vx has been researched along with sarin in 128 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (7.81) | 18.7374 |
| 1990's | 27 (21.09) | 18.2507 |
| 2000's | 37 (28.91) | 29.6817 |
| 2010's | 44 (34.38) | 24.3611 |
| 2020's | 10 (7.81) | 2.80 |
| Authors | Studies |
|---|---|
| Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A | 1 |
| Bajgar, J | 3 |
| Anderson, DR; Harris, LW; Lennox, WJ; Murrow, ML; Solana, RP; Wade, JV | 1 |
| Dettbarn, WD; Gupta, RC | 1 |
| Anderson, DR; Harris, LW; Koplovitz, I; Lennox, WJ; Stewart, JR | 1 |
| Fiekers, JF; Heppner, TJ | 1 |
| Bokonjić, D; Rosić, N | 1 |
| Dettbarn, WD; Gupta, RC; Patterson, GT | 1 |
| Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP; Talbot, BG | 1 |
| Bide, RW; Parker, D; Sawyer, TW; Thomas, N; Weiss, MT | 1 |
| Naseem, SM | 1 |
| Eldefrawi, AT; Eldefrawi, ME; Silveira, CL | 1 |
| Albuquerque, EX; Aracava, Y; Boyne, AF; Deshpande, SS; Idriss, M; Kawabuchi, M; Rickett, DL | 1 |
| Artursson, E; Bucht, G; Puu, G | 1 |
| Andersen, RA; Fonnum, F; Malthe-Sørenssen, D; Odden, E | 1 |
| Désiré, B; Saint-André, S | 1 |
| Dawson, RM; Gray, PJ | 1 |
| Beers, ET; Glenn, JF; Rickett, DL | 1 |
| Liu, CH; Pei, SQ; Wang, ZX; Zhao, DL | 1 |
| Harvey, B; Sellers, DJ; Watts, P | 1 |
| Beck, HC; Benschop, HP; Van den Berg, GR | 1 |
| Binenfeld, Z; Maksimović, M; Markov, V | 1 |
| Szinicz, L; Worek, F | 1 |
| Aikawa, N; Fujishima, S; Hori, S; Nogawa, S; Nozaki, H; Shinozawa, Y; Suzuki, M | 1 |
| Brndiar, M; Fusek, J; Monhart, V; Tlustakova, M | 1 |
| Koplovitz, I; Stewart, JR | 1 |
| Ashani, Y; Cohen, E; Grunwald, J; Marcus, D; Papier, Y; Raveh, L | 1 |
| Degenhardt-Langelaan, CE; Kientz, CE | 1 |
| Belkin, M; Solberg, Y | 1 |
| Ianno, LV; Musiĭchuk, IuI | 1 |
| Holstege, CP; Kirk, M; Sidell, FR | 1 |
| Munro, N | 1 |
| Albuquerque, EX; Aracava, Y; Chebabo, SR; Rocha, ES; Santos, MD | 1 |
| Broomfield, CA; Lockridge, O; Millard, CB | 1 |
| Maxwell, DM; Sweeney, RE | 1 |
| Acharya, J; Dube, SN; Dubey, DK; Kumar, D; Sikder, AK | 1 |
| Jäppinen, A; Kukkonen, J; Nieminen, K; Nikmo, J; Riikonen, K | 1 |
| Hartmann, HM | 1 |
| Eyer, P; Reiter, G; Szinicz, L; Worek, F | 1 |
| Klein, R; Leikin, JB; Meislin, HW; Thomas, RG; Walter, FG | 1 |
| Amundson, DE; Devereaux, A; Lazarus, AA; Parrish, JS | 1 |
| Bueters, TJ; Danhof, M; Groen, B; IJzerman, AP; Van Helden, HP | 1 |
| Collins, GE; Mulchandani, A; Pumera, M; Wang, J | 1 |
| Campo-Flores, A | 1 |
| Huebner, HJ; Li, Y; Lum, KT; Phillips, TD; Raushel, FM | 1 |
| Ashani, Y; Pistinner, S | 1 |
| Lobert, S; Martin, T | 1 |
| Kassa, J; Kuca, K | 1 |
| Niven, AS; Roop, SA | 1 |
| Newmark, J | 1 |
| Inoue, N | 1 |
| Feng, C; Xie, J | 1 |
| Cramer, CJ; Emnett, RJ; Menke, JL; Patterson, EV; Seckute, J | 1 |
| Seto, Y; Tsuge, K | 1 |
| Gratziany, N; Heleg-Shabtai, V; Liron, Z | 1 |
| Cohen, O; Kronman, C; Mazor, O; Ordentlich, A; Raveh, L; Shafferman, A | 1 |
| Benton, BJ; Crouse, CL; Dabisch, PA; Jakubowski, EM; Matson, KL; McGuire, JM; Mioduszewski, RJ; Sommerville, DR; Thomson, SA | 1 |
| Becker, G; Gutzeit, D; Kawan, A; Szinicz, L; Worek, F | 1 |
| Bajgar, J; Jun, D; Kuca, K | 1 |
| Ekström, F; Hörnberg, A; Tunemalm, AK | 1 |
| Antonijevic, B; Stojiljkovic, MP | 1 |
| Amine, A; Arduini, F; Moscone, D; Palleschi, G; Ricci, F | 1 |
| Grauer, E; Levy, A | 1 |
| Germanchuk, VG; Kadushkin, AM; Mandych, VG; Zabrodskii, PF | 1 |
| Hrobak, PK | 1 |
| Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F | 1 |
| Beck, JM; Hadad, CM | 1 |
| Kanamori-Kataoka, M; Seto, Y | 2 |
| Columbus, I; Gershonov, E; Zafrani, Y | 1 |
| McDonough, JH; Shih, TM; Skovira, JW | 1 |
| Estour, F; Lafont, O; Le Provost, R; Müller, S; Reiter, G; Tenberken, O; Thiermann, H; Wille, T; Worek, F | 1 |
| Cui, W; Ge, X; Luo, W; Wang, H | 1 |
| Thiermann, H; Wille, T; Worek, F | 1 |
| McDonough, JH; O'Donnell, JC; Shih, TM | 2 |
