Page last updated: 2024-08-23

vx and asoxime chloride

vx has been researched along with asoxime chloride in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.33)18.7374
1990's4 (16.67)18.2507
2000's8 (33.33)29.6817
2010's10 (41.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A1
Anderson, DR; Harris, LW; Lennox, WJ; Woodard, CL1
Tanasijević, D1
Artursson, E; Bucht, G; Puu, G1
Kirchner, T; Szinicz, L; Worek, F1
Koplovitz, I; Stewart, JR1
Kassa, J; Vachek, J1
Eyer, P; Reiter, G; Szinicz, L; Worek, F1
Kassa, J; Kuca, K1
Aurbek, N; Eyer, P; Szinicz, L; Thiermann, H; Worek, F1
Cabal, J; Hrabinova, M; Jun, D; Kassa, J; Kuca, K1
Becker, G; Gutzeit, D; Kawan, A; Szinicz, L; Worek, F1
Bajgar, J; Jun, D; Kuca, K1
Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F1
Bajgar, J; Caisberger, F; Karasova, JZ; Kassa, J; Sepsova, V1
Armstrong, SJ; Docx, CJ; Green, AC; Mumford, H; Price, ME; Tattersall, JE1
Aas, P; Enger, S; Mariussen, E; Myhrer, T1
Arboléas, M; Calas, AG; Dias, J; Jean, L; Mercey, G; Nachon, F; Renard, PY; Rousseau, C; Touvrey-Loiodice, M1
Kovarik, Z; Maček Hrvat, N; Radić, Z; Taylor, P; Žunec, S1
Thiermann, H; von der Wellen, J; Wille, T; Worek, F1
C C França, T; Cuya, T; da Silva, JAV; Gonçalves, ADS; Kuca, K; Ramalho, TC1
Armstrong, SJ; Cook, AR; Emery, E; Flint, D; Mann, T; Price, ME; Rice, H; Roughley, N; Stubbs, S; Tattersall, JEH; Whitmore, C1
Emery, ER; Green, AC; Laws, TR; Mann, TM; McColm, RR; Perrott, RL; Price, ME; Rice, H; Tattersall, JEH; Whitmore, CL1
Bae, SY; Bester, SM; Cheung, J; Guelta, MA; Height, JJ; Myslinski, J; Pegan, SD; Winemiller, MD1

Other Studies

24 other study(ies) available for vx and asoxime chloride

ArticleYear
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine

2008
The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats.
    Drug and chemical toxicology, 1992, Volume: 15, Issue:4

    Topics: Animals; Antidotes; Cholinesterase Inhibitors; Male; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Soman

1992
[The effect of atropine, Hi-6 and diazepam on the levels and metabolism of monoamines in the brain of rats poisoned with VX].
    Godisnjak Vojnomedicinske akademije = Annual of the Military Medical Academy, 1986, Volume: 28

    Topics: Animals; Atropine; Caudate Nucleus; Cholinesterase Inhibitors; Diazepam; Neurotransmitter Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats

1986
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
    Biochemical pharmacology, 1986, May-01, Volume: 35, Issue:9

    Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism

1986
Effect of atropine, HLö 7 and HI 6 on respiratory and circulatory function in guinea-pigs poisoned by O-ethyl S-[2-(diisopropylamino) ethyl] methylphosponothioate (VX).
    Pharmacology & toxicology, 1994, Volume: 75, Issue:5

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Combinations; Erythrocytes; Female; Guinea Pigs; Hemodynamics; Organothiophosphorus Compounds; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Respiration

1994
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
    Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms

1994
[The effect of parasympatholytics on the therapeutic effectiveness of the oxime HI-6 against organophosphorus compounds (Soman, substance VX, Fosdrin) in mice].
    Casopis lekaru ceskych, 1997, Feb-12, Volume: 136, Issue:4

    Topics: Animals; Antidotes; Atropine; Benactyzine; Biperiden; Cholinesterase Reactivators; Male; Mevinphos; Mice; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Parasympatholytics; Pyridinium Compounds; Soman

