vx-745 has been researched along with perphenazine in 4 studies
| Studies (vx-745) | Trials (vx-745) | Recent Studies (post-2010) (vx-745) | Studies (perphenazine) | Trials (perphenazine) | Recent Studies (post-2010) (perphenazine) |
|---|---|---|---|---|---|
| 58 | 1 | 35 | 1,666 | 243 | 128 |
| Protein | Taxonomy | vx-745 (IC50) | perphenazine (IC50) |
|---|---|---|---|
| ubiquitin-conjugating enzyme E2 N | Homo sapiens (human) | 14.79 | |
| Aldehyde oxidase 1 | Mus musculus (house mouse) | 6.1 | |
| Retinal dehydrogenase 1 | Homo sapiens (human) | 0.5242 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 4.216 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.0003 | |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | 1.4 | |
| Aldehyde oxidase | Homo sapiens (human) | 0.033 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 4.216 | |
| Aldehyde oxidase 1 | Macaca fascicularis (crab-eating macaque) | 3.6 | |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | 4.216 | |
| Aldehyde oxidase 1 | Rattus norvegicus (Norway rat) | 0.74 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR | 1 |
| Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR | 1 |
| Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR | 1 |
4 other study(ies) available for vx-745 and perphenazine
| Article | Year |
|---|---|
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Highly predictive and interpretable models for PAMPA permeability.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine | 2017 |
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility | 2019 |
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States | 2020 |