| Cabal, J; Holas, O; Karasova, JZ; Korabecny, J; Kuca, K; Pikula, J; Pohanka, M | 1 |
| Columbus, I; Mizrahi, DM; Saphier, S | 1 |
| Evans, RA; Jakubowski, EM; Johnson, RC; Lemire, SW; Noort, D; Renner, JA; Schmidt, JG; Sporty, JL; van der Schans, MJ; Williams, RF | 1 |
| Guarisco, JA; Kan, RK; McDonough, JH; Myers, TM; Shih, TM | 1 |
| Kaljurand, M; Kubáň, P; Makarõtševa, N; Seiman, A; Vaher, M | 1 |
| Columbus, I; Goldvaser, M; Marciano, D; Zafrani, Y | 1 |
| Alamneh, Y; Biggemann, L; Costante, M; Doctor, BP; Garcia, G; Nambiar, MP; Nigam, S; Short, R; Soojhawon, I; Valiyaveettil, M | 1 |
| Bao, Y; Chen, J; Lin, Y; Liu, Q; Wu, B; Xie, J | 1 |
| Creasy, WR; Fry, RA; McGarvey, DJ | 1 |
| Collins, JL; Lee, R; Peng, X; Pierre, Z; Sciuto, AM; Witriol, A | 1 |
| Chambers, HW; Chambers, JE; Meek, EC; Pringle, RB | 2 |
| Bahnson, BJ; Cerasoli, DM; Kirby, SD; Norris, JR; Richard Smith, J | 1 |
| Babu, UM; Condon, P; Mendez, A; Sambursky, R; VanDine, R | 1 |
| Kehe, K; Thiermann, H; Worek, F | 1 |
| Esposito, EX; Madura, JD; Stouch, TR; Wymore, T | 1 |
| Blake, TA; Carter, MD; Crow, BS; Johnson, RC; Pantazides, BG; Perez, JW; Thomas, JD; Watson, CM | 1 |
| Coleman, RM; Crow, BS; Hamelin, EI; Jakubowski, EM; Johnson, RC; Lawrence, RJ; Schulze, ND; Shaner, RL | 1 |
| Chen, J; Feng, J; Guo, L; Li, C; Lin, Y; Liu, Q; Wu, B; Xie, J; Yan, L | 1 |
| Acharya, J; Karade, HN; Kaushik, MP; Valiveti, AK | 1 |
| Columbus, I; Elisha, S; Kaplan, D; Nir, I; Osovsky, R; Rotter, H | 1 |
| Blake, TA; Brewer, BN; Carter, MD; Crenshaw, MD; Crow, BS; Evans, RA; Garton, JW; Johnson, RC; Pantazides, BG; Perez, JW; Quiñones-González, J; Read, RW; Riches, JR; Stubbs, SJ; Thomas, JD; Tomcik, DJ; Watson, CM | 1 |
| Bhavaraju, MH; Chambers, HW; Chambers, JE; Funck, KE; Gwaltney, SR; Meek, EC; Pringle, RB | 1 |
| Acharya, BN; Acharya, J; Bhalerao, UM; Halve, AK; Karade, HN; Kaushik, MP; Raviraju, G; Valiveti, AK | 1 |
| Bajgar, J; Cabal, J; Kassa, J; Pavlík, M | 1 |
| Caetano, MS; da Cunha, EF; de Castro, AA; Mancini, DT; Ramalho, TC; Rocha, EP; Silva, TC | 1 |
| Chambers, HW; Chambers, JE; Meek, EC | 1 |
| Chambers, HW; Chambers, JE; Funck, KE; Meek, EC; Pringle, RB; Ross, MK | 1 |
| Acharya, BN; Acharya, J; Bhalerao, U; Karade, HN; Raviraju, G; Valiveti, AK | 1 |
| Egoz, I; Gore, A; Grauer, E; Nili, U | 1 |
| C C França, T; Cuya, T; da Silva, JAV; Gonçalves, ADS; Kuca, K; Ramalho, TC | 1 |
| Gupta, AK; Kumar, V; Rana, H; Rao, VK; Raviraju, G | 1 |
| Bealer, SL; Dudek, FE; Ekstrand, JJ; Lehmkuhle, MJ; McDonough, JH; Miller-Smith, SM; Scholl, EA | 1 |
| Bae, SY; Winemiller, MD | 1 |
| Balasubramanian, N; Chao, CK; Gerdes, JM; Thompson, CM | 1 |
| Caetano, MS; da Cunha, EFF; de Castro, AA; Mancini, DT; Pereira, AF; Ramalho, TC; Silva, DR; Silva, TC; Soares, FV | 1 |
| Crowley, M; Dando, M; Shang, L | 1 |
| Chambers, JE; Meek, EC | 2 |
| Ardinger, C; Dunn, E; Haines, K; Lee-Stubbs, R; Matson, L; McCarren, H; McDonough, J; Miller-Smith, S; Whitten, K | 1 |
| Egoz, I; Gez, R; Gore, A; Kadar, T; Lazar, S; Nili, U; Rabinowitz, I; Yacov, G | 1 |
| Kalisiak, J; Kovarik, Z; Maček Hrvat, N; Radić, Z; Sharpless, KB; Šinko, G; Taylor, P | 1 |
| Escher, B; Job, L; Köhler, A; Skerra, A; Worek, F | 1 |
| Garrett, TJ; Goldberger, BA; Rubin, KM | 1 |
| Ardinger, CE; Berger, KE; Dunn, EN; Haines, KM; Jackson Piercy, CE; Lee-Stubbs, RB; Matson, LM; McCarren, HS; McDonough, JH; Miller-Smith, SM; Whitten, KA | 1 |
| Bouknight, KD; Compton, JR; Guelta, MA; Harvey, SP; Jurkouich, KM; Khavrutskii, IV; Legler, PM | 1 |
| Chen, J; Gao, R; Guo, L; Lin, Y; Liu, H; Liu, Q; Liu, Y; Lu, X; Wang, H; Wu, J; Xie, J; Xu, B; Zhang, M; Zhang, Y | 1 |
| Leif, RN; Valdez, CA | 1 |
| John, H; Lindl, T; Reuter, H; Schmeißer, W; Schrader, M; Thiermann, H | 1 |
14 review(s) available for vx and sarin
| Article | Year |
|---|---|
The role of excitotoxicity in organophosphorous nerve agents central poisoning.
