolic; Isoflurophate; Organophosphorus Compounds; Organothiophosphorus Compounds; Pseudomonas; Soman | 1995 |
The efficacy of different decontaminants in rats and pigs percutaneously poisoned with organophosphates.
Topics: Administration, Cutaneous; Aluminum Silicates; Animals; Clay; Decontamination; Ethanolamines; Female; Gas Poisoning; Male; Ointments; Organothiophosphorus Compounds; Oximes; Polyethylene Glycols; Rats; Rats, Wistar; Soman; Survival Rate; Swine; Time Factors; Treatment Outcome | 1993 |
The efficacy of different formulations of protective-decontaminating ointments based on polyethylene glycol in rats percutaneously poisoned with highly toxic organophosphates.
Topics: Administration, Cutaneous; Animals; Decontamination; Female; Gas Poisoning; Ointments; Organothiophosphorus Compounds; Oximes; Polyethylene Glycols; Rats; Rats, Wistar; Soman; Time Factors; Treatment Outcome | 1993 |
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms | 1994 |
Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization.
Topics: Animals; Antidotes; Butyrylcholinesterase; Cholinesterase Inhibitors; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Neutralization Tests; Organophosphates; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman | 1993 |
Capillary gas chromatographic analysis of nerve agents using large volume injections.
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Chromatography, Gas; Hydrogen-Ion Concentration; Isoflurophate; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Water | 1996 |
[The effect of parasympatholytics on the therapeutic effectiveness of the oxime HI-6 against organophosphorus compounds (Soman, substance VX, Fosdrin) in mice].
Topics: Animals; Antidotes; Atropine; Benactyzine; Biperiden; Cholinesterase Reactivators; Male; Mevinphos; Mice; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Parasympatholytics; Pyridinium Compounds; Soman | 1997 |
The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase.
Topics: Animals; Behavior, Animal; Biological Availability; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Injections, Intramuscular; Injections, Intravenous; Lethal Dose 50; Macaca mulatta; Models, Biological; Organothiophosphorus Compounds; Poisoning; Random Allocation; Soman; Spatial Behavior; Statistics as Topic | 1997 |
[Acute poisoning by neuroparalytic agents and its long-term effects].
Topics: Acute Disease; Adult; Chemical Industry; Chemical Warfare Agents; Cholinesterase Inhibitors; Female; Follow-Up Studies; Humans; Male; Middle Aged; Occupational Diseases; Occupations; Organothiophosphorus Compounds; Sarin; Soman; Time Factors | 1997 |
Differential inhibition of the brain acetylcholinesterase molecular forms following sarin, soman and VX intoxication in laboratory rats.
Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Female; Organothiophosphorus Compounds; Rats; Rats, Wistar; Sarin; Soman | 1997 |
Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization.
Topics: Animals; Benzoylcholine; Binding Sites; Butyrylcholinesterase; Butyrylthiocholine; Cephamycins; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Design; Echothiophate Iodide; Humans; Hydrolysis; Inactivation, Metabolic; Kinetics; Mutagenesis, Site-Directed; Organophosphates; Organothiophosphorus Compounds; Protein Engineering; Sarin; Soman; Torpedo | 1999 |
A theoretical model of the competition between hydrolase and carboxylesterase in protection against organophosphorus poisoning.
Topics: Acetylcholinesterase; Animals; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Dichlorvos; Esterases; Isoflurophate; Lethal Dose 50; Models, Biological; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Sarin; Soman | 1999 |
Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphonylation of the enzyme.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Ferric Compounds; Ferricyanides; Humans; Organophosphonates; Organothiophosphorus Compounds; Oximes; Phosphorylation; Protein Binding; Pyridinium Compounds; Soman | 1999 |
Measurements of chemical warfare agent degradation products using an electrophoresis microchip with contactless conductivity detector.
Topics: Chemical Warfare Agents; Electric Conductivity; Electrophoresis; Microchemistry; Miniaturization; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Sensitivity and Specificity; Soman | 2002 |
Organophosphate nerve agent toxicity in Hydra attenuata.
