Page last updated: 2024-09-05

vx-745 and quinazolines

vx-745 has been researched along with quinazolines in 3 studies

Compound Research Comparison

Studies (vx-745)	Trials (vx-745)	Recent Studies (post-2010) (vx-745)	Studies (quinazolines)	Trials (quinazolines)	Recent Studies (post-2010) (quinazolines)
58	1	35	19,235	2,417	8,835

Protein Interaction Comparison

Protein	Taxonomy	vx-745 (IC50)	quinazolines (IC50)
Epidermal growth factor receptor	Homo sapiens (human)		0.027

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Becker, JW; Cameron, PM; Fitzgerald, CE; O'Keefe, SJ; Patel, SB; Pikounis, VB; Scapin, G; Zaller, D	1
Laufer, S; Wagner, G	1
Natarajan, SR; O'Keefe, SJ; O'Neill, EA; Thompson, JE; Wisnoski, DD	1

Reviews

1 review(s) available for vx-745 and quinazolines

Article	Year
Small molecular anti-cytokine agents. Medicinal research reviews, 2006, Volume: 26, Issue:1 Topics: ADAM Proteins; ADAM17 Protein; Animals; Caspase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytokines; Humans; Hydroxamic Acids; Imidazoles; Matrix Metalloproteinase Inhibitors; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridazines; Pyridines; Pyrimidines; Quinazolines; Structure-Activity Relationship; Succinates; Thiazoles; Tumor Necrosis Factor-alpha; Urea	2006

Article

Year

Small molecular anti-cytokine agents.

Medicinal research reviews, 2006, Volume: 26, Issue:1

Topics: ADAM Proteins; ADAM17 Protein; Animals; Caspase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytokines; Humans; Hydroxamic Acids; Imidazoles; Matrix Metalloproteinase Inhibitors; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridazines; Pyridines; Pyrimidines; Quinazolines; Structure-Activity Relationship; Succinates; Thiazoles; Tumor Necrosis Factor-alpha; Urea

2006

Other Studies

2 other study(ies) available for vx-745 and quinazolines

Article	Year
Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity. Nature structural biology, 2003, Volume: 10, Issue:9 Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Enzyme Inhibitors; Glycine; Imidazoles; Inhibitory Concentration 50; Kinetics; Mice; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinases; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutation; Peptides; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Pyridazines; Pyridines; Pyrimidines; Quinazolines; Sequence Homology, Amino Acid	2003
p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones. Bioorganic & medicinal chemistry letters, 2006, Aug-15, Volume: 16, Issue:16 Topics: Chemistry, Pharmaceutical; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Models, Chemical; p38 Mitogen-Activated Protein Kinases; Pyridazines; Pyridines; Pyrimidines; Pyrimidinones; Quinazolines; Structure-Activity Relationship	2006

Article

Year

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.

Nature structural biology, 2003, Volume: 10, Issue:9

Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Enzyme Inhibitors; Glycine; Imidazoles; Inhibitory Concentration 50; Kinetics; Mice; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinases; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutation; Peptides; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Pyridazines; Pyridines; Pyrimidines; Quinazolines; Sequence Homology, Amino Acid

2003

p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones.

Bioorganic & medicinal chemistry letters, 2006, Aug-15, Volume: 16, Issue:16

Topics: Chemistry, Pharmaceutical; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Models, Chemical; p38 Mitogen-Activated Protein Kinases; Pyridazines; Pyridines; Pyrimidines; Pyrimidinones; Quinazolines; Structure-Activity Relationship

2006