Topics: Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Excitatory Amino Acid Antagonists; Humans; Neurons; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Receptors, N-Methyl-D-Aspartate; Sarin; Seizures; Soman; Synaptic Transmission | 1997 |
Chemical warfare. Nerve agent poisoning.
Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Disaster Planning; Emergency Medical Services; Humans; Nervous System Diseases; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman | 1997 |
Toxicity of the organophosphate chemical warfare agents GA, GB, and VX: implications for public protection.
Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Environmental Pollutants; Humans; Lethal Dose 50; Organophosphates; Organothiophosphorus Compounds; Sarin | 1994 |
A review of nerve agent exposure for the critical care physician.
Topics: Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Nervous System; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman | 2002 |
Vesicants and nerve agents in chemical warfare. Decontamination and treatment strategies for a changed world.
Topics: Antidotes; Arsenicals; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Information Services; Internet; Irritants; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Primary Prevention; Protective Clothing; Sarin; Soman | 2002 |
Chemical warfare. Toxicity of nerve agents.
Topics: Antidotes; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Nervous System; Organophosphates; Organothiophosphorus Compounds; Sarin | 2003 |
Inhalational exposure to nerve agents.
Topics: Chemical Warfare Agents; Disaster Planning; Humans; Lung Diseases; Lung Injury; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman; United States | 2004 |
Therapy for nerve agent poisoning.
Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman | 2004 |
[Neurological effects of chemical and biological weapons].
Topics: Animals; Anthrax; Bacillus anthracis; Biological Warfare; Bioterrorism; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Nervous System Diseases; Organothiophosphorus Compounds; Sarin; Smallpox; Variola virus | 2003 |
Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.
Topics: Acetylcholinesterase; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Humans; Insecticides; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin; Trimedoxime | 2007 |
Limitations and challenges in treatment of acute chemical warfare agent poisoning.
Topics: Antidotes; Atropine; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Mustard Gas; Organothiophosphorus Compounds; Oximes; Sarin | 2013 |
Novel centrally active oxime reactivators of acetylcholinesterase inhibited by surrogates of sarin and VX.
Topics: Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Organothiophosphorus Compounds; Oximes; Sarin | 2020 |
Central neuroprotection demonstrated by novel oxime countermeasures to nerve agent surrogates.
Topics: Acetylcholinesterase; Animals; Antidotes; GPI-Linked Proteins; Male; Nerve Agents; Neuroprotection; Organothiophosphorus Compounds; Pralidoxime Compounds; Rats; Sarin; United States | 2020 |
Analysis of Organophosphorus-Based Nerve Agent Degradation Products by Gas Chromatography-Mass Spectrometry (GC-MS): Current Derivatization Reactions in the Analytical Chemist's Toolbox.
Topics: Alkylation; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Methylation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman | 2021 |
114 other study(ies) available for vx and sarin
| Article | Year |
|---|---|
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine | 2008 |
Biological monitoring of exposure to nerve agents.
Topics: Acetylcholinesterase; Animals; Brain; Diaphragm; Dogs; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Salivation; Sarin; Seizures; Soman | 1992 |
Successful pretreatment/therapy of soman, sarin and VX intoxication.
Topics: Animals; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organothiophosphorus Compounds; Phenylpropionates; Physostigmine; Poisoning; Sarin; Soman; Trihexyphenidyl; Tropanes | 1992 |
Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX.
Topics: Acetylcholinesterase; Acute Disease; Animals; Atropine; Cholinesterase Inhibitors; Male; Memantine; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman; Tubocurarine | 1992 |
Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents.
Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin | 1992 |
The effects of irreversible acetylcholinesterase inhibitors on transmission through sympathetic ganglia of the bullfrog.
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Carbachol; Cholinesterase Inhibitors; Ganglia, Sympathetic; Organothiophosphorus Compounds; Rana catesbeiana; Sarin; Soman; Synaptic Transmission | 1991 |
The influence of inhibitors and other factors on cholinesterases.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Female; Organophosphorus Compounds; Organothiophosphates; Organothiophosphorus Compounds; Rats; Sarin; Soman | 1991 |
Anticonvulsive and protective effects of diazepam and midazolam in rats poisoned by highly toxic organophosphorus compounds.
Topics: Animals; Anticonvulsants; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Male; Midazolam; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1991 |
Comparison of cholinergic and neuromuscular toxicity following acute exposure to sarin and VX in rat.
Topics: Acetylcholinesterase; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Male; Muscles; Necrosis; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin | 1991 |
Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication.
Topics: Animals; Atropine; Benztropine; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organothiophosphorus Compounds; Physostigmine; Sarin; Soman; Trihexyphenidyl | 1991 |
Efficacy of an oximate-based skin decontaminant against organophosphate nerve agents determined in vivo and in vitro.
Topics: Acetylcholinesterase; Animals; Brain; Chick Embryo; Cholinesterase Inhibitors; Decontamination; Diacetyl; Female; Male; Neurons; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1991 |
Effect of organophosphates on dopamine and muscarinic receptor binding in rat brain.
Topics: Animals; Brain; Cholinesterase Inhibitors; Female; N-Methylscopolamine; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Muscarinic; Sarin; Scopolamine Derivatives; Soman; Spiperone | 1990 |
Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases.
