Page last updated: 2024-08-23

vx and obidoxime chloride

vx has been researched along with obidoxime chloride in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's0 (0.00)18.2507
2000's8 (50.00)29.6817
2010's6 (37.50)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Artursson, E; Bucht, G; Puu, G1
Eyer, P; Reiter, G; Szinicz, L; Worek, F1
Kassa, J; Kuca, K1
Cabal, J; Hrabinova, M; Jun, D; Kassa, J; Kuca, K1
Becker, G; Gutzeit, D; Kawan, A; Szinicz, L; Worek, F1
Bajgar, J; Jun, D; Kuca, K1
Antonijevic, B; Stojiljkovic, MP1
Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F1
Joosen, MJ; van der Schans, MJ; van Helden, HP1
Thiermann, H; von der Wellen, J; Wille, T; Worek, F1
Babin, MC; Jett, DA; Platoff, GE; Snider, TH; Yeung, DT1
Acharya, BN; Acharya, J; Bhalerao, U; Karade, HN; Raviraju, G; Valiveti, AK1
Bloch-Shilderman, E; Cohen, L; Egoz, I; Gez, R; Gutman, H; Nili, U; Rabinovitz, I; Yacov, G1
Celmar Costa França, T; da Silva, JAV; Kuca, K; Nepovimova, E; Ramalho, TC1
Barry, J; Bohnert, S; Cochrane, L; Cornelissen, AS; Joosen, MJA; Kentrop, J; Klaassen, SD; Savransky, V; van Groningen, T1
Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A1

Reviews

1 review(s) available for vx and obidoxime chloride

ArticleYear
Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.
    Clinical medicine & research, 2007, Volume: 5, Issue:1

    Topics: Acetylcholinesterase; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Humans; Insecticides; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin; Trimedoxime

2007

Other Studies

15 other study(ies) available for vx and obidoxime chloride

ArticleYear
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
    Biochemical pharmacology, 1986, May-01, Volume: 35, Issue:9

    Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism

1986
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
    Archives of toxicology, 2002, Volume: 76, Issue:9

    Topics: Acetylcholinesterase; Algorithms; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rabbits; Rats; Sarin; Species Specificity

2002
In vitro reactivation of acetylcholinesterase using the oxime K027.
    Veterinary and human toxicology, 2004, Volume: 46, Issue:1

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2004
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
    Journal of toxicology and environmental health. Part A, 2006, Volume: 69, Issue:15

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime

2006
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
    Archives of toxicology, 2007, Volume: 81, Issue:6

    Topics: Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Half-Life; Kinetics; Models, Chemical; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Spectrophotometry, Ultraviolet

2007
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
    Drug and chemical toxicology, 2007, Volume: 30, Issue:1

    Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime

2007
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
    Toxicology and applied pharmacology, 2008, Sep-01, Volume: 231, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment.
    Chemico-biological interactions, 2010, Oct-06, Volume: 188, Issue:1

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Diazepam; Guinea Pigs; Obidoxime Chloride; Organothiophosphorus Compounds; Skin

2010
Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6.
    Archives of toxicology, 2017, Volume: 91, Issue:3

    Topics: Acetylcholinesterase; Binding Sites; Blood Specimen Collection; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Erythrocytes; Freezing; Humans; Inactivation, Metabolic; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds

2017
Toxicity and median effective doses of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig.
    The Journal of toxicological sciences, 2016, Volume: 41, Issue:4

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Lethal Dose 50; Male; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds; Time Factors

2016
Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).
    Bioorganic & medicinal chemistry, 2016, 09-15, Volume: 24, Issue:18

    Topics: Acetamides; Aminopyridines; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Niacinamide; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin

2016
Repetitive antidotal treatment is crucial in eliminating eye pathology, respiratory toxicity and death following whole-body VX vapor exposure in freely moving rats.
    Archives of toxicology, 2019, Volume: 93, Issue:5

    Topics: Animals; Antidotes; Atropine; Benactyzine; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Administration Schedule; Drug Combinations; Environmental Exposure; Eye Diseases; Male; Obidoxime Chloride; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Trimedoxime

2019
Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach.
    Journal of enzyme inhibition and medicinal chemistry, 2019, Volume: 34, Issue:1

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Structure-Activity Relationship

2019
Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride co-formulation against VX in a guinea pig model.
    Regulatory toxicology and pharmacology : RTP, 2021, Volume: 119

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Drug Combinations; Guinea Pigs; Male; Muscarinic Antagonists; Obidoxime Chloride; Organothiophosphorus Compounds; Treatment Outcome

2021
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine

2008