Compounds > vx-745
Page last updated: 2024-09-05

vx-745 and scio-469

vx-745 has been researched along with scio-469 in 4 studies

Compound Research Comparison

Studies
(vx-745)		Trials
(vx-745)		Recent Studies (post-2010)
(vx-745)		Studies
(scio-469)		Trials
(scio-469)		Recent Studies (post-2010) (scio-469)
5813535415

Protein Interaction Comparison

ProteinTaxonomyvx-745 (IC50)scio-469 (IC50)
Aminopeptidase NSus scrofa (pig)0.01
Mitogen-activated protein kinase 11Homo sapiens (human)0.098
Mitogen-activated protein kinase 14Homo sapiens (human)0.032

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Goldstein, DM; Kuglstatter, A; Lou, Y; Soth, MJ1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Genovese, MC1
Azevedo, R; de Vlieg, J; Kazemier, B; Oubrie, A; Raaijmakers, H; van Zeeland, M1

Other Studies

4 other study(ies) available for vx-745 and scio-469

ArticleYear
Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
    Journal of medicinal chemistry, 2010, Mar-25, Volume: 53, Issue:6

    Topics: Arthritis, Rheumatoid; Chronic Disease; Clinical Trials, Phase II as Topic; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Indoles; Inflammatory Bowel Diseases; Models, Molecular; Molecular Structure; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; Protein Binding; Psoriasis; Pyridones; Pyrimidines; Treatment Outcome

2010
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Inhibition of p38: has the fat lady sung?
    Arthritis and rheumatism, 2009, Volume: 60, Issue:2

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Enzyme Inhibitors; Humans; Indoles; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; Pyrazoles; Pyridazines; Pyridones; Pyrimidines; Rheumatology

2009
X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors.
    Acta crystallographica. Section D, Biological crystallography, 2012, Volume: 68, Issue:Pt 8

    Topics: Adenosine Triphosphate; Benzamides; Catalytic Domain; Cloning, Molecular; Crystallization; Crystallography, X-Ray; Humans; Imidazoles; Indoles; Ligands; p38 Mitogen-Activated Protein Kinases; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Pyridazines; Pyridines; Pyrimidines; Structure-Activity Relationship; Thiazoles

2012