Topics: Animals; Cholinesterase Inhibitors; Dioxolanes; Dose-Response Relationship, Drug; Echothiophate Iodide; Insecticides; Male; Myocardium; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Parasympathomimetics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sarin; Soman; Tritium | 1990 |
Multiple actions of anticholinesterase agents on chemosensitive synapses: molecular basis for prophylaxis and treatment of organophosphate poisoning.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Female; Ganglionic Blockers; Grasshoppers; In Vitro Techniques; Muscle Contraction; Organophosphate Poisoning; Organothiophosphorus Compounds; Physostigmine; Rana pipiens; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Sarin; Synapses | 1985 |
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism | 1986 |
Effects of organophosphates on presynaptic events in the vascularly perfused phrenic nerve-hemidiaphragm preparation from the rat.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; Female; In Vitro Techniques; Isoflurophate; Male; Muscles; Organophosphorus Compounds; Organothiophosphorus Compounds; Perfusion; Phrenic Nerve; Rats; Rats, Inbred Strains; Sarin; Soman; Synapses | 1987 |
Inactivation of sarin and soman by cyclodextrins in vitro.
Topics: alpha-Cyclodextrins; beta-Cyclodextrins; Cyclodextrins; Dextrins; gamma-Cyclodextrins; Kinetics; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Starch | 1987 |
Kinetic constants for the inhibition of eel and rabbit brain acetylcholinesterase by some organophosphates and carbamates of military significance.
Topics: Animals; Brain; Carbamates; Chemical Warfare Agents; Cholinesterase Inhibitors; Eels; Kinetics; Neostigmine; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Physostigmine; Rabbits; Sarin; Soman | 1987 |
Central respiratory effects versus neuromuscular actions of nerve agents.
Topics: Animals; Cats; Cholinesterase Inhibitors; Diaphragm; Female; Male; Neuromuscular Junction; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Respiratory Center; Respiratory Insufficiency; Sarin; Soman | 1986 |
[Effect of soman, sarin and VX on specific binding of 3H-quinuclidinyl benzilate in rat cerebral cortex homogenates].
Topics: Animals; Cerebral Cortex; Cholinesterase Inhibitors; In Vitro Techniques; Male; Organophosphorus Compounds; Organothiophosphorus Compounds; Quinuclidines; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Sarin; Soman; Tritium | 1983 |
The reactivation by oximes of phosphonylated acetylcholinesterase: the possible erroneous interpretation of reactivating potency.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Organothiophosphorus Compounds; Oximes; Sarin; Soman | 1984 |
Stereochemical analysis of the nerve agents soman, sarin, tabun, and VX by proton NMR-spectroscopy with optically active shift reagents.
Topics: Cholinesterase Inhibitors; Indicators and Reagents; Magnetic Resonance Spectroscopy; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Stereoisomerism | 1984 |
[Direct reactions of pyridinium oximes with organophosphorus compounds].
Topics: Chemical Phenomena; Chemical Warfare Agents; Chemistry; Drug Interactions; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Sarin; Soman | 1984 |
Cardiorespiratory function in nerve agent poisoned and oxime + atropine treated guinea-pigs: effect of pyridostigmine pretreatment.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Drug Synergism; Female; Guinea Pigs; Heart Function Tests; Organothiophosphorus Compounds; Oximes; Pyridostigmine Bromide; Respiration; Respiratory Function Tests; Sarin | 1995 |
A case of VX poisoning and the difference from sarin.
Topics: Cholinesterase Inhibitors; Diagnosis, Differential; Humans; Male; Middle Aged; Organothiophosphorus Compounds; Poisoning; Sarin | 1995 |
Treatment of nerve gas poisoning.
Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman | 1995 |
Use of hemoperfusion in experimental intoxication with nerve agents.
Topics: Animals; Cholinesterase Inhibitors; Dogs; Hemoperfusion; Male; Organothiophosphorus Compounds; Poisoning; Sarin | 1994 |
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms | 1994 |
Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization.
Topics: Animals; Antidotes; Butyrylcholinesterase; Cholinesterase Inhibitors; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Neutralization Tests; Organophosphates; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman | 1993 |
Capillary gas chromatographic analysis of nerve agents using large volume injections.
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Chromatography, Gas; Hydrogen-Ion Concentration; Isoflurophate; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Water | 1996 |
[Acute poisoning by neuroparalytic agents and its long-term effects].
Topics: Acute Disease; Adult; Chemical Industry; Chemical Warfare Agents; Cholinesterase Inhibitors; Female; Follow-Up Studies; Humans; Male; Middle Aged; Occupational Diseases; Occupations; Organothiophosphorus Compounds; Sarin; Soman; Time Factors | 1997 |
Differential inhibition of the brain acetylcholinesterase molecular forms following sarin, soman and VX intoxication in laboratory rats.
Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Female; Organothiophosphorus Compounds; Rats; Rats, Wistar; Sarin; Soman | 1997 |
An analysis of low level doses of cholinesterase inhibitors in cultured neurons and hippocampal slices of rats.
Topics: Alkaloids; Animals; Cells, Cultured; Cholinesterase Inhibitors; Culture Techniques; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Neurons; Organophosphorus Compounds; Organothiophosphorus Compounds; Patch-Clamp Techniques; Rats; Sarin; Sesquiterpenes; Tetrodotoxin | 1998 |
Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization.
Topics: Animals; Benzoylcholine; Binding Sites; Butyrylcholinesterase; Butyrylthiocholine; Cephamycins; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Design; Echothiophate Iodide; Humans; Hydrolysis; Inactivation, Metabolic; Kinetics; Mutagenesis, Site-Directed; Organophosphates; Organothiophosphorus Compounds; Protein Engineering; Sarin; Soman; Torpedo | 1999 |
A theoretical model of the competition between hydrolase and carboxylesterase in protection against organophosphorus poisoning.
Topics: Acetylcholinesterase; Animals; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Dichlorvos; Esterases; Isoflurophate; Lethal Dose 50; Models, Biological; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Sarin; Soman | 1999 |
Antidotal efficacy of pyridinium oximes and cholineacetyltransferase inhibitors against organophosphorus intoxication in rodents.