Topics: Administration, Oral; Animals; Artemia; Biological Assay; Chemical Warfare Agents; Hydra; Models, Molecular; Organothiophosphorus Compounds; Sarin; Soman; Stereoisomerism; Structure-Activity Relationship; Time Factors; Toxicity Tests | 2003 |
A comparison of the decontamination efficacy of foam-making blends based on cationic and nonionic tensides against organophosphorus compounds determined in vitro and in vivo.
Topics: Administration, Cutaneous; Animals; Cations; Chemical Warfare Agents; Decontamination; Dose-Response Relationship, Drug; Hydrogen Peroxide; In Vitro Techniques; Lethal Dose 50; Male; Organothiophosphorus Compounds; Rats; Rats, Wistar; Soman; Surface-Active Agents | 2003 |
Estimation of the upper limit of human butyrylcholinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Erythrocytes; Esterases; Humans; In Vitro Techniques; Inactivation, Metabolic; Models, Biological; Nervous System Diseases; Neuroprotective Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Soman | 2004 |
[Determination of five nerve agents in contaminated serum by gas chromatography].
Topics: Chemical Warfare Agents; Chromatography, Gas; Humans; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Serum; Soman | 2005 |
Detection of human butyrylcholinesterase-nerve gas adducts by liquid chromatography-mass spectrometric analysis after in gel chymotryptic digestion.
Topics: Amino Acid Sequence; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Humans; Molecular Sequence Data; Molecular Structure; Organothiophosphorus Compounds; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization | 2006 |
Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds.
Topics: Acetylcholinesterase; Animals; Binding Sites; Butyrylcholinesterase; Humans; Lethal Dose 50; Male; Mice; Organophosphorus Compounds; Organothiophosphorus Compounds; Polyethylene Glycols; Recombinant Proteins; Sarin; Soman; Survival Analysis; Tissue Distribution | 2006 |
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime | 2007 |
The effect of sublethal doses of cholinesterase inhibitors on spontaneous motor activity in laboratory rats.
Topics: Animals; Cholinesterase Inhibitors; Depression, Chemical; Dose-Response Relationship, Drug; Motor Activity; Organothiophosphorus Compounds; Rats; Soman | 1991 |
Nerve agents: implications for anesthesia providers.
Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors | 2008 |
Hydrolysis of nerve agents by model nucleophiles: a computational study.
Topics: Chemical Warfare Agents; Hydrolysis; Organothiophosphorus Compounds; Sarin; Soman | 2008 |
Gender difference in the miotic potency of soman vapor in rats.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Eye; Female; Infrared Rays; Male; Miosis; Models, Animal; Organophosphorus Compounds; Organothiophosphorus Compounds; Pupil; Rats; Rats, Sprague-Dawley; Sex Characteristics; Soman | 2008 |
Paraoxonase activity against nerve gases measured by capillary electrophoresis and characterization of human serum paraoxonase (PON1) polymorphism in the coding region (Q192R).
Topics: Aryldialkylphosphatase; Electrophoresis, Capillary; Genotype; Humans; Hydrolysis; Molecular Structure; Open Reading Frames; Organothiophosphorus Compounds; Polymerase Chain Reaction; Polymorphism, Genetic; Sarin; Soman | 2009 |
Synergism of activated carbon and undoped and nitrogen-doped TiO2 in the photocatalytic degradation of the chemical warfare agents soman, VX, and yperite.
Topics: Adsorption; Catalysis; Charcoal; Chemical Warfare Agents; Mustard Gas; Nitrogen; Organothiophosphorus Compounds; Photochemical Processes; Soman; Spectrophotometry, Ultraviolet; Titanium | 2009 |
Safety of administration of human butyrylcholinesterase and its conjugates with soman or VX in rats.
