vx has been researched along with pralidoxime in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, DR; Harris, LW; Lennox, WJ; Woodard, CL | 1 |
| Koplovitz, I; Stewart, JR | 1 |
| Eyer, P; Reiter, G; Szinicz, L; Worek, F | 1 |
| Kassa, J; Kuca, K | 1 |
| Newmark, J | 1 |
| Cabal, J; Hrabinova, M; Jun, D; Kassa, J; Kuca, K | 1 |
| Becker, G; Gutzeit, D; Kawan, A; Szinicz, L; Worek, F | 1 |
| Bajgar, J; Jun, D; Kuca, K | 1 |
| Antonijevic, B; Stojiljkovic, MP | 1 |
| Hrobak, PK | 1 |
| Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F | 1 |
| Clark, MG; Finneran, K; Hilmas, CJ; Poole, MJ; Williams, PT | 1 |
| Bennett, JP; Bennett, WS; Chambers, HW; Chambers, JE; Leach, CA; Meek, EC; Pringle, RB; Wills, RW | 1 |
| Arboléas, M; Calas, AG; Dias, J; Jean, L; Mercey, G; Nachon, F; Renard, PY; Rousseau, C; Touvrey-Loiodice, M | 1 |
| Babin, MC; Jett, DA; Platoff, GE; Snider, TH; Yeung, DT | 1 |
| Acharya, BN; Acharya, J; Bhalerao, U; Karade, HN; Raviraju, G; Valiveti, AK | 1 |
| Derat, E; Driant, T; Nachon, F; Ollivier, C; Renard, PY | 1 |
| Celmar Costa França, T; da Silva, JAV; Kuca, K; Nepovimova, E; Ramalho, TC | 1 |
| Chambers, JE; Meek, EC | 1 |
| Cornelissen, AS; Garcia, EE; Joosen, MJA; Laney, J; Raulli, RE | 1 |
3 review(s) available for vx and pralidoxime
| Article | Year |
|---|---|
Therapy for nerve agent poisoning.
Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman | 2004 |
Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.
Topics: Acetylcholinesterase; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Humans; Insecticides; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin; Trimedoxime | 2007 |
Central neuroprotection demonstrated by novel oxime countermeasures to nerve agent surrogates.
Topics: Acetylcholinesterase; Animals; Antidotes; GPI-Linked Proteins; Male; Nerve Agents; Neuroprotection; Organothiophosphorus Compounds; Pralidoxime Compounds; Rats; Sarin; United States | 2020 |
18 other study(ies) available for vx and pralidoxime
| Article | Year |
|---|---|
The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Male; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Soman | 1992 |
Treatment of nerve gas poisoning.
Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman | 1995 |
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms | 1994 |
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
Topics: Acetylcholinesterase; Algorithms; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rabbits; Rats; Sarin; Species Specificity | 2002 |
In vitro reactivation of acetylcholinesterase using the oxime K027.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2004 |
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2006 |
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
Topics: Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Half-Life; Kinetics; Models, Chemical; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Spectrophotometry, Ultraviolet | 2007 |
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime | 2007 |
Nerve agents: implications for anesthesia providers.
Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors | 2008 |
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2008 |
Galantamine is a novel post-exposure therapeutic against lethal VX challenge.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Erythrocytes; Galantamine; Guinea Pigs; Male; Muscle Fatigue; Muscle Tonus; Neurotoxicity Syndromes; Organothiophosphorus Compounds; Paralysis; Phrenic Nerve; Pralidoxime Compounds; Seizures; Time Factors | 2009 |
Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates.
Topics: Acetylcholinesterase; Animals; Antidotes; Behavior, Animal; Brain; Cholinesterase Inhibitors; Male; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyrrolidines; Rats; Rats, Sprague-Dawley; Seizures; Survival Analysis | 2016 |
An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice.
Topics: Acetylcholinesterase; Animals; Blood Chemical Analysis; Blood-Brain Barrier; Chemical Warfare Agents; Cholinesterase Reactivators; Erythrocytes; Half-Life; Humans; Injections, Intraperitoneal; Male; Mice; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Protective Agents; Pyridinium Compounds | 2017 |
Toxicity and median effective doses of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Lethal Dose 50; Male; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds; Time Factors | 2016 |
Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).
Topics: Acetamides; Aminopyridines; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Niacinamide; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin | 2016 |
On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach.
Topics: Acetylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Computer Simulation; Glutamic Acid; Histidine; Models, Chemical; Molecular Structure; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Protons; Quantum Theory; Serine | 2017 |
Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Structure-Activity Relationship | 2019 |
A delayed treatment model for the evaluation of scopolamine for VX nerve agent intoxication.
Topics: Animals; Atropine; Chemical Warfare Agents; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Guinea Pigs; Male; Midazolam; Nerve Agents; Organothiophosphorus Compounds; Pralidoxime Compounds; Scopolamine; Survival Rate; Time-to-Treatment | 2021 |