Topics: Animals; Antidotes; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Enzyme Inhibitors; In Vitro Techniques; Lethal Dose 50; Male; Mice; Neuromuscular Junction; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin | 2000 |
Modelling aerosol processes related to the atmospheric dispersion of sarin.
Topics: Aerosols; Atmosphere; Chemical Warfare Agents; Mathematics; Models, Theoretical; Mustard Gas; Organothiophosphorus Compounds; Sarin; Thermodynamics | 2001 |
Evaluation of risk assessment guideline levels for the chemical warfare agents mustard, GB, and VX.
Topics: Chemical Warfare Agents; Disaster Planning; Dose-Response Relationship, Drug; Guidelines as Topic; Inhalation Exposure; Maximum Allowable Concentration; Military Medicine; Mustard Gas; Organothiophosphorus Compounds; Public Health; Risk Assessment; Sarin | 2002 |
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
Topics: Acetylcholinesterase; Algorithms; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rabbits; Rats; Sarin; Species Specificity | 2002 |
Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication.
Topics: Acetylcholine; Adenosine; Animals; Cholinesterase Inhibitors; Cholinesterases; Corpus Striatum; Male; Microdialysis; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Parathion; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Sarin | 2002 |
Measurements of chemical warfare agent degradation products using an electrophoresis microchip with contactless conductivity detector.
Topics: Chemical Warfare Agents; Electric Conductivity; Electrophoresis; Microchemistry; Miniaturization; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Sensitivity and Specificity; Soman | 2002 |
The nerve gas next door.
Topics: Alabama; Chemical Warfare Agents; Hazardous Waste; Humans; Organothiophosphorus Compounds; Sarin; Waste Management | 2002 |
Organophosphate nerve agent toxicity in Hydra attenuata.
Topics: Administration, Oral; Animals; Artemia; Biological Assay; Chemical Warfare Agents; Hydra; Models, Molecular; Organothiophosphorus Compounds; Sarin; Soman; Stereoisomerism; Structure-Activity Relationship; Time Factors; Toxicity Tests | 2003 |
Estimation of the upper limit of human butyrylcholinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Erythrocytes; Esterases; Humans; In Vitro Techniques; Inactivation, Metabolic; Models, Biological; Nervous System Diseases; Neuroprotective Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Soman | 2004 |
In vitro reactivation of acetylcholinesterase using the oxime K027.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2004 |
[Determination of five nerve agents in contaminated serum by gas chromatography].
Topics: Chemical Warfare Agents; Chromatography, Gas; Humans; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Serum; Soman | 2005 |
Ab initio molecular orbital and density functional studies on the solvolysis of sarin and O,S-dimethyl methylphosphonothiolate, a VX-like compound.
Topics: Alkalies; Computational Biology; Hydrolysis; Hydroxides; Models, Molecular; Molecular Conformation; Organothiophosphorus Compounds; Oxidation-Reduction; Sarin; Solubility | 2005 |
Detection of human butyrylcholinesterase-nerve gas adducts by liquid chromatography-mass spectrometric analysis after in gel chymotryptic digestion.
Topics: Amino Acid Sequence; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Humans; Molecular Sequence Data; Molecular Structure; Organothiophosphorus Compounds; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization | 2006 |
Separation and detection of VX and its methylphosphonic acid degradation products on a microchip using indirect laser-induced fluorescence.
Topics: Biodegradation, Environmental; Chemical Warfare Agents; Electrophoresis, Microchip; Eosine Yellowish-(YS); Fluorescence; Fluorescent Dyes; Lasers; Organothiophosphorus Compounds; Sarin; Sensitivity and Specificity | 2006 |
Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds.
Topics: Acetylcholinesterase; Animals; Binding Sites; Butyrylcholinesterase; Humans; Lethal Dose 50; Male; Mice; Organophosphorus Compounds; Organothiophosphorus Compounds; Polyethylene Glycols; Recombinant Proteins; Sarin; Soman; Survival Analysis; Tissue Distribution | 2006 |
Effects of whole-body VX vapor exposure on lethality in rats.
Topics: Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; Lethal Dose 50; Male; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Sex Characteristics; Volatilization | 2006 |
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
Topics: Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Half-Life; Kinetics; Models, Chemical; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Spectrophotometry, Ultraviolet | 2007 |
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime | 2007 |
Crystal structures of acetylcholinesterase in complex with organophosphorus compounds suggest that the acyl pocket modulates the aging reaction by precluding the formation of the trigonal bipyramidal transition state.
Topics: Acetylcholinesterase; Amino Acid Sequence; Animals; Cholinesterase Inhibitors; Histidine; Isoflurophate; Mice; Models, Molecular; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin | 2007 |
Fast, sensitive and cost-effective detection of nerve agents in the gas phase using a portable instrument and an electrochemical biosensor.
Topics: Biosensing Techniques; Butyrylcholinesterase; Chemical Warfare Agents; Electrochemistry; Electrodes; Environmental Monitoring; Ferrocyanides; Gases; Organothiophosphorus Compounds; Paraoxon; Sarin; Sensitivity and Specificity; Terrorism; Time Factors | 2007 |
Oxotremorine-induced hypothermia as a method for evaluating long-term neuronal changes following poisoning by cholinesterase inhibitors in rats.
Topics: Aldicarb; Animals; Body Temperature; Carbamates; Central Nervous System; Cholinesterase Inhibitors; Disease Models, Animal; Hypothermia; Lethal Dose 50; Male; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Organophosphorus Compounds; Organothiophosphorus Compounds; Oxotremorine; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Recovery of Function; Reproducibility of Results; Sarin; Seizures; Time Factors; Toxicity Tests | 2007 |
Role of Th1 and Th2 lymphocytes and cytokines produced by these cells in suppression of immune reactions during subacute poisoning with anticholinesterase toxicants.
Topics: Animals; Cholinesterase Inhibitors; Female; Interferon-gamma; Interleukin-2; Interleukin-4; Male; Organophosphate Poisoning; Organothiophosphorus Compounds; Poisoning; Rats; Rats, Wistar; Sarin; Th1 Cells; Th2 Cells | 2007 |
Nerve agents: implications for anesthesia providers.
Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors | 2008 |
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2008 |
Hydrolysis of nerve agents by model nucleophiles: a computational study.
Topics: Chemical Warfare Agents; Hydrolysis; Organothiophosphorus Compounds; Sarin; Soman | 2008 |
Paraoxonase activity against nerve gases measured by capillary electrophoresis and characterization of human serum paraoxonase (PON1) polymorphism in the coding region (Q192R).
Topics: Aryldialkylphosphatase; Electrophoresis, Capillary; Genotype; Humans; Hydrolysis; Molecular Structure; Open Reading Frames; Organothiophosphorus Compounds; Polymerase Chain Reaction; Polymorphism, Genetic; Sarin; Soman | 2009 |
Facile hydrolysis-based chemical destruction of the warfare agents VX, GB, and HD by alumina-supported fluoride reagents.
Topics: Adsorption; Aluminum Oxide; Chemical Warfare Agents; Fluorides; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Structure; Mustard Gas; Organothiophosphorus Compounds; Potassium Compounds; Reference Standards; Sarin; Surface Properties; Time Factors | 2009 |
Effects of 4-pyridine aldoxime on nerve agent-inhibited acetylcholinesterase activity in guinea pigs.
Topics: Acetylcholinesterase; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Longevity; Male; Neurotoxicity Syndromes; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Salivation; Sarin; Seizures; Tears | 2009 |
Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay.
Topics: Acetylcholinesterase; beta-Cyclodextrins; Biological Assay; Buffers; Chemical Warfare Agents; Cholinesterase Inhibitors; Erythrocyte Membrane; Humans; Hydrogen-Ion Concentration; Molecular Structure; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Reference Standards; Reproducibility of Results; Sarin; Time Factors | 2009 |
Targeting cholinesterase inhibitor poisoning with a novel blocker against both nicotinic and muscarinic receptors.
Topics: Animals; Atropine; Benzilates; Cell Line; Cholinergic Antagonists; Cholinesterase Inhibitors; Guinea Pigs; Membrane Potentials; Mice; Organothiophosphorus Compounds; Patch-Clamp Techniques; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Receptors, Nicotinic; Sarin | 2010 |
Development of a high-throughput screening for nerve agent detoxifying materials using a fully-automated robot-assisted biological assay.
Topics: Animals; Biological Assay; Biological Warfare Agents; Biomarkers; Cholinesterase Reactivators; Cyclodextrins; Drug Evaluation, Preclinical; Erythrocytes; Guinea Pigs; Humans; In Vitro Techniques; Macaca mulatta; Organothiophosphorus Compounds; Phosphoric Triester Hydrolases; Rabbits; Rats; Robotics; Sarin; Software; Species Specificity; Swine | 2010 |
Changes in extracellular striatal acetylcholine and brain seizure activity following acute exposure to nerve agents in freely moving guinea pigs.
Topics: Acetylcholine; Animals; Brain; Chemical Warfare Agents; Choline; Cholinesterase Inhibitors; Corpus Striatum; Electroencephalography; Guinea Pigs; Male; Organothiophosphorus Compounds; Sarin; Seizures; Soman | 2010 |
Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX.
Topics: Chemical Warfare Agents; Color; Colorimetry; Limit of Detection; Organophosphates; Organothiophosphorus Compounds; Paraoxon; Pesticides; Sarin | 2010 |
Efficient heterogeneous and environmentally friendly degradation of nerve agents on a tungsten-based POM.
Topics: Chemical Warfare Agents; Crystallization; Environmental Pollution; Indicators and Reagents; Magnetic Resonance Spectroscopy; Microscopy, Electron, Scanning; Mustard Gas; Organothiophosphorus Compounds; Oxidation-Reduction; Particle Size; Powders; Sarin; Tungsten; Tungsten Compounds | 2010 |
Immunomagnetic separation and quantification of butyrylcholinesterase nerve agent adducts in human serum.
Topics: Antibodies, Monoclonal; Butyrylcholinesterase; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Humans; Immunomagnetic Separation; Organothiophosphorus Compounds; Pepsin A; Peptides; Sarin; Tandem Mass Spectrometry | 2010 |
The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs.
Topics: Animals; Cholinesterase Reactivators; Guinea Pigs; Male; Organophosphorus Compounds; Organothiophosphorus Compounds; Pralidoxime Compounds; Prodrugs; Sarin; Seizures | 2011 |
In situ determination of nerve agents in various matrices by portable capillary electropherograph with contactless conductivity detection.
Topics: Chemical Warfare Agents; Chromatography, High Pressure Liquid; Drug Stability; Electric Conductivity; Electrophoresis, Capillary; Gas Chromatography-Mass Spectrometry; Linear Models; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Sensitivity and Specificity; Soil; Soman; Specimen Handling | 2011 |
In vivo microdialysis and electroencephalographic activity in freely moving guinea pigs exposed to organophosphorus nerve agents sarin and VX: analysis of acetylcholine and glutamate.
Topics: Acetylcholine; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Electroencephalography; Glutamic Acid; Guinea Pigs; Male; Microdialysis; Multivariate Analysis; Organothiophosphorus Compounds; Sarin; Seizures; Severity of Illness Index | 2011 |
Catalytic degradation of the nerve agent VX by water-swelled polystyrene-supported ammonium fluorides.
Topics: Adsorption; Ammonium Compounds; Animals; Catalysis; Chemical Warfare Agents; Chemistry, Organic; Civil Defense; Fluorides; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Organophosphonates; Organothiophosphorus Compounds; Polystyrenes; Quaternary Ammonium Compounds; Sarin; Water | 2011 |
Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis.
Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Dipeptidases; Humans; Hydrolysis; Isoflurophate; Kidney; Liver; Organophosphates; Organothiophosphorus Compounds; Recombinant Proteins; Sarin; Skin | 2012 |
Quantification of nerve agent adducts with albumin in rat plasma using liquid chromatography-isotope dilution tandem mass spectrometry.