Topics: Animals; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Motor Activity; Organothiophosphorus Compounds; Oxotremorine; Rats; Soman | 2010 |
Changes in extracellular striatal acetylcholine and brain seizure activity following acute exposure to nerve agents in freely moving guinea pigs.
Topics: Acetylcholine; Animals; Brain; Chemical Warfare Agents; Choline; Cholinesterase Inhibitors; Corpus Striatum; Electroencephalography; Guinea Pigs; Male; Organothiophosphorus Compounds; Sarin; Seizures; Soman | 2010 |
Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX.
Topics: Animals; Antidotes; Butyrylcholinesterase; Chemical Warfare Agents; Dose-Response Relationship, Drug; Female; Guinea Pigs; Half-Life; Humans; Male; Organothiophosphorus Compounds; Soman | 2011 |
In situ determination of nerve agents in various matrices by portable capillary electropherograph with contactless conductivity detection.
Topics: Chemical Warfare Agents; Chromatography, High Pressure Liquid; Drug Stability; Electric Conductivity; Electrophoresis, Capillary; Gas Chromatography-Mass Spectrometry; Linear Models; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Sensitivity and Specificity; Soil; Soman; Specimen Handling | 2011 |
Treatment of chemical warfare agents by zero-valent iron nanoparticles and ferrate(VI)/(III) composite.
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Iron; Microscopy, Electron, Scanning; Mustard Gas; Nanoparticles; Organothiophosphorus Compounds; Oxidation-Reduction; Powder Diffraction; Soman; Water Pollutants, Chemical; Water Purification; X-Ray Diffraction | 2012 |
Quantification of nerve agent adducts with albumin in rat plasma using liquid chromatography-isotope dilution tandem mass spectrometry.
Topics: Animals; Biomarkers; Butyrylcholinesterase; Chromatography, Liquid; Limit of Detection; Male; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sarin; Serum Albumin; Soman; Tandem Mass Spectrometry; Tyrosine | 2012 |
Ge4+ doped TiO2 for stoichiometric degradation of warfare agents.
Topics: Chemical Warfare Agents; Decontamination; Germanium; Metal Nanoparticles; Mustard Gas; Organothiophosphorus Compounds; Soman; Titanium | 2012 |
Reaction of nerve agents with phosphate buffer at pH 7.
Topics: Buffers; Chemical Warfare Agents; Half-Life; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Organophosphonates; Organothiophosphorus Compounds; Phosphates; Sarin; Soman; Water | 2012 |
Median lethal dose determination for percutaneous exposure to soman and VX in guinea pigs and the effectiveness of decontamination with M291 SDK or SANDIA foam.
Topics: Administration, Cutaneous; Animals; Chemical Warfare Agents; Decontamination; Dosage Forms; Emollients; Guinea Pigs; Lethal Dose 50; Male; Ointments; Organothiophosphorus Compounds; Skin; Skin Absorption; Skin Care; Soman; Toxicity Tests, Acute | 2012 |
Determination of LCt(50)s in anesthetized rats exposed to aerosolized nerve agents.
Topics: Administration, Inhalation; Aerosols; Anesthesia; Animals; Chemical Warfare Agents; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Neurotoxins; Organothiophosphorus Compounds; Rats; Sarin; Soman | 2013 |
Identification and characterization of novel catalytic bioscavengers of organophosphorus nerve agents.
Topics: Antidotes; Aryldialkylphosphatase; Bacillales; Bacterial Proteins; Chemical Warfare Agents; Drug Discovery; Drug Evaluation, Preclinical; Haloarcula; Hydrolysis; Micromonospora; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Soman | 2013 |
Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents.
Topics: Amino Acid Substitution; Antidotes; Aryldialkylphosphatase; Catalytic Domain; Chemical Warfare Agents; Humans; Hydrolysis; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Protein Engineering; Recombinant Proteins; Sarin; Soman; Substrate Specificity | 2013 |
A 10-minute point-of-care assay for detection of blood protein adducts resulting from low level exposure to organophosphate nerve agents.
