vx has been researched along with asoxime chloride in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 8 (33.33) | 29.6817 |
| 2010's | 10 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A | 1 |
| Anderson, DR; Harris, LW; Lennox, WJ; Woodard, CL | 1 |
| Tanasijević, D | 1 |
| Artursson, E; Bucht, G; Puu, G | 1 |
| Kirchner, T; Szinicz, L; Worek, F | 1 |
| Koplovitz, I; Stewart, JR | 1 |
| Kassa, J; Vachek, J | 1 |
| Eyer, P; Reiter, G; Szinicz, L; Worek, F | 1 |
| Kassa, J; Kuca, K | 1 |
| Aurbek, N; Eyer, P; Szinicz, L; Thiermann, H; Worek, F | 1 |
| Cabal, J; Hrabinova, M; Jun, D; Kassa, J; Kuca, K | 1 |
| Becker, G; Gutzeit, D; Kawan, A; Szinicz, L; Worek, F | 1 |
| Bajgar, J; Jun, D; Kuca, K | 1 |
| Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F | 1 |
| Bajgar, J; Caisberger, F; Karasova, JZ; Kassa, J; Sepsova, V | 1 |
| Armstrong, SJ; Docx, CJ; Green, AC; Mumford, H; Price, ME; Tattersall, JE | 1 |
| Aas, P; Enger, S; Mariussen, E; Myhrer, T | 1 |
| Arboléas, M; Calas, AG; Dias, J; Jean, L; Mercey, G; Nachon, F; Renard, PY; Rousseau, C; Touvrey-Loiodice, M | 1 |
| Kovarik, Z; Maček Hrvat, N; Radić, Z; Taylor, P; Žunec, S | 1 |
| Thiermann, H; von der Wellen, J; Wille, T; Worek, F | 1 |
| C C França, T; Cuya, T; da Silva, JAV; Gonçalves, ADS; Kuca, K; Ramalho, TC | 1 |
| Armstrong, SJ; Cook, AR; Emery, E; Flint, D; Mann, T; Price, ME; Rice, H; Roughley, N; Stubbs, S; Tattersall, JEH; Whitmore, C | 1 |
| Emery, ER; Green, AC; Laws, TR; Mann, TM; McColm, RR; Perrott, RL; Price, ME; Rice, H; Tattersall, JEH; Whitmore, CL | 1 |
| Bae, SY; Bester, SM; Cheung, J; Guelta, MA; Height, JJ; Myslinski, J; Pegan, SD; Winemiller, MD | 1 |
24 other study(ies) available for vx and asoxime chloride
| Article | Year |
|---|---|
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine | 2008 |
The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Male; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Soman | 1992 |
[The effect of atropine, Hi-6 and diazepam on the levels and metabolism of monoamines in the brain of rats poisoned with VX].
Topics: Animals; Atropine; Caudate Nucleus; Cholinesterase Inhibitors; Diazepam; Neurotransmitter Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats | 1986 |
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism | 1986 |
Effect of atropine, HLö 7 and HI 6 on respiratory and circulatory function in guinea-pigs poisoned by O-ethyl S-[2-(diisopropylamino) ethyl] methylphosponothioate (VX).
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Combinations; Erythrocytes; Female; Guinea Pigs; Hemodynamics; Organothiophosphorus Compounds; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Respiration | 1994 |
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms | 1994 |
[The effect of parasympatholytics on the therapeutic effectiveness of the oxime HI-6 against organophosphorus compounds (Soman, substance VX, Fosdrin) in mice].
Topics: Animals; Antidotes; Atropine; Benactyzine; Biperiden; Cholinesterase Reactivators; Male; Mevinphos; Mice; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Parasympatholytics; Pyridinium Compounds; Soman | 1997 |
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
Topics: Acetylcholinesterase; Algorithms; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rabbits; Rats; Sarin; Species Specificity | 2002 |
In vitro reactivation of acetylcholinesterase using the oxime K027.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2004 |
Application of kinetic-based computer modelling to evaluate the efficacy of HI 6 in percutaneous VX poisoning.
Topics: Administration, Cutaneous; Algorithms; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Computer Simulation; Humans; Kinetics; Lethal Dose 50; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Species Specificity; Swine | 2006 |
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2006 |
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
Topics: Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Half-Life; Kinetics; Models, Chemical; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Spectrophotometry, Ultraviolet | 2007 |
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime | 2007 |
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2008 |
A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Lethal Dose 50; Male; Mice; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2011 |
Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Reactivators; Diazepam; Guinea Pigs; Humans; Injections, Intramuscular; Male; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds | 2013 |
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats.
Topics: Animals; Anticonvulsants; Antidotes; Body Weight; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Lethal Dose 50; Levetiracetam; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Piracetam; Procyclidine; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman | 2015 |
An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice.
Topics: Acetylcholinesterase; Animals; Blood Chemical Analysis; Blood-Brain Barrier; Chemical Warfare Agents; Cholinesterase Reactivators; Erythrocytes; Half-Life; Humans; Injections, Intraperitoneal; Male; Mice; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Protective Agents; Pyridinium Compounds | 2017 |
HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants.
Topics: Acetylcholinesterase; Animals; Binding Sites; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Kinetics; Male; Mice; Mutagenesis, Site-Directed; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Recombinant Proteins; Survival Rate | 2016 |
Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6.
Topics: Acetylcholinesterase; Binding Sites; Blood Specimen Collection; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Erythrocytes; Freezing; Humans; Inactivation, Metabolic; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds | 2017 |
The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study.
Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin | 2018 |
The efficacy of HI-6 DMS in a sustained infusion against percutaneous VX poisoning in the guinea-pig.
Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Infusions, Intravenous; Male; Muscarinic Antagonists; Nerve Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Survival Analysis | 2018 |
Bioscavenger is effective as a delayed therapeutic intervention following percutaneous VX poisoning in the guinea-pig.
Topics: Administration, Cutaneous; Animals; Antidotes; Atropine; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Reactivators; Cholinesterases; Dipeptides; Guinea Pigs; Male; Muscarinic Antagonists; Nerve Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Time-to-Treatment; Toxicokinetics | 2018 |
Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6.
Topics: Acetylcholinesterase; Binding Sites; Biocatalysis; Catalytic Domain; Cholinesterase Reactivators; Crystallography, X-Ray; Humans; Molecular Dynamics Simulation; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Recombinant Proteins; Stereoisomerism | 2018 |