Topics: Animals; Biomarkers; Butyrylcholinesterase; Chromatography, Liquid; Limit of Detection; Male; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sarin; Serum Albumin; Soman; Tandem Mass Spectrometry; Tyrosine | 2012 |
Reaction of nerve agents with phosphate buffer at pH 7.
Topics: Buffers; Chemical Warfare Agents; Half-Life; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Organophosphonates; Organothiophosphorus Compounds; Phosphates; Sarin; Soman; Water | 2012 |
Determination of LCt(50)s in anesthetized rats exposed to aerosolized nerve agents.
Topics: Administration, Inhalation; Aerosols; Anesthesia; Animals; Chemical Warfare Agents; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Neurotoxins; Organothiophosphorus Compounds; Rats; Sarin; Soman | 2013 |
Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates.
Topics: Acetylcholinesterase; Animals; Blood-Brain Barrier; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Evaluation, Preclinical; GPI-Linked Proteins; Male; Organophosphates; Organothiophosphorus Compounds; Oximes; Rats; Rats, Sprague-Dawley; Sarin; Seizures | 2013 |
Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents.
Topics: Amino Acid Substitution; Antidotes; Aryldialkylphosphatase; Catalytic Domain; Chemical Warfare Agents; Humans; Hydrolysis; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Protein Engineering; Recombinant Proteins; Sarin; Soman; Substrate Specificity | 2013 |
A 10-minute point-of-care assay for detection of blood protein adducts resulting from low level exposure to organophosphate nerve agents.
Topics: Adult; Blood Chemical Analysis; Blood Proteins; Chemical Warfare Agents; Cholinesterase Inhibitors; Cross Reactions; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Point-of-Care Systems; Sarin; Soman | 2013 |
Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Chemistry, Physical; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Mice; Models, Molecular; Molecular Structure; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Rats; Reproducibility of Results; Sarin; Structure-Activity Relationship | 2014 |
An enhanced butyrylcholinesterase method to measure organophosphorus nerve agent exposure in humans.
Topics: Antibodies, Monoclonal; Biological Assay; Butyrylcholinesterase; Chemical Warfare Agents; Chromatography, Liquid; Humans; Immunomagnetic Separation; In Vitro Techniques; Organothiophosphorus Compounds; Sarin; Tandem Mass Spectrometry | 2014 |
Quantitation of five organophosphorus nerve agent metabolites in serum using hydrophilic interaction liquid chromatography and tandem mass spectrometry.
Topics: Ammonium Compounds; Biotransformation; Buffers; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Fluorides; Humans; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Limit of Detection; Organophosphorus Compounds; Organothiophosphorus Compounds; Quaternary Ammonium Compounds; Sarin; Solid Phase Extraction; Soman; Tandem Mass Spectrometry | 2014 |
Determination of nerve agent metabolites in human urine by isotope-dilution gas chromatography-tandem mass spectrometry after solid phase supported derivatization.
Topics: Biotransformation; Chemical Warfare Agents; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Indicator Dilution Techniques; Limit of Detection; Liquid-Liquid Extraction; Organophosphonates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman | 2014 |
Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE).
Topics: Acetamides; Acetylcholinesterase; Enzyme Assays; Humans; Kinetics; Organothiophosphorus Compounds; Oximes; Protein Binding; Pyridines; Sarin | 2014 |
Decontamination of adsorbed chemical warfare agents on activated carbon using hydrogen peroxide solutions.
Topics: Adsorption; Charcoal; Chemical Warfare Agents; Decontamination; Hydrogen Peroxide; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Mustard Gas; Organothiophosphorus Compounds; Oxidation-Reduction; Sarin; Solutions; Temperature; Water | 2014 |
Simultaneous measurement of tabun, sarin, soman, cyclosarin, VR, VX, and VM adducts to tyrosine in blood products by isotope dilution UHPLC-MS/MS.
Topics: Blood Chemical Analysis; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Humans; Organophosphorus Compounds; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization; Time Factors; Tyrosine | 2014 |
Novel nucleophiles enhance the human serum paraoxonase 1 (PON1)-mediated detoxication of organophosphates.
Topics: Antidotes; Aryldialkylphosphatase; Catalytic Domain; Enzyme Activation; Enzyme Activators; Humans; Hydrolysis; Hydroxides; Inactivation, Metabolic; Molecular Dynamics Simulation; Nitrophenols; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Spectrophotometry; Water | 2015 |
Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE).
Topics: Acetylcholinesterase; Binding Sites; Catalytic Domain; Chemical Warfare Agents; Cholinesterase Reactivators; Humans; Kinetics; Molecular Docking Simulation; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Thiazoles | 2015 |
Measurement of breakthrough volumes of volatile chemical warfare agents on a poly(2,6-diphenylphenylene oxide)-based adsorbent and application to thermal desorption-gas chromatography/mass spectrometric analysis.
Topics: Adsorption; Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Phenols; Polymers; Sarin; Soman; Volatilization | 2015 |
Natural Detoxification Capacity to Inactivate Nerve Agents Sarin and VX in the Rat Blood.
Topics: Animals; Cholinesterase Inhibitors; Cholinesterases; Female; Inactivation, Metabolic; Organophosphate Poisoning; Organothiophosphorus Compounds; Rats; Rats, Wistar; Sarin | 2015 |
Molecular Docking, Metal Substitution and Hydrolysis Reaction of Chiral Substrates of Phosphotriesterase.
Topics: Aluminum; Catalytic Domain; Cholinesterase Inhibitors; Hydrolysis; Kinetics; Metals; Molecular Docking Simulation; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Phosphoric Triester Hydrolases; Sarin; Soman; Stereoisomerism | 2016 |
Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates.
Topics: Animals; Brain; Cholinesterase Inhibitors; Cholinesterases; Drug Evaluation, Preclinical; Enzyme Activation; Organothiophosphorus Compounds; Oximes; Rats; Sarin; Survival Analysis | 2016 |
Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX.