Topics: Adult; Blood Chemical Analysis; Blood Proteins; Chemical Warfare Agents; Cholinesterase Inhibitors; Cross Reactions; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Point-of-Care Systems; Sarin; Soman | 2013 |
Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detergents.
Topics: Administration, Cutaneous; Animals; Chemical Warfare Agents; Decontamination; Detergents; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Organothiophosphorus Compounds; Paraoxon; Pesticides; Protective Agents; Rats; Rats, Wistar; Soman; Survival Rate | 2013 |
Quantitation of five organophosphorus nerve agent metabolites in serum using hydrophilic interaction liquid chromatography and tandem mass spectrometry.
Topics: Ammonium Compounds; Biotransformation; Buffers; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Fluorides; Humans; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Limit of Detection; Organophosphorus Compounds; Organothiophosphorus Compounds; Quaternary Ammonium Compounds; Sarin; Solid Phase Extraction; Soman; Tandem Mass Spectrometry | 2014 |
Determination of nerve agent metabolites in human urine by isotope-dilution gas chromatography-tandem mass spectrometry after solid phase supported derivatization.
Topics: Biotransformation; Chemical Warfare Agents; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Indicator Dilution Techniques; Limit of Detection; Liquid-Liquid Extraction; Organophosphonates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman | 2014 |
Effects of repeated low-dose exposure of the nerve agent VX on monoamine levels in different brain structures in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cholinesterase Inhibitors; Cholinesterases; Dopamine; Male; Mice, Inbred BALB C; Organothiophosphorus Compounds; Serotonin; Soman | 2014 |
Development of haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents. 1: evaluation of in vitro clotting efficacy in the presence of certain contaminants.
Topics: Animals; Blood Coagulation; Chemical Warfare Agents; Decontamination; Female; Hemostatics; Mustard Gas; Organothiophosphorus Compounds; Petrolatum; Soman; Swine; Wounds and Injuries | 2015 |
Development of haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents. 2: evaluation of in vitro topical decontamination efficacy using undamaged skin.
Topics: Aluminum Compounds; Animals; Chemical Warfare Agents; Decontamination; Hemostatics; Magnesium Compounds; Mustard Gas; Organothiophosphorus Compounds; Silicates; Skin; Skin Absorption; Soman; Swine; Wounds and Injuries | 2015 |
Simultaneous measurement of tabun, sarin, soman, cyclosarin, VR, VX, and VM adducts to tyrosine in blood products by isotope dilution UHPLC-MS/MS.
Topics: Blood Chemical Analysis; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Humans; Organophosphorus Compounds; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization; Time Factors; Tyrosine | 2014 |
Measurement of breakthrough volumes of volatile chemical warfare agents on a poly(2,6-diphenylphenylene oxide)-based adsorbent and application to thermal desorption-gas chromatography/mass spectrometric analysis.
Topics: Adsorption; Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Phenols; Polymers; Sarin; Soman; Volatilization | 2015 |
Self-regeneration of neuromuscular function following soman and VX poisoning in spinal cord-skeletal muscle cocultures.
Topics: Animals; Cell Survival; Chemical Warfare Agents; Coculture Techniques; Mice, Inbred C57BL; Microscopy, Video; Muscle Contraction; Muscle, Skeletal; Neuromuscular Junction; Organothiophosphorus Compounds; Recovery of Function; Regeneration; Soman; Spinal Cord; Time Factors; Tissue Culture Techniques | 2016 |
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats.
Topics: Animals; Anticonvulsants; Antidotes; Body Weight; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Lethal Dose 50; Levetiracetam; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Piracetam; Procyclidine; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman | 2015 |
Effect of exposure area on nerve agent absorption through skin in vitro.
Topics: Animals; Diffusion; Guinea Pigs; In Vitro Techniques; Nerve Agents; Organothiophosphorus Compounds; Skin Absorption; Soman; Swine | 2015 |
Molecular Docking, Metal Substitution and Hydrolysis Reaction of Chiral Substrates of Phosphotriesterase.