1997
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
    Archives of toxicology, 2002, Volume: 76, Issue:9

    Topics: Acetylcholinesterase; Algorithms; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rabbits; Rats; Sarin; Species Specificity

2002
In vitro reactivation of acetylcholinesterase using the oxime K027.
    Veterinary and human toxicology, 2004, Volume: 46, Issue:1

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2004
Application of kinetic-based computer modelling to evaluate the efficacy of HI 6 in percutaneous VX poisoning.
    Toxicology, 2006, Jul-05, Volume: 224, Issue:1-2

    Topics: Administration, Cutaneous; Algorithms; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Computer Simulation; Humans; Kinetics; Lethal Dose 50; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Species Specificity; Swine

2006
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
    Journal of toxicology and environmental health. Part A, 2006, Volume: 69, Issue:15

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime

2006
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
    Archives of toxicology, 2007, Volume: 81, Issue:6

    Topics: Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Half-Life; Kinetics; Models, Chemical; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Spectrophotometry, Ultraviolet

2007
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
    Drug and chemical toxicology, 2007, Volume: 30, Issue:1

    Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime

2007
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
    Toxicology and applied pharmacology, 2008, Sep-01, Volume: 231, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice.
    International journal of toxicology, 2011, Volume: 30, Issue:5

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Lethal Dose 50; Male; Mice; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime

2011
Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Reactivators; Diazepam; Guinea Pigs; Humans; Injections, Intramuscular; Male; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds

2013
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats.
    Neurotoxicology, 2015, Volume: 50

    Topics: Animals; Anticonvulsants; Antidotes; Body Weight; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Lethal Dose 50; Levetiracetam; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Piracetam; Procyclidine; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman

2015
An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice.
    Chemico-biological interactions, 2017, Apr-01, Volume: 267

    Topics: Acetylcholinesterase; Animals; Blood Chemical Analysis; Blood-Brain Barrier; Chemical Warfare Agents; Cholinesterase Reactivators; Erythrocytes; Half-Life; Humans; Injections, Intraperitoneal; Male; Mice; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Protective Agents; Pyridinium Compounds

2017
HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants.
    Chemico-biological interactions, 2016, Nov-25, Volume: 259, Issue:Pt B

    Topics: Acetylcholinesterase; Animals; Binding Sites; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Kinetics; Male; Mice; Mutagenesis, Site-Directed; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Recombinant Proteins; Survival Rate

2016
Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6.
    Archives of toxicology, 2017, Volume: 91, Issue:3

    Topics: Acetylcholinesterase; Binding Sites; Blood Specimen Collection; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Erythrocytes; Freezing; Humans; Inactivation, Metabolic; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds

2017
The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study.
    Journal of biomolecular structure & dynamics, 2018, Volume: 36, Issue:13

    Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin

2018
The efficacy of HI-6 DMS in a sustained infusion against percutaneous VX poisoning in the guinea-pig.
    Toxicology letters, 2018, Sep-01, Volume: 293

    Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Infusions, Intravenous; Male; Muscarinic Antagonists; Nerve Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Survival Analysis

2018
Bioscavenger is effective as a delayed therapeutic intervention following percutaneous VX poisoning in the guinea-pig.
    Toxicology letters, 2018, Sep-01, Volume: 293

    Topics: Administration, Cutaneous; Animals; Antidotes; Atropine; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Reactivators; Cholinesterases; Dipeptides; Guinea Pigs; Male; Muscarinic Antagonists; Nerve Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Time-to-Treatment; Toxicokinetics

2018
Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6.
    Chemical research in toxicology, 2018, 12-17, Volume: 31, Issue:12

    Topics: Acetylcholinesterase; Binding Sites; Biocatalysis; Catalytic Domain; Cholinesterase Reactivators; Crystallography, X-Ray; Humans; Molecular Dynamics Simulation; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Recombinant Proteins; Stereoisomerism

2018