Topics: Acetylcholinesterase; Animals; Brain; Cattle; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Male; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridines; Rats; Rats, Sprague-Dawley; Sarin; Tandem Mass Spectrometry | 2016 |
Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).
Topics: Acetamides; Aminopyridines; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Niacinamide; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin | 2016 |
Optimization of the Ocular Treatment Following Organophosphate Nerve Agent Insult.
Topics: Animals; Antidotes; Atropine; Eye; Male; Miosis; Nerve Agents; Organothiophosphorus Compounds; Pupil; Rats; Rats, Long-Evans; Sarin; Tropanes; Vision, Ocular | 2017 |
The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study.
Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin | 2018 |
Highly selective and sensitive chromogenic detection of nerve agents (sarin, tabun and VX): a multianalyte detection approach.
Topics: Ferrous Compounds; Fluorescent Dyes; Molecular Structure; Nerve Agents; Organophosphates; Organothiophosphorus Compounds; Sarin | 2017 |
Age-dependent behaviors, seizure severity and neuronal damage in response to nerve agents or the organophosphate DFP in immature and adult rats.
Topics: Animals; Behavior, Animal; Brain; Female; Isoflurophate; Male; Nerve Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Seizures | 2018 |
Trace Level Analysis of Sarin and VX in Food Using Normal Phase Silica Gel and Ultra-Performance Liquid Chromatography-Time-of-Flight Mass Spectrometry (UPLC-TOF-MS).
Topics: Animals; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Eggs; Food Contamination; Fruit and Vegetable Juices; Milk; Organothiophosphorus Compounds; Sarin; Silica Gel; Solid Phase Extraction; Tandem Mass Spectrometry | 2018 |
The inhibition, reactivation and mechanism of VX-, sarin-, fluoro-VX and fluoro-sarin surrogates following their interaction with HuAChE and HuBuChE.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Reactivators; Enzyme Activation; Fluorescence; Humans; Kinetics; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Sarin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2018 |
Asymmetric biodegradation of the nerve agents Sarin and VX by human dUTPase: chemometrics, molecular docking and hybrid QM/MM calculations.
Topics: Biodegradation, Environmental; Catalytic Domain; Humans; Hydrogen Bonding; Molecular Docking Simulation; Nerve Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Principal Component Analysis; Pyrophosphatases; Quantum Theory; Sarin | 2019 |
Act now to close chemical-weapons loophole.
Topics: Central Nervous System; Chemical Warfare; Congresses as Topic; Humans; Law Enforcement; Nerve Agents; Organophosphates; Organothiophosphorus Compounds; Sarin | 2018 |
Neuroprotection From Organophosphate-Induced Damage by Novel Phenoxyalkyl Pyridinium Oximes in Rat Brain.
Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Glial Fibrillary Acidic Protein; Male; Neuroprotection; Organophosphates; Organothiophosphorus Compounds; Oximes; Piriform Cortex; Rats; Rats, Sprague-Dawley; Sarin | 2018 |
Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Electrocorticography; Female; Male; Midazolam; Nerve Agents; Nervous System Diseases; Neuroprotective Agents; Organothiophosphorus Compounds; Pregnancy; Rats; Rats, Sprague-Dawley; Sarin; Seizures; Status Epilepticus | 2019 |
Ocular surface histopathological insult following sarin and VX exposure and potential treatments in the rat model.
Topics: Acetylcholinesterase; Animals; Antidotes; Blinking; Chemical Warfare Agents; Cholinesterase Inhibitors; Cytoprotection; Dose-Response Relationship, Drug; Eye; GPI-Linked Proteins; Male; Miosis; Muscarinic Antagonists; Organothiophosphorus Compounds; Rats, Long-Evans; Sarin; Time Factors | 2019 |
Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; GPI-Linked Proteins; Humans; Kinetics; Nerve Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Protein Conformation; Sarin; Structure-Activity Relationship | 2020 |
A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds.
Topics: Antidotes; Bacterial Proteins; Caulobacteraceae; Drug Stability; Enzyme Stability; Hot Temperature; Mutation; Nerve Agents; Organophosphate Poisoning; Organophosphorus Compounds; Organothiophosphorus Compounds; Oxidation-Reduction; Phosphoric Triester Hydrolases; Protein Denaturation; Recombinant Proteins; Sarin; Soman | 2020 |
Detection of Chemical Weapon Nerve Agents in Bone by Liquid Chromatography-Mass Spectrometry.
Topics: Animals; Bone and Bones; Chemical Warfare Agents; Chromatography, Liquid; Humans; Limit of Detection; Nerve Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Swine | 2020 |
Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Disease Models, Animal; Female; Levetiracetam; Male; Organothiophosphorus Compounds; Phenytoin; Propofol; Rats, Sprague-Dawley; Sarin; Sex Factors; Status Epilepticus | 2020 |
Structural and kinetic evidence of aging after organophosphate inhibition of human Cathepsin A.
Topics: Acetylcholinesterase; Binding Sites; Cathepsin A; Cell Line; Chemical Warfare Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Gene Expression; GPI-Linked Proteins; HEK293 Cells; Humans; Isoflurophate; Kinetics; Models, Molecular; Organophosphorus Compounds; Organothiophosphorus Compounds; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Proteins; Sarin; Soman; Substrate Specificity; Time Factors | 2020 |
Sensitive Untargeted Screening of Nerve Agents and Their Degradation Products Using Liquid Chromatography-High Resolution Mass Spectrometry.
Topics: Chemical Warfare Agents; Chromatography, Liquid; Databases, Chemical; Mass Spectrometry; Organothiophosphorus Compounds; Sarin; Sensitivity and Specificity; Small Molecule Libraries; Soman | 2020 |
Phosphonylated tyrosine and lysine residues as biomarkers of local exposure of human hair to the organophosphorus nerve agents sarin and VX.
Topics: Biomarkers; Chemical Warfare Agents; Hair; Humans; Lysine; Nerve Agents; Organophosphorus Compounds; Sarin; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2023 |