Topics: Aluminum; Catalytic Domain; Cholinesterase Inhibitors; Hydrolysis; Kinetics; Metals; Molecular Docking Simulation; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Phosphoric Triester Hydrolases; Sarin; Soman; Stereoisomerism | 2016 |
Simultaneous Time-concentration Analysis of Soman and VX Adducts to Butyrylcholinesterase and Albumin by LC-MS-MS.
Topics: Animals; Biomarkers, Pharmacological; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromatography, Affinity; Chromatography, High Pressure Liquid; Immunomagnetic Separation; Injections, Intravenous; Limit of Detection; Macaca mulatta; Male; Molecular Structure; Nerve Agents; Oligopeptides; Organothiophosphorus Compounds; Peptide Fragments; Reproducibility of Results; Serum Albumin; Soman; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Toxicokinetics; Tyrosine | 2018 |
Further studies of the efficacy of military, commercial and novel skin decontaminants against the chemical warfare agents sulphur Mustard, Soman and VX.
Topics: Animals; Chemical Warfare Agents; Decontamination; Female; Mustard Gas; Organothiophosphorus Compounds; Skin; Skin Absorption; Soman; Swine | 2019 |
Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication.
Topics: Animals; Area Under Curve; Butyrylcholinesterase; Chemical Warfare Agents; Guinea Pigs; Humans; Injections, Intramuscular; Injections, Intravenous; Lethal Dose 50; Male; Metabolic Clearance Rate; Nerve Agents; Neuroprotective Agents; Organothiophosphorus Compounds; Poisoning; Soman; Stereoisomerism | 2020 |
A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds.
Topics: Antidotes; Bacterial Proteins; Caulobacteraceae; Drug Stability; Enzyme Stability; Hot Temperature; Mutation; Nerve Agents; Organophosphate Poisoning; Organophosphorus Compounds; Organothiophosphorus Compounds; Oxidation-Reduction; Phosphoric Triester Hydrolases; Protein Denaturation; Recombinant Proteins; Sarin; Soman | 2020 |
Detection of Chemical Weapon Nerve Agents in Bone by Liquid Chromatography-Mass Spectrometry.
Topics: Animals; Bone and Bones; Chemical Warfare Agents; Chromatography, Liquid; Humans; Limit of Detection; Nerve Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Swine | 2020 |
Structural and kinetic evidence of aging after organophosphate inhibition of human Cathepsin A.
Topics: Acetylcholinesterase; Binding Sites; Cathepsin A; Cell Line; Chemical Warfare Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Gene Expression; GPI-Linked Proteins; HEK293 Cells; Humans; Isoflurophate; Kinetics; Models, Molecular; Organophosphorus Compounds; Organothiophosphorus Compounds; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Proteins; Sarin; Soman; Substrate Specificity; Time Factors | 2020 |
Sensitive Untargeted Screening of Nerve Agents and Their Degradation Products Using Liquid Chromatography-High Resolution Mass Spectrometry.
Topics: Chemical Warfare Agents; Chromatography, Liquid; Databases, Chemical; Mass Spectrometry; Organothiophosphorus Compounds; Sarin; Sensitivity and Specificity; Small Molecule Libraries; Soman | 2020 |
Conjugates of human serum butyrylcholinesterase and nerve agents are behaviorally safe in rhesus macaques.
Topics: Animals; Butyrylcholinesterase; Diazepam; Female; Humans; Macaca mulatta; Male; Memory; Nerve Agents; Organothiophosphorus Compounds; Soman | 2021 |
Evaluation of 6-OxP-CD, an Oxime-based cyclodextrin as a viable medical countermeasure against nerve agent poisoning: Experimental and molecular dynamic simulation studies on its inclusion complexes with cyclosarin, soman and VX.
Topics: Chemical Warfare Agents; Cyclodextrins; Medical Countermeasures; Molecular Dynamics Simulation; Nerve Agents; Organophosphorus Compounds; Oximes; Phosphorus; Soman | 2023 |